Copper Deficiency (copper + deficiency)

Distribution by Scientific Domains


Selected Abstracts


Subacute Combined Degeneration Due to Copper Deficiency

JOURNAL OF NEUROIMAGING, Issue 4 2007
Joseph M. Ferrara MD
ABSTRACT There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill-defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration. [source]


Copper deficiency and diet

AMERICAN JOURNAL OF HEMATOLOGY, Issue 7 2007
Leslie M. Klevay
No abstract is available for this article. [source]


Rat brain iron concentration is lower following perinatal copper deficiency

JOURNAL OF NEUROCHEMISTRY, Issue 3 2005
Joseph R. Prohaska
Abstract Experiments performed with Holtzman rats demonstrated that brain iron (Fe) was lower by postnatal day 13 (P13) in pups born and nursed by dams that began copper-deficient (,Cu) treatment at embryonic day 7. Transcardial perfusion of P24,P26 males and females to remove blood Fe contamination revealed that brain Fe was still 20% lower in ,Cu than +Cu rats. Estimated blood content of brain for ,Cu rats was greater than for +Cu rats; for all groups, values ranged between 0.43 and 1.03%. Using group-specific data and regression analyses, r = 0.99, relating blood Fe to hemoglobin, brain Fe in non-perfused rats in a replicate study was lower by 33% at P13 and 39% at P24 in ,Cu rats. Brain extracts from these rats and from P50 rats from a post-weaning model were compared by immunobloting for transferrin receptor (TfR1). P24 brain ,Cu/+Cu TfR1 was 3.08, suggesting that brains of ,Cu rats were indeed Fe deficient. This ratio in P13 rats was 1.44, p < 0.05. No change in P50 ,Cu rat brain TfR1 or Fe content was detected despite a 50% reduction in plasma Fe. The results suggest that brain Fe accumulation depends on adequate Cu nutriture during perinatal development. [source]


Subacute Combined Degeneration Due to Copper Deficiency

JOURNAL OF NEUROIMAGING, Issue 4 2007
Joseph M. Ferrara MD
ABSTRACT There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill-defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration. [source]


Myelodysplasia and copper deficiency induced by denture paste,

AMERICAN JOURNAL OF HEMATOLOGY, Issue 9 2009
Anjali Sibley
No abstract is available for this article. [source]


Late-onset neutropenia in very low birthweight infants

ACTA PAEDIATRICA, Issue 2002
G Chirico
Aim: To evaluate the incidence and duration of late-onset neutropenia (defined as an absolute neutrophil count (ANC) <1500 mm,3 at a postnatal age of >3 wk) in a population of infants with birthweight <2000 g, and to determine whether copper deficiency, a possible cause of both anemia and neutropenia, may be associated with this complication. Methods: Complete blood cell count and differential were assessed in 247 low (LBW) and very low birthweight (VLBW) infants who were discharged after 3 wk of life. In neutropenic infants plasma copper and ceruloplasmin levels were also measured. Results: Late-onset neutropenia was detected in 11 out of 147 VLBW infants (7.5%) and in 7 out of 127 LBW infants (5.5%). A neutrophil count of <1000 mm,3 was observed in 14 infants (5.1%). A significantly lower gestational age was found in neutropenic infants compared with non-neutropenic infants. In neutropenic infants ANCs were significantly correlated with hemoglobin and hematocrit. In addition, a significant negative correlation was found between neutrophil and reticulocyte counts. Plasma copper concentration was significantly correlated with birthweight. Oral copper sulfate was administered to infants with plasma copper concentration <50 ,g dl,1, and did not seem to affect ANC, hemoglobin, hematocrit or reticulocyte counts. Conclusion: Late-onset neutropenia appears to be a benign condition that is not associated with any particular complication and does not require specific treatment. Reference ranges after the early neonatal period and during the first few months of life in LBW and VLBW infants should probably be set at lower values. [source]