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Chloroacetyl Chloride (chloroacetyl + chloride)
Selected AbstractsChemInform Abstract: Unusual Reaction of Chloroacetyl Chloride with 1,2-Dichloroethene.CHEMINFORM, Issue 26 2009Properties of 2-Chlorovinyl Dichloromethyl Ketone., Synthesis Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Unusual Reaction of Chloroacetyl Chloride with 1,2-Dichloroethylene.CHEMINFORM, Issue 51 20084-Trichlorobut-3-en-2-one., Synthesis of Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Rhodium-Complex-Catalyzed Addition Reactions of Chloroacetyl Chlorides to Alkynes.CHEMINFORM, Issue 17 2009Taigo Kashiwabara Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis, spectral, and antimicrobial studies of 1-butyl-3-substituted-4-(2-aryl-1H -indol-3-yl)-2-azetidinonesHETEROATOM CHEMISTRY, Issue 7 2004Vijai N. Pathak Ketene generated from acetyl chloride or chloroacetyl chloride adds on indolyl Schiff's base double bond to afford 1-butyl-3-substituted-4-(2-aryl-1H -indol-3-yl)-2-azetidinones in THF. The reaction proceeds stereospecifically via concerted trans [2+2] cycloaddition. The synthesized compounds have been characterized by elemental analyses and spectral data (IR, PMR, and mass). All synthesized compounds have been evaluated for antibacterial and antifungal activities, and 4g to 4l have shown promising results. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:494,501, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20052 [source] Synthesis, characterization and studies of new 3-benzyl-4H -1,2,4-triazole-5-thiol and thiazolo[3,2- b][1,2,4]triazole-5(6H)-one heterocyclesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 3 2008Abdelwareth A. O. Sarhan 3-Benzyl-4-phenyl-1,2,4-triazole-5-thiol (1) was synthesized and used as starting material for preparation of 1,2,4-triazole bearing substituted thiosemicarbazides moiety (4a-d) in high yields. The thiosemicarbazides 4a-d were cyclized in basic medium to give two triazole rings linked by thiomethylene group (5a-d), while cyclization of thiosemicarbazides 4a-d with chloroacetyl chloride in the presence of CHCl3 and K2CO3 afforded the thiazolidinone derivatives 6a-d. The reaction of thiosemicarbazides 4a-c with phenacyl bromide in the presence of EtOH and fused CH3COONa gave the corresponding thiazoline ring systems 7a-c. Condensation of the 3-benzyl-1,2,4-triazole-5(1H)-thiol (1) with chloroacetic acid and aromatic aldehydes (8a- g) in boiling acetic acid/acetic anhydride mixture in the presence of fused sodium acetate gave one single isomer only, which might be 9a-g or 10a-g. Upon application of Micheal addition reaction on compounds 9a-e with cyclic secondary amines such as piperidine or morpholine the 2-benzyl-6-(,-amino-aryl/methyl)-1,3-thiazolo[3,2- b][1,2,4]-triazol-5-ols (11a-j) were obtained in good yields The structure of all new compounds were determined using both spectral and elemental analyses. [source] Synthesis, characterization and biological activity of some 1,2,4-triazine derivativesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2005A. A. El-Barbary 4-Amino-6-methyl-3-(2H)-thioxo-5-(4H)-oxo-1,2,4-triazine (1) was condensed with 2-methyl (or phenyl)-4H -3,1-benzoxazin-4-one (5a,b) in boiling acetic acid to give compounds 8-11. Reacting 1 with chloroacetyl chloride afforded the corresponding chloroacetamido and triazinothiadiazine derivatives 12 and 13. Condensing 2 with succinic anhydride and/or phthalic anhydride yielded compounds 14 and 15. Benzoylation of 4-amino-6-methyl-3-(2H)-thioxo-5-(4H)-oxo-2-(2,3,4,5-tetra- O -acetyl-,-D-glucopyra-nosyl)-1,2,4-triazine (19) afforded the corresponding 4- N,N -dibenzoyl derivative 20. Deblocking of the N -2 glycoside 21 and the S -glycoside 22 by methanolic ammonia gave compounds 23 and 24. Acetylation of 4-amino glycoside 25a afforded the corresponding 4-mono- and 4-diacetyl derivatives 26 and 27. Deamination of 25a,b yielded compounds 28a,b. Methylation of compound 28b afforded the corresponding N4- and S -methyl derivatives 29 and 30. [source] Versatile 2-aminothiazoles, building blocks for highly functionalised heterocyclesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 6 2003Gerd Kaupp The reactions of quantitatively available 4-phenyl- and 4-(4-antipyrinyl)-2-aminothiazole ["4-antipyrinyl-" is used as a short-term for "4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1-H-pyrazol-4yl)-"] with chloroacetyl chloride, acetic anhydride, ethyl cyanoacetate and carbon disulphide are reported. The products are transformed further by Knoevenagel condensations and coupling reactions with aromatic diazonium salts. The latter occur both at the thiazole ring and at the active methylene sites. The tautomerism of these products is studied on the basis of density functional theory calculations at the B3LYP/6-31G* level. [source] A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chloridesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 3 2001Qi-Yi Xing In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected ,-lactam derivative of the benzo-thiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the benxothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed. [source] Synthesis and Antimycobacterial Activity of a Novel Series of Isonicotinylhydrazide DerivativesARCHIV DER PHARMAZIE, Issue 12 2009Sandip Jaju Abstract A novel series of 14 new isonicotinyl hydrazide derivatives 2a,g, 3a,g containing a 4-thiazolidinone / 2-azetidinone nucleus were synthesized by reacting N,-substituted arylidene / heteroarylidene isonicotinyl hydrazide 1a,g with thioglycollic acid in the presence of dry benzene and with chloroacetyl chloride in the presence of triethylamine, respectively. Structures of all newly synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR and 1H-NMR). All the title compounds were tested for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using Alamar-Blue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in ,g/mL. Among the series, compounds 2b, 2g, 3b, and 3g displayed an encouraging antimycobacterial activity profile as compared to that of the reference drugs isoniazid / rifampicin. [source] | ||||||||||