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Current Directions (current + direction)

Distribution by Scientific Domains

Psychology	57%

Selected Abstracts

Current Directions in Hemochromatosis Research: Towards an Understanding of the Role of Iron Overload and the HFE Gene Mutations in the Development of Clinical Disease

NUTRITION REVIEWS, Issue 1 2003
Article first published online: 16 SEP 200
Since the discovery of a candidate gene (HFE) thought to be involved in the development of hereditary hemochromatosis, there has been much interest in the potential use of genetic testing as a screening tool for the disease in the general population. However, a recent study suggests that less than 1% of subjects who are homozygous for the gene mutations will go on to develop the full-blown disease of hereditary hemochromatosis, historically termed "bronzed diabetes." The study also suggests that homozygotes have no higher risk of mortality or of any clinically significant morbidity than normal control subjects. This conclusion contradicts earlier findings that linked iron overload and HFE mutations to a number of devastating diseases, including cardiovascular disease, diabetes, and cancer. [source]

Current Directions in Videoconferencing Tele-Mental Health Research

CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 3 2009
Lisa K. Richardson
The provision of mental health services via videoconferencing tele-mental health has become an increasingly routine component of mental health service delivery throughout the world. Emphasizing the research literature since 2003, we examine (a) the extent to which the field of tele-mental health has advanced the research agenda previously suggested and (b) implications for tele-mental healthcare delivery for special clinical populations. Previous findings have demonstrated that tele-mental health services are satisfactory to patients, improve outcomes, and are probably cost effective. In the very small number of randomized controlled studies that have been conducted to date, tele-mental health has demonstrated equivalent efficacy compared to face-to-face care in a variety of clinical settings and with specific patient populations. However, methodologically flawed or limited research studies are the norm, and thus the research agenda for tele-mental health has not been fully maximized. Implications for future research and practice are discussed. [source]

Current directions at the juncture of clinical and cognitive science: Introduction

APPLIED COGNITIVE PSYCHOLOGY, Issue 3 2010
Paula T. Hertel
No abstract is available for this article. [source]

Current directions at the juncture of clinical and cognitive science: A commentary on the special issue

APPLIED COGNITIVE PSYCHOLOGY, Issue 3 2010
Colin MacLeod
The 12 experimental papers presented in this special issue brilliantly illustrate the creative and exciting ways in which the exchange of theoretical concepts and experimental methodologies, between cognitive and clinical science, is serving both to deepen our understanding of psychopathology, and to identify new ways of potentially remediating such dysfunction. These papers are not only individually excellent, but collectively they communicate some of the major themes that are presently driving new developments within this rapidly evolving field. In this brief commentary, I reflect upon the contributions made by the current studies to these important themes. I also share some suggestions concerning how future work might profitably build upon this present research, to further enhance theoretical progress and enrich therapeutic innovation. Copyright © 2010 John Wiley & Sons, Ltd. [source]

Conductance asymmetry of a slot gate Si-MOSFET in a strong parallel magnetic field

ANNALEN DER PHYSIK, Issue 12 2009
I. Shlimak
Abstract We report measurements on a Si-MOSFET sample with a slot in the upper gate, allowing for different electron densities n1,2 across the slot. The dynamic longitudinal resistance was measured by the standard lock-in technique, while maintaining a large DC current through the source-drain channel. We find that the conductance of the sample in a strong parallel magnetic field is asymmetric with respect to the DC current direction. This asymmetry increases with magnetic field. The results are interpreted in terms of electron spin accumulation or depletion near the slot. [source]

Animal models of fetal renal disease

PRENATAL DIAGNOSIS, Issue 11 2001
Craig A. Peters
Abstract Fetal models of urinary tract disease have been used for many years and have provided unique and important insights into the pathophysiology of these conditions. This review will summarize the principal model systems used and the current directions of investigation. These models (including rabbit, opossum, sheep and recently swine) have demonstrated that in utero obstruction of the urinary tract alters renal growth, differentiation and produces stereotypical patterns of tissue response, particularly fibrosis. New molecular understanding of these processes has identified specific mechanisms that may be key elements in the development of renal dysfunction due to obstruction. These factors include the renin,angiotensin system (RAS) and its interaction with TGF-, in altering growth regulation and tissue fibrosis. These factors offer the prospect of clinical utility as markers of disease progression as well as pharmacologic therapy. Gene knockout systems have opened a new horizon of molecular models of congenital obstructive uropathy with insights into the role of the RAS in particular. It remains to be defined how closely these knockouts represent the human conditions they resemble. Continued application of fetal models of urinary obstruction, integrating large animal and knockout systems offers promise for improved diagnosis and treatment in these challenging conditions. Copyright © 2001 John Wiley & Sons, Ltd. [source]

Learner and information characteristics in the design of powerful learning environments

APPLIED COGNITIVE PSYCHOLOGY, Issue 3 2006
Fred Paas
This themed issue aims to present some current directions in cognitive load research. The contributions to this issue represent a compilation of symposia contributions to the 11th European Conference for Research on Learning and Instruction (EARLI), 2005, in Nicosia, Cyprus. These cognitive load symposia were focused on empirical and theoretical perspectives on designing powerful learning environments by aligning learner characteristics, information characteristics, or both with the knowledge structures underlying the cognitive architecture. This article provides an introduction to cognitive load theory and the instructional design consequences of these characteristics, and a short overview of the contributions to this issue. Copyright © 2006 John Wiley & Sons, Ltd. [source]