Consideration

Distribution by Scientific Domains
Distribution within Medical Sciences

Kinds of Consideration

  • additional consideration
  • anatomic consideration
  • anatomical consideration
  • brief consideration
  • broader consideration
  • careful consideration
  • clinical consideration
  • cost consideration
  • critical consideration
  • design consideration
  • detailed consideration
  • diagnostic consideration
  • due consideration
  • ecological consideration
  • economic consideration
  • efficiency consideration
  • environmental consideration
  • epistemological consideration
  • equity consideration
  • essential consideration
  • ethical consideration
  • evolutionary consideration
  • explicit consideration
  • financial consideration
  • full consideration
  • fundamental consideration
  • future consideration
  • general consideration
  • geometrical consideration
  • greater consideration
  • important consideration
  • key consideration
  • legal consideration
  • little consideration
  • major consideration
  • management consideration
  • mechanistic consideration
  • methodological consideration
  • moral consideration
  • operational consideration
  • other consideration
  • particular consideration
  • physical consideration
  • policy consideration
  • political consideration
  • practical consideration
  • pragmatic consideration
  • proper consideration
  • recent consideration
  • relevant consideration
  • safety consideration
  • serious consideration
  • special consideration
  • specific consideration
  • statistical consideration
  • strategic consideration
  • structural consideration
  • technical consideration
  • theoretical consideration
  • therapeutic consideration
  • thermodynamic consideration
  • thoughtful consideration
  • treatment consideration
  • warrant consideration

  • Terms modified by Consideration

  • consideration a number
  • consideration relevant

  • Selected Abstracts


    GROSS DIMENSIONAL ASSESSMENT OF CUTANEOUS WOUNDS AS AN INDICATOR OF HEALING: IMPORTANCE OF CAREFUL CONSIDERATION

    INTERNATIONAL WOUND JOURNAL, Issue 1 2007
    Ramin Mostofi Zadeh Farahani
    No abstract is available for this article. [source]


    COST CONSIDERATION BY MEDICARE PART D PLANS MAY PROMOTE THE USE OF POTENTIALLY INAPPROPRIATE MEDICATIONS

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 5 2010
    Adam G. Golden MD
    No abstract is available for this article. [source]


    POLICY AND INTERVENTION CONSIDERATIONS OF A NETWORK ANALYSIS OF STREET GANGS,

    CRIMINOLOGY AND PUBLIC POLICY, Issue 3 2005
    JEAN MARIE MCGLOIN
    Research Summary: This study details a network analysis of the street gang landscape in Newark, New Jersey. Using individual gang members as the unit of analysis and multiple layers of associations as the linkages within the networks, the results suggest that the gangs in Newark are loosely organized with pockets of cohesion. In addition, there is variation with regard to individual connectedness within the gangs, and certain gang members emerge as "cut-points" or the only connection among gang members or groups of gang members. Policy Implications: The results lend further credence to the notion that problem analysis should precede gang interventions. In particular, the findings suggest that particular groups of gang members may be amenable to the collective accountability tactic, whereas others may become more cohesive as a consequence. Indeed, an intervention focused on individuals may be more productive in Newark. The cut-points within gangs are particularly worthy of attention, both for their capacity to act as communication agents for a deterrence message and for their potential vulnerability to the pulling levers strategy. [source]


    ON REASONS FOR DRINKING LESS: A FRAMEWORK OF METHODOLOGICAL CONSIDERATIONS

    ADDICTION, Issue 12 2005
    JOHN CUNNINGHAM
    No abstract is available for this article. [source]


    ONCE-DAILY MEMANTINE: PHARMACOKINETIC AND CLINICAL CONSIDERATIONS

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9 2010
    AGSF, Irving H. Gomolin MDCM
    No abstract is available for this article. [source]


    CLINICAL CONSIDERATIONS FOR RESTORING MANDIBULAR INCISORS WITH PORCELAIN LAMINATE VENEERS

    JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY, Issue 4 2008
    Robert D. Walter DDS Authors
    Porcelain laminate veneers have been proven to be a successful treatment modality for maxillary incisors in clinical practice and in controlled clinical studies. However, the data in clinical studies on the success of veneers for restoring mandibular incisors are limited. Clinically, the successful restoration of mandibular incisors with porcelain laminate veneers is one of the more challenging procedures in all of esthetic restorative dentistry. Limited coronal dimensions, the small amount of enamel available for bonding (particularly in the cervical areas), materials and techniques for the bonding procedures, and the response of the tooth,veneer complex to forces generated during the incisal loading in both functional as well as parafunctional contacts must be considered as potential sources of success or failure. This Critical Appraisal reviews three recent scientific articles to shed some light on these issues and, as in all research endeavors, leads the reader to identify additional areas of concern that might stimulate further scientific inquiry. The first publication studied predictors for enamel thickness for mandibular incisors. The second examined bonding protocols for exposed dentin and suggested immediate dentin sealing. The third paper addressed fracture behavior of mandibular incisors restored with porcelain laminate veneers in vitro. [source]


    SENSITIVITY CONSIDERATIONS WHEN MODELING HYDROLOGIC PROCESSES WITH DIGITAL ELEVATION MODEL,

    JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 4 2001
    Sung-Mm Cho
    ABSTRACT: The purpose of this paper is to investigate the sensitivity of a hydrologic models to the type of DEM used. This was done while modeling basin water quality with 1:24,000 and 1:250,000 U.S. Geological Survey DEMs as input to model hydrological processes. The manner in which the model results were sensitive to the choice of raster cell size (scale) is investigated in this study. The Broadhead watershed, located in New Jersey, USA, was chosen as a study area. Curve numbers were estimated by a trial and error to match simulated and observed total discharge. Monthly runoff for the watershed was used in the calibration process. Higher runoff volumes were simulated by the model when the 1:24,000 DEM were used as input data, probably due to the finer resolution which simulated increased average slope and hence higher estimated runoff from the watershed. As the simulated slope of the watershed is flatten with the 1:250,000 DEM, the response of stream flow was delayed and simulated less runoff volume. (KEY TERMS: DEM; curve number; sensitivity analysis; runoff volume; water quality; calibration.) [source]


    PUBLIC DEBT AS PRIVATE WEALTH: SOME EQUILIBRIUM CONSIDERATIONS

    METROECONOMICA, Issue 4 2006
    Article first published online: 13 NOV 200, Ekkehart Schlicht
    ABSTRACT Government bonds are interest-bearing assets. Increasing public debt increases wealth, income and consumption demand. The smaller government expenditure is, the larger consumption demand must be in equilibrium, and the larger must be public debt. Conversely, lower public debt implies higher government spending and taxation. Public debt plays, thus, an important role in establishing equilibrium. It distributes output between consumers and government. In case of insufficient demand, a larger public debt entails higher private consumption and less public spending. If upper bounds on public debt are introduced (as in the Maastricht treaty), such constraints place lower bounds on taxation and public spending and may rule out macroeconomic equilibrium. As an aside, a minor flaw in Domar's (American Economic Review, 34 (4), pp. 798,827) classical analysis is corrected. [source]


    SOFTWARE ENGINEERING CONSIDERATIONS FOR INDIVIDUAL-BASED MODELS

    NATURAL RESOURCE MODELING, Issue 1 2002
    GLEN E. ROPELLA
    ABSTRACT. Software design is much more important for individual-based models (IBMs) than it is for conventional models, for three reasons. First, the results of an IBM are the emergent properties of a system of interacting agents that exist only in the software; unlike analytical model results, an IBMs outcomes can be reproduced only by exactly reproducing its software implementation. Second, outcomes of an IBM are expected to be complex and novel, making software errors difficult to identify. Third, an IBM needs ,systems software' that manages populations of multiple kinds of agents, often has nonlinear and multi-threaded process control and simulates a wide range of physical and biological processes. General software guidelines for complex models are especially important for IBMs. (1) Have code critically reviewed by several people. (2) Follow prudent release management prac-tices, keeping careful control over the software as changes are implemented. (3) Develop multiple representations of the model and its software; diagrams and written descriptions of code aid design and understanding. (4) Use appropriate and widespread software tools which provide numerous major benefits; coding ,from scratch' is rarely appropriate. (5) Test the software continually, following a planned, multi-level, exper-imental strategy. (6) Provide tools for thorough, pervasive validation and verification. (7) Pay attention to how pseudorandom numbers are generated and used. Additional guidelines for IBMs include: (a) design the model's organization before starting to write code,(b) provide the ability to observe all parts of the model from the beginning,(c) make an extensive effort to understand how the model executes how often different pieces of code are called by which objects, and (d) design the software to resemble the system being mod-eled, which helps maintain an understanding of the software. Strategies for meeting these guidelines include planning adequate resources for software development, using software professionals to implement models and using tools like Swarm that are designed specifically for IBMs. [source]


    EPISTEMOLOGICAL CONSIDERATIONS ON NEUROIMAGING , A CRUCIAL PREREQUISITE FOR NEUROETHICS

    BIOETHICS, Issue 6 2009
    CHRISTIAN G. HUBER
    ABSTRACT Purpose: Whereas ethical considerations on imaging techniques and interpretations of neuroimaging results flourish, there is not much work on their preconditions. In this paper, therefore, we discuss epistemological considerations on neuroimaging and their implications for neuroethics. Results: Neuroimaging uses indirect methods to generate data about surrogate parameters for mental processes, and there are many determinants influencing the results, including current hypotheses and the state of knowledge. This leads to an interdependence between hypotheses and data. Additionally, different levels of description are involved, especially when experiments are designed to answer questions pertaining to broad concepts like the self, empathy or moral intentions. Interdisciplinary theoretical frameworks are needed to integrate findings from the life sciences and the humanities and to translate between them. While these epistemological issues are not specific for neuroimaging, there are some reasons why they are of special importance in this context: Due to their inferential proximity, ,neuro-images' seem to be self-evident, suggesting directness of observation and objectivity. This has to be critically discussed to prevent overinterpretation. Additionally, there is a high level of attention to neuroimaging, leading to a high frequency of presentation of neuroimaging data and making the critical examination of their epistemological properties even more pressing. Conclusions: Epistemological considerations are an important prerequisite for neuroethics. The presentation and communication of the results of neuroimaging studies, the potential generation of new phenomena and new ,dysfunctions' through neuroimaging, and the influence on central concepts at the foundations of ethics will be important future topics for this discipline. [source]


    The hydrogen atom, revisited: Parallel-field magnetic resonance,

    CONCEPTS IN MAGNETIC RESONANCE, Issue 5 2006
    John A. Weil
    Abstract Consideration of the magnetic resonance spectroscopy of the free hydrogen atom (1H0) reveals that, in addition to the well-known transitions (EPR and NMR) occurring between the four spin states when the excitation magnetic field B1 is perpendicular to the static external field B, there exists a combination line (simultaneous electronic and nuclear spin flips) when B1 , B, which becomes strong under some circumstances. The latter phenomenon is focused on and discussed herein, in some detail. © 2006 Wiley Periodicals, Inc. Concepts Magn Reson Part A 28A: 331,336, 2006 [source]


    Balancing Self-interest and Altruism: corporate governance alone is not enough

    CORPORATE GOVERNANCE, Issue 2 2004
    Sandra Dawson
    Governance has become a topic of unprecedented emotional significance and fundamental importance in the boardrooms of companies, partly as a result of a confluence of early 21st century corporate scandals, stock market falls and public rage about senior executive remuneration. A simple adherence to formal systems of corporate governance, in terms of structures, rules, procedures and codes of practice, whilst a starting point, will not alone win back confidence in markets and corporations. Consideration needs to be given to how to release entrepreneurial self interest within a moral context. This focuses attention on the role of other major social institutions which may more naturally be able to nurture a moral framework as well as the role of individual citizens and the responsibility of all of us to enact a moral framework for business activities. There is no escape from individual moral responsibility, and our part in creating and sustaining social institutions beyond corporations. [source]


    A classification of risk factors in serious juvenile offenders and the relation between patterns of risk factors and recidivism

    CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 1 2010
    Eva Mulder
    Background,There has been a lot of research on risk factors for recidivism among juvenile offenders, in general, and on individual risk factors, but less focus on subgroups of serious juvenile offenders and prediction of recidivism within these. Objective,To find an optimal classification of risk items and to test the predictive value of the resultant factors with respect to severity of recidivism among serious juvenile offenders. Method,Seventy static and dynamic risk factors in 1154 juvenile offenders were registered with the Juvenile Forensic Profile. Recidivism data were collected on 728 of these offenders with a time at risk of at least 2 years. After factor analysis, independent sample t-tests were used to indicate differences between recidivists and non-recidivists. Logistic multiple linear regression analyses were used to test the potential predictive value of the factors for violent or serious recidivism. Results,A nine-factor solution best accounted for the data. The factors were: antisocial behaviour during treatment, sexual problems, family problems, axis-1 psychopathology, offence characteristics, conscience and empathy, intellectual and social capacities, social network, and substance abuse. Regression analysis showed that the factors antisocial behaviour during treatment, family problems and axis-1 psychopathology were associated with seriousness of recidivism. Conclusions and implications for practice,The significance of family problems and antisocial behaviour during treatments suggest that specific attention to these factors may be important in reducing recidivism. The fact that antisocial behaviour during treatment consists mainly of dynamic risk factors is hopeful as these can be influenced by treatment. Consideration of young offenders by subgroup rather than as a homogenous population is likely to yield the best information about risk of serious re-offending and the management of that risk. Copyright © 2010 John Wiley & Sons, Ltd. [source]


    A Consideration of Museum Education Collections: Theory and Application

    CURATOR THE MUSEUM JOURNAL, Issue 2 2001
    Shane J. Macfarlan
    Museum education collections are used to provide visitors with opportunities to handle museum objects. These collections are primarily composed of objects that are damaged, lack provenance, or do not fit the scope of the collection. Sometimes, these collections are displayed haphazardly and their interpretation may lack thematic context. Some museum education collections are not being utilized to their fullest educational capacity. The application of cognitive, exhibition, and collections management theories can alleviate some problems with museum education collections. A critique of the education collection at the Lubbock Lake Landmark is presented as a case study of these problems and some of the potential solutions to them. The study can be used as a template by other museums to solve similar problems in their education collections. [source]


    Glandular prediction: the pride and the prejudice

    CYTOPATHOLOGY, Issue 4 2004
    C. Waddell
    For the cytologist and clinician alike, glandular lesions pose possibly the greatest challenge in cervical screening. Worldwide, with increasing confidence in cytological prediction, terminology is evolving. In the UK, with the adoption of liquid based methods, the technical aspects of cervical cytology are being addressed, it is now time to standardise our terminology in glandular reporting. Consideration of the cytological complexity, clinical needs and international protocols is essential in this endeavour. [source]


    Clinical pathologic correlations for diagnosis and treatment of nail disorders

    DERMATOLOGIC THERAPY, Issue 1 2007
    Olympia I. Kovich
    ABSTRACT:, Clinicopathologic correlation is crucial to the correct diagnosis of disorders of the nail unit. This chapter will explore four common clinical scenarios and how pathology can help differentiate between their various etiologies. These include: dark spot on the nail plate (melanin versus heme), subungual hyperkeratosis (onychomycosis versus psoriasis), longitudinal melanonychia (benign versus malignant), and verrucous papule (verruca versus squamous cell carcinoma). Consideration must be given to both when to perform a biopsy and the location of the biopsy site, which must be based on an understanding of the origin of the changes. An overarching principle is that lesions within the same differential diagnosis may be present concomitantly, such as malignant melanoma of the nail unit associated with hemorrhage. Therefore, even with a biopsy-proven diagnosis, the clinician must always monitor lesions of the nail unit for appropriate response to treatment and consider an additional biopsy for recalcitrant lesions. [source]


    The relevance of the glycaemic index to our understanding of dietary carbohydrates

    DIABETIC MEDICINE, Issue 5 2000
    G. Frost
    Summary Aims To review the evidence for the importance of glycaemic index of dietary carbohydrate in disease prevention and control Methods A critical appraisal of the literature published in English between and cited on Medline between January 1966 and October 1999. Results Using basic, intervention and epidemiological studies from experienced teams, evidence that the glycaemic index of diet may influence outcome in terms of cardiovascular risk, risk of metabolic syndrome diseases and pregnancy was found Conclusions Consideration of glycaemic indices in making dietary recommendations may be expected to produce additional health benefit. [source]


    Measurement mischief: A critique of Reynolds, Nicolson and Hambly (2003)

    DYSLEXIA, Issue 3 2003
    Chris Singleton
    Abstract Reynolds, Nicolson and Hambly (2003) report an intervention study of the effects of exercise-based training on literacy development, using literacy measures from the Dyslexia Screening Test (DST), the NFER-Nelson Group Reading Test, and the Standard Assessment Tasks (SATs). Investigation of the nature and psychometric characteristics of these measures casts serious doubt on their appropriateness in a study of this nature. Consideration of the findings obtained using these measures does not support the authors' conclusion that reading was improved by the intervention. The study by Reynolds et al. does not demonstrate that exercise-based treatment improves literacy skills and the use of its purported findings as evidence that exercise-based treatment would be beneficial for children with literacy difficulties is scientifically untenable. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    Spectrally based remote sensing of river bathymetry

    EARTH SURFACE PROCESSES AND LANDFORMS, Issue 8 2009
    Carl J. Legleiter
    Abstract This paper evaluates the potential for remote mapping of river bathymetry by (1) examining the theoretical basis of a simple, ratio-based technique for retrieving depth information from passive optical image data; (2) performing radiative transfer simulations to quantify the effects of suspended sediment concentration, bottom reflectance, and water surface state; (3) assessing the accuracy of spectrally based depth retrieval under field conditions via ground-based reflectance measurements; and (4) producing bathymetric maps for a pair of gravel-bed rivers from hyperspectral image data. Consideration of the relative magnitudes of various radiance components allowed us to define the range of conditions under which spectrally based depth retrieval is appropriate: the remotely sensed signal must be dominated by bottom-reflected radiance. We developed a simple algorithm, called optimal band ratio analysis (OBRA), for identifying pairs of wavelengths for which this critical assumption is valid and which yield strong, linear relationships between an image-derived quantity X and flow depth d. OBRA of simulated spectra indicated that water column optical properties were accounted for by a shorter-wavelength numerator band sensitive to scattering by suspended sediment while depth information was provided by a longer-wavelength denominator band subject to strong absorption by pure water. Field spectra suggested that bottom reflectance was fairly homogeneous, isolating the effect of depth, and that radiance measured above the water surface was primarily reflected from the bottom, not the water column. OBRA of these data, 28% of which were collected during a period of high turbidity, yielded strong X versus d relations (R2 from 0·792 to 0·976), demonstrating that accurate depth retrieval is feasible under field conditions. Moreover, application of OBRA to hyperspectral image data resulted in spatially coherent, hydraulically reasonable bathymetric maps, though negative depth estimates occurred along channel margins where pixels were mixed. This study indicates that passive optical remote sensing could become a viable tool for measuring river bathymetry. Copyright © 2009 John Wiley & Sons, Ltd. [source]


    Rock thermal data at the grain scale: applicability to granular disintegration in cold environments

    EARTH SURFACE PROCESSES AND LANDFORMS, Issue 8 2003
    Kevin Hall
    Abstract Consideration of the mechanisms associated with the granular disintegration of rock has been limited by available data. In most instances, both the size of the transducer and the nature of the study have negated any applicability of the resulting data to the understanding of grain-to-grain separation within rock. The application of microthermocouples (,0·15 mm diameter) and high-frequency logging (20 s intervals) at a taffoni site on southern Alexander Island and from a rock outcrop on Adelaide Island (Antarctica) provide new data pertaining to the thermal conditions, at the grain scale, of the rock surface. The results show that thermal changes (,T/t) can be very high, with values of 22 °C min,1 being recorded. Although available data indicate that there can be differences in frequency and magnitude of ,uctuations as a function of aspect, all aspects experienced some large magnitude (,2 °C min,1) ,uctuations. Further, in many instances, large thermal changes in more than one direction could occur within 1 min or in subsequent minutes. These data suggest that the surface grains experience rapidly changing stress ,elds that may, with time, effect fatigue at the grain boundaries; albedo differences between grains and the resulting thermal variations are thought to exacerbate this. The available data failed to show any indication of water freezing (an exotherm) and thus it is suggested that microgelivation may not play as large a role in granular breakdown as is often postulated for cold regions, and that in this dry, Antarctic region thermal stress may play a signi,cant role. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    Spectral shape, epsilon and record selection

    EARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 9 2006
    Jack W. Baker
    Abstract Selection of earthquake ground motions is considered with the goal of accurately estimating the response of a structure at a specified ground motion intensity, as measured by spectral acceleration at the first-mode period of the structure, Sa(T1). Consideration is given to the magnitude, distance and epsilon (,) values of ground motions. First, it is seen that selecting records based on their , values is more effective than selecting records based on magnitude and distance. Second, a method is discussed for finding the conditional response spectrum of a ground motion, given a level of Sa(T1) and its associated mean (disaggregation-based) causal magnitude, distance and , value. Records can then be selected to match the mean of this target spectrum, and the same benefits are achieved as when records are selected based on ,. This mean target spectrum differs from a Uniform Hazard Spectrum, and it is argued that this new spectrum is a more appropriate target for record selection. When properly selecting records based on either spectral shape or ,, the reductions in bias and variance of resulting structural response estimates are comparable to the reductions achieved by using a vector-valued measure of earthquake intensity. Copyright © 2006 John Wiley & Sons, Ltd. [source]


    OPEN OCCUPATIONS , WHY WORK SHOULD BE FREE

    ECONOMIC AFFAIRS, Issue 1 2009
    Jason Potts
    The benefits of openness are widely apparent everywhere except, seemingly, in occupations. Yet the case against occupational licensing still remains strong. Consideration of dynamic costs strengthens the case further. [source]


    ECONOMIC AND FINANCIAL ASPECTS OF AGED CARE

    ECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 1 2005
    Warren P. Hogan
    The focus of this article is on the Report of the inquiry into residential aged care in Australia. Consideration is given to the results of a confidential survey of financial submissions from providers of aged care. Most attention is given to labour costs and earnings before interest, taxes, depreciation and amortization (EBITDA). The most important result is the evidence showing providers whatever their size, location, ownership and resident mix, can perform in the top 10 per cent and 25 per cent of providers as measured by EBITDA. Management is vital to the performance of entities whether they be ,for-profit' or ,not-for-profit' entities. Attention is also directed to other studies about efficiency and productivity and modelling. Treating technical efficiency as a measure by which the industry lags behind best practice, the analysis of regulatory efficiency explains much about ways to secure gains in efficiency. [source]


    Cover Picture: Electrophoresis 8'09

    ELECTROPHORESIS, Issue 8 2009
    Article first published online: 20 APR 200
    Issue no. 8 is an Emphasis Issue with 12 articles in Part I on various aspects of "Fundamentals and Methodologies" while the remaining 5 articles are grouped into Part II on "Bioanalysis". In addition, this issue includes a Fast Track article that demonstrates that "omic analyses unravels molecular changes in the brain and liver of a rat model for chronic Sake (Japanese alcoholic beverage) intake". Further selected topics from issue 8 are: Introducing a new parameter for quality control of proteome profiles: Consideration of commonly expressed proteins. (10.1002/elps.200800440) Improving sensitivity in micro-free flow electrophoresis using signal averaging. (10.1002/elps.200800497) [source]


    Use of mechanistic data in IARC evaluations

    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 2 2008
    Vincent James Cogliano
    Abstract Consideration of mechanistic data has the potential to improve the analysis of both epidemiologic studies and cancer bioassays. IARC has a classification system in which mechanistic data can play a pivotal role. Since 1991, IARC has allowed an agent to be classified as carcinogenic to humans (Group 1) when there is less than sufficient evidence in humans but there is sufficient evidence in experimental animals and "strong evidence in exposed humans that the agent acts through a relevant mechanism of carcinogenicity." Mechanistic evidence can also substitute for conventional cancer bioassays when there is less than sufficient evidence in experimental animals, just as mechanistic evidence can substitute for conventional epidemiologic studies when there is less than sufficient evidence in humans. The IARC Monographs have used mechanistic data to raise or lower a classification that would be otherwise based on epidemiologic studies and cancer bioassays only. Recently, the IARC Monographs have evaluated several agents where mechanistic data were pivotal to the overall evaluation: benzo[a]pyrene, carbon black and other poorly soluble particles, ingested nitrates and nitrites, and microcystin-LR. In evaluating mechanistic data, it is important to consider alternative mechanistic hypotheses, because an agent may induce tumors through multiple mechanisms. Environ. Mol. Mutagen., 2008. © 2008 Wiley-Liss, Inc. [source]


    Effects of metal and organophosphate mixtures on Ceriodaphnia dubia survival and reproduction

    ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 7 2005
    Amy M. Mahar
    Abstract The toxicity of mixtures of copper, zinc, and diazinon were determined for Ceriodaphnia dubia using 7-d survival and reproduction tests. Fifteen treatments, including combinations of the chemicals at 0, 25, 50, 75, and 100% of their individual median lethal concentrations, adding up to one toxic unit (TU) were tested. The TU was then used to classify each mixture response as additive, greater than additive, or less than additive. For survival, additive responses occurred in the 75% zinc plus 25% diazinon and the 50% copper plus 25% zinc plus 25% diazinon treatments. For reproduction, additive responses occurred in the 75% copper plus 25% zinc, 75% copper plus 25% diazinon, and 75% zinc plus 25% diazinon treatments. Copper and zinc played a greater role in toxicity than diazinon did. Less-than-additive interactions were found in all remaining mixtures, perhaps because of differences in mode of action between diazinon and metals. Consideration of dose-response curves can help to explain inconsistencies regarding toxic response in treatments with different ratios of the same chemicals. As TU percentages changed, mixture components were taken from different locations on differently shaped dose-response curves. Because most responses were less than additive, however, water-quality criteria based on individual concentrations probably are protective for most metal-organophosphate mixtures. [source]


    Toward a New Sexual Selection Paradigm: Polyandry, Conflict and Incompatibility (Invited Article)

    ETHOLOGY, Issue 12 2003
    Jeanne A. Zeh
    Darwin's recognition that male,male competition and female choice could favor the evolution of exaggerated male traits detrimental to survival set the stage for more than a century of theoretical and empirical work on sexual selection. While this Darwinian paradigm represents one of the most profound insights in biology, its preoccupation with sexual selection as a directional evolutionary force acting on males has diverted attention away from the selective processes acting on females. Our understanding of female reproduction has been further confounded by discreet female mating tactics that have perpetuated the illusion of the monogamous female and masked the potential for conflict between the sexes. With advances in molecular techniques leading to the discovery that polyandry is a pervasive mating strategy, recognition of these shortcomings has brought the study of sexual selection to its current state of flux. In this paper, we suggest that progress in two key areas is critical to formulation of a more inclusive, sexual selection paradigm that adequately incorporates selection from the female perspective. First, we need to develop a better understanding of male × female and maternal × paternal genome interactions and the role that polyandry plays in providing females with non-additive genetic benefits such as incompatibility avoidance. Consideration of these interaction effects influencing natural selection on females is important because they can complicate and even undermine directional sexual selection on males. Secondly, because antagonistic coevolution maintains a balance between opposing sides that obscures the conflict itself, many more experimental evolution studies and interventionist investigations (e.g. gene knockouts) are needed to tease apart male manipulative adaptations and female counter-adaptations. It seems evident that the divisiveness and controversy that has plagued sexual selection theory since Darwin first proposed the idea has often stalled progress in this important field of evolutionary biology. What is now needed is a more pluralistic and integrative approach that considers natural as well as sexual selection acting on females, incorporates multiple sexual selection mechanisms, and exploits advances in physiology and molecular biology to understand the mechanisms through which males and females achieve reproductive success. [source]


    The Characterisation of Work-Based Learning by Consideration of the Theories of Experiential Learning

    EUROPEAN JOURNAL OF EDUCATION, Issue 3 2009
    C.U. CHISHOLM
    First page of article [source]


    Decomposition Cascades of Dicoordinate Copper(I) Chalcogenides

    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 33 2007
    Heiko Jacobsen
    Abstract Cu,E, Si,E, and Cu,P bond energies of R3PCuESiR3 and CuESiR3 complexes (E = O, S, Se) have been investigated using PBE density-functional calculations, and including empirical corrections for dispersive interactions (DFT-D). The bond energies have been used to investigate likely pathways of molecular decomposition. The energy profile for thermal decomposition is to a large degree independent of the nature of the phosphane ligands and silyl groups. Oxides, sulfides, and selenides have qualitatively the same thermal decomposition profile. Thermal decomposition is not likely to produce copper chalcogenide units CuE, but elemental copper Cu instead. Consideration of intermolecular van der Waals attraction suggests that the linear geometry of system tBu3PCuOSiPh3 as found in the crystal is most likely due to crystal packing and intermolecular forces.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source]


    Physical and Numerical Simulation of Cold Rolling of an AlFeSi Alloy in Consideration of Static Recovery,

    ADVANCED ENGINEERING MATERIALS, Issue 3 2010
    Christoph Heering
    The influence of static recovery on the yield stress of AA8079 was investigated in lab-scale cold rolling experiments. The yield stress of AA8079 in the cold rolling process is affected by static recovery, but the softening caused by static recovery is completely compensated in the subsequent cold rolling pass. Thus, the effect of static recovery on the yield stress of the final product is of minor importance. For the TPM, the kinetics of static recovery of the AlFeSi alloy AA8079 were determined for different temperatures and strain rates. The measured softening kinetics were then implemented in the physically based flow stress model 3IVM+. This flow stress model was extended with an empirical approach for static recovery to enable the through-process modeling of cold-rolled aluminum in consideration of static recovery. Future work will focus on physically based modeling of static recovery without using empirical approaches. [source]