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Acceptable Accuracy (acceptable + accuracy)
Selected AbstractsEffect of variation of normal force on seismic performance of resilient sliding isolation systems in highway bridgesEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 15 2005Hirokazu Iemura Abstract In this study, a series of shaking table tests are carried out on scaled models of two seismically isolated highway bridges to investigate the effect of rocking motion and vertical acceleration on seismic performance of resilient sliding isolators. In addition, performance of RSI is compared with system having solely natural rubber bearings. Test results show that variation of normal force on sliders due to rocking effect and vertical acceleration makes no significant difference in response of RSI systems. In addition, analytical response of prototype isolated bridge and the model used in experiments is obtained analytically by using non-linear model for isolation systems. It is observed that for seismically isolated bridges, dynamic response of full-scale complex structures can be predicted with acceptable accuracy by experiments using a simple model of the structure. Copyright © 2005 John Wiley & Sons, Ltd. [source] A practical grid-based method for tracking multiple refraction and reflection phases in three-dimensional heterogeneous mediaGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 1 2006M. De Kool SUMMARY We present a practical grid-based method in 3-D spherical coordinates for computing multiple phases comprising any number of reflection and transmission branches in heterogeneous layered media. The new scheme is based on a multistage approach which treats each layer that the wave front enters as a separate computational domain. A finite-difference eikonal solver known as the fast-marching method (FMM) is reinitialized at each interface to track the evolving wave front as either a reflection back into the incident layer or a transmission through to the adjacent layer. Unlike the standard FMM, which only finds first arrivals, this multistage approach can track those later arriving phases explicitly caused by the presence of discontinuities. Notably, the method does not require an irregular mesh to be constructed in order to connect interface nodes to neighbouring velocity nodes which lie on a regular grid. To improve accuracy, local grid refinement is used in the neighbourhood of a source point where wave front curvature is high. The method also provides a way to trace reflections from an interface that are not the first arrival (e.g. the global PP phase). These are computed by initializing the multistage FMM from both the source and receiver, propagating the two wave fronts to the reflecting interface, and finding stationary points of the sum of the two traveltime fields on the reflecting interface. A series of examples are presented to test the efficiency, accuracy and robustness of the new scheme. As well as efficiently computing various global phases to an acceptable accuracy through the ak135 model, we also demonstrate the ability of the scheme to track complex crustal phases that may be encountered in coincident reflection, wide-angle reflection/refraction or local earthquake surveys. In one example, a variety of phases are computed in the presence of a realistic subduction zone, which includes several layer pinch-outs and a subducting slab. Our numerical tests show that the new scheme is a practical and robust alternative to conventional ray tracing for finding various phases in layered media at a variety of scales. [source] Rain-gauge network evaluation and augmentation using geostatisticsHYDROLOGICAL PROCESSES, Issue 14 2008Ke-Sheng Cheng Abstract Rain-gauge networks are often used to provide estimates of area average rainfall or point rainfalls at ungauged locations. The level of accuracy a network can achieve depends on the total number and locations of gauges in the network. A geostatistical approach for evaluation and augmentation of an existing rain-gauge network is proposed in this study. Through variogram analysis, hourly rainfalls are shown to have higher spatial variability than annual rainfalls, with hourly Mei-Yu rainfalls having the highest spatial variability. A criterion using ordinary kriging variance is proposed to assess the accuracy of rainfall estimation using the acceptance probability defined as the probability that estimation error falls within a desired range. Based on the criterion, the percentage of the total area with acceptable accuracy Ap under certain network configuration can be calculated. A sequential algorithm is also proposed to prioritize rain-gauges of the existing network, identify the base network, and relocate non-base gauges. Percentage of the total area with acceptable accuracy is mostly contributed by the base network. In contrast, non-base gauges provide little contribution to Ap and are subject to removal or relocation. Using a case study in northern Taiwan, the proposed approach demonstrates that the identified base network which comprises of approximately two-thirds of the total rain-gauges can achieve almost the same level of performance (expressed in terms of percentage of the total area with acceptable accuracy) as the complete network for hourly Mei-Yu rainfall estimation. The percentage of area with acceptable accuracy can be raised from 56% to 88% using an augmented network. A threshold value for the percentage of area with acceptable accuracy is also recommended to help determine the number of non-base gauges which need to be relocated. Copyright © 2007 John Wiley & Sons, Ltd. [source] A simple finite element model for vibration analyses induced by moving vehiclesINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 12 2006Shen-Haw Ju Abstract This study developed a simple finite element method combining the moving wheel element, spring,damper element, lumped mass and rigid link effect to simulate complicated vehicles. The advantages of this vehicle model are (1) the dynamic matrix equation is symmetric, (2) the theory and formulations are very simple and can be added to a standard dynamic finite element codes easily and (3) very complicated vehicle models can be assembled using the proposed elements as simple as the traditional finite element method. The Fryba's solution of a simply supported beam subjected to a moving two-axle system was analysed to validate this finite element model. For a number of numerical simulations, the two solutions are almost identical, which means that the proposed finite element model of moving vehicles is considerably accurate. Field measurements were also used to validate this vehicle model through a very complicated finite element analysis, which indicates that the current moving vehicle model can be used to simulate complex problem with acceptable accuracy. Copyright © 2006 John Wiley & Sons, Ltd. [source] Optical techniques to determine thermal effects on proteinsINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 11 2008Teepakorn Kongraksawech Summary Optical rotation (OR) and transmitted light (TL) measurements were conducted on 1%, 2.5% and 5% (w/v) bovine serum albumin (BSA) in 0.01 m phosphate buffer at pH 7 and ionic strength 0.08. Denaturation temperatures (Td) obtained from OR measurements were consistent with reported differential scanning calorimetry values. Protein concentration did not affect Td in agreement with most reports. Changes in TL reflecting gel formation and protein aggregation were influenced by BSA concentration. Sugar concentration in the range used in this study (0,5%) did not affect the thermal stability of BSA. The lack of difference in sucrose, trehalose and sorbitol effects on the thermal stability of BSA was consistent with some but not all reports. The optical system used to study protein denaturation had acceptable accuracy (consistency with published Td values) and precision (coefficient of variation under 3.5%) levels. [source] Comparing clock tests for dementia screening: naïve judgments vs formal systems,what is optimal?INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 1 2002James M. Scanlan Abstract Background Clock drawing tests (CDTs) vary in format, scoring, and complexity. Herein, we compared the dementia screening performance of seven CDT scoring systems and the judgements of untrained raters. Methods 80 clock drawings by subjects of known dementia status were selected, 20 from each of four categories (Consortium to Establish a Registry for Alzheimer's disease [CERAD] defined normal, mild, moderate, and severe abnormality). An expert rater scored all clocks using published criteria for seven systems. Additionally, 20 naïve raters judged clocks as either normal or abnormal, without formal instructions. Clocks were then classified by drawers' dementia status for comparison of dementia detection across systems. Results Naïve and formal CDT systems showed 90,100% agreement in CERAD normal, moderate and severe categories, but poor agreement (mean,=,39%) for mildly impaired clocks. When CDT systems were compared for accurate dementia classification, the Mendez and CERAD systems correctly identified the greatest proportion of subjects (84,85%), and Wolf-Klein the smallest (58%). The better systems correctly identified>,70% of mildly demented individuals (CDR,=,1). In contrast, medical records from patients' personal physicians correctly identified only 24% of the mildly demented. Strikingly, naïve raters' CDT judgements were as effective as five of the seven CDT systems in dementia identification. Conclusions While the Mendez system was the most accurate overall, it was not significantly better than CERAD, which had simpler scoring rules. Untrained raters discriminated normal from abnormal clocks with acceptable accuracy for community screening purposes. Results suggest that, if used, most CDT systems would improve personal physicians' dementia recognition in difficult to detect mildly demented subjects. Copyright © 2002 John Wiley & Sons, Ltd. [source] A Tissue-Specific Model of Reentry in the Right Atrial AppendageJOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 6 2009JICHAO ZHAO Ph.D. Introduction: Atrial fibrillation is prevalent in the elderly and contributes to mortality in congestive heart failure. Development of computer models of atrial electrical activation that incorporate realistic structures provides a means of investigating the mechanisms that initiate and maintain reentrant atrial arrhythmia. As a step toward this, we have developed a model of the right atrial appendage (RAA) including detailed geometry of the pectinate muscles (PM) and crista terminalis (CT) with high spatial resolution, as well as complete fiber architecture. Methods and Results: Detailed structural images of a pig RAA were acquired using a semiautomated extended-volume imaging system. The generally accepted anisotropic ratio of 10:1 was adopted in the computer model. To deal with the regional action potential duration heterogeneity in the RAA, a Courtemanche cell model and a Luo-Rudy cell model were used for the CT and PM, respectively. Activation through the CT and PM network was adequately reproduced with acceptable accuracy using reduced-order computer models. Using a train of reducing cycle length stimuli applied to a CT/PM junction, we observed functional block both parallel with and perpendicular to the axis of the CT. Conclusion: With stimulation from the CT at the junction of a PM, we conclude: (a) that conduction block within the CT is due to a reduced safety factor; and (b) that unidirectional block and reentry within the CT is due to its high anisotropy. Regional differences in effective refractive period do not explain the observed conduction block. [source] Assessing the accuracy of a computerized decision support system for digoxin dosing in primary care: an observational studyJOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 3 2005W. L. G. Kroese Drs Summary Background:, This study was carried out as part of a European Union funded project (PharmDIS-e+), to develop and evaluate software aimed at assisting physicians with drug dosing. A drug that causes particular problems with drug dosing in primary care is digoxin because of its narrow therapeutic range and low therapeutic index. Objectives:, To determine (i) accuracy of the PharmDIS-e+ software for predicting serum digoxin levels in patients who are taking this drug regularly; (ii) whether there are statistically significant differences between predicted digoxin levels and those measured by a laboratory and (iii) whether there are differences between doses prescribed by general practitioners and those suggested by the program. Methods:, We needed 45 patients to have 95% Power to reject the null hypothesis that the mean serum digoxin concentration was within 10% of the mean predicted digoxin concentration. Patients were recruited from two general practices and had been taking digoxin for at least 4 months. Exclusion criteria were dementia, low adherence to digoxin and use of other medications known to interact to a clinically important extent with digoxin. Results:, Forty-five patients were recruited. There was a correlation of 0·65 between measured and predicted digoxin concentrations (P < 0·001). The mean difference was 0·12 ,g/L (SD 0·26; 95% CI 0·04, 0·19, P = 0·005). Forty-seven per cent of the patients were prescribed the same dose as recommended by the software, 44% were prescribed a higher dose and 9% a lower dose than recommended. Conclusion:, PharmDIS-e+ software was able to predict serum digoxin levels with acceptable accuracy in most patients. [source] Response Surface Model for the Estimation of Escherichia coli O 157:H7 Growth under Different Experimental ConditionsJOURNAL OF FOOD SCIENCE, Issue 1 2005Rose Maria García-Gimeno ABSTRACT: In this study, a Response Surface Model (RSM) of Escherichia coli O157:H7 as affected by pH levels, sodium chloride and nitrite concentrations, temperature, and aerobic/anaerobic conditions is presented. The standard error of prediction (%SEP) obtained was acceptable for the growth rate prediction (33%SEP), although a bit high for lag time (53.01 %SEP). Mathematical validation demonstrated that the RSM predicts growth rate values on the fail-safe side in aerobic conditions and within the acceptable range (bias factor [Bf] = 0.99) with acceptable accuracy (accuracy factor [Af] = 1.15), as well as for lag time (Bf = 1.05; Af = 1.25). Temperature was found to have the greatest effect on the kinetic parameters, followed by NaCl concentration and pH. In the experimental range considered here (0 to 200 ppm), NaNO2 concentration was found to have a significant effect on growth rate but not on lag time. [source] A preliminary approach to modeling gas hydrate/ice deposition from dissolved water in a liquid condensate systemAICHE JOURNAL, Issue 7 2009Joseph W. Nicholas Abstract Gas hydrate/ice deposition from a dissolved water phase in a liquid condensate system was modeled using a mass and energy balance. The same modeling parameters were used to model three flow loop experiments (1.89 and 2.83 L/min flow rate deposition tests and a 1.89 L/min dissociation test) with acceptable accuracy. Relative changes in both temperature and pressure drop were modeled using an ice deposit with a 67% void fraction. © 2009 American Institute of Chemical Engineers AIChE J, 2009 [source] An algorithm for the use of surrogate models in modular flowsheet optimizationAICHE JOURNAL, Issue 10 2008José A. Caballero Abstract In this work a methodology is presented for the rigorous optimization of nonlinear programming problems in which the objective function and (or) some constraints are represented by noisy implicit black box functions. The special application considered is the optimization of modular process simulators in which the derivatives are not available and some unit operations introduce noise preventing the calculation of accurate derivatives. The black box modules are substituted by metamodels based on a kriging interpolation that assumes that the errors are not independent but a function of the independent variables. A Kriging metamodel uses non-Euclidean measure of distance to avoid sensitivity to the units of measure. It includes adjustable parameters that weigh the importance of each variable for obtaining a good model representation, and it allows calculating errors that can be used to establish stopping criteria and provide a solid base to deal with "possible infeasibility" due to inaccuracies in the metamodel representation of objective function and constraints. The algorithm continues with a refining stage and successive bound contraction in the domain of independent variables with or without kriging recalibration until an acceptable accuracy in the metamodel is obtained. The procedure is illustrated with several examples. © 2008 American Institute of Chemical Engineers AIChE J, 2008 [source] Stroke volume averaging for individualized goal-directed fluid therapy with oesophageal DopplerACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 1 2009C. C. JØRGENSEN Background: An individualized fluid optimization strategy, based on maximization of cardiac stroke volume (SV) with colloid boluses (goal-directed therapy), improves outcome after surgery. Oesophageal Doppler (OD) is used for SV maximization in most randomized studies, but evidence-based guidelines for the SV maximization procedure are lacking and variation in SV may influence the indication for fluid administration. We measured beat-to-beat OD SV before and after fluid optimization in order to estimate the number of heartbeats for which SV needs to be averaged to provide an acceptable accuracy for goal-directed therapy with this technology. Methods: Twenty patients scheduled for surgery were anaesthetized, followed by OD SV assessment. Thirty seconds of beat-to-beat data were recorded before and after volume optimization performed by successive boluses of 200 ml colloid until SV did not increase ,10%. SV variability was assessed before and after the volume optimization when SV was measured beat to beat and when it was averaged over 2,10 heartbeats. Results: Nineteen (95%) and 17 (85%) patients demonstrated an SV variability ,10% before and after volume optimization, respectively, when SV was measured beat to beat. However, when SV was averaged over 10 heartbeats, only two (10%) and one (5%) of the patients demonstrated an SV variability ,10% before and after optimization, respectively (P<0.0001). Conclusion: OD SV variability is significantly reduced and reaches an acceptable level when SV is averaged over 10 heartbeats. The use of a shorter averaging period for SV may lead to incorrect volume administration in goal-directed fluid management. [source] Diffuse continuum transfer in H ii regionsMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 1 2009R. J. R. Williams ABSTRACT We compare the accuracy of various methods for determining the transfer of the diffuse Lyman continuum in H ii regions by comparing them with a high-resolution discrete-ordinate integration. We use these results to suggest how, in multidimensional dynamical simulations, the diffuse field may be treated with acceptable accuracy without requiring detailed transport solutions. The angular distribution of the diffuse field derived from the numerical integration provides insight into the likely effects of the diffuse field for various material distributions. [source] A validated spectrophotometric method for quantification of prenylated flavanones in pacific propolis from TaiwanPHYTOCHEMICAL ANALYSIS, Issue 2 2010Milena Popova Abstract Introduction , Because of its chemical diversity, the only way to standardise propolis is to specify multiple standards for different propolis types according to the corresponding chemical profile. So far, this has been done only for European propolis. Objective , To develop a rapid low-cost spectrophotometric procedure for quantification of bioactive prenylated flavanones in Taiwanese propolis. Methodology , The proposed method quantifies the total flavanones on the basis of their absorption as coloured phenylhydrazones formed by interaction with 2,4-dinitrophenylhydrazine. The procedure was validated through model mixture of compounds representing the composition of Taiwanese propolis according to previous studies. The major flavanones of the propolis samples (propolins C, D, F and G) were quantified by HPLC. Antiradical activity against DPPH was also measured. The DNP (dinitrophenylhydrazine) spectrophotometric method is applied for the first time for quantification of prenylated flavanones. Results , Spectophotometric procedure applicable to new type propolis (Macaranga type) was developed with recovery between 105 and 110% at the concentration range of 0.573,1.791,mg/mL. Six propolis samples were analysed by spectrophotometry using the procedure developed and validated, and by HPLC as the results demonstrated satisfactory agreement. Neither the spectrophotometric data nor the values measured by HPLC showed significant correlation with the antiradical activity against DPPH. Conclusion , The proposed spectrophotometric procedure is useful for routine analyses of Macaranga -type propolis, because of its simplicity, repeatability and acceptable accuracy. Its application to a number of commercial samples could be used as a basis for standardisation and quality control of Pacific propolis. Copyright © 2009 John Wiley & Sons, Ltd. [source] High-throughput determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteersRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 7 2006Hui-chang Bi A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method to determine carbocysteine in human plasma was developed and fully validated. After methanol-induced protein precipitation of the plasma samples, carbocysteine was subjected to LC/MS/MS analysis using electrospray ionization (ESI). The MS system was operated in the selected ion monitoring (SRM) mode. Chromatographic separation was performed on a Hypurity C18 column (i.d. 2.1,mm,×,50,mm, particle size 5,µm). The method had a chromatographic running time of 2.0,min and linear calibration curves over the concentration ranges of 0.1,20,µg/mL for carbocysteine. The lower limit of quantification (LLOQ) of the method was 0.1,µg/mL for carbocysteine. The intra- and inter-day precision was less than 7% for all quality control samples at concentrations of 0.5, 2.0, and 10.0,µg/mL. These results indicate that the method was efficient with a simple preparation procedure and a very short running time (2.0,min) for carbocysteine compared with methods reported in the literature and had high selectivity, acceptable accuracy, precision and sensitivity. The validated LC/MS/MS method has been successfully used to a bioequivalence study of two tablet formulations of carbocysteine in healthy volunteers. Copyright © 2006 John Wiley & Sons, Ltd. [source] Simultaneous assay of sildenafil and desmethylsildenafil in neonatal plasma by ultra-performance liquid chromatography,tandem mass spectrometryBIOMEDICAL CHROMATOGRAPHY, Issue 2 2010Bregje C. Witjes Abstract Sildenafil is used to treat pulmonary hypertension in neonatal and pediatric patients. Pharmacokinetic studies in these patients are complicated by the limited sample volume. We present the validation results of an assay method to quantitate sildenafil and desmethylsildenafil simultaneously in 50,µL of plasma. Deuterated sildenafil was used as an internal standard. After liquid,liquid extraction, analytes were separated on an ultra-performance liquid chromatography (UPLC)-column and quantified via tandem mass spectrometry. The calibration range was linear, with acceptable accuracy and a precision of <15% for both compounds. The lower limits of quantification were 1,ng/mL. Matrix effects were present, but inter-plasma batch variability was under 12%. The method was successfully applied to samples from a pharmacokinetic study into sildenafil pharmacokinetics in neonates, making maximum use of the limited number and amount of plasma samples available. Copyright © 2009 John Wiley & Sons, Ltd. [source] Simultaneous determination of mifepristone and monodemethyl-mifepristone in human plasma by liquid chromatography,tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic studyBIOMEDICAL CHROMATOGRAPHY, Issue 1 2009Cheng Tang Abstract A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determine mifepristone and monodemethyl-mifepristone in human plasma using levonorgestrel as the internal standard (IS). After solid-phase extraction of the plasma samples, mifepristone, monodemethyl-mifepristone and the IS were subjected to LC-MS/MS analysis using electro-spray ionization (ESI) in the multiple reaction monitoring (MRM) mode. Chromatographic separation was performed on an XTERRA MS C18 column (150 × 2.1 mm i.d., 5 µm). The method had a chromatographic run time of 4.5 min and linear calibration curves over the concentration ranges of 5,2000 ng/mL for mifepristone and monodemethyl-mifepristone. The recoveries of the method were found to be 94.5,103.7% for mifepristone and 70.7,77.3% for monodemethyl-mifepristone. The method had a lower limit of quantification (LLOQ) of 5.0 ng/mL and a lower limit of detection (LOD) of 1.0 ng/mL for both mifepristone and monodemethyl-mifepristone. The intra- and inter-batch precision was less than 15% for all quality control samples at concentrations of 10, 100 and 1000 ng/mL. These results indicate that the method was efficient with a short run time (4.5 min) and acceptable accuracy, precision and sensitivity. The validated LC-MS/MS method was successfully used in a pharmacokinetic study in healthy female volunteers after oral administration of 25 mg mifepristone tablet. Copyright © 2008 John Wiley & Sons, Ltd. [source] High-performance liquid chromatography and LC-ESI-MS method for the identification and quantification of two biologically active isomeric coumarinolignoids cleomiscosin A and cleomiscosin B in different extracts of Cleome viscosaBIOMEDICAL CHROMATOGRAPHY, Issue 12 2008Sunil K. Chattopadhyay Abstract A rapid, sensitive and simple reverse-phase high-performance liquid chromatographic,electrospray ionization,mass spectrometry method for simultaneous determination of cleomiscosin A and cleomiscosin B has been developed and validated. The isomeric coumarinolignoids cleomiscosin A (1) and cleomiscosin B (2) were separated on a Waters symmetry C18 column with a solvent system composed of acetonitrile,methanol (1:2) and acetic acid,water (0.5 : 99.5) in a gradient elution mode. The absorption at 326 nm was chosen as the measuring wavelength in which resolution and baseline separation of compounds 1 and 2 could be obtained. The identity of the two isomeric compounds 1 and 2 in the samples were determined on a triple quadrupole mass spectrometer with ESI interface operating in the positive mode. Calibration curves were linear (r2 > 0.993) over the concentration range 20,200 µg/mL for cleomiscosin A and 10,200 µg/mL for cleomiscosin B with acceptable accuracy and precision, respectively. The intra-day and inter-day precision were 1.13 and 0.82% for cleomiscosin A and 1.78 and 1.28% for cleomiscosin B, respectively. The validated method was successfully applied for the analysis of the above two compounds in different extracts of Cleome viscosa. Copyright © 2008 John Wiley & Sons, Ltd. [source] Rapid quantification of lisinopril in human plasma by liquid chromatography/tandem mass spectrometryBIOMEDICAL CHROMATOGRAPHY, Issue 4 2007Weiwei Qin Abstract An assay based on protein precipitation and liquid chromatography/tandem mass spectrometry (LC-MS/MS) has been developed and validated for the quantitative analysis of lisinopril in human plasma. After the addition of enalaprilat as internal standard (IS), plasma samples were prepared by one-step protein precipitation using perchloric acid followed by an isocratic elution with 10 mm ammonium acetate buffer (pH adjusted to 5.0 with acetic acid),methanol (70:30, v/v) on a Phenomenex Luna 5µC18 (2) column. Detection was performed on a triple-quadrupole mass spectrometer utilizing an electrospray ionization (ESI) interface operating in positive ion and selected reaction monitoring (SRM) mode with the precursor to product ion transitions m/z 406,246 for lisinopril and m/z 349,206 for enalaprilat. Calibration curves of lisinopril in human plasma were linear (r = 0.9973,0.9998) over the concentration range 2,200 ng/mL with acceptable accuracy and precision. The limit of detection and lower limit of quantification in human plasma were 1 and 2 ng/mL, respectively. The validated LC-MS/MS method has been successfully applied to a preliminary pharmacokinetic study of lisinopril in Chinese healthy male volunteers. Copyright © 2007 John Wiley & Sons, Ltd. [source] | ||||||||||||||||