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Acetyl Derivatives (acetyl + derivative)
Selected AbstractsAcetyl Derivatives of 3-(5-R-Amino- [1,3,4]thiadiazol-2-yl)-5-hydroxymethyl-8-methyl-2H-pyrano [2,3-c]pyridin-2-onesCHEMINFORM, Issue 22 2005I. A. Zhuravel' Abstract For Abstract see ChemInform Abstract in Full Text. [source] Preparation and Stereochemistry of the Isopropylidene Derivatives of 1,2-Dihydronaphtho[2,1-b]furan-1,2-diol and 1,2,9,10-Tetrahydronaphtho[2,1-b:7,8-b,]difuran-1,2,9,10-tetraol in Comparison with the Corresponding Acetyl Derivatives.CHEMINFORM, Issue 19 2005Makoto Yamaye Abstract For Abstract see ChemInform Abstract in Full Text. [source] Cytotoxic,Antineoplastic Activity of Acetyl Derivatives of Prenylnaphthohydroquinone.CHEMINFORM, Issue 46 2004Aurora Molinari Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: Acetyl Derivatives of 3-Quinuclidone.CHEMINFORM, Issue 14 2002L. N. Koikov Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Acetyl- l -carnitine improves aged brain functionGERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 2010Satoru Kobayashi The effects of acetyl- l -carnitine (ALCAR), an acetyl derivative of l -carnitine, on memory and learning capacity and on brain synaptic functions of aged rats were examined. Male Fischer 344 rats were given ALCAR (100 mg/kg bodyweight) per os for 3 months and were subjected to the Hebb,Williams tasks and AKON-1 task to assess their learning capacity. Cholinergic activities were determined with synaptosomes isolated from brain cortices of the rats. Choline parameters, the high-affinity choline uptake, acetylcholine (ACh) synthesis and depolarization-evoked ACh release were all enhanced in the ALCAR group. An increment of depolarization-induced calcium ion influx into synaptosomes was also evident in rats given ALCAR. Electrophysiological studies using hippocampus slices indicated that the excitatory postsynaptic potential slope and population spike size were both increased in ALCAR-treated rats. These results indicate that ALCAR increases synaptic neurotransmission in the brain and consequently improves learning capacity in aging rats. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S99,S106. [source] O -acetylated sialic acids: Multifaceted role in childhood acute lymphoblastic leukaemiaBIOTECHNOLOGY JOURNAL, Issue 3 2009Suchandra Chowdhury Abstract Childhood acute lymphoblastic leukaemia (ALL), a malignant transformation of the lymphoblasts, is highly responsive to chemotherapy. However, due to certain inadequacy in detection of minimal residual disease (MRD), relapse is a common phenomenon. To address this question, the present review deals with the induction of an unique O -acetyl derivative of sialic acid on a few disease-associated glycoproteins and glycolipids at the onset of childhood ALL, a finding of our group in the last decade. This information has been successfully utilized for diagnosis and prognosis of the disease. Existing literature is included for comparison. Additionally, cell surface overexpression of 9- O -acetylated sialoglycoproteins and antibodies against them present in patients' sera aid the survival of the malignant lymphoblasts and suggest a multifaceted role played by these molecules. Taken together, monitoring these molecules helps not only in unravelling the biology of this paediatric malignancy but also in personalizing the treatment strategies for the betterment of the patient population. [source] Circular dichroism of diglycosyl dichalcogenides in solution and solid state,CHIRALITY, Issue 3-4 2008Tibor Kurtán Abstract Solution and solid-state CD spectra of nine peracetylated and deacetalyted diglycosyl disulfides were measured to study the relationship between the low-energy CD transitions (n1,,*SS and n2,,*SS) and helicity of the inherently chiral disulfide chromophore as perturbed by chiral carbohydrate moieties. The solid-state CD spectra were directly correlated with the reported X-ray structures of Ac4GlcSSGlcAc4 and Ac4GlcSSGalAc4, and the CD data revealed that all the disulfides have M helicity with C1SSC1, dihedral angles ,90° < , < 0° both in solution and in the solid state. A TDDFT CD study was carried out on dimethyl diselenide which confirmed that the same quadrant rule is relevant between the signs of the low-energy CD transitions and the diselenide torsional angle as formulated previously for the disulfide chromophore. The CD spectra of Ac4GlcSeSeGlcAc4 measured in solution and in the solid state were correlated with its X-ray structure and reproduced well by TDDFT CD calculations performed on its tetra- O -acetyl derivative. Chirality, 2008. © 2007 Wiley-Liss, Inc. [source] Synthesis of Substituted 1H - and 3H -1-Benzazepines and Rearrangement of Alkyl 1H -1-Benzazepine-2-carboxylates into Isoquinolines,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 18 2007Vijay Singh Abstract The SnCl2 -mediated reduction of nitro groups in 2-nitro-4-(2-nitrobenzylidene)alkanoates and 4-nitro-2-(2-nitroalkylidene)alkanoates allows the facile synthesis of substituted 1H -1-benzazepines and 3H -1-benzazepines. This reaction proceeds via SN2, reaction of ethyl nitroacetate and nitroethane with the acetyl derivatives of Baylis,Hillman adducts deriving from 2-nitro-substituted benzaldehydes. During the study, an unprecedented rearrangement of an alkyl 1H -benzazepine-2-carboxylate to a substituted isoquinoline has been observed. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source] Synthesis of 2-amino-4h -thiazolo[5,4- b]indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activityJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 3 2001Jens Breinholt In DMSO-solution 2-amino-4H -thiazolo[5,4- b]indole is converted into a complex mixture of colored products. The three major conversion end-products, of which two are inhibitors of protein tyrosine phos-phatases (PTPs), were isolated by chromatographic methods and their structures characterized by spectro-scopic analysis, including NMR and MS combined with computer assisted structure elucidation, and, finally, confirmed by independent chemical synthesis. Synthesis of 2-amino-4H -thiazolo[5,4- b]indole as well as its N -acetyl derivatives prepared from either oxindole or 2-bromo-1-(2-nitro-phenyl)ethanone is described. [source] | ||||||||||