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Dynamic Aspects (dynamic + aspect)
Selected AbstractsForeword Preface to the JMR Special Issue on ,Dynamic Aspects of Molecular Recognition'JOURNAL OF MOLECULAR RECOGNITION, Issue 2 2010Olivier Michielin No abstract is available for this article. [source] Dynamic Aspects Of Platelet Adhesion Under FlowCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 5-6 2001Sacha M Dopheide SUMMARY 1. Cell,cell and cell,matrix adhesive interactions are critical for a wide range of physiological processes, including embryogenesis, inflammation, immunity and haemostasis. 2. The ability of circulating blood cells, such as platelets and leucocytes, to adhere to sites of vascular injury is complicated by the presence of blood flow, which imposes hydrodynamic forces on adhesion contacts. 3. To overcome this problem, platelets and leucocytes have evolved specific adhesion receptors with unique biomechanical properties that enable these cells to adhere to the vessel wall under flow conditions. 4. Platelet adhesion in the normal circulation appears to be a multiple-step process involving an initial reversible interaction between the platelet adhesion receptor glycoprotein Ib-IX-V and the vascular adhesion protein von Willebrand factor. Once tethered to the vessel wall, platelets form irreversible adhesion contacts through the binding of one or more platelet integrins to specific subendothelial matrix proteins. 5. There is now a wealth of evidence demonstrating that these receptors not only mediate platelet adhesion, but also transduce signals leading to platelet activation. 6. In the present review, we will briefly discuss the current understanding of the specific roles of individual platelet receptors in supporting the haemostatic function of platelets and discuss mechanisms by which these receptors induce platelet activation. [source] Structures of the Chromophore Binding Sites in BLUF Domains as Studied by Molecular Dynamics and Quantum Chemical Calculations,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 4 2008Kazuya Obanayama BLUF (blue-light sensing using FAD) domains constitute a new family of flavin-based blue light photoreceptors. The photocycle of BLUF is unique in the sense that a few hydrogen bond rearrangements are accompanied by only slight structural changes in the bound chromophore. The hydrogen bond rearrangements upon illumination have been inferred from spectral changes in the chromophore: ,10 nm redshift of the absorption maximum and ,16 cm,1 downshift of the C4=O stretching frequency. However, the exact features of the hydrogen bond network around the active site are still the subject of some controversy. In particular, the orientation of a conserved Gln (Gln63 in AppA) is presently one of the most questioned topics in the field. Here we perform molecular dynamics simulations for the wild-type AppA, AppA1-124C20S, BlrB and T110078 and furthermore quantum chemical calculations to investigate their spectroscopic properties in the dark and signaling states. On the basis of these results, we reveal the dynamic aspect of hydrogen bonding networks at the active site and propose theoretically reasonable models for the dark and signaling states of the BLUF domains. [source] What causes the extremely heavy rainfall in Taiwan during Typhoon Morakot (2009)?ATMOSPHERIC SCIENCE LETTERS, Issue 1 2010Dr Xuyang Ge Abstract Despite its category-2 intensity only, Typhoon (tropical cyclone in the Western Pacific) Morakot produced a record-breaking rainfall in Taiwan. A cloud-resolving model is used to simulate this extreme rainfall event and understand the dynamic aspect under this event. Due to the interaction between Morakot and a monsoon system, a peripheral gale force monsoon surge appears to the south of Taiwan. The monsoon surge remains even in a sensitivity experiment in which Taiwan terrain is reduced. However, the rainfall amount in Taiwan is greatly reduced without high topography over Taiwan, suggesting the important role the local topography plays in producing heavy rainfall. The overall numerical results indicate that it is the interaction among the typhoon, monsoon system, and local terrain that led to this extreme event. Copyright © 2010 Royal Meteorological Society [source] Prospective cohort study comparing sequential organ failure assessment and acute physiology, age, chronic health evaluation III scoring systems for hospital mortality prediction in critically ill cirrhotic patientsINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 2 2006Y-C Chen Summary The aim of the study was to evaluate the usefulness of sequential organ failure assessment (SOFA) and acute physiology, age, chronic health evaluation III (APACHE III) scoring systems obtained on the first day of intensive care unit (ICU) admission in predicting hospital mortality in critically ill cirrhotic patients. The study enrolled 102 cirrhotic patients consecutively admitted to ICU during a 1-year period. Twenty-five demographic, clinical and laboratory variables were analysed as predicators of survival. Information considered necessary to calculate the Child,Pugh, SOFA and APACHE III scores on the first day of ICU admission was also gathered. Overall hospital mortality was 68.6%. Multiple logistic regression analysis revealed that mean arterial pressure, SOFA and APACHE III scores were significantly related to prognosis. Goodness-of-fit was good for the SOFA and APACHE III models. Both predictive models displayed a similar degree of the best Youden index (0.68) and overall correctness (84%) of prediction. The SOFA and APACHE III models displayed good areas under the receiver,operating characteristic curve (0.917 ± 0.028 and 0.912 ± 0.029, respectively). Finally, a strong and significant positive correlation exists between SOFA and APACHE III scores for individual patients (r2 = 0.628, p < 0.001). This investigation confirms the grave prognosis for cirrhotic patients admitted to ICU. Both SOFA and APACHE III scores are excellent tools to predict the hospital mortality in critically ill cirrhotic patients. The overall predictive accuracy of SOFA and APACHE III is superior to that of Child,Pugh system. The role of these scoring systems in describing the dynamic aspects of clinical courses and allocating ICU resources needs to be clarified. [source] An Extension of the Structural Change Model to International Economic RelationsMETROECONOMICA, Issue 4 2003Ricardo Azevedo Araujo ABSTRACT In this paper Pasinetti's model of structural economic dynamics (1981) is extended to consider international economic relations. Conditions for full employment, full expenditure of income and equilibrium of the trade balance are established for an open economy that requires capital goods to produce final commodities. Analytical results concerning the benefits from free trade and international learning are formally studied. In addition, static and dynamic aspects of the ,principle of comparative cost advantage' are analysed considering the determinants of the specialization level. [source] Ordnungspolitik auf illegalen Märkten: Der Drogen- und WaffenmarktPERSPEKTIVEN DER WIRTSCHAFTSPOLITIK, Issue 1 2002Hanno Beck In this paper, the economic structure of illegal markets with special reference to the markets for illegal drugs and arms is analyzed. Analytical tools of System Dynamics are employed to emphasize the dynamic aspects of these markets. The results of our analysis enable us to evaluate state intervention in the illegal markets for drugs and arms. It seems possible to mitigate the drugs problem by supplying drugs to heavily addicted people on the basis of health care measures. However, a similar policy seems not to exist for the illegal arms trade. This shows that each illegal market requires a deeper understanding before it can be fought effectively. [source] Sustainable governance of natural resources and institutional change,an analytical frameworkPUBLIC ADMINISTRATION & DEVELOPMENT, Issue 2 2007Anke Fischer Abstract This article presents a conceptual framework for analysing the governance of natural resource use, as governance is often the primary issue when natural resources are overexploited and degraded. It addresses both spontaneous and active governance, including institutional change induced by development co-operation. Drawing on existing frameworks of institutional analysis, fundamental modifications are presented to adapt the concept to the context of international co-operation, and to include dynamic aspects of institutional change as well as multiple actor interactions. Tested in several case studies, the framework was found suitable and relevant for use in project planning and evaluation, as well as for comparing governance issues across cases in a conceptually rigorous way. Copyright © 2007 John Wiley & Sons, Ltd. [source] Time-series integrated "omic" analyses to elucidate short-term stress-induced responses in plant liquid cultures,BIOTECHNOLOGY & BIOENGINEERING, Issue 1 2009Bhaskar Dutta Abstract The research that aims at furthering our understanding of plant primary metabolism has intensified during the last decade. The presented study validated a systems biology methodological framework for the analysis of stress-induced molecular interaction networks in the context of plant primary metabolism, as these are expressed during the first hours of the stress treatment. The framework involves the application of time-series integrated full-genome transcriptomic and polar metabolomic analyses on plant liquid cultures. The latter were selected as the model system for this type of analysis, because they provide a well-controlled growth environment, ensuring that the observed plant response is due only to the applied perturbation. An enhanced gas chromatography,mass spectrometry (GC,MS) metabolomic data correction strategy and a new algorithm for the significance analysis of time-series "omic" data are used to extract information about the plant's transcriptional and metabolic response to the applied stress from the acquired datasets; in this article, it is the first time that these are applied for the analysis of a large biological dataset from a complex eukaryotic system. The case-study involved Arabidopsis thaliana liquid cultures subjected for 30 h to elevated (1%) CO2 stress. The advantages and validity of the methodological framework are discussed in the context of the known A. thaliana or plant, in general, physiology under the particular stress. Of note, the ability of the methodology to capture dynamic aspects of the observed molecular response allowed for 9 and 24 h of treatment to be indicated as corresponding to shifts in both the transcriptional and metabolic activity; analysis of the pathways through which these activity changes are manifested provides insight to regulatory processes. Biotechnol. Bioeng. 2009;102: 264,279. © 2008 Wiley Periodicals, Inc. [source] BRIEF PSYCHOANALYTIC PSYCHOTHERAPY: THE IMPACT OF ITS FUNDAMENTALS ON THE THERAPEUTIC PROCESSBRITISH JOURNAL OF PSYCHOTHERAPY, Issue 2 2001Ilana Laor ABSTRACT By identifying the three fundamentals of brief psychoanalytic psychotherapy , (1) time limit, (2) therapeutic focus, (3) therapist's activity , this type of therapy is established as a distinct therapeutic modality with distinct ,active containing'. The way this ,custom-tailored structure' may be adapted to the patient and used to reflect and intensify dynamic aspects of the treatment's focus is demonstrated through clinical material. [source] | ||||||||||||||||