Home About us Contact
|
Home About us Contact | ||
|
|
||
Adequate Fit (adequate + fit)
Selected AbstractsPsychometric properties of the Retrospective Self Report of Inhibition (RSRI) in a representative German sampleINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 2 2008Heike Rohrbacher Abstract The present study examined the internal consistency, factorial structure, and construct validity of the German version of the Retrospective Self Report of Inhibition (RSRI), a questionnaire measure of behavioral inhibition. The research was based on data from a German prospective-longitudinal community study of 3021 adolescents and young adults (aged 14,24 years at baseline). Diagnostic assessment was based on the DSM-IV/M-CIDI and general psychopathological distress was assessed with SCL-90-R. Results of confirmatory factor analysis indicated adequate fit of the two-factor model, suggested by the authors of the original version. Indices of internal consistency of the RSRI and its subscales ,social/school' and ,fear/illness' were shown to be sufficient for the total sample and even higher in subgroups of subjects with certain DSM-IV diagnoses. Associations with variables such as mental distress, parental psychopathology, and DSM-IV disorders were in line with theoretical assumptions and confirm different aspects of the validity (convergent, concurrent, predictive) of the instrument. The psychometric properties of the German RSRI were found to be comparable to those of the English version. The applicability of this questionnaire in German-speaking countries is therefore recommended for adolescents and young adults. Copyright © 2008 John Wiley & Sons, Ltd. [source] Index of sources of stress in nursing students: a confirmatory factor analysisJOURNAL OF ADVANCED NURSING, Issue 5 2009Chris Gibbons Abstract Title.,Index of sources of stress in nursing students: a confirmatory factor analysis. Aim., This paper is a report of a study to test the proposed factor structure of the Index of Sources of Stress in Nursing Students. Background., Research across many countries has identified a number of sources of distress in nursing students but little attempt has been made to understand and measure sources of eustress or those stressors likely to enhance performance and well-being. The Index of Sources of Stress in Nursing Students was developed to do this. Exploratory factor analysis suggested a three-factor structure, the factors being labelled: learning and teaching; placement-related and course organization. It is important, however, to subject the instrument to confirmatory factor analysis as a further test of construct validity. Method., A convenience sample of final year nursing students (n = 176) was surveyed in one university in Northern Ireland in 2007. The Index of Sources of Stress in Nursing Students, which measures sources of stress likely to contribute to distress and eustress, was completed electronically. The lisrel programme was used to carry out the confirmatory factor analysis and test the factor structure suggested in the exploratory analysis. Findings., The proposed factor structure for the items measuring ,Uplifts' proved to be a good fit to the data and the proposed factor structure for the items measuring ,Hassles' showed adequate fit. Conclusion., In nursing programmes adopting the academic model and combining university-based learning with placement experience, this instrument can be used to help identify the sources of stress or course demands that students rate as distressing and those that help them to achieve. The validity of the ISSN could be further evaluated in other education settings. [source] Conceptualization and assessment of disengagement in romantic relationshipsPERSONAL RELATIONSHIPS, Issue 3 2008ROBIN A. BARRY Research examining relationship distress and dissolution highlights the importance of romantic disengagement. Nevertheless, prior conceptualizations and measures of romantic disengagement have tended to combine disengagement with related but distinct constructs hindering the study of romantic disengagement. The present research used exploratory and confirmatory factor analyses to clarify the conceptualization of romantic disengagement and to develop a novel measure,the Romantic Disengagement Scale (RDS). The RDS demonstrated adequate fit across samples of dating individuals (n = 203), married couples (n = 77), and women in physically aggressive relationships (n = 42) from the Midwestern United States. The RDS also demonstrated strong divergent and incremental validity. The discussion focuses on implications for enhancing conceptual models, research methodology, and clinical interventions. [source] Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patientsBRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Issue 6 2008Jung-Ryul Kim WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT , Almost all reported studies have investigated the pharmacokinetics of aripiprazole in healthy volunteers. , The pharmacokinetics of dehydroaripiprazole have not been identified in a combined model with aripiprazole. WHAT THIS STUDY ADDS , The data on aripiprazole and dehydroaripiprazole in psychiatric patients were modelled jointly using a population approach. , The apparent clearance of aripiprazole in cytochrome P450 (CYP) 2D6 intermediate metabolizers (IM) was approximately 60% of that in CYP2D6 extensive metabolizers (EM) having two functional alleles, but the exposure to dehydroaripiprazole in CYP2D6 IM was similar to that in EM. AIMS The aims of this study were to develop a combined population pharmacokinetic model for both aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients and to identify to what extent the genetic polymorphisms of cytochrome P450 (CYP) enzymes contribute to the variability in pharmacokinetics (PK). METHODS A population pharmacokinetic analysis was performed using NONMEM software based on 141 plasma concentrations at steady state from 80 patients receiving multiple oral doses of aripiprazole (10,30 mg day,1). RESULTS A one-compartment model with first-order kinetics for aripiprazole and dehydroaripiprazole each was developed to describe simultaneously the concentration data. The absorption rate constant was fixed to 1.06 h,1. The typical value of apparent distribution volume of aripiprazole was estimated to be 192 l. Covariate analysis showed that CYP2D6 genetic polymorphisms significantly influenced the apparent clearance of aripiprazole (CL/F), reducing the interindividual variability on CL/F from 37.8% CV (coefficient of variation) to 30.5%. The CL/F in the CYP2D6 IMs was approximately 60% of that in CYP2D6 EMs having two functional alleles. Based on the CYP2D6 genotype, the metabolic ratios were calculated at 0.20,0.34. However, the plasma concentration : dose ratios of dehydroaripiprazole were not different across the CYP2D6 genotype. CONCLUSIONS This population pharmacokinetic model provided an adequate fit to the data for both aripiprazole and dehydroaripiprazole in psychiatric patients. The usefulness of CYP genotyping as an aid to select the starting dose should be further investigated. [source] The properties of the stellar populations in ULIRGs , I. Sample, data and spectral synthesis modellingMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 3 2009J. Rodríguez Zaurín ABSTRACT We present deep long-slit optical spectra for a sample of 36 ultraluminous infrared galaxies (ULIRGs), taken with the William Herschel Telescope on La Palma with the aim of investigating the star formation histories and testing evolutionary scenarios for such objects. Here we present the sample, the analysis techniques and a general overview of the properties of the stellar populations; a more detailed discussion will be presented in a forthcoming paper. Spectral synthesis modelling has been used in order to estimate the ages of the stellar populations found in the diffuse light sampled by the spectra in both the nuclear and extended regions of the target galaxies. We find that adequate fits can be obtained using combinations of young stellar populations (YSPs; tYSP, 2 Gyr), with ages divided into two groups: very young stellar populations (VYSPs; tVYSP, 100 Myr) and intermediate-young stellar populations (IYSPs; 0.1 < tIYSP, 2 Gyr). Our results show that YSPs are present at all locations of the galaxies covered by our slit positions, with the exception of the northern nuclear region of the ULIRG IRAS 23327+2913. Furthermore, VYSPs are present in at least 85 per cent of the 133 extraction apertures used for this study, being more significant in the nuclear regions of the galaxies. Old stellar populations (OSPs; tOSP > 2 Gyr) do not make a major contribution to the optical light in the majority of the apertures extracted. In fact they are essential for fitting the spectra in only 5 per cent (seven) of the extracted apertures. The estimated total masses for the YSPs (VYSPs + IYSPs) are in the range 0.18 × 1010,MYSP, 50 × 1010 M,. We have also estimated the bolometric luminosities associated with the stellar populations detected at optical wavelengths, finding that they fall in the range 0.07 × 1012 < Lbol < 2.2 × 1012 L,. In addition, we find that reddening is significant at all locations in the galaxies. This result emphasizes the importance of accounting for reddening effects when modelling the stellar populations of star-forming galaxies. [source] | ||||||||||