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Adenoma Formation (adenoma + formation)
Selected AbstractsFamily history of colorectal cancer: A determinant of advanced adenoma stage or adenoma multiplicity?INTERNATIONAL JOURNAL OF CANCER, Issue 2 2009Petra A. Wark Abstract A family history of colorectal cancer may increase colorectal cancer risk by influencing adenoma growth or enhancing the formation of new lesions. Data of men from the prospective Health Professionals Follow-Up Study who underwent an endoscopy between 1986 and 2004 were used to evaluate whether a family history of colorectal cancer is associated with adenoma multiplicity or advanced adenoma stage (,1 cm, histology with villous component or carcinoma in situ). 21.4% of the 3,881 adenoma patients and 13.9% of the 24,959 adenoma-free men had a first-degree relative with colorectal cancer. Thousand four hundred and ninety-six men were classified as having advanced and 1,507 as having nonadvanced adenomas. Six hundred and twenty-two men had multiple and 1,985 had single adenomas in the distal colon and rectum. A family history of colorectal cancer was similarly associated with advanced and nonadvanced adenomas [multivariable odds ratio (OR) (95% confidence interval): advanced vs. nonadvanced, 0.98 (0.82,1.17), advanced vs. adenoma-free: 1.67 (1.47,1.91), nonadvanced vs. adenoma-free: 1.70 (1.49,1.94)], although potential differences according to adenoma location were seen. A family history of colorectal cancer was more strongly associated with multiple distally located adenomas [odds ratio (95% confidence interval): multiple vs. single, 1.35 (1.09,1.68), multiple vs. no distally located adenomas: 2.02 (1.67,2.44), single vs. no distally located adenomas: 1.49 (1.32,1.68)]. The number of adenomas was also positively associated with a family history of colorectal cancer. Our findings suggest that at the population level, heritable factors may be more important in earlier stages of adenoma formation than at stages of adenoma advancement for at least distally located adenomas. © 2009 UICC [source] Comparative proteomics analysis of human pituitary adenomas: Current status and future perspectivesMASS SPECTROMETRY REVIEWS, Issue 6 2005Xianquan Zhan Abstract This article will review the published research on the elucidation of the mechanisms of pituitary adenoma formation. Mass spectrometry (MS) plays a key role in those studies. Comparative proteomics has been used with the long-term goal to locate, detect, and characterize the differentially expressed proteins (DEPs) in human pituitary adenomas; to identify tumor-related and -specific biomarkers; and to clarify the basic molecular mechanisms of pituitary adenoma formation. The methodology used for comparative proteomics, the current status of human pituitary proteomics studies, and future perspectives are reviewed. The methodologies that are used in comparative proteomics studies of human pituitary adenomas are readily exportable to other different areas of cancer research. © 2004 Wiley Periodicals, Inc., Mass Spec Rev 24:783,813, 2005 [source] What can humans learn from flies about adenomatous polyposis coli?BIOESSAYS, Issue 9 2002Angela I.M. Barth Somatic or inherited mutations in the adenomatous polyposis coli (APC) gene are a frequent cause of colorectal cancer in humans. APC protein has an important tumor suppression function to reduce cellular levels of the signaling protein ,-catenin and, thereby, inhibit ,-catenin and T-cell-factor-mediated gene expression. In addition, APC protein binds to microtubules in vertebrate cells and localizes to actin-rich adherens junctions in epithelial cells of the fruit fly Drosophila (Fig. 1). Very little is known, however, about the function of these cytoskeletal associations. Recently, Hamada and Bienz have described a potential role for Drosophila E-APC in cellular adhesion,1 which offers new clues to APC function in embryonic development, and potentially colorectal adenoma formation and tumor progression in humans. BioEssays 24:771,774, 2002. © 2002 Wiley Periodicals, Inc. [source] Ileostomy carcinomas a review: the latent risk after colectomy for ulcerative colitis and familial adenomatous polyposisCOLORECTAL DISEASE, Issue 6 2005H. M. Quah Abstract Background, Ileostomy carcinoma after colectomy for ulcerative colitis and familial adenomatous polyposis is rare. Methods, Forty-three case reports from the literature and a case of ours are reviewed. Results, The risk of malignancy following ileostomy formation appears to be increased compared to the very low incidence of primary small bowel carcinoma. Chronic physical or chemical irritation of the stoma may predispose the ileal mucosa to colonic metaplasia with subsequent adenoma formation, dysplasia and invasive malignant change. This is particularly so where ileostomies are fashioned for familial adenomatous polyposis and ulcerative colitis. Conclusion, Routine surveillance of patients who have had an ileostomy for 15 years or longer may lead to earlier detection of this complication. [source] | ||||||||||