Current Relevance (current + relevance)

Distribution by Scientific Domains

Selected Abstracts

Comparison of Quantitative T-Wave Alternans Profiles of Healthy Subjects and ICD Patients

B.Eng., Euler De Vilhena Garcia Ph.D., M.Sc.
Background: Current relevance of T-wave alternans is based on its association with electrical disorder and elevated cardiac risk. Quantitative reports would improve understanding on TWA augmentation mechanisms during mental stress or prior to tachyarrhythmias. However, little information is available about quantitative TWA values in clinical populations. This study aims to create and compare TWA profiles of healthy subjects and ICD patients, evaluated on treadmill stress protocols. Methods: Apparently healthy subjects, not in use of any medication were recruited. All eligible ICD patients were capable of performing an attenuated stress test. TWA analysis was performed during a 15-lead treadmill test. The derived comparative profile consisted of TWA amplitude and its associated heart rate, at rest (baseline) and at peak TWA value. Chi-square or Mann-Whitney tests were used with p values , 0.05. Discriminatory performance was evaluated by a binary logistic regression model. Results: 31 healthy subjects (8F, 23M) and 32 ICD patients (10F, 22M) were different on baseline TWA (1 2 ,V; 8 9 ,V; p < 0.001) and peak TWA values (26 13 ,V; 37 20 ,V; p = 0,009) as well as on baseline TWA heart rate (79 10 bpm; 67 15 bpm; p < 0.001) and peak TWA heart rate (118 8 bpm; 90 17 bpm; p < 0.001). The logistic model yielded sensitivity and specificity values of 88.9% and 92.9%, respectively. Conclusions: Healthy subjects and ICD patients have distinct TWA profiles. The new TWA profile representation (in amplitude-heart rate pairs) may help comparison among different research protocols. [source]

Photopatch testing , a retrospective review using the 1 day and 2 day irradiation protocols

R. J. Batchelor
Photopatch testing is indicated in the investigation of patients with eczematous eruptions, affecting mainly light-exposed sites and in those who give a history of worsening of their condition with sun exposure. 3 different protocols are described by the British Photodermatology Group (Br J Dermatol 1997:136:371,376), 1 of which includes irradiation of allergens 1 day after application and 2 using irradiation of allergens 2 days after application. There is no evidence for superiority of any of these protocols. We reviewed the records of all patients who underwent photopatch testing in Leeds over a 50-month period, who had had the allergens applied in triplicate with 1 set irradiated after 1 day occlusion and another after 2 days. The control was occluded for 2 days. Readings were performed at 2 days and 4 days. 15 of 74 patients photopatch tested during this period had 49 positive results between them. 43 of these were felt to be of current relevance to their clinical problem. 34 of the positive results were indicative of photoallergy. Additional photoallergic reactions were detected following 2 days occlusion and irradiation compared with 1 day occlusion (16 versus 5). In conclusion, our case series suggests that 2 days occlusion before irradiation of allergens is more sensitive at detecting photoallergy. [source]

FS01.2 Contact dermatitis to disperse blue 106 in Portugal

Francisco M Brandao
Disperse blue 106 is one of the most important allergenic textile dyes. We reviewed all the patients that proved to be allergic to this dye, in 10 contact clinics, in Portugal, from 01/2000 to 06/2003. In the first 2 years disperse blue 106 was only tested in suspected cases, while in 2002/2003 it was routinely tested in our standard series. A total of 8957 patients (2797M + 6160F) were tested; fifty five patients (17M + 38F)(0.6%) were allergic to the dye, with a significant difference in incidence between the 2 periods (0.2 to 0.9%); a current relevance was found in 38 (69%) patients. In 5 patients the dermatitis was considered occupational. The main localizations were the axillae (25p), the antecubital fossae and the face (13p each), the neck (11p), the feet (8p), the hands and then trunk (7p each). Thirty six out of 44 patients (80%) that were tested with disperse blue 124 were allergic to this dye. Simultaneous reactions to PPDA and to fragrance mix were observed in 12 and 11 patients, respectively. Allergy to other dyes was found in 15 patients. Blouses and skirts were the main offending garments that induced contact allergy. Although both disperse blue 106 and 124 have been reported as frequent sensitizers, it proved not to be such an important allergen in Portugal. However, if tested routinely it can pick up some unexpected relevant allergic patients. [source]

Experience, change and vulnerability: consumer education for older people revisited

Phil Lyon
Abstract Everyday consumer transactions have the same potential for unexpected consequence whatever the age of the consumers involved. Young and old alike can find that products and services fail to live up to performance claims and that they are left with problems not easily resolved, or costs that are difficult to recover. While not overlooking consumer heterogeneity , especially on the basis of age , older consumers are arguably distinguishable in terms of the social and financial context in which they make decisions and attempt to redress problems. In 1988, attention was drawn to the need for consumer education to look beyond generic objectives to the specific situation of older people and their transactions. More than a decade later, in an allegedly consumer-oriented society, the issue is revisited here to assess the argument's current relevance. Despite the increased availability of information for decisions and consumer protection, difficulties persist in the way information is presented or accessed. Chameleon-like, old problems become manifest in new unfamiliar ways and invalidate experience. Consumer education today is as important as it was in 1988. Arguably, technological change means that the need for a better understanding of dangers, rights and redress procedures is greater than ever and the needs of older people in increasingly complex private and public sector transaction environments are all the more pressing. However, a fundamental revision of the way we approach the design of products, services and environments is needed to improve prospects for older consumers. [source]

Allergic contact dermatitis in 136 children patch tested between 2000 and 2006

L. Mark Hammonds MD
Background, Allergic contact dermatitis is often under-recognized in the pediatric population but it may affect greater than 20% of this age group. Methods, We conducted a retrospective review of the Mayo Rochester, Jacksonville and Arizona patch test database of all children 18 or younger over a 7-year period (January 1, 2000,December 31, 2006). Results, One-hundred thirty-six children were patch tested from age 3 to 18. Females constituted 66% of those tested and males 34%. Eighty percent of the children were equally distributed between age groups 11,15 and 16,18, with the remainder being 10 years or younger. Sixty-one percent of the children tested positive to at least one allergen. Fifty-three percent of these reactions were deemed to be of current relevance, 31% questionable relevance, 5% past relevance, and 10% not relevant. Males younger than 10 were most likely to have a positive patch test. However, the percent of positive tests in males decreased with increasing age. Females younger than age 10 were less likely to have a positive test than older females. The most common allergens were nickel, cobalt, gold, and thimerosal. Conclusion, In children suspected to have allergic contact dermatitis, 61% were confirmed to have a positive reaction to at least one allergen. The utility of patch testing children whose clinical presentation is suggestive for allergic contact dermatitis is high. [source]

Network Updating and Exploratory Learning Environment*

Mooweon Rhee
abstract This paper examines how the current relevance of social capital derived from a task-advice network affects an actor's exploratory learning environment. Building on Burt's (1992) structural holes hypothesis that a large, sparse task advice network enhances an actor's exploratory learning environment, I propose that such effects hold only when the direct and indirect network ties are composed of current network contacts (ones that have been updated since the last change in positions of an actor). Analyses of data from a sample of 230 salaried employees of a high-technology manufacturing corporation support my arguments. In addition to the focus of social capital research on network structure, therefore, this study emphasizes the time-contingent value of social capital. [source]


The question of the relation between Judaism and natural law is important both for scholars and for reflective persons with an interest in the grounds of Jewish moral thought. There is a rich history of natural law theorizing that has had considerable influence, and there has been a revival of natural law theorizing in the contemporary period. The topic of the present discussion is of more than historical interest; it is a live question of real, current relevance. [source]