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Coding
Kinds of Coding Terms modified by Coding Selected AbstractsIII. CODING, ANALYTIC PLAN, AND PRELIMINARY ANALYSESMONOGRAPHS OF THE SOCIETY FOR RESEARCH IN CHILD DEVELOPMENT, Issue 2 2005Article first published online: 12 SEP 200 First page of article [source] Compression of Human Motion Capture Data Using Motion Pattern IndexingCOMPUTER GRAPHICS FORUM, Issue 1 2009Qin Gu I.3.7 [Computer Graphics]: Three-Dimensional Graphics and Realism; E.4 [Coding and Information Theory]: Data Compaction and Compression Abstract In this work, a novel scheme is proposed to compress human motion capture data based on hierarchical structure construction and motion pattern indexing. For a given sequence of 3D motion capture data of human body, the 3D markers are first organized into a hierarchy where each node corresponds to a meaningful part of the human body. Then, the motion sequence corresponding to each body part is coded separately. Based on the observation that there is a high degree of spatial and temporal correlation among the 3D marker positions, we strive to identify motion patterns that form a database for each meaningful body part. Thereafter, a sequence of motion capture data can be efficiently represented as a series of motion pattern indices. As a result, higher compression ratio has been achieved when compared with the prior art, especially for long sequences of motion capture data with repetitive motion styles. Another distinction of this work is that it provides means for flexible and intuitive global and local distortion controls. [source] A study on video performance of multipoint-to-point video streaming with multiple description coding over ad hoc networksELECTRICAL ENGINEERING IN JAPAN, Issue 4 2010Keisuke Utsu Abstract Supporting multimedia applications over wireless networks has become a very active research topic recently because video applications are forecast to receive high demand in future wireless networks, such as ad hoc networks. However, enabling video transmission over wireless ad hoc networks is more challenging than over other wireless networks due to node mobility, interference, and the absence of a supporting infrastructure. This paper addresses the problem of video transmission over ad hoc networks. We propose to combine Multiple Description Coding (MDC) with multiple source transport (Multipoint-to-Point transfer: MP2P) in order to maintain smooth video streaming over wireless ad hoc networks. In this paper, we describe a comprehensive simulation and test bed experiment designed to show the effect of the proposed MP2P video transfer with MDC for two description cases of video streaming over wireless ad hoc networks. The results show that the proposed mechanism successfully improves video transfer performance in terms of video packet reachability and throughput. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 170(4): 43,50, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20999 [source] Fatigue and processing speed are related in multiple sclerosisEUROPEAN JOURNAL OF NEUROLOGY, Issue 2 2010A. K. Andreasen Background:, Fatigue is common in multiple sclerosis (MS) and could be related to impaired processing speed caused by MS specific brain alterations. The objective of this study was to examine the relationship between processing speed and fatigue in patients with relapsing remitting MS. Methods:, Patients with EDSS score ,3.5 were grouped as fatigued [Fatigue Severity Scale (FSS) score ,5.0] or non-fatigued (FSS score ,4.0). Patients with FSS scores ,5 were categorized as primary or secondary fatigued according to various indices. A cognitive test battery obtained from Wechsler's Adult Intelligence Scale-III/Wechsler's Memory Scale-III was applied. Results:, Processing speed (Digit Symbol Coding) was lower amongst all MS patients being 9.4(2.9) in primary fatigued, 8.3(2.8) in secondary fatigued and 10.3(2.7) in non-fatigued versus 12.3(3.0) in healthy controls. In the combined group of primary and secondary fatigued MS patients, processing speed was slower than that in non-fatigued MS patients and inversely related to fatigue (r = ,0.35; P < 0.05). No such relationship could be established in non-fatigued MS patients or in healthy controls. Conclusion:, The degree of fatigue in MS is related to processing speed impairment and longitudinal studies should clarify their mutual dependency. [source] Common Coding of Observation and Execution of Action in 9-Month-Old InfantsINFANCY, Issue 1 2006Matthew R. Longo Do 9-month-old infants motorically simulate actions they perceive others perform? Two experiments tested whether action observation, like overt reaching, is sufficient to elicit the Piagetian A-not-B error. Infants recovered a toy hidden at location A or observed an experimenter recover the toy. After the toy was hidden at location B, infants in both conditions perseverated in reaching to A, demonstrating that active search by the infant is not necessary for the A-not-B error. Consistent with prior research, infants displayed an ipsilateral bias when reaching, the so-called mysterious midline barrier. A similar ipsilateral bias was also observed depending on the manner in which the experimenter reached; infants perseverated following observation of ipsi- but not contralateral reaches by the experimenter. Thus, infants perseverated only following observation of actions they themselves were able to perform, suggesting that they coded others' actions in terms of motor simulation. [source] Sustained withdrawal behavior in clinic-referred and nonreferred infantsINFANT MENTAL HEALTH JOURNAL, Issue 3 2006Daphna Dollberg To examine the relations between infants' sustained withdrawal behavior and children's mental health status and maternal and child relational behavior, 36 clinic-referred and 43 control infants were evaluated. Families were visited at home, mother-child free play and feeding interactions were videotaped, and mothers completed self-report measures. Interactions were coded for sustained withdrawal using the Alarm Distress Baby Scale (ADBB; Guedeney and Fermanian, 2001) and for global relational patterns with the Coding of Interactive Behavior (CIB; Feldman, 1998). Higher ADBB scores were found for the referred group, with many infants (38.9% ) scoring above the clinical cutoff (vs. 11.6% in the control group). More negative relational patterns were found for the withdrawn group in terms of higher maternal intrusiveness, lower reciprocity, and lower child involvement. Associations were found between maternal and child behavior during play and feeding and child sustained withdrawal behavior at play. Sustained withdrawal also was associated with unpredictable child temperament and lower sense of parental self-efficacy. Maternal depressive symptoms were higher in the referred group and correlated with maternal and child relational patterns. The findings contribute to the construct and discriminant validity of the CIB and the ADBB coding systems, and suggest that sustained withdrawal may serve as a risk indicator for early socioemotional disorders. [source] Two-Minute Mental Health Care for Elderly Patients: Inside Primary Care VisitsJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 12 2007(See editorial comments by Drs. Charles Reynolds, Bruce L. Rollman), Carrie Farmer Teh, Mario Cruz OBJECTIVES: To assess how care is delivered for mental disorders using videotapes of office visits involving elderly patients. DESIGN: Mixed-method observational analysis of the nature of the topics discussed, content of discussion, and the time spent on mental health. SETTINGS: Three types of settings: an academic medical center, a managed care group, and fee-for-service solo practitioners. PARTICIPANTS: Thirty-five primary care physicians and 366 of their elderly patients. MEASUREMENTS: Videotapes of 385 visits covering 2,472 diverse topics were analyzed. Coding of the videotapes identified topics, determined talk time, and coded the dynamics of talk. RESULTS: Mental health topics occurred in 22% of visits, although patient survey indicated that 50% of the patients were depressed. A typical mental health discussion lasted approximately 2 minutes. Qualitative analysis suggested wide variations in physician effort in providing mental health care. Referrals to mental health specialists were rare even for severely depressed and suicidal patients. CONCLUSION: Little time is spent on mental health care for elderly patients despite heavy disease burdens. Standards of care based on a count of visits "during which a mental health problem is discussed" may need to be supplemented with guidelines about what should happen during the visit. System-level interventions are needed. [source] Association Between Apolipoprotein E4 and Cognitive Decline in Elderly AdultsJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 11 2007Chris J. Packard DSc OBJECTIVE: To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women. DESIGN: Prospective study. SETTING: Scotland, Ireland, and the Netherlands. PARTICIPANTS: Five thousand eight hundred four subjects aged 70 to 82 from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). MEASUREMENTS: Subjects were assessed at baseline and over a mean 3.2-year (range 0.7,4.2) follow-up for memory (Picture-Word Recall), speed of information processing (Stroop and Letter-Digit Coding), global cognitive function (Mini-Mental State Examination), and activities of daily living. RESULTS: At baseline, subjects with apolipoprotein E4 versus those without E4 had poorer memory performance (mean score difference ,0.20 (95% confidence interval (CI)=,0.31 to ,0.09) for immediate recall and ,0.32 (95% CI=,0.48 to ,0.16) for delayed recall and slower information processing (difference in Stroop, 2.79 seconds, (95% CI=1.20,4.28); Letter-Digit score, ,0.36, (95% CI=,0.77,0.05). Subjects with apolipoprotein E4 showed a greater decline in immediate (,0.22, 95% CI=,0.33 to ,0.11) and delayed (,0.30, 95% CI=,0.46 to ,0.15) memory scores but no significant change in speed of information processing (Stroop, P=.17; Letter-Digit, P=.06). Memory scores decreased 2.5% from baseline in those without E4, 4.3% in E4 heterozygotes (P=.01 for immediate and P=.03 for delayed, vs no E4) and 8.9% to 13.8% in E4 homozygotes (P=.04 for immediate and P=.004 for delayed, vs heterozygotes). Apolipoprotein E4 was associated with greater decline in instrumental activities of daily living (P<.001). Cognitive decline was not associated with lipoprotein levels. CONCLUSION: Findings in PROSPER indicate that E4 is associated with more-rapid cognitive decline and may, therefore, predispose to dementia. [source] Optimizing Coding and Reimbursement to Improve Management of Alzheimer's Disease and Related DementiasJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 11 2002Howard Fillit MD The objectives of this study were to review the diagnostic, International Classification of Disease, 9th Revision, Clinical Modification (ICD-9-CM), diagnosis related groups (DRGs), and common procedural terminology (CPT) coding and reimbursement issues (including Medicare Part B reimbursement for physicians) encountered in caring for patients with Alzheimer's disease and related dementias (ADRD); to review the implications of these policies for the long-term clinical management of the patient with ADRD; and to provide recommendations for promoting appropriate recognition and reimbursement for clinical services provided to ADRD patients. Relevant English-language articles identified from MEDLINE about ADRD prevalence estimates; disease morbidity and mortality; diagnostic coding practices for ADRD; and Medicare, Medicaid, and managed care organization data on diagnostic coding and reimbursement were reviewed. Alzheimer's disease (AD) is grossly undercoded. Few AD cases are recognized at an early stage. Only 13% of a group of patients receiving the AD therapy donepezil had AD as the primary diagnosis, and AD is rarely included as a primary or secondary DRG diagnosis when the condition precipitating admission to the hospital is caused by AD. In addition, AD is often not mentioned on death certificates, although it may be the proximate cause of death. There is only one ICD-9-CM code for AD,331.0,and no clinical modification codes, despite numerous complications that can be directly attributed to AD. Medicare carriers consider ICD-9 codes for senile dementia (290 series) to be mental health codes and pay them at a lower rate than medical codes. DRG coding is biased against recognition of ADRD as an acute, admitting diagnosis. The CPT code system is an impediment to quality of care for ADRD patients because the complex, time-intensive services ADRD patients require are not adequately, if at all, reimbursed. Also, physicians treating significant numbers of AD patients are at greater risk of audit if they submit a high frequency of complex codes. AD is grossly undercoded in acute hospital and outpatient care settings because of failure to diagnose, limitations of the coding system, and reimbursement issues. Such undercoding leads to a lack of recognition of the effect of AD and its complications on clinical care and impedes the development of better care management. We recommend continuing physician education on the importance of early diagnosis and care management of AD and its documentation through appropriate coding, expansion of the current ICD-9-CM codes for AD, more appropriate use of DRG coding for ADRD, recognition of the need for time-intensive services by ADRD patients that result in a higher frequency of use of complex CPT codes, and reimbursement for CPT codes that cover ADRD care management services. [source] ISBT 128 implementation plan for cellular therapy productsJOURNAL OF CLINICAL APHERESIS, Issue 5 2007Paul Ashford Abstract The publication of new standards for terminology and labeling marks an important step in ensuring consistency and traceability of cellular therapies at the global level. However, it is only with the widespread implementation of the standard that the benefits can be truly realized. This paper provides guidance on the practical aspects of adopting these new standards for organizations with differing current levels of computerization. It discusses project management, equipment, licensing, and validation topics. J. Clin. Apheresis, 2007. © 2007 Internal Cellular Therapy Coding and Labeling Advisory Group. [source] Coding and documentation: Medicare severity diagnosis-related groups and present-on-admission documentationJOURNAL OF HOSPITAL MEDICINE, Issue 2 2009Noel H. Ballentine MD Abstract Effective October 1, 2007, the Centers for Medicare and Medicaid Services has changed its methodology for determining the diagnosis-related group for hospitalized patients. In an effort to more accurately reflect severity of illness, the 538 diagnosis-related groups have been converted to 745 new Medicare severity diagnosis-related groups. In addition, selected hospital-acquired complications not identified as present on admission will no longer be reimbursed. The changes will have profound effects on reimbursement for hospitalizations. To minimize financial losses under the new rules, hospitals and physicians will have to devote significant resources and attention to improved documentation. This article will discuss the new payment system, the physician's role in ensuring that all clinically important diagnoses are captured by coding specialists, and strategies that can be employed to respond proactively to the challenge. Journal of Hospital Medicine 2009;4:124,130. © 2009 Society of Hospital Medicine. [source] Chemical Coding of GABAB Receptor-Immunoreactive Neurones in Hypothalamic Regions Regulating Body WeightJOURNAL OF NEUROENDOCRINOLOGY, Issue 1 2003M. Bäckberg Abstract ,-aminobutyric acid (GABA) interacts with hypothalamic neuronal pathways regulating feeding behaviour. GABA has been reported to stimulate feeding via both ionotropic GABAA and metabotropic GABAB receptors. The functional form of the GABAB receptor is a heterodimer consisting of GABAB receptor-1 (GABABR1) and GABAB receptor-2 (GABABR2) proteins. Within the heterodimer, the GABA-binding site is localized to GABABR1. In the present study, we used an antiserum to the GABABR1 protein in order to investigate the cellular localization of GABABR1-immunoreactive neurones in discrete hypothalamic regions implicated in the control of body weight. The colocalization of GABABR1 immunoreactivity with different chemical messengers that regulate food intake was analysed. GABABR1-immunoreactive cell bodies were found in the periventricular, paraventricular (PVN), supraoptic, arcuate, ventromedial hypothalamic, dorsomedial hypothalamic, tuberomammillary nuclei and lateral hypothalamic area (LHA). Direct double-labelling showed that glutamic acid decarboxylase (GAD)-positive terminals were in close contact with GABABR1-containing cell bodies located in all these regions. In the ventromedial part of the arcuate nucleus, GABABR1-immunoreactive cell bodies were found to contain neuropeptide Y, agouti-related peptide (AGRP) and GAD. In the ventrolateral part of the arcuate nucleus, GABABR1-immunoreactive cell bodies were shown to contain pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript. In the LHA, GABABR1 immunoreactivity was present in both melanin-concentrating hormone- and orexin-containing cell populations. In the tuberomammillary nucleus, GABABR1-immunoreactive cell bodies expressed histidine decarboxylase, a marker for histamine-containing neurones. In addition, GAD and AGRP were found to be colocalized in some nerve terminals surrounding GABABR1-immunoreactive cell bodies in the parvocellular part of the PVN. The results may provide a morphological basis for the understanding of how GABA regulates the hypothalamic control of food intake and body weight via GABAB receptors. [source] Identifying cumulative trauma disorders of the upper extremity in workers' compensation databasesAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 5 2003Dianne Zakaria MSc (PT), PhD (Candidate) Abstract Background Impeding the use of workers' compensation databases for surveillance of cumulative trauma disorder of the upper extremity (CTDUE) is the lack of valid and reliable extraction strategies. Methods Using the Z795-96 Coding of Work Injury or Disease Information standard, analgorithm was developed to classify claims as definite, possible, or non-CTDUE. Reliability was assessed with standardized claim reviews. Results Moderate to substantial agreement (Kappa,=,0.48, 95% CI 0.42,0.54, n,=,328; weighted Kappa,=,0.75, 95% CI 0.70,0.80, n,=,328) was demonstrated. The algorithm produced relatively homogeneous groups of definite and non-CTDUE claims but 29.1% of the possible CTDUE claims were categorized as definite CTDUE by claim review. Part of body agreement was almost perfect (Kappa,=,0.81,1.00) when determining whether the upper extremity or specific parts of the upper extremity were involved. Conclusions The algorithm can be used to estimate the number of CTDUE and extract homogeneous groups of definite and non-CTDUE claims. Furthermore, certain upper extremity part of body codes can be used to target anatomically defined claims. Am. J. Ind. Med. 43:507,518, 2003. © 2003 Wiley-Liss, Inc. [source] ,What does it mean?' uncertainty, trust and communication following treatment for pre-cancerous cervical abnormalitiesPSYCHO-ONCOLOGY, Issue 6 2007Ilona Juraskova Abstract The early detection of pre-cancerous cervical conditions has risen dramatically, prompting more in-depth investigations regarding psychological implications inherent within the diagnosis and treatment of this condition. This study aimed to identify factors that influence women's experience of diagnosis and treatment of cervical abnormalities and factors that facilitate positive adjustment. Using a semi-structured telephone interview, we interviewed 21 women (age 24,54) treated at a colposcopy clinic. Systematic recruitment of women with varying degrees of cervical abnormality (CIN 1,3) and time since treatment was undertaken to ensure representation of all relevant experiences and allow the identification of long-term factors. Coding of audio-taped, transcribed interviews and searching for themes was achieved by using NUD*IST software. The results identified uncertainty, trust and communication as the key factors for women following diagnosis and treatment. The primary concern following diagnosis was related to cancer but changed to a more prominent concern with future reproductive issues in the post-treatment period. The majority of women acknowledged the importance of the doctor's empathic communication style. These findings have important implications for future studies and clinical practice. Copyright © 2006 John Wiley & Sons, Ltd. [source] In vivo recordings from rat geniculate ganglia: taste response properties of individual greater superficial petrosal and chorda tympani neuronesTHE JOURNAL OF PHYSIOLOGY, Issue 3 2005Suzanne I. Sollars Coding of gustatory information is complex and unique among sensory systems; information is received by multiple receptor populations located throughout the oral cavity and carried to a single central relay by four separate nerves. The geniculate ganglion is the location of the somata of two of these nerves, the greater superficial petrosal (GSP) and the chorda tympani (CT). The GSP innervates taste buds on the palate and the CT innervates taste buds on the anterior tongue. To obtain requisite taste response profiles of GSP neurones, we recorded neurophysiological responses to taste stimuli of individual geniculate ganglion neurones in vivo in the rat and compared them to those from the CT. GSP neurones had a distinct pattern of responding compared to CT neurones. For example, a small subset of GSP neurones had high response frequencies to sucrose stimulation, whereas no CT neurones had high response frequencies to sucrose. In contrast, NaCl elicited high response frequencies in a small subset of CT neurones and elicited moderate response frequencies in a relatively large proportion of GSP neurones. The robust whole-nerve response to sucrose in the GSP may be attributable to relatively few, narrowly tuned neurones, whereas the response to NaCl in the GSP may relate to proportionately more, widely tuned neurones. These results demonstrate the diversity in the initial stages of sensory coding for two separate gustatory nerves involved in the ingestion or rejection of taste solutions, and may have implications for central coding of gustatory quality and concentration as well as coding of information used in controlling energy, fluid and electrolyte homeostasis. [source] Silent Functional Magnetic Resonance Imaging (fMRI) of Tonotopicity and Stimulus Intensity Coding in Human Primary Auditory Cortex,THE LARYNGOSCOPE, Issue 3 2004F. Zerrin Yetkin MD Abstract Objectives The aims of this study were to determine the feasibility of obtaining auditory cortex activation evoked by pure tones presented at threshold and suprathreshold hearing levels, to evaluate tonotopicity of the primary auditory cortex, and to determine the effect of stimulus intensity on auditory cortex activation using silent functional magnetic resonance imaging (fMRI). Methods Sixteen subjects with normal hearing underwent silent fMRI. An audiometer was used to deliver pure tones of 1,000, 2,000, and 4,000 Hz to the left ear. Two levels of acoustic stimulation were used: 1) threshold, hearing level determined in the scanner room and 2) suprathreshold, 70 dB hearing loss (HL). Tonotopicity and stimulus intensity coding was assessed on the basis of the location, extent, and amount of the auditory cortex activation. Results The localization of activation moved to more medial and posterior regions of the primary auditory cortex as the frequency of the pure tone increased. Compared with a threshold stimulus, a suprathreshold stimulus evoked the same regions with increased spatial extent. The average increase in the right auditory cortex activation in response to suprathreshold stimulus was 57% at 1,000, 51% at 2,000, and 45% at 4,000 Hz compared with that activated by the threshold stimulus. Conclusions Silent fMRI can be used to evaluate auditory cortex activation using low-intensity stimuli. The level of stimulus intensity increases the amount of auditory cortex activation and influences the fMRI mapping of the tonotopic organization of the primary auditory cortex. [source] Recommendations for the Assessment and Reporting of Multivariable Logistic Regression in Transplantation LiteratureAMERICAN JOURNAL OF TRANSPLANTATION, Issue 7 2010A. C. Kalil Multivariable logistic regression is an important method to evaluate risk factors and prognosis in solid organ transplant literature. We aimed to assess the quality of this method in six major transplantation journals. Eleven analytical criteria and four documentation criteria were analyzed for each selected article that used logistic regression. A total of 106 studies (6%) out of 1,701 original articles used logistic regression analyses from January 1, 2005 to January 1, 2006. The analytical criteria and their respective reporting percentage among the six journals were: Linearity (25%); Beta coefficient (48%); Interaction tests (19%); Main estimates (98%); Ovefitting prevention (84%); Goodness-of-fit (3.8%); Multicolinearity (4.7%); Internal validation (3.8%); External validation (8.5%). The documentation criteria were reported as follows: Selection of independent variables (73%); Coding of variables (9%); Fitting procedures (49%); Statistical program (65%). No significant differences were found among different journals or between general versus subspecialty journals with respect to reporting quality. We found that the report of logistic regression is unsatisfactory in transplantation journals. Because our findings may have major consequences for the care of transplant patients and for the design of transplant clinical trials, we recommend a practical solution for the use and reporting of logistic regression in transplantation journals. [source] International Colour Coding for syringe drug labels: a surveyANAESTHESIA, Issue 10 2004R. Baba No abstract is available for this article. [source] Origin and Chemical Coding of Primary Afferent Neurones Supplying the Prostate of the DogANATOMIA, HISTOLOGIA, EMBRYOLOGIA, Issue 6 2004M. B. Arciszewski Summary Retrograde tracing technique combined with the double-fluorescent immunohistochemistry were used to investigate the distribution and chemical coding of primary afferent neurones supplying the canine prostate. After the injection of Fast Blue (FB) into the prostatic tissue retrogradely-labelled (FB+) primary afferent neurones were localized in bilateral L1,Ca1 dorsal root ganglia (DRG). Statistical analysis using anova test showed that there are two major sources of afferent prostate innervation. The vast majority of prostate-supplying primary afferent neurones were located in bilateral L2,L4 DRG (56.9 ± 0.6%). The second source of the afferent innervation of canine prostate were bilateral S1,Ca1 DRG (40.6 ± 1.0%). No statistically significant differences were found between average number of FB+ neurones localized in the left and right DRG (49.5 ± 1.7 and 50.5 ± 1.7%, respectively). Immunohistochemistry revealed that FB+ primary afferent neurones contain several neuropeptides in various combinations. In the prostate-supplying neurones of lumbar and sacro-caudal DRG the immunoreactivity to substance P (SP) and calcitonin gene-related peptide (CGRP) was found most frequently (50 ± 3.7 and 37.3 ± 1.9%, respectively). Both in the lumbar and sacro-caudal DRG, considerable population of FB+ neurones immunoreactive neither to SP nor CGRP were also found (23 ± 2.6 and 32.8 ± 2.3%, respectively). In the lumbar DRG 10.7 ± 1.1% of SP-immunoreactive FB+ neurones also contained galanin (GAL). In 9.2 ± 2.2% of the prostate-supplying primary afferent neurones located in the sacro-caudal DRG the co-localization of SP and GAL was also reported. Results of the retrograde tracing experiment demonstrated for the first time sources of afferent innervation of the canine prostate. Double immunohistochemistry revealed that many of the prostate-supplying primary afferent neurones express some of sensory neuropeptides which presumably may be involved in nociception and some pathological processes like inflammation or nerve injury. [source] An elaborate education of basic genetic programming using C++COMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 3 2010Nirod C. Sahoo Abstract Evolutionary search is a global search method based on natural selection. In engineering curriculum, these techniques are taught in courses like Evolutionary Computation, Engineering Optimization, etc. Genetic algorithm (GA) is popular among these algorithms. Genetic programming (GP), developed by John Koza, is a powerful extension of GA where a chromosome/computer program (CP) is coded as a rooted point-labeled tree with ordered branches. The search space is the space of all possible CPs (trees) consisting of functions and terminals appropriate to the problem domain. GP uses, like GA, crossover and mutation for evolution. Due to tree-structured coding of individuals, the initial population generation, genetic operators' use, and tree decoding for fitness evaluations demand careful computer programming. This article describes the programming steps of GP implementation (using C++ language) for students' easy understanding with pseudocodes for each step. Two application examples are also illustrated. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 434,448, 2010; View this article online at wileyonlinelibrary.com; DOI 10.1002/cae.20165 [source] Out-of-core compression and decompression of large n -dimensional scalar fieldsCOMPUTER GRAPHICS FORUM, Issue 3 2003Lawrence Ibarria We present a simple method for compressing very large and regularly sampled scalar fields. Our method is particularlyattractive when the entire data set does not fit in memory and when the sampling rate is high relative to thefeature size of the scalar field in all dimensions. Although we report results foranddata sets, the proposedapproach may be applied to higher dimensions. The method is based on the new Lorenzo predictor, introducedhere, which estimates the value of the scalar field at each sample from the values at processed neighbors. The predictedvalues are exact when the n-dimensional scalar field is an implicit polynomial of degreen, 1. Surprisingly,when the residuals (differences between the actual and predicted values) are encoded using arithmetic coding,the proposed method often outperforms wavelet compression in anL,sense. The proposed approach may beused both for lossy and lossless compression and is well suited for out-of-core compression and decompression,because a trivial implementation, which sweeps through the data set reading it once, requires maintaining only asmall buffer in core memory, whose size barely exceeds a single (n,1)- dimensional slice of the data. Categories and Subject Descriptors (according to ACM CCS): I.3.5 [Computer Graphics]: Compression, scalar fields,out-of-core. [source] Mediation by any other name would smell as sweet,or would it?CONFLICT RESOLUTION QUARTERLY, Issue 3 2009The struggle to define mediation, its various approaches This article reports on two studies. The analysis of the first study, a survey of 250 mediators, finds four distinct groups of mediator "clusters," based on self-reported strategies. These four clusters are described in detail and mediators' self-defined labels are then correlated with the four clusters. There is little consistency between the labels mediators give their approach and the cluster into which they actually fall in this survey. The analysis of the second study, which involved observation and coding of actual mediations, finds that those mediators who were observed to use any directive strategies tended to use mostly directive strategies and those mediators who were observed to use any elicitive strategies tended to use mostly elicitive strategies throughout the observed mediation case. This challenges the notion that mediators may use both directive and elicitive strategies together in the same mediation. [source] Validity and reliability of the guidelines of the Surveillance of Cerebral Palsy in Europe for the classification of cerebral palsyDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 11 2008Mary Gainsborough MRCPCH The validity and reliability of the guidelines of the Surveillance of Cerebral Palsy in Europe (SCPE) for the classification of cerebral palsy (CP) were tested by administering 10 written case vignettes via an interactive web-based link to 30 SCPE partners. There was a moderately good level of agreement (,=0.59) about inclusion as a CP case on the SCPE database. Classification by CP subtype differed in two main areas: assigning spastic versus dyskinetic and judgement of distribution of spastic involvement. Agreement on Gross Motor Function Classification System (GMFCS) level was less good than reported in previous studies. Twenty respondents repeated the test 5 months later and there was good repeatability for case inclusion (,= 0.72) but considerable variation in assignment of CP subtype and GMFCS level. There is a need for further collaborative work and training to improve harmonization of the classification of CP, including examination, application of SCPE guidelines, and register coding. [source] Seasonal changes in frequency tuning and temporal processing in single neurons in the frog auditory midbrainDEVELOPMENTAL NEUROBIOLOGY, Issue 1 2005Jozien BM Goense Abstract Frogs rely on acoustic signaling to detect, discriminate, and localize mates. In the temperate zone, reproduction occurs in the spring, when frogs emerge from hibernation and engage in acoustically guided behaviors. In response to the species mating call, males typically show evoked vocal responses or other territorial behaviors, and females show phonotactic responses. Because of their strong seasonal behavior, it is possible that the frog auditory system also displays seasonal variation, as evidenced in their vocal control system. This hypothesis was tested in male Northern leopard frogs by evaluating the response characteristics of single neurons in the torus semicircularis (TS; a homolog of the inferior colliculus) to a synthetic mating call at different times of the year. We found that TS neurons displayed a seasonal change in frequency tuning and temporal properties. Frequency tuning shifted from a predominance of TS units sensitive to intermediate frequencies (700,1200 Hz) in the winter, to low frequencies (100,600 Hz) in the summer. In winter and early spring, most TS neurons showed poor, or weak, time locking to the envelope of the amplitude-modulated synthetic call, whereas in late spring and early summer the majority of TS neurons showed robust time-locked responses. These seasonal differences indicate that neural coding by auditory midbrain neurons in the Northern leopard frog is subject to seasonal fluctuation. © 2005 Wiley Periodicals, Inc. J. Neurobiol, 2005 [source] Peripheral coding of bitter taste in DrosophilaDEVELOPMENTAL NEUROBIOLOGY, Issue 2 2003Nicolas Meunier Abstract Taste receptors play a crucial role in detecting the presence of bitter compounds such as alkaloids, and help to prevent the ingestion of toxic food. In Drosophila, we show for the first time that several taste sensilla on the prothoracic legs detect bitter compounds both through the activation of specific taste neurons but also through inhibition of taste neurons activated by sugars and water. Each sensillum usually houses a cluster of four taste neurons classified according to their best stimulus (S for sugar, W for Water, L1 and L2 for salts). Using a new statistical approach based on the analysis of interspike intervals, we show that bitter compounds activate the L2 cell. Bitter-activated L2 cells were excited with a latency of at least 50 ms. Their sensitivity to bitter compounds was different between sensilla, suggesting that specific receptors to bitter compounds are differentially expressed among L2 cells. When presented in mixtures, bitter compounds inhibited the responses of S and W, but not the L1 cell. The inhibition was effective even in sensilla where bitter compounds did not activate the L2 cell, indicating that bitter compounds directly interact with the S and W cells. Interestingly, this inhibition occurred with latencies similar to the excitation of bitter-activated L2 cells. It suggests that the inhibition in the W and S cells shares similar transduction pathways with the excitation in the L2 cells. Combined with molecular approaches, the results presented here should provide a physiological basis to understand how bitter compounds are detected and discriminated. © 2003 Wiley Periodicals, Inc. J Neurobiol 56: 139,152, 2003 [source] Olfactory neurons expressing identified receptor genes project to subsets of glomeruli within the antennal lobe of Drosophila melanogasterDEVELOPMENTAL NEUROBIOLOGY, Issue 4 2003Sheetal Bhalerao Abstract We have used green fluorescent protein to trace the projection patterns of olfactory neurons expressing identified candidate odorant receptors to the brain of Drosophila. At the periphery, receptor expression correlates with specific sense-organ subtype, independent of location on the antennal surface. The majority of neurons expressing a given receptor converge onto one or two major glomeruli as described previously. However, we detected a few additional glomeruli, which are less intensely innervated and also tend to be somewhat variable. This means that functionally similar olfactory neurons connect to small subsets of glomeruli rather than to a single glomerulus as believed previously. This finding has important implications for our understanding of odor coding and the generation of olfactory behavior. © 2003 Wiley Periodicals, Inc. J Neurobiol 54: 577,592, 2003 [source] N-cadherin is regulated by gonadal steroids in adult sexually dimorphic spinal motoneuronsDEVELOPMENTAL NEUROBIOLOGY, Issue 4 2001Douglas A. Monks Abstract Gonadal steroids influence the morphology and function of neurons in the adult spinal cord through cellular and molecular mechanisms that are largely unknown. The cadherins are cell adhesion molecules that participate in the formation and organization of the CNS during embryonic development, and recent evidence suggests that the cadherins continue to regulate neural structure and function in adulthood. Using degenerate oligonucleotides coding conserved regions of the catenin-binding domain of classical cadherins in a RT-PCR cloning strategy, we identified several cadherin subtypes, the most frequently cloned being N-, E-, and R-cadherin, suggesting that these are the major classical cadherin subtypes present in the adult male rat lumbosacral spinal cord. We then examined cadherin expression levels of these cadherin subtypes under steroid conditions known to induce plastic changes in spinal motoneurons. Semiquantitative PCR revealed that mRNA levels of N-cadherin, but not E-cadherin or R-cadherin, are elevated in castrated rats treated with testosterone, 17,-estradiol, or dihydrotestosterone relative to castrate rats not treated with steroids. Immunolocalization of N-cadherin revealed that steroid treatment increased N-cadherin expression levels in functionally related neural populations whose morphology and function are regulated by steroids. These results suggest a role for N-cadherin in steroid-induced neuroplastic change in the adult lumbar spinal cord. © 2001 John Wiley & Sons, Inc. J Neurobiol 47: 255,264, 2001 [source] Early recognition of newborn goat kids by their mother: II.DEVELOPMENTAL PSYCHOBIOLOGY, Issue 4 2003Auditory recognition, evidence of an individual acoustic signature in the neonate Abstract The vocal recognition of newborn kids by their mother at 2 days postpartum and the possible existence of interindividual differences in the voice structure of newborn kids were investigated in two separate studies. The ability of goats to discriminate between the bleats of their own versus an alien kid was tested at 2 days postpartum in mothers being prevented access to visual and olfactory cues from the young. Goats spent significantly more time on the side of the enclosure from which their own kid was bleating, looked in its direction for longer, and responded more frequently to the bleats of their own than to those of the alien kid (p,<,0.05). In the second study, the sonograms of 13 kids, studied from Days 1 to 5, showed significant interindividual differences for the five variables taken into account and on each of the 5 days (duration of bleat, fundamental frequency, peak frequency, and numbers of segments and of harmonics). The potential for individual coding ranged between 1.1 and 4.1, indicating that for some variables variations between individuals were greater than intraindividual variations. Furthermore, when considering the five parameters together, the discriminating scores showed an average of 95% in the 78 combinations of any 2 kids for any given day. Finally, some significant intraindividual differences also were found between days, suggesting ontogenic changes in the characteristics of the kid's voice in early life. Therefore, mother goats are likely to recognize the vocalizations of their 48-hr-old kids, as they show sufficient interindividual variability to allow the existence of individual vocal signatures, even though some of the characteristics of the bleats change rapidly over time. © 2003 Wiley Periodicals, Inc. Dev Psychobiol 43: 311,320, 2003. [source] The changing prevalence of diagnosed diabetes and its associated vascular complications in a large region of the UK*DIABETIC MEDICINE, Issue 6 2010C. L. Morgan Diabet. Med. 27, 673,678 (2010) Abstract Aims, To characterize the prevalence of diabetes in a large health district in 2004 and compare it with a previous estimate made in 1996. Methods, The study population comprised the resident population of Cardiff and the Vale of Glamorgan. Routine record linkage was used to identify patients from various sources of hospital and mortality data. Patients with diabetes were identified according to biochemistry test results, coding on routine data or attendance at a diabetes-related clinic. Diabetes-related complications were ascribed according to coding on routine data. Results, It was possible to identify 17 088 people with diabetes alive on 1 January 2005. Of these patients, 9064 (53.0%) were male and 8024 (47.0%) were female. Mean age (± sd) was 59.6 ± 18.9 years for males and 61.2 ± 20.4 years for females. The crude prevalence of diabetes in 2005 was 3.9% (3.4% adjusted) compared with 2.5% in 1996 (2.3% adjusted). With the exception of females aged , 75 years, the prevalence of diabetes increased in all age- and sex-specific subgroups. Within the 2005 cohort, over two-thirds has no recorded complications compared with approximately one half of the 1996 cohort. The prevalence of individual complications decreased, with the exception of renal complications. Conclusions, The prevalence of identified diabetes appears to have increased substantially over a relatively short period of 9 years to 2004. The increase in prevalence was 46%, with an increase in numbers of patients with diabetes of 53%. A number of factors are likely to have contributed to this, including an increase in case ascertainment. [source] Incorrect and incomplete coding and classification of diabetes: a systematic reviewDIABETIC MEDICINE, Issue 5 2010M. A. Stone Diabet. Med. 27, 491,497 (2010) Abstract Aims, To conduct a systematic review to identify types and implications of incorrect or incomplete coding or classification within diabetes or between diabetes and other conditions; also to determine the availability of evidence regarding frequency of occurrence. Methods, Medical Subject Headings (MeSH) and free-text terms were used to search relevant electronic databases for papers published to the end of August 2008. Two researchers independently reviewed titles and abstracts and, subsequently, the full text of potential papers. Reference lists of selected papers were also reviewed and authors consulted. Three reviewers independently extracted data. Results, Seventeen eligible studies were identified, including five concerned with distinguishing between Type 1 and Type 2 diabetes. Evidence was also identified regarding: the distinction between diabetes and no-diabetes, failure to specify type of diabetes, and diagnostic errors or difficulties involving maturity-onset diabetes of the young, latent autoimmune diabetes in adults, pancreatic diabetes, persistence of foetal haemoglobin and acquired immune deficiency syndrome (AIDS). The sample was too heterogeneous to derive accurate information about frequency, but our findings suggested that misclassification occurs most commonly in young people. Implications relating to treatment options and risk management were highlighted, in addition to psychological and financial implications and the potential impact on the validity of quality of care evaluations and research. Conclusions, This review draws attention to the occurrence and implications of incorrect or incomplete coding or classification of diabetes, particularly in young people. A pragmatic and clinically relevant approach to classification is needed to assist those involved in making decisions about types of diabetes. [source] | ||||||||||||||||||||||||||||