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Cyclooxygenase-2 Inhibitors (cyclooxygenase-2 + inhibitor)
Selected AbstractsA New Potential Cyclooxygenase-2 Inhibitor, Pyridinic Analogue of NimesulideCHEMINFORM, Issue 17 2006Catherine Michaux Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Design, Synthesis, and Biological Evaluation of 1,5-Diaryl-1,2,4-triazole Derivatives as Selective Cyclooxygenase-2 InhibitorsARCHIV DER PHARMAZIE, Issue 9 2010Bo Jiang Abstract A series of 1,5-diaryl-1,2,4-triazole derivatives were synthesized and evaluated as cyclooxygenase-2 (COX-2) inhibitors. The results of the preliminary biological assays in vivo showed that eight compounds 5b, 6b, 6c, 7c, 8b, 8d, 9c, and 9d have potent anti-inflammatory activity (P,<,0.01), while compounds 6b, 6c, and 9c exhibit marked potency. Compound 6c was then selected for further investigation. In the COX inhibition assay in vitro, compound 6c was identified as a potent and selective inhibitor of COX-2 (COX-2 IC50,=,0.37,µM; SI,=,0.018), being equipotent to celecoxib (COX-2 IC50,=,0.26,µM; SI,=,0.015). In a rat carrageenan-induced paw edema assay, 6c exhibited moderate anti-inflammatory activity (35% inhibition of inflammation) at 2,h after administration of 15,mg/kg as an oral dose. A docking study also revealed that compound 6c binds in the active site of COX-2 in a similar mode to that of the known selective COX-2 inhibitor SC-558. [source] Rational Design of 6-Methylsulfonylindoles as Selective Cyclooxygenase-2 Inhibitors.CHEMINFORM, Issue 52 2004Jeffrey A. Campbell Abstract For Abstract see ChemInform Abstract in Full Text. [source] Conformationally Restricted 3,4-Diarylfuranones (2,3a,4,5-Tetrahydronaphthofuranones) as Selective Cyclooxygenase-2 Inhibitors.CHEMINFORM, Issue 37 2003Manojit Pal Abstract For Abstract see ChemInform Abstract in Full Text. [source] The safety of the perioperative administration of Cyclooxygenase-2 inhibitors for post-surgical painACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 3 2005S. S. Reuben MD No abstract is available for this article. [source] | ||||||||||