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Common Observation (common + observation)
Selected AbstractsTubular reabsorption and diabetes-induced glomerular hyperfiltrationACTA PHYSIOLOGICA, Issue 1 2010P. Persson Abstract Elevated glomerular filtration rate (GFR) is a common observation in early diabetes mellitus and closely correlates with the progression of diabetic nephropathy. Hyperfiltration has been explained to be the result of a reduced load of sodium and chloride passing macula densa, secondarily to an increased proximal reabsorption of glucose and sodium by the sodium-glucose co-transporters. This results in an inactivation of the tubuloglomerular feedback (TGF), leading to a reduced afferent arteriolar vasoconstriction and subsequently an increase in GFR. This hypothesis has recently been questioned due to the observation that adenosine A1 -receptor knockout mice, previously shown to lack a functional TGF mechanism, still display a pronounced hyperfiltration when diabetes is induced. Leyssac demonstrated in the 1960s (Acta Physiol Scand58, 1963:236) that GFR and proximal reabsorption can work independently of each other. Furthermore, by the use of micropuncture technique a reduced hydrostatic pressure in Bowman's space or in the proximal tubule of diabetic rats has been observed. A reduced pressure in Bowman's space will increase the pressure gradient over the filtration barrier and can contribute to the development of diabetic hyperfiltration. When inhibiting proximal reabsorption with a carbonic anhydrase inhibitor, GFR decreases and proximal tubular pressure increases. Measuring intratubular pressure allows a sufficient time resolution to reveal that net filtration pressure decreases before TGF is activated which highlights the importance of intratubular pressure as a regulator of GFR. Taken together, these results imply that the reduced intratubular pressure observed in diabetes might be crucial for the development of glomerular hyperfiltration. [source] Prevalence and significance of Exit Block During Arrhythmias Arising in Pulmonary VeinsJOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 4 2000HUNG-FAT TSE M.D. Exit Block. Introduction: Recent studies described the occurrence of conduction block within pulmonary veins. The purpose of this study was to evaluate the prevalence of exit block during arrhythmias that arise in pulmonary veins. Methods and Results: Twenty-five patients with atrial tachycardia/fibrillation underwent successful ablation of 28 arrhythmogenic foci within a pulmonary vein. The prevalence of exit block in the pulmonary veins was determined in 28 arrhythmogenic pulmonary veins and 40 nonarrhythmogenic pulmonary veins. During isolated premature depolarizations, exit block in a pulmonary vein was observed at 50% of arrhythmogenic pulmonary vein sites and was never observed within pulmonary veins that did not generate a tachycardia (P < 0.01). During tachycardia, exit block from a pulmonary vein was observed in 61% of the arrhythmogenic pulmonary veins. The mean cycle length of the pulmonary vein tachycardias associated with exit block was significantly shorter than the cycle length of tachycardia that were not associated with exit block (163 ± 32 vs 251 ± 45 msec, P < 0.001), Exit block in two pulmonary veins during the same episode of tachycardia was observed in 3 of the 28 arrhythmogenic pulmonary veins (11%) in three different patients. Simultaneous recordings in the two pulmonary veins demonstrated bursts of tachycardia in both veins that were not synchronized. Radiofrequency catheter ablation of the arrhythmogenic site in one of the pulmonary veins eliminated spontaneous recurrences of tachycardia from the other pulmonary vein. Conclusion: Exit block from pulmonary veins is a common observation during tachycardias generated within pulmonary veins and indicates that an arrhythmogenic pulmonary vein has been identified. The occurrence of exit block in more than one pulmonary vein most likely is attributable to simultaneous tachycardias, one or both of which may be tachycardia induced and perpetuated by the other. [source] Role of UGT1A1 mutation in fasting hyperbilirubinemiaJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 6 2001Tomoaki Ishihara Abstract Background and Aim: Low-grade fasting hyperbilirubinemia is a common observation in healthy subjects (HS), whereas high-grade fasting hyperbilirubinemia is believed to be a characteristic finding of Gilbert's syndrome. This study was undertaken to assess the role of mutation in bilirubin UDP- glycosyltransferase gene (UGT1A1) on fasting hyperbilirubinemia. Methods: Analysis of UGT1A1 and a caloric restriction test (400 kcal for 24 h) were performed in 56 healthy subjects (25 males, 31 females), and 28 patients with Gilbert's syndrome (18 males, 10 females). There were 29 healthy subjects with no mutation in UGT1A1, and 27 healthy subjects and 26 Gilbert's syndrome patients with mutations in the coding and/or promoter (TATA box) regions of UGT1A1. Results: The mean increment of serum bilirubin (,SB) was 9.6 ,mol/L (males) and 4.1 ,mol/L (females) in subjects with no UGT1A1 mutation. Subjects with mutation in UGT1A1 showed higher levels of ,SB than individuals without mutation. Among healthy subjects, gender difference in ,SB values was observed only in individuals with the wild type of UGT1A1, but not in those with mutations in this gene. Conclusion: The results of the present study suggest that UGT1A1 mutation has a role in the development of high-grade fasting hyperbilirubinemia after caloric restriction. [source] The Diffusion of Management Innovations: The Possibilities and Limitations of MemeticsJOURNAL OF MANAGEMENT STUDIES, Issue 8 2007Joseph O'Mahoney abstract This paper applies a theory of memetics to help explain the diffusion of management innovations as a dynamic evolutionary process. Existing analyses of diffusion frequently note the variation, selection or replication of management innovations, yet few have linked these together with the common observation that some innovations seem to ,evolve'. This paper draws on qualitative evidence from two case-studies of BPR implementation to illustrate that the replication, selection and variation of management innovations can form evolutionary algorithms (,memes') which support diffusion processes, and, in doing so, clarifies the ways in which innovations contribute to their own replication and explains how the high ,failure' rates associated with BPR can sometimes improve its chances of reproduction. [source] LEARNING TO SOLVE PROBLEMS FROM EXERCISESCOMPUTATIONAL INTELLIGENCE, Issue 4 2008Prasad Tadepalli It is a common observation that learning easier skills makes it possible to learn the more difficult skills. This fact is routinely exploited by parents, teachers, textbook writers, and coaches. From driving, to music, to science, there hardly exists a complex skill that is not learned by gradations. Natarajan's model of "learning from exercises" captures this kind of learning of efficient problem solving skills using practice problems or exercises (Natarajan 1989). The exercises are intermediate subproblems that occur in solving the main problems and span all levels of difficulty. The learner iteratively bootstraps what is learned from simpler exercises to generalize techniques for solving more complex exercises. In this paper, we extend Natarajan's framework to the problem reduction setting where problems are solved by reducing them to simpler problems. We theoretically characterize the conditions under which efficient learning from exercises is possible. We demonstrate the generality of our framework with successful implementations in the Eight Puzzle, symbolic integration, and simulated robot planning domains illustrating three different representations of control knowledge, namely, macro-operators, control rules, and decision lists. The results show that the learning rates for the exercises framework are competitive with those for learning from problems solved by the teacher. [source] Genetic association with rheumatoid arthritis,Genetic Analysis Workshop 15: summary of contributions from Group 2GENETIC EPIDEMIOLOGY, Issue S1 2007Marsha A. Wilcox Abstract The papers in presentation group 2 of Genetic Analysis Workshop 15 (GAW15) conducted association analyses of rheumatoid arthritis data. The analyses were carried out primarily in the data provided by the North American Rheumatoid Arthritis Consortium (NARAC). One group conducted analyses in the data provided by the Canadian Rheumatoid Arthritis Genetics Study (CRAGS). Analysis strategies included genome-wide scans, the examination of candidate genes, and investigations of a region of interest on chromosome 18q21. Most authors employed relatively new methods, proposed extensions of existing methods, or introduced completely novel methods for aspects of association analysis. There were several common observations; a group of papers using a variety of methods found stronger association, on chromosomes 6 and 18 and in candidate gene PTPN22 among women with early onset. Generally, models that considered haplotypes or multiple markers showed stronger evidence for association than did single marker analyses. Genet. Epidemiol. 31 (Suppl. 1):S12,S21, 2007. © 2007 Wiley-Liss, Inc. [source] | |||||||||||||