			Home About us Contact

Consumption Coagulopathy (consumption + coagulopathy)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Impact of platelet adhesion on Thromboelastometry in dilutional consumption coagulopathy with either HES or Gelatin

ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 6 2010
R. Huet
No abstract is available for this article. [source]

Perioperative Results of the Aortic Root Replacement in Strict Graft Inclusion Technique

JOURNAL OF CARDIAC SURGERY, Issue 5 2008
Niyazi Cebi M.D.
Therefore, the strict graft inclusion technique has been developed to avoid major complications. We present the early results after aortic root replacement in strict graft inclusion technique. Materials and Methods: The strict graft inclusion technique was performed in 28 patients between April 2001 and June 2006 in St-Johannes-Hospital-Dortmund, Dortmund, Germany. There were nine female and 19 male patients. The mean age was 57.78 ± 12.01 years (28 to 77 years). A type A aortic dissection and an ascending aortic aneurysm with aortic valve lesion were the indication to operation in patients. Results: There were no early mortality and postoperative rethoracotomy. The mean postoperative bleeding over mediastinal drains was 565 ± 310 mL. (100,2250 mL). In exception of the patients with preoperative double thrombocyte aggregation inhibitors therapy and postoperative consumption coagulopathy, the mean postoperative bleeding over mediastinal drain was 443.04 ± 171.59 mL (100,1100) in the first 24 hours, the transfusion rate was minimal, mean 0.39 ± 0.64 packed red blood cells (RBC) (0,4) and mean 0.14 ± 0.27 packed fresh frozen plasma (FFP) (0,4), whereas only in 18 patients (78.26%) out of 23 patients was a transfusion not necessary. The intraoperative and postoperative requirement for substitution of erythrocyte concentrate was mean 1 ± 1.28 packed RBC (0,5) and FFP concentrate was mean 1.21 ± 1.90 packed FFP (0,12). Conclusions: The strict graft inclusion technique for aortic root replacement represents a safe and feasible method to avoid bleeding from coronary ostial anastomoses, from aortic annular suture lines, and annular leak. [source]

Activation of the coagulation system occurs within rather than outside cutaneous haemangiomas

ACTA PAEDIATRICA, Issue 10 2001
J Antovic
Haemangiomas are the commonest tumours of infancy. They can become even more serious if followed by consumption coagulopathy and even life-threatening in cases of Kasabach,Merritt syndrome, with thrombocytopenia and haemorrhage. Data exist concerning systemic coagulation abnormalities in children with haemangiomas but to our knowledge there are no data on local consumption coagulopathy in haemangioma per se. We examined blood coagulation and fibrinolysis parameters in blood withdrawn from haemangioma blood vessels and blood withdrawn from the systemic vein in 14 children with cutaneous haemangiomas (3M, 11F; age range 3 mo to 10 y). Compared with controls, significant decreases in fibrinogen levels, FVII activity, antithrombin and plasmin inhibitor levels and increases in international normalized ratio (INR) and D-dimer levels were observed in the blood samples withdrawn directly from haemangioma blood vessels. Fibrinogen and antithrombin levels in samples withdrawn from systemic veins were reduced in relation to control values whilst INR values increased, but within normal ranges. D-dimer levels were increased in peripheral blood. The fibrinogen level was significantly lower and the INR and D-dimer levels were significantly higher in blood samples from haemangiomas compared to systemic blood. Clinical signs of systemic disseminated intravascular coagulation were not observed. Conclusions: Our results suggest a strong local activation and local consumption coagulopathy in haemangioma, along with less conspicuous but observable systemic changes in coagulation and fibrinolysis parameters, although without signs of consumptive coagulopathy. These systemic changes could be a reflection of intra-lesion coagulation activation although there is no evidence to suggest truly systemic disseminated intravascular coagulation. [source]