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Channel System (channel + system)
Selected AbstractsImpulse conduction and gap junctional remodelling by endothelin-1 in cultured neonatal rat ventricular myocytesJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Issue 3 2009Y. Reisner Abstract Endothelin-1 (ET-1) is an important contributor to ventricular hypertrophy and failure, which are associated with arrhythmogenesis and sudden death. To elucidate the mechanism(s) underlying the arrhythmogenic effects of ET-1 we tested the hypothesis that long-term (24 hrs) exposure to ET-1 impairs impulse conduction in cultures of neonatal rat ventricular myocytes (NRVM). NRVM were seeded on micro-electrode-arrays (MEAs, Multi Channel Systems, Reutlingen, Germany) and exposed to 50 nM ET-1 for 24 hrs. Hypertrophy was assessed by morphological and molecular methods. Consecutive recordings of paced activation times from the same cultures were conducted at baseline and after 3, 6 and 24 hrs, and activation maps for each time period constructed. Gap junctional Cx43 expression was assessed using Western blot and confocal microscopy of immunofluorescence staining using anti-Cx43 antibodies. ET-1 caused hypertrophy as indicated by a 70% increase in mRNA for atrial natriuretic peptide (P < 0.05), and increased cell areas (P < 0.05) compared to control. ET-1 also caused a time-dependent decrease in conduction velocity that was evident after 3 hrs of exposure to ET-1, and was augmented at 24 hrs, compared to controls (P < 0.01). ET-1 increased total Cx43 protein by ,40% (P < 0.05) without affecting non- phosphorylated Cx43 (NP-Cx43) protein expression. Quantitative confocal microscopy showed a ,30% decrease in the Cx43 immunofluorescence per field in the ET-1 group (P < 0.05) and a reduced field stain intensity (P < 0.05), compared to controls. ET-1-induced hypertrophy was accompanied by reduction in conduction velocity and gap junctional remodelling. The reduction in conduction velocity may play a role in ET-1 induced susceptibility to arrhythmogenesis. [source] Effects of earthquake and cyclone sequencing on landsliding and fluvial sediment transfer in a mountain catchmentEARTH SURFACE PROCESSES AND LANDFORMS, Issue 9 2008Guan-Wei Lin Abstract Patterns and rates of landsliding and fluvial sediment transfer in mountain catchments are determined by the strength and location of rain storms and earthquakes, and by the sequence in which they occur. To explore this notion, landslides caused by three tropical cyclones and a very large earthquake have been mapped in the Chenyoulan catchment in the Taiwan Central Range, where water and sediment discharges and rock strengths are well known. Prior to the MW 7·6 Chi-Chi earthquake in 1999, storm-driven landslide rates were modest. Landslides occurred primarily low within the landscape in shallow slopes, reworking older colluvial material. The Chi-Chi earthquake caused wide-spread landsliding in the steepest bedrock slopes high within the catchment due to topographic focusing of incoming seismic waves. After the earthquake landslide rates remained elevated, landslide patterns closely tracking the distribution of coseismic landslides. These patterns have not been strongly affected by rock strength. Sediment loads of the Chenyoulan River have been limited by supply from hillslopes. Prior to the Chi-Chi earthquake, the erosion budget was dominated by one exceptionally large flood, with anomalously high sediment concentrations, caused by typhoon Herb in 1996. Sediment concentrations were much higher than normal in intermediate size floods during the first 5 years after the earthquake, giving high sediment yields. In 2005, sediment concentrations had decreased to values prevalent before 1999. The hillslope response to the Chi-Chi earthquake has been much stronger than the five-fold increase of fluvial sediment loads and concentrations, but since the earthquake, hillslope sediment sources have become increasingly disconnected from the channel system, with 90 per cent of landslides not reaching into channels. Downslope advection of landslide debris associated with the Chi-Chi earthquake is driven by the impact of tropical cyclones, but occurs on a time-scale longer than this study. Copyright © 2008 John Wiley & Sons, Ltd. [source] Geomorphic changes in a complex gully system measured from sequential digital elevation models, and implications for managementEARTH SURFACE PROCESSES AND LANDFORMS, Issue 10 2003Harley D. Betts Abstract High-resolution digital elevation models (DEMs) were derived from sequential aerial photography of an active ,uvio-mass movement (gully) complex in New Zealand's North Island East Coast region, to measure geomorphic changes over approximately one year. The gully showed a complex behaviour, combining ,uvial and mass movement erosion, deposition, and reworking of materials stored in an active debris fan. During the measurement period 5200 ± 1700 m3 of material were eroded from the 8·7 ha gully complex and 670 ± 180 m3 from the 0·8 ha depositional fan, giving a total of 5870 ± 1710 m3 for the entire gully complex,fan system. The results provide a high-resolution description of gully behaviour over a short time period, and also demonstrate that mass movement (slumping and debris ,ows) accounted for almost 90 per cent (4660 ± 200 m3) of the sediment generated. This erosional response is described in terms of gully evolution by comparing the gully complex to other systems in the region in various stages of development. The effect of gully evolution on geomorphic coupling between the gully complex and channel system is described, and coupling is also shown to vary with the magnitude and frequency of rainfall events. From a land management perspective the success of strategies, such as tree planting, to mitigate against gully erosion depends on the stage of gully development , particularly on whether or not mass movement erosion has begun. In contrast to gully rehabilitation efforts elsewhere, basin-wide afforestation in the early stages of gully incision is favoured over riparian planting, given that mass movement assisted by excessive groundwater pressure is the main process leading to uncontrollable gully expansion. To protect land effectively against continuing gully erosion of headwater catchments and resulting downstream aggradation, it is necessary for land managers to understand the spatial and temporal variability of gully development fully so that mitigation efforts can be targeted appropriately. Copyright © 2003 John Wiley & Sons, Ltd. [source] Interchannel hydraulic geometry and hydraulic efficiency of the anastomosing Columbia River, southeastern British Columbia, CanadaEARTH SURFACE PROCESSES AND LANDFORMS, Issue 8 2003Kevin K. Tabata Abstract The morphodynamics of the anastomosing channel system of upper Columbia River in southeastern British Columbia, Canada, is examined using an adaptation of conventional hydraulic geometry termed ,interchannel hydraulic geometry'. Interchannel hydraulic geometry has some of the characteristics of downstream hydraulic geometry but differs in that it describes the general bankfull channel form and hydraulics of primary and secondary channels in the anastomosing channel system. Interchannel hydraulic geometry generalizes these relationships and as such becomes a model of the geomorphology of channel division and combination. Interchannel hydraulic geometry of upper Columbia River, based on ,eld measurements of ,ow velocity and channel form at 16 test sections, is described well by simple power functions: wbf = 3·24Qbf0·64; dbf = 1·04Qbf0·19; vbf = 0·30Qbf0·17. These results, with other related measurements of ,ow resistance, imply that channel splitting leads to hydraulic inef,ciency (higher ,ow resistance) on the anastomosing Columbia River. Because these ,ndings differ from those reported in studies elsewhere, we conclude that hydraulic ef,ciency does not provide a general explanation for anabranching in river channels. Copyright © 2003 John Wiley & Sons, Ltd. [source] HYDROLOGY AND GEOMORPHIC EFFECTS OF A HIGH-MAGNITUDE FLOOD IN AN ALPINE RIVERGEOGRAFISKA ANNALER SERIES A: PHYSICAL GEOGRAPHY, Issue 1 2007DAVID MORCHE ABSTRACT. The catchment of the River Partnach, a torrent situated in a glacial valley in the Northern Calcareous Alps of Bavaria/Germany, was affected by a high-magnitude flood on 22/23 August 2005 with a peak discharge of more than 16 m3s -1 at the spring and about 50 m3s -1 at the catchment outlet. This flood was caused by a long period of intense rainfall with a maximum intensity of 230 mm per day. During this event, a landslide dam, which previously held a small lake, failed. The flood wave originating from the dam breach transported a large volume of sediment (more than 50 000 m3) derived from bank erosion and the massive undercutting of a talus cone. This caused a fundamental transformation of the downstream channel system including the redistribution of large woody debris and channel switching. Using terrestrial survey and aerial photography, erosional and depositional consequences of the event were mapped, pre- and post-event surfaces were compared and the sediment budget of the event calculated for ten consecutive channel reaches downstream of the former lake. According to the calculations more than 100 000 tonnes of sediment were eroded, 75% of which was redeposited within the channel and the proximal floodplain. A previous large flood which occurred a few weeks prior to the August 2005 event had a significant effect on controlling the impact of this event. [source] The Ridgeway Conglomerate Formation of SW Wales, and its implications.GEOLOGICAL JOURNAL, Issue 1 2007The end of the Lower Old Red Sandstone? Abstract The Devonian Old Red Sandstone Ridgeway Conglomerate Formation crops out in Pembrokeshire, SW Wales. It was deposited as part of a dryland alluvial fan, axial fluvial valley deposystem. It conformably overlies the mid Lochkovian Freshwater West Formation and probably predates deposition of the Lower Cosheston Group Mill Bay Formation indicating an Early Devonian (latest Lochkovian to earliest Pragian) age, rather than a Middle Devonian age as suggested by previous workers. It therefore represents the youngest preserved formation of the Milford Haven Group south of the Ritec Fault. The Formation thickens drastically into the Ritec Fault, indicating its control on sedimentation. The half-graben topography initiated deposition of a hangingwall alluvial fan that was sourced from a southerly Lower Palaeozoic/Precambrian provenance within the present-day Bristol Channel. The Formation is heterolithic in nature, with deposits on the fan reflecting a mixture of processes. Conglomerates were deposited primarily by laterally extensive sheetfloods, and as bars in low-relief, laterally accreted channels. Sandstones were also predominantly deposited by sheetfloods. Gritty mudrocks in comparison demonstrate deposition by cohesive debris flows. The fan prograded northward and interfingered with a low-gradient, high-sinuosity fluvial channel system dominated by inclined and non-inclined heterolithic stratification. Thinly laminated mudstone and sandstone interbeds were deposited in ephemeral fan-toe and axial valley lakes that may have developed during sub-humid climatic episodes. The lacustrine heterolithic association has associated matgrounds and possible ,algal roll-up' structures. Calcretized peetee structures and root traces comprise a lake margin calcrete association. Fan gravels prograded into the axial fluvial valley during periods of increased sediment flux that may represent semi-arid conditions and/or episodes of tectonic activity. Calcretes of varying development were established in both the fan and axial valley zones. Calcretes with lower stages of development are more proximal to the Ritec Fault reflecting decreased soil residence times and high deposition rates within the axial valley. More strongly developed soil profiles on the fan may indicate sequence boundaries associated with low sediment flux, or increased soil residence time due to active fan-channel migration (the pedofacies concept). Groundwater calcretes have sharp-based and layer-bound calcrete profiles. Gully-bed cements are locally developed within the fan gravels. Copyright © 2007 John Wiley & Sons, Ltd. [source] Dynamic and Reversible Organization of Zeolite L Crystals Induced by Holographic Optical TweezersADVANCED MATERIALS, Issue 37 2010Mike Woerdemann Organization and patterning of zeolite L crystals with their unique properties such as their one-dimensional nano channel system is of highest topical interest with various applications in many areas of science. We demonstrate full three-dimensional optical control of single zeolite L crystals and for the first time fully reversible, dynamic organization of a multitude of individually controlled zeolite L crystals. [source] Integrating the scene length characteristics of MPEG video bitstreams into a direct broadcast satellite network with return channel systemINTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS AND NETWORKING, Issue 2 2004Fatih Alagöz Abstract In order to optimize the network resources, we should incorporate all the available information into the network design. However, incorporating irrelevant information may increase the design complexity and/or decrease the performance of the network. In this paper, we investigate the relevance of integrating the scene length characteristics of moving pictures expert group (MPEG) coded video bitstreams into a direct broadcast satellite (DBS) network with return channel system (DVB-RCS). Due to the complexity of the studied system, unless disputable simplifications are made, it is hard to achieve a mathematical foundation for this integration. Our analysis relies on extensive set of simulations. Firstly, we achieve the scene length distributions for MPEG bitstreams based on the proposed scene change models and their subjective observations of the actual video. We show that these models may be used to estimate the scene length of MPEG bitstreams. We then integrate this estimation into a DBS network simulator. Finally, we show that the scene length characteristics may be used to improve the DBS network performance under certain conditions. Copyright © 2004 John Wiley & Sons, Ltd. [source] Improved artifact correction for combined electroencephalography/functional MRI by means of synchronization and use of vectorcardiogram recordingsJOURNAL OF MAGNETIC RESONANCE IMAGING, Issue 3 2008Karen J. Mullinger BSc Abstract Purpose To demonstrate that two methodological developments (synchronization of the MR scanner and electroencephalography [EEG] clocks and use of the scanner's vectorcardiogram [VCG]) improve the quality of EEG data recorded in combined EEG/functional MRI experiments in vivo. Materials and Methods EEG data were recorded using a 32-channel system, during simultaneous multislice EPI acquisition carried out on a 3 Tesla scanner. Recordings were made on three subjects in the resting state and on five subjects using a block paradigm involving visual stimulation with a 10-Hz flashing checkerboard. Results Gradient artifacts were significantly reduced in the EEG data recorded in vivo when synchronization and a TR equal to a multiple of the EEG clock period were used. This was evident from the greater attenuation of the signal at multiples of the slice acquisition frequency. Pulse artifact correction based on R-peak markers derived from the VCG was shown to offer a robust alternative to the conventionally used ECG-based method. Driven EEG responses at frequencies of up to 60 Hz due to the visual stimulus could be more readily detected in data recorded with EEG and MR scanner clock synchronization. Conclusion Synchronization of the scanner and EEG clocks, along with VCG-based R-peak detection is advantageous in removing gradient and pulse artifacts in combined EEG/fMRI recordings. This approach is shown to allow the robust detection of high frequency driven activity in the EEG data. J. Magn. Reson. Imaging 2008;27:607,616. © 2008 Wiley-Liss, Inc. [source] THE PALEOCENE SANDY SIRI FAIRWAY: AN EFFICIENT "PIPELINE" DRAINING THE PROLIFIC CENTRAL GRABEN?JOURNAL OF PETROLEUM GEOLOGY, Issue 1 2006S.E. Ohm A new petroleum charge model is presented for the sand-dominated Paleocene channel system known as the Siri Fairway in the Central Graben of the North Sea. The Siri Fairway is located in the platform area along the Danish - Norwegian border and extends from the Norwegian palaeo shelf into the Tail-End Graben and Søgne Basin. The nearest known expelling source rocks are located in the Central Graben. The discovery of the Siri oilfield and later the Cecilie and the Nini fields proves that petroleum has migrated through these Paleocene sandstones for up to 70 km, which is a considerable distance in the North Sea. If the Siri Fairway has acted as a "pipeline" for petroleum migrating from the Graben to the platform area, the chemical composition of the hydrocarbons discovered in the Graben and within the Fairway itself should be similar in terms of maturity and organic facies signature. This study shows this not to be the case. The Graben oils have a mature signature, whereas the oils from the Siri field have an early mature signature and are mixed with biogenic gas generated in situ. The biogenic gas "signature", which was inherited from gas which accumulated in the trap before the arrival of the oil charge, should have disappeared if petroleum had continuously been introduced to the Fairway. It therefore appears that hydrocarbon charging to the Fairway ceased for some reason before the source rocks in the Graben entered the main oil window; the Siri Fairway therefore represents an aborted migration route, and limited charging of the Paleocene sandstone deposits in the platform has occurred. The chemical composition of the oils from the Siri field indicates that the Fairway was charged from two different basins with different subsidence histories. The Siri-2 trap is thus interpreted to have been filled with the same oil as that found in Siri-1 and Siri-3, but this oil was later partly displaced by oil generated in a shallower sub-basin. The sandstones in the Siri Fairway were deposited as turbidites and/or gravity slides in the Late Paleocene, and consist of stacked interfingering sandstone lobes which are encased to varying degrees in fine-grained sediments. Although long distance migration through the sandstones has been proved to occur, connectivity between individual sandlobes may be problematic. The number of dry wells drilled in the Fairway and the early-mature character of the analysed oils, together with the general absence of more mature later petroleum, indicate that migration routes in this region are limited and difficult to predict. [source] Multichannel mapping of fetal magnetocardiogram in an unshielded hospital settingPRENATAL DIAGNOSIS, Issue 5 2005Donatella Brisinda Abstract Objectives To evaluate the feasibility of unshielded in-hospital multichannel mapping of fetal magnetocardiogram (FMCG), with a 36-channel system for standard adult magnetocardiographic (MCG) recordings, and its reliability according to the recommended standards for FMCG. Methods FMCG was ambulatory mapped with a 36-channel MCG system, in six normal pregnancies at different gestational ages. MCG analysis included adaptive digital filtering of 50 Hz, signal averaging, reconstruction of magnetic field distribution (MFD) and source localization. Fixed Point Independent Component Analysis algorithm (FastICA) was used to reconstruct the FMCG, separating them from maternal contamination and noise. Results The quality of FMCG recorded after the 32nd gestational week and reconstructed with FastICA was close to FMCG obtained in shielded rooms, and good enough to measure cardiac intervals and heart rate variability parameters. In two cases, reconstruction of the MFD during the QRS allowed three-dimensional localization of ventricular sources. Conclusions A first demonstration has been given that multichannel mapping of FMCG can be performed in unshielded clinical environments, with resolution good enough for contactless assessment of fetal cardiac electrophysiology. FastICA processing on unshielded FMCG, recorded after the 32nd week, provided beat-to-beat analysis and heart rate variability assessment. Further work is needed to improve signal reconstruction in early pregnancy. Copyright © 2005 John Wiley & Sons, Ltd. [source] Continuous scalable blood filtration device using inertial microfluidicsBIOTECHNOLOGY & BIOENGINEERING, Issue 2 2010Albert J. Mach Abstract Cell separation is broadly useful for applications in clinical diagnostics, biological research, and potentially regenerative medicine. Recent attention has been paid to label-free size-based techniques that may avoid the costs or clogging issues associated with centrifugation and mechanical filtration. We present for the first time a massively parallel microfluidic device that passively separates pathogenic bacteria cells from diluted blood with macroscale performance. The device was designed to process large sample volumes in a high-throughput, continuous manner using 40 single microchannels placed in a radial array with one inlet and two rings of outlets. Each single channel consists of a short focusing, gradual expansion and collection region and uses unique differential transit times due to size-dependent inertial lift forces as a method of cell separation. The gradual channel expansion region is shown to manipulate cell equilibrium positions close to the microchannel walls, critical for higher efficiency collection. We demonstrate >80% removal of pathogenic bacteria from blood after two passes of the single channel system. The massively parallel device can process 240,mL/h with a throughput of 400 million cells/min. We expect that this parallelizable, robust, and label-free approach would be useful for filtration of blood as well as for other cell separation and concentration applications from large volume samples. Biotechnol. Bioeng. 2010;107: 302,311. © 2010 Wiley Periodicals, Inc. [source] Synthesis, structure and photoluminescence of two zinc carboxylate polymers with different coordination architecturesCHINESE JOURNAL OF CHEMISTRY, Issue 10 2003Hong Ding Abstract The hydrothermal reaction of ZnO with benzene-1,4-dicarboxylic add gave Zn·BDC·2H2O (1) and Zn-BDC·H2O (2) (BDC = benzene-1, 4-dicarboxylate), respectively. Polymer 1 (C4H4O3ZH0.5) shows a one-dimensional zigzag chain structure built up from the alternate connection of tetrahedral ZnO4 and BDC units. Polymer 2 (C4H3O2.5Zn0.5) possesses a three-dimensional framework containing infinite zigzag Zn·Zn·Zn pseudochains generated by five-coordinate zinc centers and a rectangular channel system including three groups of different straight channels along the [001], [010] and [60,1] directions. The two metal-organic polymeric compounds exhibit strong photoluminescent emission bands at 402 nm (,ex = 260 nm) (for 1) and at 344 nm and 385 nm (,ex = 279 nm) (for 2) in the solid state at room temperature. [source] Exploration of a Standing Mesochannel System with Antimatter/Matter Atomic Probes,ADVANCED MATERIALS, Issue 24 2008Hiroyuki K. M. Tanaka Positronium, a system consisting of an electron and its antimatter, a positron, offers a new technique to explore vertical accessibility and connectivity. Here, we show how this technique can be used to map out the vertical profile of mesoporous silica channel systems by comparing a standing (perpendicular to the substrate) 2D hexagonal with a lying (parallel to the substrate) 2D hexagonal mesoporous film. [source] Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: The possible contribution of 86Rb+ efflux and 45Ca2+ uptakeCELL BIOCHEMISTRY AND FUNCTION, Issue 8 2008M. Töpfer Abstract Due to the lack of specific agonists and antagonists the role of adenosine receptor subtypes with respect to their effect on the insulin secretory system is not well investigated. The A1 receptor may be linked to different 2nd messenger systems, i.e. cAMP, K+ - and 45Ca2+ channel activity. Partial A1 receptor agonists are going to be developed in order to improve diabetes (increase in insulin sensitivity, lowering of FFA and triglycerides). In this study newly synthesized selective A1 receptor agonists and antagonists were investigated thereby integrating three parameters, insulin release (RIA), 45Ca2+ uptake and 86Rb+ efflux (surrogate for K+ efflux) of INS-1 cells, an insulin secretory cell line. The presence of A1 -receptors was demonstrated by Western blotting. The receptor nonselective adenosine analogue NECA (5,- N -ethylcarboxyamidoadenosine) at high concentration (10,µM) had no effect on insulin release and 45Ca2+ uptake which could be interpreted as the sum of effects mediated by mutual antagonistic adenosine receptor subtypes. However, an inhibitory effect mediated by A1 receptor agonism was detected at 10,nM NECA and could be confirmed by adding the A1 receptor antagonist PSB-36 (1-butyl-8-(3-noradamantyl)-3-(3-hydroxy-propyl)xanthine). NECA inhibited 86Rb+ efflux which, however, did not fit with the simultaneous inhibition of insulin secretion. The selective A1 receptor agonist CHA (N6 -cyclohexyladenosine) inhibited insulin release; the simultaneously increased Ca2+ uptake (nifedipine dependent) and inhibition of 86Rb+ efflux did not fit the insulin release data. The CHA effect (even the maximum effect at 50,µM) can be increased by 10,µM NECA indicating that CHA and NECA have nonspecific and physiologically non-relevant effects on 86Rb+ efflux in addition to their A1 -receptor interaction. Since PSB-36 did not influence the NECA-induced inhibition of 86Rb+ efflux, the NECA effect is not mediated by potassium channel-linked A1 receptors. The nonselective adenosine receptor antagonist caffeine increased insulin release which was reversed by CHA as expected when hypothesizing that both act via A1 receptors in this case. In conclusion, stimulation of A1 receptors by receptor selective and nonselective compounds reduced insulin release which is not coupled to opening of potassium channels (86Rb+ efflux experiments) or inhibition of calcium channels (45Ca2+ uptake experiments). It may be expected that of all pleiotropic 2nd messengers, the cAMP system (not tested here) is predominant for A1 receptor effects and the channel systems (K+ and Ca2+) are of minor importance and do not contribute to insulin release though being coupled to the receptor in other tissues. Copyright © 2008 John Wiley & Sons, Ltd. [source] Monetary Policy in a World Without MoneyINTERNATIONAL FINANCE, Issue 2 2000Michael Woodford This paper considers whether the development of ,electronic money' poses any threat to the ability of central banks to control the value of their national currencies through conventional monetary policy. It argues that, even if the demand for base money for use in facilitating transactions is largely or even completely eliminated, monetary policy should continue to be effective. Macroeconomic stabilization depends only upon the ability of central banks to control a short-term nominal interest rate, and this would continue to be possible, in particular through the use of a ,channel' system for the implementation of policy, like those currently used in Canada, Australia and New Zealand. [source] | ||||||||||||||||