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Access Port (access + port)
Selected AbstractsAtypical dose,route-dependent food effects of eplerenone in the dog: Presence of food effects following intravenous dosing and lack of food effects of following oral dosingJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 3 2002Chyung S. Cook Abstract This study was conducted to investigate why a food effect was observed following an intravenous dose of eplerenone (EP) in the dog, but not following oral dosing. Three female dogs were implanted with a chronic portal vein access port and received radiolabeled EP doses orally (15 mg/kg in solution) and intravenously (7.5 mg/kg via cephalic and portal veins) under fasted and fed conditions. Mean AUC values for EP after infusion through the cephalic vein were 23.0,±,2.7 and 18.2,±,1.1 h,·,,g/mL under fasted and fed conditions, respectively. Corresponding values after infusion through the portal vein were 20.7,±,3.2 and 12.9,±,1.3 h,·,,g/mL, respectively. After oral administration, EP was absorbed 82.0,±,6.9 and 98.0,±,8.3% under fasted and fed conditions; corresponding mean AUC values were 32.0,±,2.0 and 30.8,±,3.6 h,·,,g/mL, respectively. The AUC value for SC-70303 acid (the open lactone form of EP) was lower under fed conditions after cephalic vein infusion, but was greater under fed conditions after portal vein infusion or oral solution administration. The hepatic first-pass effect of EP was 12.6,±,6.3% under fasted conditions and 27.1,±,6.0% under fed conditions. Pharmacokinetic analysis of EP concentrations after portal vein infusion and oral administration showed that under fed conditions the rate constants for bile excretion and for liver metabolism and urinary excretion were increased while the rate constant for elimination and/or metabolism in the gastrointestinal tract was reduced. In conclusion, the apparent lack of food effect after oral administration was observed because enhanced clearance was compensated by increased absorption. © 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 91:607,614, 2002 [source] Editorial regarding use of modified femoral vein approach as method for implanting a totally implantable access port in patients with synchrounous bilateral mastectomes (Chen et al.)JOURNAL OF SURGICAL ONCOLOGY, Issue 3 2008Harold J. Wanebo MD No abstract is available for this article. [source] Long-term pericardial catheterization is associated with minimum foreign-body responseCATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 2 2007Carlo R. Bartoli BS Abstract Objectives: The goals of this study were to assess the feasibility and to characterize the foreign-body response of a long-term catheter in the pericardium. Background: Long-term access to the normal pericardial space provides opportunities for diagnostic sampling and therapeutic intervention. Methods: After thoracotomy, in 7 anesthetized canines, the pericardium was opened and a 5 French silicone vascular access catheter was advanced 10 cm into the pericardial sac toward the apex of the heart. A hydraulic coronary balloon occluder was implanted (N = 6). Pericardium was sealed with Prolene suture. Catheters were tunneled to the nape of the neck, attached to a subcutaneous vascular access port, and buried in the fascia. Animals underwent multiple experimental coronary artery occlusions across months. At sacrifice, we assessed the histopathological response of pericardium and epicardium to chronically indwelling silicone catheters. Results: Post-mortem examinations were performed at 213 days post-operatively (mean, range = 96,413, N = 6), with one animal maintained for longer-term study. At sacrifice, all catheters were bidirectionally patent and completely mobile in the pericardium without evidence of tissue overgrowth around the intrapericardial segment. Adhesion tissue was found only at the site of catheter entry through the pericardium. Microscopic histopathological examination at catheter entry site, surrounding pericardium, and myocardium revealed minimum chronic inflammation. Conclusions: This subcutaneous system provides dependable, chronic access to the normal pericardial space for drug delivery and sampling. The presence of a chronic silicone catheter in the pericardium does not precipitate clinically significant pathologic changes even after repeated ischemic events. © 2007 Wiley-Liss, Inc. [source] Trigger arrhythmia to confirm the position of totally implantable access ports (TIAP)JOURNAL OF SURGICAL ONCOLOGY, Issue 5 2007Huan-Fa Hsieh MD Abstract Background Totally implantable access ports (TIAP) with cutdown method has few complications, but needs assessment of fluoroscopic system. Methods We present a method to confirm the position of TIAP catheter without fluoroscopic assessment. We use the cutdown method and trigger arrhythmia while introducing the TIAP catheter. Results This method was applied in 54 patients and no complications were found. Conclusions Checking the position by triggering arrhythmia while performing TIAP with cephalic vein cutdown in case of C-arm was not available is simple and safe. J. Surg. Oncol. 2007;96:436,437. © 2007 Wiley-Liss, Inc. [source] Comparison of radiologically inserted arm ports versus surgically placed chest ports for chemotherapyASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Issue 3 2009Andrew WEICKHARDT Abstract Aim: Central venous access ports (CVAP) are often required to deliver chemotherapy to cancer patients. Arm-sited CVAP are an alternative to traditional chest-sited CVAP, but their durability and complication rates have not been thoroughly compared. Methods: A retrospective analysis at a single institution was conducted of all patients who had a chest port inserted for chemotherapy over a 30-month period and compared to patients who had an arm port inserted over a subsequent 30-month period. The minimum follow-up period in patients who did not die from cancer was 6 months. The primary endpoint was successful use of the port, defined as a patient completing chemotherapy without a complication prompting removal of the port. Results: The success rate was not significantly different between arm port (92 patients) or chest port (49 patients) groups (88 vs 92%). There were no significant differences between infective or thrombotic complications in the two groups. Conclusion: Arm CVAP were found to be equivalent in durability and complications compared to chest CVAP for chemotherapy administration at a regional oncology unit. [source] | ||||||||||