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Acetic Acid Derivatives (acetic + acid_derivative)
Selected AbstractsChemInform Abstract: Synthesis and Hypolipidemic Activity of Novel 2-(4-(2-Substituted-aminothiazole-4-yl)phenoxy) Acetic Acid Derivatives.CHEMINFORM, Issue 40 2010Santosh N. Mokale Abstract All synthesized compounds (I) are evaluated for their hypolipidemic activity by using high fat-diet induced hyperlipidemia in Sprague-Dawley rats. [source] ChemInform Abstract: Efficient Synthesis of 2,6-Dioxo-1,2,3,4,5,6-hexahydroindoles Based on the Synthesis and Reactions of (2,4-Dioxocyclohex-1-yl)acetic Acid Derivatives.CHEMINFORM, Issue 29 2008Benard Juma Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis of (3-Amino-7-chloro-8-methyl-1,1-dioxo-4H-1,5,2-benzo [f]dithiazepin-4-ylidene)acetic Acid Derivatives as Potential Antitumor Agents.CHEMINFORM, Issue 21 2008Z. Brzozowski Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT4 receptorJOURNAL OF PEPTIDE SCIENCE, Issue 7 2007Andreas Axén Abstract Angiotensin IV analogs encompassing aromatic scaffolds replacing parts of the backbone of angiotensin IV have been synthesized and evaluated in biological assays. Several of the ligands displayed high affinities to the insulin-regulated aminopeptidase (IRAP)/AT4 receptor. Displacement of the C -terminal of angiotensin IV with an o -substituted aryl acetic acid derivative delivered the ligand 4, which exhibited the highest binding affinity (Ki = 1.9 nM). The high affinity of this ligand provides support to the hypothesis that angiotensin IV adopts a ,-turn in the C -terminal of its bioactive conformation. Ligand (4) inhibits both human IRAP and aminopeptidase N-activity and induces proliferation of adult neural stem cells at low concentrations. Furthermore, ligand 4 is degraded considerably more slowly in membrane preparations than angiotensin IV. Hence, it might constitute a suitable research tool for biological studies of the (IRAP)/AT4 receptor. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd. [source] Synthesis of 1,3,4-oxa(or thia)diazaheterocycles starting from 2-(pyrrol-1'-y1)phthalimideJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 6 2001Anita Guesdon 1-(1,3-Dioxo-1,3-dihydro-2H -isoindol-2-yl)-1H -pyrrol-2 carbaldehyde 4 was synthesized by Vilsmeier-Haack reaction from 2-(pyrrol-1-yl) phthalimide. Reduction of 4 by sodium borohydride, or action of Grignard reagents on 4 led to the corresponding alcohols 5 which were cyclized to pyrroloxadiazino isoin-doles 1 by heating in the presence of silica gel. Transformation of the hydroxylactam 6 with acetic acid derivatives led to the esters 7 which gave, after saponification, pyrroloxa(or thia)diazepinoisoindolones 2 by intramolecular cyclization. [source] | ||||||||||