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Cognitive Benefits (cognitive + benefit)

Distribution by Scientific Domains

Psychology	50%
Medical Sciences	33%

Selected Abstracts

Randomized double-blind placebo-controlled donepezil augmentation in antidepressant-treated elderly patients with depression and cognitive impairment: a pilot study

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 7 2008
Gregory H. Pelton
Abstract Objective To assess combined antidepressant and cognitive enhancer treatment in elderly patients presenting with depression plus cognitive impairment. Methods Twenty-three elderly (>50 years old) depressed, cognitively impaired (DEP-CI) patients participated in a pilot study. We evaluated whether, after 8 weeks of open antidepressant treatment, donepezil HCl (Aricept) would afford added cognitive benefit compared to placebo in a randomized 12-week trial. A subsample continued in an 8-month extension phase of open treatment with donepezil. Neuropsychological testing (NPT) was performed and antidepressant response monitored at baseline and the 8, 20, and 52-week time points. Results At 8-weeks, the antidepressant response rate was 61% (14/23). Improvement in SRT immediate recall (SRT-IR; e.g. episodic verbal memory) was observed in responders compared to non-responders. During the 12-week, placebo-controlled, donepezil add-on trial, patients on donepezil showed further improvement in SRT-IR versus patients on placebo. In the open extension phase, patients who continued open donepezil treatment (n,=,6) maintained improvement in memory and tended to show an advantage over patients who never received donepezil and were evaluated at the 52-week time point (n,=,6). There were no observed significant donepezil effects on non-memory cognitive domains. Conclusion These preliminary findings suggest that addition of a cholinesterase inhibitor (AChEI) following antidepressant medication treatment in elderly Dep-CI patients may improve cognition, and support the need for a confirmatory, larger randomized placebo-controlled trial. Copyright © 2007 John Wiley & Sons, Ltd. [source]

Gesturing Saves Cognitive Resources When Talking About Nonpresent Objects

COGNITIVE SCIENCE - A MULTIDISCIPLINARY JOURNAL, Issue 4 2010
Raedy Ping
Abstract In numerous experimental contexts, gesturing has been shown to lighten a speaker's cognitive load. However, in all of these experimental paradigms, the gestures have been directed to items in the "here-and-now." This study attempts to generalize gesture's ability to lighten cognitive load. We demonstrate here that gesturing continues to confer cognitive benefits when speakers talk about objects that are not present, and therefore cannot be directly indexed by gesture. These findings suggest that gesturing confers its benefits by more than simply tying abstract speech to the objects directly visible in the environment. Moreover, we show that the cognitive benefit conferred by gesturing is greater when novice learners produce gestures that add to the information expressed in speech than when they produce gestures that convey the same information as speech, suggesting that it is gesture's meaningfulness that gives it the ability to affect working memory load. [source]

Developmental neural plasticity and its cognitive benefits: olivocerebellar reinnervation compensates for spatial function in the cerebellum

EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 5 2007
Melina L. Willson
Abstract The adult mammalian central nervous system displays limited reinnervation and recovery from trauma. However, during development, post-lesion plasticity may generate alternative paths, thus providing models to investigate reinnervation and repair. After unilateral transection of the neonatal rat olivocerebellar path (pedunculotomy), axons from the remaining inferior olive reinnervate the denervated hemicerebellum. Unfortunately, reinnervation to the cerebellar hemisphere is incomplete; therefore, its capacity to mediate hemispheric function (navigation) is unknown. We studied sensorimotor control and spatial cognition of rats with and without transcommissural reinnervation using simple (bridge and ladder) and complex (wire) locomotion tests and the Morris water maze (hidden, probe and cued paradigms). Although pedunculotomized animals completed locomotory tasks more slowly than controls, all groups performed equally in the cued maze, indicating that lesioned animals could orientate to and reach the platform. In animals pedunculotomized on day 3 (Px3), which develop olivocerebellar reinnervation, final spatial knowledge was as good as controls, although they learned more erratically, failing to retain all information from one day to the next. By contrast, animals pedunculotomized on day 11 (Px11), which do not develop reinnervation, did not learn the task, taking less direct routes and more time to reach the platform than controls. In the probe test, control and Px3, but not Px11, animals swam directly to the remembered location. Furthermore, the amount of transcommissural reinnervation to the denervated hemisphere correlated directly with spatial performance. These results show that transcommissural olivocerebellar reinnervation is associated with spatial learning, i.e. even partial circuit repair confers significant functional benefit. [source]

Do statins slow down Alzheimer's disease?

JOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 3 2004
A review
Summary More than 4 million people suffer from Alzheimer's disease (AD) in the United States. The prevalence increases with age as the rate is 3% in those between 65 and 74 years compared with 47% among those over 85 years of age. Some epidemiological studies have reported a decrease in the incidence of AD with the use of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins). Other studies have shown statins to decrease A, peptides, but data regarding cognitive benefits is lacking in this patient population. There are also concerns that statins, which cross the blood,brain barrier may cause more side-effects, but more information is needed. Adverse events were either infrequently noted or not reported in most of the published studies, and at this time there is insufficient evidence to suggest the use of statins for cognitive improvements in patients with AD. [source]

An overview of how sports, out-of-school time, and youth well-being can and do intersect

NEW DIRECTIONS FOR YOUTH DEVELOPMENT, Issue 115 2007
Suzanne Le Menestrel
This article examines the benefits and disadvantages of participation in organized youth sports and describes a youth development approach to sports programming. The authors summarize what is known about the physical, socioemotional, and cognitive benefits of sports participation. These include health benefits (for example, a reduction in heart disease and diabetes) as well as socioemotional benefits, among them the coping skills of being able to bounce back from problems. The authors describe some of the disadvantages of participation as well. In particular, studies in this area have focused on health risk behaviors and engagement in problem behaviors. The authors present an innovative approach to youth sports and the advantages of implementing this approach using the emerging community youth development framework. Specific examples of youth sports programs are provided that use a positive youth development framework. [source]