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Chalcone Derivatives (chalcone + derivative)
Selected AbstractsElectrochemical Approach to the Radical Anion Formation from 2,-Hydroxy Chalcone DerivativesELECTROANALYSIS, Issue 5 2006P. Quintana-Espinoza Abstract Three 2,-hydroxy chalcone derivatives were electrochemically reduced to the radical anion by a reversible one-electron transfer followed by a chemical dimerization reaction. Under suitable conditions of the medium, the one-electron reduction produces very well resolved cyclic voltammograms due to the formation of the radical anion. By using appropriately the wide versatility of the cyclic voltammetric technique, was possible to study the generation of the radical anion and its stability. [source] ChemInform Abstract: A Facile and General Synthesis of Tropolonyl-Substituted Chalcone DerivativesCHEMINFORM, Issue 42 2010Mingqin Chang Abstract via Claisen,Schmidt condensation of 3-acetyltropolone with aromatic aldehydes under mild conditions (22 examples) [source] ChemInform Abstract: Microwave Studies on the Synthesis of Biologically Active Chalcone Derivatives.CHEMINFORM, Issue 41 2008Sushama Katade Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis of 3-Aryl-2-benzoylbenzofuran Derivatives Using Manganese(III) Acetate,Mediated Addition of Dimedon to Chalcone Derivatives.CHEMINFORM, Issue 38 2008Mustafa Ceylan Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and Characterization of , -Bromo Chalcone DerivativesCHINESE JOURNAL OF CHEMISTRY, Issue 8 2009Yakup BUDAK Abstract , -Bromo chalcones containing 2-thiene ring were prepared in good yields by the condensation of 1-(thien-3-yl)ethanone with aromatic aldehydes, followed by bromination with bromine and selective dehydrobromination with triethyl amine at room temperature. [source] Chalcones as potent antiplatelet agents and calcium channel blockersDRUG DEVELOPMENT RESEARCH, Issue 1 2001Chun-Nan Lin Abstract In an effort to continually develop potent antiplatelet agents with vasorelaxing and antiinflammatory actions, a novel series of antiinflammatory chalcones was continually screened to evaluate their antiplatelet and vasorelaxing effects. Their structure,activity relationships and mode of action were discussed and characterized. A novel series of antiinflammatory chalcones was studied on antiplatelet effect in rabbit washed platelets and human platelet-rich plasma (PRP) and vasorelaxing effect in rat thoracic aorta. Arachidonic acid-induced platelet aggregation was potently inhibited by almost all the chalcone derivatives and 13,15 also had a potent inhibitory effect on cyclooxygenase. The selective chalcones 12,16 tested in human PRP significantly inhibited secondary aggregation induced by adrenaline. In rat thoracic aorta, most of chalcones at high concentration significantly depressed the contractions induced by Ca2+ (1.9 mM) in high K+ (80 mM) medium and the phasic and tonic contractions caused by norepinephrine (3 ,M). In the rat thoracic aorta, the phenylephrine- and high K+ -induced 45Ca2+ influx were both inhibited by a selective chalcone derivative, 14. These results indicate that the antiplatelet actions of chalcones are mainly mediated through the suppression of cyclooxygenase activity and reduced thromboxane formation and their inhibitory effects on the contractile response caused by high K+ and norepinephrine in rat thoracic aorta are mainly due to inhibition of Ca2+ influx through both voltage-dependent and receptor-operated Ca2+ channels. Drug Dev. Res. 53:9,14, 2001. © 2001 Wiley-Liss, Inc. [source] 2,-Hydroxy-4,,-dimethylaminochalconeACTA CRYSTALLOGRAPHICA SECTION C, Issue 8 2002Zhiqiang Liu The title compound, 3-[4-(dimethylamino)phenyl]-1-(2-hydroxyphenyl)prop-2-en-1-one, C17H17NO2, is a chalcone derivative substituted by 2,-hydroxyl and 4,,-dimethylamino groups. The crystal structure indicates that the aniline and hydroxyphenyl groups are nearly coplanar, with a dihedral angle of 10.32,(16)° between their phenyl rings. The molecular planarity of this substituted chalcone is strongly affected by the 2,-hydroxyl group. [source] Chalcones as potent antiplatelet agents and calcium channel blockersDRUG DEVELOPMENT RESEARCH, Issue 1 2001Chun-Nan Lin Abstract In an effort to continually develop potent antiplatelet agents with vasorelaxing and antiinflammatory actions, a novel series of antiinflammatory chalcones was continually screened to evaluate their antiplatelet and vasorelaxing effects. Their structure,activity relationships and mode of action were discussed and characterized. A novel series of antiinflammatory chalcones was studied on antiplatelet effect in rabbit washed platelets and human platelet-rich plasma (PRP) and vasorelaxing effect in rat thoracic aorta. Arachidonic acid-induced platelet aggregation was potently inhibited by almost all the chalcone derivatives and 13,15 also had a potent inhibitory effect on cyclooxygenase. The selective chalcones 12,16 tested in human PRP significantly inhibited secondary aggregation induced by adrenaline. In rat thoracic aorta, most of chalcones at high concentration significantly depressed the contractions induced by Ca2+ (1.9 mM) in high K+ (80 mM) medium and the phasic and tonic contractions caused by norepinephrine (3 ,M). In the rat thoracic aorta, the phenylephrine- and high K+ -induced 45Ca2+ influx were both inhibited by a selective chalcone derivative, 14. These results indicate that the antiplatelet actions of chalcones are mainly mediated through the suppression of cyclooxygenase activity and reduced thromboxane formation and their inhibitory effects on the contractile response caused by high K+ and norepinephrine in rat thoracic aorta are mainly due to inhibition of Ca2+ influx through both voltage-dependent and receptor-operated Ca2+ channels. Drug Dev. Res. 53:9,14, 2001. © 2001 Wiley-Liss, Inc. [source] Electrochemical Approach to the Radical Anion Formation from 2,-Hydroxy Chalcone DerivativesELECTROANALYSIS, Issue 5 2006P. Quintana-Espinoza Abstract Three 2,-hydroxy chalcone derivatives were electrochemically reduced to the radical anion by a reversible one-electron transfer followed by a chemical dimerization reaction. Under suitable conditions of the medium, the one-electron reduction produces very well resolved cyclic voltammograms due to the formation of the radical anion. By using appropriately the wide versatility of the cyclic voltammetric technique, was possible to study the generation of the radical anion and its stability. [source] Claisen,Schmidt Condensation Catalyzed by Metal-Organic FrameworksADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 4 2010Amarajothi Dhakshinamoorthy Abstract Metal-organic framework [Fe(BTC) (BTC=1,3,5-benzenetricarboxylic acid)] is a convenient heterogeneous catalyst for the carbon-carbon bond forming reaction in toluene between acetophenone and benzaldehyde to give selectively chalcone in high yield. Fe(BTC) appears as a general catalyst able to synthesize selectively different chalcone derivatives bearing various functionalities. Fe(BTC) could be recycled with no significant loss of catalytic efficiency and crystallinity in subsequent runs. [source] Synthesis of polyfunctionally substituted heteroaromatic compounds via benzotriazolyl chalcones with antimicrobial and antifungal activitiesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 3 2004Fatima Al-Omran The utility of both 3-(1-benzotriazolyl) chalcone derivatives 3a-c and 2-(1-benzotriazolyl)-1,4-pentadien-3-one (18) in the synthesis of some new 2-(1H)-pyridone, pyridine, pyrazole and isoxazole derivatives is reported. Antimicrobial and antifungal screening of some selected examples from the synthesized products were carried out. The structure of the newly synthesized compounds was elucidated by elemental analysis, ir, 1H and 13C nmr investigations. [source] Highly Enantioselective Synthesis of ,-Heteroaryl-Substituted Dihydrochalcones Through Friedel,Crafts Alkylation of Indoles and PyrroleCHEMISTRY - A EUROPEAN JOURNAL, Issue 5 2010Wentao Wang Abstract A highly enantioselective Friedel,Crafts (F,C) alkylation of indoles and pyrrole with chalcone derivatives catalyzed by a chiral N,N, -dioxide,Sc(OTf)3 complex has been developed that tolerates a wide range of substrates. The reaction proceeds in moderate to excellent yields and high enantioselectivities (85,92,% enantiomeric excess) using 2,mol,% (for indole) or 0.5,mol,% (for pyrrole) catalyst loading, which showed the potential value of the catalyst system. Meanwhile, a strong positive nonlinear effect was observed. On the basis of the experimental results and previous reports, a possible working model is proposed to explain the origin of the activation and asymmetric induction. [source] | ||||||||||||||||||||||