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Acetylenic Compounds (acetylenic + compound)
Selected AbstractsChemInform Abstract: Synthesis of Nicotinamide and Isonicotinamide Derivatives via Multicomponent Reaction of Alkyl Isocyanides and Acetylenic Compounds in the Presence of Nicotinic or Isonicotinic Acid.CHEMINFORM, Issue 2 2008Abdolali Alizadeh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis of Thiazolo[3,2-d][1,2,4] Triazines Through Palladium-Catalyzed Heteroannulation of Acetylenic Compounds.CHEMINFORM, Issue 38 2007Majid M. Heravi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] A Novel Synthetic Approach to Fluorine-Containing Acetylenic Compounds Based on Nicholas Reaction.CHEMINFORM, Issue 38 2006Tsutomu Konno Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis of thiazolo[3,2- d][1,2,4] triazines through palladium-catalyzed heteroannulation of acetylenic compoundsJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 3 2007Majid M. Heravia The reaction of 6-methyl-5-(prop-2-ynylthio)-5,6-dihydro-1,2,4-triazin-3(4H)-one 1 with various iodobenzenes 2 in the presence of palladium catalyst leads to the formation of substituted triazolotriazines. [source] Separation of cannabinoid receptor affinity and efficacy in delta-8-tetrahydrocannabinol side-chain analoguesBRITISH JOURNAL OF PHARMACOLOGY, Issue 2 2001Graeme Griffin The activities of a number of side-chain analogues of delta-8-tetrahydrocannabinol (,8 -THC) in rat cerebellar membrane preparations were tested. The affinities of each compound for the CB1 receptor were compared by their respective abilities to displace [3H]-SR141716A and their efficacies compared by stimulation of [35S]-GTP,S binding. It was found that the affinities varied from 0.19±0.03 nM for 3-norpentyl-3-[6,-cyano,1,,1,-dimethyl]hexyl-,8 -THC to 395±66.3 nM for 5,-[N-(4-chlorophenyl)]-1,,1,-dimethyl-carboxamido-,8 -THC. The efficacies of these compounds varied greatly, ranging from the very low efficacy exhibited to acetylenic compounds such as 1,-heptyn-,8 -THC and 4,-octyn-,8 -THC to higher efficacy compounds such as 5,-(4-cyanophenoxy)-1,,1,-dimethyl-,8 -THC and 5,-[N-(4-aminosulphonylphenyl)]-1,,1, dimethyl-carboxamido ,8 -THC. All agonist activities were antagonized by the CB1 -selective antagonist SR141716A. It was found that a ligand's CB1 affinity and efficacy are differentially altered by modifications in the side-chain. Decreasing the flexibility of the side-chain reduced efficacy but largely did not alter affinity. Additionally, the positioning of electrostatic moieties, such as cyano groups, within the side-chain also has contrasting effects on these two properties. In summary, this report details the characterization of a number of novel ,8 -THC analogues in rat cerebellar membranes. It provides the first detailed pharmacological analysis of how the inclusion of electrostatic moieties in the side-chain and also how alteration of the side-chain's flexibility may differentially affect a CB1 cannabinoid receptor ligand's affinity and efficacy. British Journal of Pharmacology (2001) 132, 525,535; doi:10.1038/sj.bjp.0703827 [source] | ||||||||||