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Cyclic Amines (cyclic + amine)
Selected AbstractsChemInform Abstract: ,-Arylation of Cyclic Amines by Aryl Transfer in Lithiated Ureas.CHEMINFORM, Issue 26 2009Renaud Bach Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: High Regioselectivity in Electrochemical ,-Methoxylation of N-Protected Cyclic Amines.CHEMINFORM, Issue 41 2008Samuel S. Libendi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Sequential Addition Reaction of Lithium Acetylides and Grignard Reagents to Thioiminium Salts from Thiolactams Leading to 2,2-Disubstituted Cyclic Amines.CHEMINFORM, Issue 41 2006Toshiaki Murai Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Double Reduction of Cyclic Aromatic Sulfonamides: A Novel Method for the Synthesis of 2- and 3-Aryl-Substituted Cyclic Amines.CHEMINFORM, Issue 18 2005Paul Evans Abstract For Abstract see ChemInform Abstract in Full Text. [source] Cp*Ir Complex-Catalyzed N-Heterocyclization of Primary Amines with Diols: A New Catalytic System for Environmentally Benign Synthesis of Cyclic Amines.CHEMINFORM, Issue 4 2005Ken-ichi Fujita Abstract For Abstract see ChemInform Abstract in Full Text. [source] Electrochemical Deallylation of ,-Allyl Cyclic Amines and Synthesis of Optically Active Quaternary Cyclic Amino AcidsCHEMISTRY - A EUROPEAN JOURNAL, Issue 13 2010Peter Abstract Electrochemical oxidation of ,-allylated and ,-benzylated N -acylated cyclic amines by using a graphite anode easily affords the corresponding ,-methoxylated products with up to 76,% yield. Ease of oxidation was affected by the type of electrode, the size of cyclic amine, and the nature of the protecting group. This method was successfully applied to the synthesis of optically active N -acylated ,-alkyl-,-amino acid esters with up to 99,%,ee. [source] Synthesis and in-vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cellsJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 8 2009Irene Banti Abstract Objectives The aim of the study was to evaluate the antitumour effect in vitro of newly synthesized 7-substituted 2,3-dihydro-1,8-naphthyridines. Methods Characterization tools included cell viability assay, caspase 3/7 induction, DNA fragmentation, fibroblast growth factor type 1 receptor kinase inhibition, and in-vitro antiangiogenic analysis. Key findings Treatment of MIA PaCa-2 human pancreatic cancer cells with test compounds showed time- and concentration-dependent cytotoxicity with IC50 values in the micromolar range. Compounds with an aminoalkyl or a diaminoalkyl side chain at the 7-position exhibited remarkable cytotoxicity, whereas the presence of a methyl group or a cyclic amine in the same position led to a significant decrease in their biological activity. Cytotoxicity screening demonstrated that the most active was compound 11 (mean 50% inhibition of cell proliferation (IC50) 11 ,M). This compound had an in-vitro antitumour efficacy superior to 5-fluorouracil (the lowest cell viability value after treatment (Emax) 0.2% and 19%, respectively) and proved to be less toxic than 5-fluorouracil against non-cancerous human oral epithelial cells. In addition, compound 11 induced apoptosis in MIA PaCa-2 cells and it was able to promote antiangiogenic effects in vitro. Finally, its cytotoxicity was enhanced in pancreatic cancer cells stimulated with fibroblast growth factor, while no substantial effect was observed on human bronchial smooth muscle cells stimulated with the same growth factor. Conclusions These findings suggest that 1,8-naphthyridine derivatives are a promising class of compounds in cancer research. In particular, the antitumour activity of compound 11 is worth further investigation. [source] Electrochemical Deallylation of ,-Allyl Cyclic Amines and Synthesis of Optically Active Quaternary Cyclic Amino AcidsCHEMISTRY - A EUROPEAN JOURNAL, Issue 13 2010Peter Abstract Electrochemical oxidation of ,-allylated and ,-benzylated N -acylated cyclic amines by using a graphite anode easily affords the corresponding ,-methoxylated products with up to 76,% yield. Ease of oxidation was affected by the type of electrode, the size of cyclic amine, and the nature of the protecting group. This method was successfully applied to the synthesis of optically active N -acylated ,-alkyl-,-amino acid esters with up to 99,%,ee. [source] Yttrium(III)-Catalyzed Intramolecular Alkyne HydroaminationsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2006Hyunseok Kim Abstract The neutral Y(III) complex 4 has been shown to be an effective precatalyst for intramolecular alkyne hydroaminations that provide cyclic amines in good to excellent yields. [source] Azetidine, pyrrolidine and hexamethyleneimine at 170,KACTA CRYSTALLOGRAPHICA SECTION C, Issue 10 2008Andrew D. Bond The crystal structures of the cyclic amines azetidine (C3H7N), pyrrolidine (C4H9N) and hexamethyleneimine (homopiperidine, C6H13N), of the series (CH2)nNH, with n = 3, 4 and 6, respectively, have been determined at 170,K, following in situ crystallization from the melt. These structures provide crystallographic data to complete the homologous series of cyclic amines (CH2)nNH, for n = 2,6. Azetidine and pyrrolidine contain chains propagating along 21 screw axes, in which the molecules are linked by co-operative N,H...N hydrogen bonds. Azetidine has two molecules in its asymmetric unit, while pyrrolidine has only one. Hexamethyleneimine contains tetrameric hydrogen-bonded rings formed about crystallographic inversion centres, with two molecules in its asymmetric unit. The observation of crystallographically distinct molecules in the hydrogen-bonded chains of azetidine and cyclic hydrogen-bonded motifs in hexamethyleneimine is consistent with expectations derived from comparison with monoalcohols forming chains or rings by co-operative O,H...O hydrogen bonds. The next member of the cyclic amine series, heptamethyleneimine, forms a cubic plastic phase on cooling from the melt. [source] Electrochemical Deallylation of ,-Allyl Cyclic Amines and Synthesis of Optically Active Quaternary Cyclic Amino AcidsCHEMISTRY - A EUROPEAN JOURNAL, Issue 13 2010Peter Abstract Electrochemical oxidation of ,-allylated and ,-benzylated N -acylated cyclic amines by using a graphite anode easily affords the corresponding ,-methoxylated products with up to 76,% yield. Ease of oxidation was affected by the type of electrode, the size of cyclic amine, and the nature of the protecting group. This method was successfully applied to the synthesis of optically active N -acylated ,-alkyl-,-amino acid esters with up to 99,%,ee. [source] | ||||||||||