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Compression Fractures (compression + fractures)

Distribution by Scientific Domains

Medical Sciences	50%
Life Sciences	20%

Kinds of Compression Fractures

vertebral compression fractures

Selected Abstracts

Vertebral Compression Fractures in Elderly Osteoporosis Patients Receiving Glucocorticoid Intra-articular Injections

PAIN PRACTICE, Issue 3 2006
Marc Huntoon MD
First page of article [source]

Some types of vertebral pathologies in the Argar Culture (Bronze Age, SE Spain)

INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 1 2010
S. A. Jiménez-Brobeil
Abstract A collection of 1825 vertebrae belonging to 105 individuals from several Argaric Culture sites (Bronze Age, SE of Spain) were studied. Several pathologies that could provide information about activity patterns were analysed, including spondylolysis, compression fractures and Schmorl's nodes. Spondylolysis appears exclusively in men. Compression fractures seem to be more related to age (osteoporosis) and are more frequent in women, but without statistical significance. Schmorl's nodes affect a large number of the individuals studied, with a slight predominance in men; there are no differences by age. The results obtained were compared with the available archaeological and anthropological information, which shows a clear division of activities by sex in the Argaric population. The validity of studying these pathologies as activity patterns is discussed. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Spinal pathological findings in ancient Egyptians of the Greco-Roman period living in Bahriyah Oasis

INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 5 2009
F. H. Hussien
Abstract The spine can provide a large amount of information about an individual's physical condition and possible lifestyle through palaeopathological investigations. The aim of this research was to study spinal diseases among Greco-Roman ancient Egyptians from Bahriyah Oasis, and to compare them with those from Giza of the Old Kingdom. The material used in the study included 809 single vertebrae and 77 adult sacra of ancient Egyptians from the Greco-Roman period (332,30 BC) that were excavated from Bahriyah Oasis. The spinal elements were examined for pathological conditions, degenerative diseases, trauma, congenital abnormalities, infectious diseases and neoplasms. The most common lesions of the spine were those due to degenerative processes. The articular facets were more affected than the vertebral bodies. Compression fractures of the bodies, mostly due to osteoporosis, were found in 1.44% and 5.07% of thoracic and lumbar vertebrae respectively. The percentage of spina bifida occulta among ancient Egyptians from Bahriyah Oasis was 62.33%, while among those from Giza was only 3.33%. Few cases of lumbar spondylolysis and one case of DISH were recorded. No cases of infectious or neoplastic diseases were found. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Medium-term results of percutaneous vertebroplasty in multiple myeloma

EUROPEAN JOURNAL OF HAEMATOLOGY, Issue 1 2006
Luis Ramos
Abstract:, Vertebral compression fractures (VCFs) are common in multiple myeloma (MM). Percutaneous vertebroplasty (PVP) is used to stabilize vertebral collapse and treat the pain. Few studies have been carried out on PVP in MM and follow-up has tended to be short. We have prospectively evaluated the safety and efficacy of PVP in the VCFs resulting from MM or plasmacytomas. Nineteen PVP were performed in 12 consecutive patients. We monitored their pain and functional status using visual analog (VAS) and Eastern Cooperative Oncology Group (ECOG) scale, respectively. For a subjective assessment, every patient was asked about his/her degree of satisfaction. The mean age of the participants was 66 yr. Significant improvement occurred 1 d after PVP according to the VAS score (7.5 pre-PVP to 3.7, P < 0.0001) and ECOG assessment (3.1 to 2.5, P = 0.002). This significant improvement was maintained after 3.2 yr of follow-up. Sixty-three percent of patients were highly satisfied with the result of the PVP and 37% were satisfied. The peri-operative mortality was 0%. Leakage of the cement outside of the vertebral body was noted in 16 of 19 injected vertebrae (84%) but none of the patients developed any clinical or neurological symptoms. At the last follow-up, no further collapse in the treated or neighboring vertebrae was noted. VCFs caused by MM or plasmacytomas can be effectively treated by vertebroplasty. PVP is associated with early clinical improvement of pain and function and can be maintained after a long follow-up without major procedure-related complications. [source]

Some types of vertebral pathologies in the Argar Culture (Bronze Age, SE Spain)

Methods and applications of diffusion imaging of vertebral bone marrow

JOURNAL OF MAGNETIC RESONANCE IMAGING, Issue 6 2006
José G. Raya MSc
Abstract Diffusion-weighted imaging (DWI) is an MRI technique that is sensitive to random water movements at spatial scales far below typical MRI voxel dimensions. DWI is a valuable tool for the diagnoses of diseases that involve alterations in water mobility. In the spine, DWI has proven to be a highly useful method for the differential diagnosis of benign and malignant compression fractures. In these pathologies, the microscopic structure of bone marrow is altered in a very different ways, leading to different water mobility, which can be depicted by DWI. Most of the pulse sequences developed for MRI can be adapted for DWI. However, these DWI-adapted sequences are frequently affected by artifacts, mostly caused by physiological motion. Therefore, the introduction of additional correction techniques, or even the development of new sequences is necessary. The first part of this article describes the principles of DWI and the sequences used for DWI of the spine: spin echo (SE), turbo spin echo (TSE), single-shot echo planar imaging (EPI), and steady-state free precession (SSFP) sequences. In the second part, clinical applications of DWI of the spinal bone marrow are extensively discussed. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc. [source]

ORIGINAL ARTICLE: Long-term outcomes of vertebroplasty for osteoporotic compression fractures

JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, Issue 4 2010
J Thillainadesan
Abstract Introduction: This study aimed to determine outcomes of percutaneous vertebroplasty for osteoporotic vertebral compression fractures (VCFs). Methods: Prospective assessment of short-term (,6 weeks), medium-term (6 months) and long-term (29 months) outcomes of vertebroplasty, followed by a retrospective long-term follow-up of patients treated with vertebroplasty compared with conservative therapy. Outcomes measured were visual analogue scale pain scores, analgesic use, disability scores using the Roland Morris Disability questionnaire and a number of new VCFs. Results: In 27 patients with acute VCFs followed prospectively, vertebroplasty resulted in significant reductions in pain levels (56-mm reduction on a 100-mm scale) and disability scores (11.8-point reduction on a 24-point scale) at all follow-up points up to a mean of 29 months compared with pre-vertebroplasty levels (P < 0.001). Analgesic use was significantly less intense in the short and medium term after vertebroplasty (P < 0.005). In 25 patients who had vertebroplasty for VCF, a sustained reduction in all outcomes was demonstrated at a mean follow-up of 30 months, with less pain, significantly lower disability scores (P < 0.05) and less analgesic use (P < 0.05) compared with nine conservatively treated subjects. During the follow-up period, six new VCFs occurred in 4/25 vertebroplasty patients compared with four new VCFs in 2/9 control subjects. Conclusions: Vertebroplasty provides significant and clinically meaningful reductions in pain, analgesic use, and disability in the short, medium and long term. Compared with conservative therapy, vertebroplasty provides significantly greater functional improvement and reduction in analgesic use. The procedure is relatively safe with no clearly increased risk of new vertebral fractures. [source]

Effect of vertebroplasty filler materials on viability and gene expression of human nucleus pulposus cells

JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 5 2008
Áron Lazáry
Abstract Consequences of intradiscal cement leakage,often occurring after vertebral cement augmentation for the treatment of vertebral compression fractures,are still unknown. In this study, we have investigated the influences of vertebroplasty filler materials (polymethylmethacrylate-, calcium phosphate- and calcium sulfate-based bone cement) on isolated nucleus pulposus cells. Cell viability of cultured human nucleus pulposus cells were measured after treatment with vertebroplasty filler materials. Gene expression profile of selected genes was determined with quantitative real-time PCR. The widely used polymethylmethacrylate and calcium phosphate cement significantly decreased cell number in a dose- and time-dependent manner while calcium sulfate cement affected cell viability less. Expression of genes involved in matrix metabolism of nucleus pulposus,aggrecan, collagens, small proteoglycans,as well as important transcription factors have also significantly changed due to treatment (e.g., 2.5-fold decrease in aggrecan expression was determined in cultures due to polymethylmethacrylate treatment). Our results suggest that vertebroplasty filler materials,depending on the type of applied material,can accelerate the degeneration of nucleus pulposus cells resulting in a less flexible disc in case of intradiscal cement leakage. This process may increase the risk of a subsequent new vertebral fracture, the main complication of vertebral augmentation. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:601,607, 2008 [source]

Expanding the phenotypic spectrum of Caffey disease

CLINICAL GENETICS, Issue 3 2007
K Suphapeetiporn
Infantile cortical hyperostosis (ICH) is an inherited disorder characterized by hyperirritability, acute inflammation of soft tissues, and massive subperiosteal new bone formation. It typically appears in early infancy and is considered a benign self-limiting disease. We report a three-generation Thai family with ICH, the oldest being a 75-year-old man. A heterozygous mutation for a 3040C,T in exon 41 of COL1A1 was found in affected individuals, further confirming the autosomal dominance of Caffey disease that is caused by this particular mutation. The novel findings in our studies include short stature and persistent bony deformities in the elderly. The height mean Z-score of the five affected individuals was ,1.75, compared to 0.53 of the other seven unaffected individuals giving a p-value of 0.008. Short stature may be partly due to progressive height loss from scoliosis, compression fractures of the spine and genu varus. These features, which have not previously been described, expand the phenotypic spectrum of the Caffey disease. [source]