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Circumstances
Kinds of Circumstances Selected AbstractsAct and Circumstance in the Crime of Aggression*THE JOURNAL OF POLITICAL PHILOSOPHY, Issue 2 2007Larry May First page of article [source] Modeling and Optimization of Photosynthetic Hydrogen Gas Production by Green Alga Chlamydomonas reinhardtii in Sulfur-Deprived CircumstanceBIOTECHNOLOGY PROGRESS, Issue 2 2006Ji Hye Jo Biological hydrogen production by the green alga Chlamydomonas reinhardtii under sulfur-deprived conditions has attracted great interest due to the fundamental and practical importance of the process. The photosynthetic hydrogen production rate is dependent on various factors such as strain type, nutrient composition, temperature, pH, and light intensity. In this study, physicochemical factors affecting biological hydrogen production by C. reinhardtii were evaluated with response surface methodology (RSM). First, the maximum specific growth rate of the alga associated with simultaneous changes of ammonium, phosphate, and sulfate concentrations in the culture medium were investigated. The optimum conditions were determined as NH4+ 8.00 mM, PO43, 1.11 mM, and SO42, 0.79 mM in Tris-acetate-phosphate (TAP) medium. The maximum specific growth rate with the optimum nutrient concentrations was 0.0373 h,1. Then, the hydrogen production rate of C. reinhardtii under sulfur-deprivation conditions was investigated by simultaneously changing two nutrient concentrations and pH in the medium. The maximum hydrogen production was 2.152 mL of H2 for a 10-mL culture of alga with density of 6 × 106 cells mL,1 for 96 h under conditions of NH4+ 9.20 mM, PO43, 2.09 mM, and pH 7.00. The obtained hydrogen production rate was approximately 1.55 times higher than that with the typical TAP medium under sulfur deficiency. [source] The impact of a social network intervention on retention in Belgian therapeutic communities: a quasi-experimental studyADDICTION, Issue 7 2006Veerle Soyez ABSTRACT Background Although numerous studies recognize the importance of social network support in engaging substance abusers into treatment, there is only limited knowledge of the impact of network involvement and support during treatment. The primary objective of this research was to enhance retention in Therapeutic Community treatment utilizing a social network intervention. Aims The specific goals of this study were (1) to determine whether different pre-treatment factors predicted treatment retention in a Therapeutic Community; and (2) to determine whether participation of significant others in a social network intervention predicted treatment retention. Design, setting and participants Consecutive admissions to four long-term residential Therapeutic Communities were assessed at intake (n = 207); the study comprised a mainly male (84.9%) sample of polydrug (41.1%) and opiate (20.8%) abusers, of whom 64.4% had ever injected drugs. Assessment involved the European version of the Addiction Severity Index (EuropASI), the Circumstances, Motivation, Readiness scales (CMR), the Dutch version of the family environment scale (GKS/FES) and an in-depth interview on social network structure and perceived social support. Network members of different cohorts were assigned to a social network intervention, which consisted of three elements (a video, participation at an induction day and participation in a discussion session). Findings Hierarchical regression analyses showed that client-perceived social support (F1,198 = 10.9, P = 0.001) and treatment motivation and readiness (F1,198 = 8.8; P = 0.003) explained a significant proportion of the variance in treatment retention (model fit: F7,197 = 4.4; P = 0.000). By including the variable ,significant others' participation in network intervention' (network involvement) in the model, the fit clearly improved (F1,197 = 6.2; P = 0.013). At the same time, the impact of perceived social support decreased (F1,197 = 2.9; P = 0.091). Conclusions Participation in the social network intervention was associated with improved treatment retention controlling for other client characteristics. This suggests that the intervention may be of benefit in the treatment of addicted individuals. [source] Examining the Impact of Opportunity Bursaries on the Financial Circumstances and Attitudes of Undergraduate Students in EnglandHIGHER EDUCATION QUARTERLY, Issue 2 2009Anne West Notwithstanding the expansion of higher education across the OECD, there continues to be concern about the levels of participation amongst those from disadvantaged backgrounds. In response to this, a new form of financial support for students from low-income families, the ,opportunity bursary', was introduced for a limited period in England from 2001/02. Surveys of two cohorts of opportunity-bursary applicants were carried out and these suggested possible psychological, behavioural and economic impacts. Fewer opportunity-bursary recipients than non-recipients reported that part-time work had interfered with their studies and more reported that the bursary had made them less worried about meeting the costs of going to university. There was some evidence that the scheme led to increased retention in the first year of university study; it also appeared to lead to lower levels of debt, in particular bank overdrafts or credit card debt. [source] Bastard Feudalism, Overmighty Subjects and Idols of the Multitude during the Wars of the RosesHISTORY, Issue 279 2000Michael Hicks A handful of overmighty subjects exercised a disproportionate influence on the events of the Wars of the Roses. This article considers how and why. Circumstances were certainly propitious. Not only did the greatest noblemen command exceptional resources of their own, albeit always less than the king, but they deployed the principal military commands against the crown and sought to enlist the populace on their side. Successful overmighty subjects were also idols of the multitude. Generally they failed and almost all died violently. Their misfortunes, a recovery of royal power and the disappearance of the desire to disturb the realm all help to explain the demise of their type. [source] Expecting the worst: circumstances surrounding pregnancy discrimination at work and progress to formal redressINDUSTRIAL RELATIONS JOURNAL, Issue 3 2008Paula McDonald ABSTRACT This study explored the details of 318 cases of alleged workplace pregnancy discrimination reported to a community advocacy organisation in Australia. Circumstances surrounding pregnancy discrimination included derogatory comments about physical appearance, changed working conditions, denial of access to opportunities and less favourable work performance appraisals. Dismissal or constructive dismissal was often reported. The study also highlights the complexity and difficulty in navigating formal complaints processes and examines some of the outcomes for women who chose this course of action. [source] Immigrants, Natives and Social Assistance: Comparable Take-Up Under Comparable CircumstancesINTERNATIONAL MIGRATION REVIEW, Issue 3 2001Edward J. Castronova Are immigrants on welfare because they are more likely to be eligible or because they are more likely to claim benefits for which they are eligible? The answer is politically important, but because most current research on immigration and welfare is based on data from the United States, the answer is difficult due to the complexities of the transfer system which make eligibility determinations difficult. In Germany, by contrast, eligibility for the main cash transfer program, Sozialhilfe (Social Assistance), is determined by a comparatively simple nationwide formula. We use data from the German Socio-Economic Panel to test whether immigrants to Germany are more likely than natives to claim welfare benefits for which they are eligible. We find that immigrants are more likely than native Germans to receive welfare, both because immigrants are more likely to be eligible and because they are more likely, when eligible, to claim their benefits. However, we also find that this greater propensity to take-up benefits is not related to immigrant status per se: when other sociodemographic factors are accounted for in an appropriate manner, immigrant households are no more likely to take-up benefits than native households. [source] Reactions to a Motor-Vehicle Accident in Relation to Mitigating Circumstances and the Gender and Moral Worth of the Driver,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 1 2000NORMAN T. FEATHER Male and female students (N= 153) at the Flinders University of South Australia read scenarios describing a motor-vehicle accident that varied mitigating circumstances (driving on a slippery road vs. driving at high speed), gender of driver, and the moral worth of the driver (very dependable and trustworthy vs. not dependable and a bit untrustworthy). Results showed that mitigation affected judgments about the driver's responsibility, seriousness of the offense, driver's deservingness of penalty imposed, harshness of penalty, positive affect about the penalty, and sympathy for the driver, consistent with a social cognitive process model (Feather, 1996c, 1998). Moral worth affected judgments about the driver's moral character, harshness of penalty, and liking and sympathy for the driver. Participants attributed higher moral character to the female driver and also reported more liking for the female driver. There was some limited evidence for an in-group gender bias. [source] Toxicology and Circumstances of Completed Suicide by Means Other than Overdose,JOURNAL OF FORENSIC SCIENCES, Issue 2 2009Shane Darke Ph.D. Abstract:, To determine the prevalence and circumstances of psychoactive substances amongst nonoverdose completed suicide, 1436 consecutive cases autopsied at the NSW Department of Forensic Medicine over the period 1/1/1997,12/31/2006 were analyzed. Substances were detected in 67.2% of cases, and illicit drugs in 20.1%. Alcohol was present in 40.6% of cases. Males were more likely to be positive for alcohol, cannabis, and psychostimulants, and females for pharmaceuticals. Illicits were associated with younger age. Alcohol was most prominent amongst toxicity cases, as were opioids, psychostimulants amongst gunshot cases, and pharmaceuticals amongst drownings. Cases in which drug and alcohol histories were noted were more likely to have a substance detected. Alcohol was more common where a suicide note was left and where relationship problems were involved. Pharmaceuticals were more common where a previous attempt was noted. Licit and illicit substances are strongly associated with suicide, even when the method does not involve drug overdose. [source] Toxicology and Circumstances of Death of Homicide Victims in New South Wales, Australia 1996,2005JOURNAL OF FORENSIC SCIENCES, Issue 2 2008Shane Darke Ph.D. Abstract:, To determine the prevalence and circumstances of psychoactive substances amongst homicide victims, 485 consecutive cases autopsied at the NSW Department of Forensic Medicine (1/1/1996,12/31/2005) were analyzed. Substances were detected in 62.6% of cases, and illicit drugs in 32.8%. Alcohol, cannabis, opioids, and psychostimulants were most commonly detected. Alcohol and cannabis were both more prevalent amongst males. Mean ages were significantly younger for decedents who tested positive for a substance and for an illicit drug. Cases where death resulted from a physical altercation were more likely to have had alcohol and cannabis present. Illicit drugs were prominent amongst firearms deaths. The proportion of alcohol positive cases increased from 25.0% on Monday to 49.4% for Saturdays/Sundays. Alcohol was more common in incidents in the 0001,0600 h and 1800,2400 h periods. Psychoactive substances appear to substantially increase the risk of homicide, although there are important differences between drug classes in the circumstances of such incidents. [source] Sexual assault history and social support: Six general population studies,JOURNAL OF TRAUMATIC STRESS, Issue 3 2002Jacqueline M. Golding Abstract We evaluated the association of sexual assault history with later social support, operationalized as network size, marital status, presence of a partner, frequency of network contacts, and emotional support from friends and family, from spouse, and from partner. Data came from six independent general population surveys (pooled N = 9,865) whose results were summarized using meta-analysis. People who had been sexually assaulted were less likely than others to he married (OR = 0.75. 95% CI = 0.65, 0.87) or to report at least weekly contact with friends and relatives (OR = 0.48,95% CI = 0.31, 0.75), and reported less emotional support from friends and family (OR = 0.72,95% CI = 0.58,0.89) and spouse (OR = 0.67, 95% CI = 0.54, 0.82). Results were consistent across studies, genders, and ethnic groups. Circumstances of sexual assault were sometimes related to social support. [source] The multiple meteorite fall of Neuschwanstein: Circumstances of the event and meteorite search campaignsMETEORITICS & PLANETARY SCIENCE, Issue 10 2004J. OBERST From analysis of the images, a prediction on the geographic location of the meteorite strewn field could be made. Following systematic ground searches in difficult high-mountain terrain, three fragments of a rare EL6 enstatite chondrite were recovered during search campaigns in the summers of 2002 and 2003. "Neuschwanstein" is the fourth meteorite fall in history that has been photographed by fireball networks and the fragments of which have been found subsequently. It is the first time since the beginning of the EN operation in the early sixties that the photographic observations have made a meteorite recovery possible. [source] Partnership Dissolution in the UK , the Role of Economic CircumstancesOXFORD BULLETIN OF ECONOMICS & STATISTICS, Issue 2 2001Rene Boheim Estimates based on couples with dependent children in the first eight years of the British Household Panel Study (1991-98) indicate that changes in a couple's economic circumstances affect the probability that a partnership dissolves. In particular, unexpected improvements in finances substantially reduce the dissolution risk, which strongly supports the importance of new information in decisions concerning partnership dissolution. Measures of a couple's own expectations concerning their financial situation over the coming year have been used in conjunction with realised changes to gauge the impact of unexpected changes. The study also finds that the risk of partnership dissolution increases with the number of children. [source] Circumstances of Women's First Birth May Be Linked to Their Health During Middle AgePERSPECTIVES ON SEXUAL AND REPRODUCTIVE HEALTH, Issue 1 2008D. Hollander No abstract is available for this article. [source] Circumstances of fatal lockout/tagout-related injuries in manufacturingAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 10 2008Maria T. Bulzacchelli PhD Abstract Background Over the past few decades, hundreds of manufacturing workers have suffered fatal injuries while performing maintenance and servicing on machinery and equipment. Using lockout/tagout procedures could have prevented many of these deaths. Methods A narrative text analysis of OSHA accident investigation report summaries was conducted to describe the circumstances of lockout/tagout-related fatalities occurring in the US manufacturing industry from 1984 to 1997. Results The most common mechanisms of injury were being caught in or between parts of equipment, electrocution, and being struck by or against objects. Typical scenarios included cleaning a mixer or blender, cleaning a conveyor, and installing or disassembling electrical equipment. Lockout procedures were not even attempted in the majority (at least 58.8%) of fatal incidents reviewed. Conclusions Lockout/tagout-related fatalities occur under a wide range of circumstances. Enhanced training and equipment designs that facilitate lockout and minimize worker contact with machine parts may prevent many lockout/tagout-related injuries. Am. J. Ind. Med. 51:728,734, 2008. Published 2008 Wiley-Liss, Inc. [source] Testing the Effects of Sale Method Restrictions in Municipal Bond Issuance: The Case of New JerseyPUBLIC BUDGETING AND FINANCE, Issue 2 2002Mark D. Robbins Can state governments save money by restricting the practice of selling tax-exempt bonds through negotiation, or do such regulations impose additional costs? Circumstances in New Jersey recently created a natural experiment to test this proposition. This study finds significant cost savings for those issues sold through competition both before and after such restrictions were put in place. All else equal, issues sold competitively after the policy change did not have significantly higher interest costs, despite a shift in volume toward competitive sales, suggesting that there exists room for increased use of competitive sales without incurring a cost penalty. [source] Equality of Opportunity and Differences in Social CircumstancesTHE PHILOSOPHICAL QUARTERLY, Issue 216 2004Andrew Mason It is often supposed that the point of equality of opportunity is to create a level playing-field. This is understood in different ways, however. A common proposal is what I call the neutralization view: that people's social circumstances should not differentially affect their life chances in any serious way. I raise problems with this view, before developing an alternative conception of equal opportunity which allows some variations in social circumstances to create differences in life prospects. The meritocratic conception which I defend is grounded in the idea of respect for persons, and provides a less demanding interpretation of fair access to qualifications; it nevertheless places constraints on the behaviour of parents, and has implications for educational provision in schools. [source] National Competitiveness: A Question of Cost Conditions or Institutional Circumstances?BRITISH JOURNAL OF MANAGEMENT, Issue 3 2004Edmund R. Thompson The issue of national competitiveness is a matter of considerable importance to both managers and public policy makers alike. Business scholars reflect this importance by their annual production of international indices of country competitiveness. Nevertheless, the notion of national competitiveness is controversial and has both (i) a narrow, concise conception that relates primarily to cost conditions as determined by exchange rates, and (ii) a broader, more nebulous conception that comprises the institutional and systemic circumstances of an economy, such as legal, governmental, public policy and other factors framing countries' wider business environments. In practical managerial terms, national competitiveness is a combination of both these narrow and broad conceptions. However, exactly how important cost conditions as opposed to institutional circumstances are to national competitiveness from a practical business perspective has never been investigated and is not known. This study uses qualitative and quantitative data gathered from senior firm executives in a specimen economy to find out. Hierarchical regression analyses suggest that institutional circumstances are significantly more important than cost conditions to the competitiveness of an economy from a practical managerial viewpoint. [source] Linked Lives: Stability and Change in Maternal Circumstances and Trajectories of Antisocial Behavior in ChildrenCHILD DEVELOPMENT, Issue 1 2004Ross Macmillan Drawing on the notion of linked lives, this study examined the effects of stability and change in maternal circumstance on developmental trajectories of antisocial behavior in children 4 to 7 years of age. Using data from a national sample of young mothers and growth curve analysis, the study demonstrated that early maternal circumstances influences early antisocial behavior, whereas stability and change in these circumstances both exacerbate and ameliorate behavior problems. Of particular note, meaningful escape from poverty attenuates antisocial behavior whereas persistence in poverty or long-term movement into poverty intensifies such problems. These findings highlight the importance of structural context for parenting practices and the need to consider child development in light of dynamic and changing life-course fortunes of parents. [source] Synthesis and separation in the history of "nature" and "nurture"DEVELOPMENTAL PSYCHOBIOLOGY, Issue 8 2007Cheryl A. Logan Abstract For much of the 20th century scientific psychology treated the relative contributions of nature and nurture to the development of phenotypes as the result of two quite separate sources of influence. One, nature, was linked to biological perspectives, often manifest as "instinct", while the other, nurture, was taken to reflect psychological influences. We argue that this separation was contingent on historical circumstance. Prior to about 1920, several perspectives in biology and psychology promoted the synthesis of nature and nurture. But between 1930 and 1980 that synthetic consensus was lost in America as numerous influences converged to promote a view that identified psychological and biological aspects of mind and behavior as inherently separate. Around 1960, during the hegemony of behaviorism, Daniel Lehrman, Gilbert Gottlieb, and other pioneers of developmental psychobiology developed probabilistic epigenesis to reject predeterminist notions of instinct and restore a synthesis. We describe the earlier and later periods of synthesis and discuss several influences that led to the separation of nature and nurture in the middle of the 20th century. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 758,769, 2007. [source] Do Characteristics of Parental Child Homicide in Sweden Fit Evolutionary Predictions?ETHOLOGY, Issue 11 2007Johanna Nordlund Evolutionary models have been used to explain parental child homicide. One idea is that children with low fitness value to their parents will be less loved and cared for and therefore more at risk in conflict situations. It is then important to investigate if conflicts with the children are the major pattern in cases of parental child homicide. The aim of this study is to survey the background circumstances of parental child homicide in Sweden and relate them to the evolutionary model suggested. We more specifically investigate if the homicides occur in conflict situations with the child, the frequency of several victims (including the partner or former partner) and if there are differences in characteristics of homicides between stepparents and genetic parents. Our results show that parental child homicide is a heterogeneous phenomenon, where relatively few cases were the result of a conflict with the child-victims. Instead severe conflicts between parents were the most common circumstance in which children were killed. Many children were victims of an extended suicide, which often included several members of the family. Step-parents were more likely to kill children aggressively in conflicts with them than genetic parents. The complexity of the phenomenon suggests that an evolutionary model based upon a mechanism related to conflicts with the child-victim has limited explanatory value on parental child homicide in general. [source] The Camera's Positioning: Brides, Grooms, and Their Photographers in Taipei's Bridal IndustryETHOS, Issue 2 2004Bonnie Adrian This article analyzes the intense orchestration of the bride's appearance,both her physical beauty and her ability to appear to captivate her groom,in Taiwanese bridal salons. Historical circumstance, competitive consumption, and family politics combine to render young women willing if not always eager subjects. Photographers, in turn, attempt to provoke specific subjective states in their clients so as to produce atractive, naturalistic poses and facial expressions. Through attention to positioning processes, the subtleties of the relationships among subjective experience, social performance, and cultural belief are examined. [source] A TADPOLE-INDUCED POLYPHENISM IN THE SALAMANDER HYNOBIUS RETARDATUSEVOLUTION, Issue 10 2002Hirofumi Michimae Abstract., Larvae of the salamander Hynobius retardatus have two distinct morphs: normal and broad-headed, cannibal morphs. We performed three experiments to differentiate among the following hypotheses: The broad-headed morph is induced to allow: (1) feeding on nutritious conspecifics; (2) exclusion of strong competitors for food or space; or (3) feeding on large, tough prey when smaller prey items are unavailable. When newly hatched larvae were reared with a heterospecific, Rana pirica (an anuran amphibian) tadpoles, the broad-headed morph was induced more frequently compared with those reared with conspecifics. The phenotype expressed depended on the size of the tadpoles: The broad-headed morph occurred more frequently with small and the normal morph with large tadpoles. Metamorphosis occurred sooner in larvae fed conspecifics compared with those fed heterospecific tadpoles, and the mean growth rate of larvae fed conspecifics was significantly faster than that of those fed tadpoles, suggesting that the heterospecific tadpoles were less nutritive than the conspecifics. These results do not support the hypotheses that the broad-headed morph evolved for consuming conspecifics because of their better balance of nutrients or for excluding strong competitors for food or space. We tentatively conclude that the morph evolved to eat large, tough prey, including both conspecifics and heterospecific tadpoles. Because H. retardatus usually spawns very early in the spring in small ponds partially covered with ice and snow, newly hatched larvae may starve from the lack of proper food owing to extremely low water temperatures. Thus, the broad-headed morph of H. retardatus may represent a cold-habitat adaptation to overcome the severe circumstance when the only food items available are relatively large conspecifics or heterospecific tadpoles. [source] Federalism and the Failure of Imperial Reform, 1774,1775HISTORY, Issue 282 2001Neil York The dispute that pitted British imperialists against American colonists was only superficially constitutional. Belief in indivisible sovereignty and the supremacy of crown and parliament, which prevailed at Whitehall and Westminster, became irreconcilable with American aspirations as a result of actual circumstance not theoretical incompatibility. This was clearly demonstrated by the failure of various proposals made in 1774 and 1775 to reform the empire. These proposals sought to improve relations through a better sharing of power that would in some sense federalize the empire. Whether the reformers called for Americans to be seated in parliament or to be allowed an intercolonial congress of their own, the great stumbling block was political not constitutional. Whatever the merits of their plans, the reformers could not satisfy either side, even though both professed to want compromise that would prevent confrontation. In the process a sense of common identity was lost that could not be recovered, at least in the manner suggested by the reformers. Only with the breakdown of the idealized Atlantic community did constitutional differences lead to an impasse. [source] The Elusive Path to Cartilage RegenerationADVANCED MATERIALS, Issue 32-33 2009Ernst B. Hunziker Abstract Numerous attempts have been made to develop an efficacious strategy for the repair of articular cartilage. These endeavors have been undaunted, if not spurred, by the challenge of the task and by the largely disappointing outcomes in animal models. Of the strategies that have been lately applied in a clinical setting, the autologous-chondrocyte-transplantation technique is the most notorious example. This methodology, which was prematurely launched on the clinical scene, was greeted with enthusiasm and has been widely adopted. However, a recent prospective and randomized clinical trial has revealed the approach to confer no advantage over conventional microfracturing. Why is the repair of articular cartilage such a seemingly intractable problem? The root of the evil undoubtedly lies in the tissue's poor intrinsic healing capacity. But the failure of investigators to tackle the biological stumbling blocks systematically rather than empirically is hardly a less inauspicious circumstance. Moreover, it is a common misbelief that the formation of hyaline cartilage per se suffices, whereas to be durable and functionally competent, the tissue must be fully mature. An appreciation of this necessity, coupled with a thorough understanding of the postnatal development of articular cartilage, would help to steer investigators clear of biological cul-de-sacs. [source] A uniform nodal strain tetrahedron with isochoric stabilizationINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 4 2009M. W. Gee Abstract A stabilized node-based uniform strain tetrahedral element is presented and analyzed for finite deformation elasticity. The element is based on linear interpolation of a classical displacement-based tetrahedral element formulation but applies nodal averaging of the deformation gradient to improve mechanical behavior, especially in the regime of near-incompressibility where classical linear tetrahedral elements perform very poorly. This uniform strain approach adopted here exhibits spurious modes as has been previously reported in the literature. We present a new type of stabilization exploiting the circumstance that the instability in the formulation is related to the isochoric strain energy contribution only and we therefore present a stabilization based on an isochoric,volumetric splitting of the stress tensor. We demonstrate that by stabilizing the isochoric energy contributions only, reintroduction of volumetric locking through the stabilization can be avoided. The isochoric,volumetric splitting can be applied for all types of materials with only minor restrictions and leads to a formulation that demonstrates impressive performance in examples provided. Copyright © 2008 John Wiley & Sons, Ltd. [source] Protein folding simulations: From coarse-grained model to all-atom modelIUBMB LIFE, Issue 6 2009Jian Zhang Abstract Protein folding is an important and challenging problem in molecular biology. During the last two decades, molecular dynamics (MD) simulation has proved to be a paramount tool and was widely used to study protein structures, folding kinetics and thermodynamics, and structure,stability,function relationship. It was also used to help engineering and designing new proteins, and to answer even more general questions such as the minimal number of amino acid or the evolution principle of protein families. Nowadays, the MD simulation is still undergoing rapid developments. The first trend is to toward developing new coarse-grained models and studying larger and more complex molecular systems such as protein,protein complex and their assembling process, amyloid related aggregations, and structure and motion of chaperons, motors, channels and virus capsides; the second trend is toward building high resolution models and explore more detailed and accurate pictures of protein folding and the associated processes, such as the coordination bond or disulfide bond involved folding, the polarization, charge transfer and protonate/deprotonate process involved in metal coupled folding, and the ion permeation and its coupling with the kinetics of channels. On these new territories, MD simulations have given many promising results and will continue to offer exciting views. Here, we review several new subjects investigated by using MD simulations as well as the corresponding developments of appropriate protein models. These include but are not limited to the attempt to go beyond the topology based G,-like model and characterize the energetic factors in protein structures and dynamics, the study of the thermodynamics and kinetics of disulfide bond involved protein folding, the modeling of the interactions between chaperonin and the encapsulated protein and the protein folding under this circumstance, the effort to clarify the important yet still elusive folding mechanism of protein BBL, the development of discrete MD and its application in studying the ,,, conformational conversion and oligomer assembling process, and the modeling of metal ion involved protein folding. © 2009 IUBMB IUBMB Life, 61(6): 627,643, 2009 [source] Myometrial mechanoadaptation during pregnancy: implications for smooth muscle plasticity and remodellingJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Issue 4 2008X. Wu Abstract The smooth muscle of the uterus during pregnancy presents a unique circumstance of physiological mechanotransduction as the tissue remodels in response to stretches imposed by the growing foetus(es), yet the nature of the molecular and functional adaptations remain unresolved. We studied, in myometrium isolated from non-pregnant (NP) and pregnant mice, the active and passive length,tension curves by myography and the expression and activation by immunoblotting of focal adhesion-related proteins known in other systems to participate in mechanosensing and mechanotransduction. In situ uterine mass correlated with pup number and weight throughout pregnancy. In vitro myometrial active, and passive, length-tension curves shifted significantly to the right during pregnancy indicative of altered mechanosensitivity; at term, maximum active tension was generated following 3.94 ± 0.33-fold stretch beyond slack length compared to 1.91 ± 0.12-fold for NP mice. Moreover, mechanotransduction was altered during pregnancy as evidenced by the progressive increase in absolute force production at each optimal stretch. Pregnancy was concomitantly associated with an increased expression of the dense plaque-associated proteins FAK and paxillin, and elevated activation of FAK, paxillin, c-Src and extracellular signal-regulated kinase (ERK1/2) which reversed 1 day post-partum. Electron microscopy revealed close appositioning of neighbouring myometrial cells across a narrow extracellular cleft adjoining plasmalemmal dense plaques. Collectively, these results suggest a physiological basis of myometrial length adaptation, long known to be a property of many smooth muscles, whereupon plasmalemmal dense plaque proteins serve as molecular signalling and structural platforms contributing to functional (contractile) remodelling in response to chronic stretch. [source] Can you keep a secret?JOURNAL OF CLINICAL PSYCHOLOGY, Issue 5 2008Confidentiality in psychotherapy Abstract Confidentiality is the secret-keeping duty that arises from the establishment of the professional relationship psychologists develop with their clients. It is a duty created by the professional relationship, it is set forth in the American Psychological Association's (2002) Ethical Principles and Code of Conduct, and it is codified in many state regulations. However, the difference between confidentiality and legal privilege; how, why, and when it can be violated; and the reasons for so doing are not well understood by many practitioners. While on the surface confidentiality might seem to be an easy concept to apply to professional practice, in fact it is quite complex and filled with exceptions that frequently differ from circumstance to circumstance and from state to state. A lack of respect for and a lack of familiarity with the significance of these exceptions could have dire professional consequences. This article reviews the ethical imperative of confidentiality and then provides examples of legal cases that help to better understand its complexity. Then, we offer strategies designed to help metal health practitioners when they are confronted with questions regarding confidentiality and privilege. © 2008 Wiley Periodicals, Inc. J Clin Psychol: In Session 64: 1,12, 2008. [source] Daily interpersonal events in pain patients: Applying action theory to chronic illnessJOURNAL OF CLINICAL PSYCHOLOGY, Issue 9 2006Mary C. Davis Action theory proposes that individuals actively shape and then respond to their environments, highlighting the role of stable person characteristics in the development and maintenance of life's interpersonal difficulties. In this study, the authors adopt the action perspective in their examination of predictors of daily interpersonal events among chronic pain patients with rheumatoid arthritis. They probe the extent to which stable symptoms of illness explained between-person variation, and fluctuating symptoms explain day-to-day variation in both positive and negative events. Their evaluation of patients' daily diary reports indicate that between-person differences accounted for more variance in the occurrence of positive events relative to negative events (48% vs. 31%, respectively). Likewise, between-person factors accounted for more variance in appraisals of positive compared to negative events across relationship domains. Both intractable illness symptoms and disability, and daily fluctuations in pain and fatigue, were only weakly related to patients' reports of their interpersonal experiences. Consistent with action theory, these results suggest that stable person characteristics are strongly related to daily stressors and particularly daily positive events in pain patients, but still account for less than 50% of the variance in events and their appraisals. In contrast, elevations in illness-related features, both between individuals and within individuals from day-to-day, are not robust predictors of positive or negative social exchanges. These findings point to the value of capturing the experiences of individuals intensively over time, an approach that can help to elaborate the contributions of both stable factors and circumstance in shaping social contexts in chronic illness. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 1097,1113, 2006. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||