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Kinds of Center Terms modified by Center Selected AbstractsCONSERVATION'S RADICAL CENTER IN GEOGRAPHYGEOGRAPHICAL REVIEW, Issue 1-2 2001JOHN B. WRIGHT First page of article [source] ENTRY-LEVEL POLICE CANDIDATE ASSESSMENT CENTER: AN EFFICIENT TOOL OR A HAMMER TO KILL A FLY?PERSONNEL PSYCHOLOGY, Issue 4 2002KOBI DAYAN The study examined the validity of the assessment center (AC) as a selection process for entry-level candidates to die police and its unique value beyond cognitive ability tests. The sample included 712 participants who responded to personality and cognitive ability testing (CAT), and underwent an AC procedure. AC results included the overall assessment rating (OAR) and peer evaluation (PE). Seven criterion measures were collected for 585 participants from a training stage and on-the-job performance. Results showed that the selection system was valid. Findings yielded significant unique validities of OAR and PE beyond CAT and of PE beyond OAR even after corrections for restriction of range. Results support the use of ACs for entry-level candidates. [source] Titelbild: Beton- und Stahlbetonbau 4/2010BETON- UND STAHLBETONBAU, Issue 4 2010Article first published online: 9 APR 2010 Auf dem Titelbild zu sehen ist das ROLEX LEARNING CENTER in Lausanne. Die architektonische Landschaft umfasst eine Fläche von 121,5 m x 162,5 m und wird durch zwei Schalenkonstruktionen mit 80 m bzw. 40 m Spannweite und dazwischen liegende flache Deckenbereiche gebildet. Überdacht wird die Landschaft durch ein Stahldach. Patios ermöglichen eine natürliche Belichtung und Belüftung des Gebäudes. Der Bericht ab Seite 248 beschäftigt sich mit dem Tragwerksentwurf im Allgemeinen, mit der Formfindung der Schalen sowie der Entwicklung ihres Tragwerkskonzept, mit der statischen Berechnung des Tragwerks, insbesondere der Schalen und ihrer Ausführungsplanung. (© EPFL) [source] Das ROLEX Learning Center der EPFL in LausanneBETON- UND STAHLBETONBAU, Issue 4 2010Klaus Bollinger Prof. Dr.-Ing. Abstract Das ROLEX LEARNING CENTER in Lausanne besticht nicht nur durch sein ungewöhnliches architektonisches Konzept, sondern bedeutete für alle Planungsbeteiligten und insbesondere für die Tragwerksplaner eine große Herausforderung. Gefragt war im architektonischen Wettbewerb, der im Jahr 2005 durchgeführt wurde, der Entwurf eines Gebäudes mit ausreichend Platz für eine Bibliothek, Studentenarbeitsplätze und kulturelle Aktivitäten, das gleichzeitig den neuen zentralen Eingang der EPFL repräsentieren sollte. Die Architekten Kazujo Sejima und Ryue Nishizawa (SANAA) entwarfen hierfür eine architektonische Landschaft, die eine natürliche Trennung der verschiedenen Nutzungszonen durch Täler und Hügel an Stelle von Wänden und Decken vorsah. Der vorliegende Bericht beschäftigt sich mit dem Tragwerksentwurf im Allgemeinen, mit der Formfindung der Schalen sowie der Entwicklung ihres Tragwerkskonzeptes, mit der design-statischen Berechnung des Tragwerks, insbesondere der Schalen und ihrer Ausführungsplanung. [source] AFTER-SCHOOL PROGRAM EFFECTS ON BEHAVIOR: RESULTS FROM THE 21ST CENTURY COMMUNITY LEARNING CENTERS PROGRAM NATIONAL EVALUATIONECONOMIC INQUIRY, Issue 1 2008SUSANNE JAMES-BURDUMY This paper presents evidence on after-school programs' effects on behavior from the national evaluation of the U.S. Department of Education's 21st Century Community Learning Centers after-school program. Findings come from both of the study's components: (1) an elementary school component based on random assignment of 2,308 students in 12 school districts and (2) a middle school component based on a matched comparison design including 4,264 students in 32 districts. Key findings include higher levels of negative behavior for elementary students and some evidence of higher levels of negative behaviors for middle school students. (JEL I21) [source] DEVELOPMENT ENGAGEMENT WITHIN AND FOLLOWING DEVELOPMENTAL ASSESSMENT CENTERS: CONSIDERING FEEDBACK FAVORABILITY AND SELF,ASSESSOR AGREEMENTPERSONNEL PSYCHOLOGY, Issue 4 2008SANG E. WOO This study sought to understand employees' level of behavioral engagement in response to feedback received in developmental assessment center (DAC) programs. Hypotheses were drawn from theories of self-enhancement and self-consistency and from findings in the multisource feedback and assessment center literatures regarding recipients' perceptions of feedback. Data were gathered from 172 U.S. middle managers participating in a DAC program. Results suggested that more favorable feedback was related to higher behavioral engagement. When discrepancies between self- and assessor ratings were examined, overraters (participants whose overall self-ratings were higher than their assessor ratings) tended to show less engagement in the program compared to underraters. However, pattern agreement on the participant's dimension profile did not significantly correlate with behavioral engagement. Based on these findings, avenues for future research are presented and practical implications are discussed. [source] Coping With Missing Attribute Values Based on Closest Fit in Preterm Birth Data: A Rough Set ApproachCOMPUTATIONAL INTELLIGENCE, Issue 3 2001Jerzy W. Grzymala-Busse Data mining is frequently applied to data sets with missing attribute values. A new approach to missing attribute values, called closest fit, is introduced in this paper. In this approach, for a given case (example) with a missing attribute value we search for another case that is as similar as possible to the given case. Cases can be considered as vectors of attribute values. The search is for the case that has as many as possible identical attribute values for symbolic attributes, or as the smallest possible value differences for numerical attributes. There are two possible ways to conduct a search: within the same class (concept) as the case with the missing attribute values, or for the entire set of all cases. For comparison, we also experimented with another approach to missing attribute values, where the missing values are replaced by the most common value of the attribute for symbolic attributes or by the average value for numerical attributes. All algorithms were implemented in the system OOMIS. Our experiments were performed on the preterm birth data sets provided by the Duke University Medical Center. [source] Investigative Visual Analysis of Global TerrorismCOMPUTER GRAPHICS FORUM, Issue 3 2008Xiaoyu Wang Abstract Recent increases in terrorist activity around the world have made analyzing and understanding such activities more critical than ever. With the help of organizations such as the National Center for the Study of Terrorism and Responses to Terrorism (START), we now have detailed historical information on each terrorist event around the world since 1970. However, due to the size and complexity of the data, identifying terrorists' patterns and trends has been difficult. To better enable investigators in understanding terrorist activities, we propose a visual analytical system that focuses on depicting one of the most fundamental concepts in investigative analysis, the five W's (who, what, where, when, and why). Views in our system are highly correlated, and each represents one of the W's. With this approach, an investigator can interactively explore terrorist activities efficiently and discover reasons of attacks (why) by identifying patterns temporally (when), geo-spatially (where), between multiple terrorist groups (who), and across different methods or modes of attacks (what). By coupling a global perspective with the details gleaned from asking these five questions, the system allows analysts to think both tactically and strategically. [source] Immersive Integration of Physical and Virtual EnvironmentsCOMPUTER GRAPHICS FORUM, Issue 3 2004Henry Fuchs We envision future work and play environments in which the user's computing interface is more closely integrated with the physical surroundings than today's conventional computer display screens and keyboards. We are working toward realizable versions of such environments, in which multiple video projectors and digital cameras enable every visible surface to be both measured in 3D and used for display. If the 3D surface positions were transmitted to a distant location, they may also enable distant collaborations to become more like working in adjacent offices connected by large windows. With collaborators at the University of Pennsylvania, Brown University, Advanced Network and Services, and the Pittsburgh Supercomputing Center, we at Chapel Hill have been working to bring these ideas to reality. In one system, depth maps are calculated from streams of video images and the resulting 3D surface points are displayed to the user in head-tracked stereo. Among the applications we are pursuing for this tele-presence technology, is advanced training for trauma surgeons by immersive replay of recorded procedures. Other applications display onto physical objects, to allow more natural interaction with them "painting" a dollhouse, for example. More generally, we hope to demonstrate that the principal interface of a future computing environment need not be limited to a screen the size of one or two sheets of paper. Just as a useful physical environment is all around us, so too can the increasingly ubiquitous computing environment be all around us -integrated seamlessly with our physical surroundings. [source] Parallel heterogeneous CBIR system for efficient hyperspectral image retrieval using spectral mixture analysisCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 9 2010Antonio J. Plaza Abstract The purpose of content-based image retrieval (CBIR) is to retrieve, from real data stored in a database, information that is relevant to a query. In remote sensing applications, the wealth of spectral information provided by latest-generation (hyperspectral) instruments has quickly introduced the need for parallel CBIR systems able to effectively retrieve features of interest from ever-growing data archives. To address this need, this paper develops a new parallel CBIR system that has been specifically designed to be run on heterogeneous networks of computers (HNOCs). These platforms have soon become a standard computing architecture in remote sensing missions due to the distributed nature of data repositories. The proposed heterogeneous system first extracts an image feature vector able to characterize image content with sub-pixel precision using spectral mixture analysis concepts, and then uses the obtained feature as a search reference. The system is validated using a complex hyperspectral image database, and implemented on several networks of workstations and a Beowulf cluster at NASA's Goddard Space Flight Center. Our experimental results indicate that the proposed parallel system can efficiently retrieve hyperspectral images from complex image databases by efficiently adapting to the underlying parallel platform on which it is run, regardless of the heterogeneity in the compute nodes and communication links that form such parallel platform. Copyright © 2009 John Wiley & Sons, Ltd. [source] Concepts for computer center power managementCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 2 2010A. DiRienzo Abstract Electrical power usage contributes significantly to the operational costs of large computer systems. At the Hypersonic Missile Technology Research and Operations Center (HMT-ROC) our system usage patterns provide a significant opportunity to reduce operating costs since there are a small number of dedicated users. The relatively predictable nature of our usage patterns allows for the scheduling of computational resource availability. We take advantage of this predictability to shut down systems during periods of low usage to reduce power consumption. With interconnected computer cluster systems, reducing the number of online nodes is more than a simple matter of throwing the power switch on a portion of the cluster. The paper discusses these issues and an approach for power reduction strategies for a computational system with a heterogeneous system mix that includes a large (1560-node) Apple Xserve PowerPC supercluster. In practice, the average load on computer systems may be much less than the peak load although the infrastructure supporting the operation of large computer systems in a computer or data center must still be designed with the peak loads in mind. Given that a significant portion of the time, systems loads can be less than full peak, an opportunity exists for cost savings if idle systems can be dynamically throttled back, slept, or shut off entirely. The paper describes two separate strategies that meet the requirements for both power conservation and system availability at HMT-ROC. The first approach, for legacy systems, is not much more than a brute force approach to power management which we call Time-Driven System Management (TDSM). The second approach, which we call Dynamic-Loading System Management (DLSM), is applicable to more current systems with ,Wake-on-LAN' capability and takes a more granular approach to the management of system resources. The paper details the rule sets that we have developed and implemented in the two approaches to system power management and discusses some results with these approaches. Copyright © 2009 John Wiley & Sons, Ltd. [source] Parallel processing of remotely sensed hyperspectral imagery: full-pixel versus mixed-pixel classificationCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 13 2008Antonio J. Plaza Abstract The rapid development of space and computer technologies allows for the possibility to store huge amounts of remotely sensed image data, collected using airborne and satellite instruments. In particular, NASA is continuously gathering high-dimensional image data with Earth observing hyperspectral sensors such as the Jet Propulsion Laboratory's airborne visible,infrared imaging spectrometer (AVIRIS), which measures reflected radiation in hundreds of narrow spectral bands at different wavelength channels for the same area on the surface of the Earth. The development of fast techniques for transforming massive amounts of hyperspectral data into scientific understanding is critical for space-based Earth science and planetary exploration. Despite the growing interest in hyperspectral imaging research, only a few efforts have been devoted to the design of parallel implementations in the literature, and detailed comparisons of standardized parallel hyperspectral algorithms are currently unavailable. This paper compares several existing and new parallel processing techniques for pure and mixed-pixel classification in hyperspectral imagery. The distinction of pure versus mixed-pixel analysis is linked to the considered application domain, and results from the very rich spectral information available from hyperspectral instruments. In some cases, such information allows image analysts to overcome the constraints imposed by limited spatial resolution. In most cases, however, the spectral bands collected by hyperspectral instruments have high statistical correlation, and efficient parallel techniques are required to reduce the dimensionality of the data while retaining the spectral information that allows for the separation of the classes. In order to address this issue, this paper also develops a new parallel feature extraction algorithm that integrates the spatial and spectral information. The proposed technique is evaluated (from the viewpoint of both classification accuracy and parallel performance) and compared with other parallel techniques for dimensionality reduction and classification in the context of three representative application case studies: urban characterization, land-cover classification in agriculture, and mapping of geological features, using AVIRIS data sets with detailed ground-truth. Parallel performance is assessed using Thunderhead, a massively parallel Beowulf cluster at NASA's Goddard Space Flight Center. The detailed cross-validation of parallel algorithms conducted in this work may specifically help image analysts in selection of parallel algorithms for specific applications. Copyright © 2008 John Wiley & Sons, Ltd. [source] Experimental analysis of a mass storage systemCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 15 2006Shahid Bokhari Abstract Mass storage systems (MSSs) play a key role in data-intensive parallel computing. Most contemporary MSSs are implemented as redundant arrays of independent/inexpensive disks (RAID) in which commodity disks are tied together with proprietary controller hardware. The performance of such systems can be difficult to predict because most internal details of the controller behavior are not public. We present a systematic method for empirically evaluating MSS performance by obtaining measurements on a series of RAID configurations of increasing size and complexity. We apply this methodology to a large MSS at Ohio Supercomputer Center that has 16 input/output processors, each connected to four 8 + 1 RAID5 units and provides 128 TB of storage (of which 116.8 TB are usable when formatted). Our methodology permits storage-system designers to evaluate empirically the performance of their systems with considerable confidence. Although we have carried out our experiments in the context of a specific system, our methodology is applicable to all large MSSs. The measurements obtained using our methods permit application programmers to be aware of the limits to the performance of their codes. Copyright © 2006 John Wiley & Sons, Ltd. [source] Early Surgical Morbidity and Mortality in Adults with Congenital Heart Disease: The University of Michigan ExperienceCONGENITAL HEART DISEASE, Issue 2 2008Ginnie L. Abarbanell MD ABSTRACT Objectives., To review early surgical outcomes in a contemporary series of adults with congenital heart disease (CHD) undergoing cardiac operations at the University of Michigan, and to investigate possible preoperative and intraoperative risk factors for morbidity and mortality. Methods., A retrospective medical record review was performed for all patients ,18 years of age who underwent open heart operations by a pediatric cardiothoracic surgeon at the University of Michigan Congenital Heart Center between January 1, 1998 and December 31, 2004. Records from a cohort of pediatric patients ages 1,17 years were matched to a subset of the adult patients by surgical procedure and date of operation. Results., In total, 243 cardiac surgical operations were performed in 234 adult patients with CHD. Overall mortality was 4.7% (11/234). The incidence of major postoperative complications was 10% (23/234) with a 19% (45/23) minor complication rate. The most common postoperative complication was atrial arrhythmias in 10.8% (25/234). The presence of preoperative lung or liver disease, prolonged cardiopulmonary bypass and aortic cross clamp times, and postoperative elevated inotropic score and serum lactates were significant predictors of mortality in adults. There was no difference between the adult and pediatric cohorts in terms of mortality and morbidity. Conclusions., The postoperative course in adults following surgery for CHD is generally uncomplicated and early survival should be expected. Certain risk factors for increased mortality in this patient population may include preoperative presence of chronic lung or liver dysfunction, prolonged cardiopulmonary bypass and aortic cross-clamp times, and postoperative elevated inotropic score and serum lactate levels. [source] The Analogy of Love: Divine and Human Love at the Center of Christian Theology , By Gary ChartierCONVERSATIONS IN RELIGION & THEOLOGY, Issue 1 2008Brian Hebblethwaite First page of article [source] Universal Owners: challenges and opportunitiesCORPORATE GOVERNANCE, Issue 3 2007James Hawley This special issue of Corporate Governance is devoted to the concept of "universal ownership" (UO) and grows out of a conference of universal owners, institutional investors, investment professionals and academics held in April 2006 at Saint Mary's College of California, under the sponsorship of the Center for the Study of Fiduciary Capitalism (A report of the conference is available at http://www.fidcap.org). Four of the seven articles in this issue are based on papers presented at the conference, while an additional three (by Lydenberg, Syse and Gjessing, and Lippman et al.) were written specifically for this issue. The conference purposefully developed a practitioners' perspective on universal ownership and these articles reflect this orientation, although each article in its own way breaks new ground which academics, policy researchers and practitioners can and should develop. [source] Compassion and Repression: The Moral Economy of Immigration Policies in FranceCULTURAL ANTHROPOLOGY, Issue 3 2005Didier Fassin Immigration policies in Europe in the last three decades have become increasingly restrictive. During the 1990s, political asylum lost much of its legitimacy, as new criteria based on humanitarian claims became more common in appeals for immigration. Asylum seekers were increasingly identified as illegal immigrants and therefore candidates for expulsion, unless humanitarian reasons could be found to requalify them as victims deserving sympathy. This substitution of a right to asylum by an obligation in terms of charity leads to a reconsideration of Giorgio Agamben's separation of the humanitarian and the political, suggesting instead a humanitarianization of policies. Sangatte Center, often referred to as a transit camp, became a symbol of this ambiguous European treatment of the "misery of the world" and serves here as an analytical thread revealing the tensions between repression and compassion as well as the moral economy of contemporary biopolitics. [source] "A Large Object with a Small Museum": A Narrative Analysis of Tlotlo's Experience of an Astronomy Science CenterCURATOR THE MUSEUM JOURNAL, Issue 3 2009Anthony Lelliott We illustrate the power of narrative in illuminating the importance of the student's perspective in understanding the conditions for learning in a museum setting. Using principles of narrative presentation, the paper describes Tlotlo's thinking throughout his participation in a school visit to the visitors' center at a radio telescope. The paper discusses six features of the visit: student misconceptions; inadequate preparation and followup; memories and imaginings; enjoyment; discussing the visit afterwards; and socioeconomic constraints on visits. These features are examined within the context of a developing country: both confirming previous research on school visits and providing new insights into how such visits can be interpreted. The significance of narrative analysis for science center educators is discussed and suggested as appropriate for current research in museums. [source] A Pride of Museums in the Desert: Saudi Arabia and the "Gift of Friendship" ExhibitionCURATOR THE MUSEUM JOURNAL, Issue 1 2005John Coppola ABSTRACT The task of developing and presenting an exhibition at the King Abdul Aziz Historical Center in Riyadh, Saudi Arabia illustrates the challenges of museum work in a global environment filled with widely differing social, cultural, political, and professional norms. The exhibition, The Gift of Friendship, was largely drawn from the collections of the Franklin D. Roosevelt Library, in New York State. Saudi Arabia and its neighboring countries view museums as a source of national pride and public engagement, and frequently draw on Western expertise in building them. There are implications for exhibition development and interpretation in a society undergoing rapid modernization, but also one noted for an aversion to social science research. A postscript looks at museum trends in Oman, after 9/11 and the Iraq war. [source] An Empirical Study of the Effect of Knowledge Management Processes at Individual, Group, and Organizational Levels,DECISION SCIENCES, Issue 2 2003Rajiv Sabherwal ABSTRACT To enhance our understanding of knowledge management, this paper focuses on a specific question: How do knowledge management processes influence perceived knowledge management effectiveness? Prior literature is used to develop the research model, including hypotheses about the effects of four knowledge management processes (internalization, externalization, socialization, and combination) on perceived individual-level, group-level, and organizational-level knowledge management effectiveness. The study was conducted at the John F. Kennedy Space Center of the National Aeronautics and Space Administration using a survey of 159 individuals and two rounds of personal interviews. Structural equation modeling was performed to test measurement and structural models using the survey data. The emergent model suggests that internalization and externalization impact perceived effectiveness of individual-level knowledge management. Socialization and combination influence perceived effectiveness of knowledge management at group and organizational levels, respectively. The results also support the expected upward impact in perceived effectiveness of knowledge management, from individual to group level, as well as from group level to organizational level. The study's limitations and implications for practice and future research are described. [source] Traumatic injuries to permanent teeth in Turkish children, AnkaraDENTAL TRAUMATOLOGY, Issue 3 2009Ceyhan Altun From a total of 4956 children aged 6,12 years (mean age: 8.91 ± 1.95) applying to the Center, 472 children (9.5%) were found to have suffered dental injuries during a period of 2 years. Injuries were classified according to drawings and texts based on the WHO classification system, as modified by Andreasen and Andreasen. Injury rates were highest among children age 6 and ages 8,10. The most frequently injured permanent teeth were the maxillary central incisors (88.2%), and the maxillary right central permanent incisor made up 47.2% of all injured teeth. The most common cause of dental trauma was falling while walking or running (40.3%). Most injuries involved a single tooth (64.8%). The most common type of injury was enamel fracture (44.6%). There was a significant difference in gender, where boys more often suffered from a dental hard tissue and pulp injury than girls (P = 0.019), whereas there was no difference in gender (P = 0.248) in the distribution of periodontal injuries. Injuries were found to occur more frequently during the summer (P < 0.001). Children with increased overjet were 2.19 times more likely to have dental injuries than other children. Considering that the incidence of traumatic dental injury is highest among children ages 6 and ages 8,10 as well as the fact that patients with increased overjet are more prone to dental trauma, preventive orthodontic treatment in early mixed dentition may play an important role in reducing traumatic dental injuries. [source] Risk factors related to traumatic dental injuries in Brazilian schoolchildrenDENTAL TRAUMATOLOGY, Issue 5 2004Evelyne Pessoa Soriano Abstract,,, The aim of this pilot study was to analyse whether overjet, lip coverage and obesity represented risk factors associated with the occurrence of dental trauma in the permanent anterior teeth of schoolchildren in Recife, Brazil. It included a random sample of 116 boys and girls aged 12 years, attending both public and private schools. Data was collected through clinical examinations and interviews. Dental trauma was classified according to Andreasen's criteria (1994). Overjet was considered as risk factor when it presented values higher than 5 mm. Lip coverage was classified as adequate or inadequate, while obesity was considered according to National Center for Health Statistics (NCHS) procedures for the assessment of nutritional status. The prevalence of dental injuries was 23.3%. Boys experienced more injuries than girls, 30 and 16.1%, respectively (P > 0.05). There was a statistically significant difference between traumatic dental injuries and overjet (P < 0.05) and between traumatic dental injuries and lip coverage (P = 0.000). No statistical significant differences were found when obesity and dental trauma were analysed (P < 0.05). It was concluded that boys from lower social strata attending public schools, presenting an overjet size greater than 5 mm and an inadequate lip coverage, were more likely to have traumatic dental injuries in Recife, Brazil. Obesity was not a risk factor for dental trauma in this sample. [source] Factorial validity of the center for epidemiologic studies-depression (CES-D) scale in military peacekeepersDEPRESSION AND ANXIETY, Issue 1 2003Jennifer A. Boisvert M.A. Abstract Despite widespread use of the Center for Epidemiologic Studies Depression Scale [CES-D], there are no investigations that examine its factor structure in a military sample. Separate confirmatory factor analyses were performed on responses to the CES-D obtained from 102 female and 102 male Canadian military peacekeepers in order to compare the fit of a four-factor intercorrelated (lower-order) model to a four-factor hierarchical (higher-order) model. The intercorrelated and hierarchical models fit the data well for both women and men, with hierarchical models fitting the data slightly better for women than men. These findings suggest that, for military women and men, the CES-D can be used to measure a set of distinct but interrelated depressive symptoms as well as a global construct of depression. Implications and future directions are discussed. Depression and Anxiety 17:19,25, 2003. © 2003 Wiley-Liss, Inc. [source] Treatment of Vitiligo on Difficult-to-Treat Sites Using Autologous Noncultured Cellular GraftingDERMATOLOGIC SURGERY, Issue 1 2009SANJEEV V. MULEKAR MD BACKGROUND Because of the limitations of medical treatment, various surgical therapies have been developed and are being accepted to treat vitiligo. However, certain areas such as the fingers and toes, palms and soles, lips, eyelids, nipples and areolas, elbows and knees, and genitals are considered difficult-to-treat areas. OBJECTIVE To evaluate data pertaining to individual sites considered to be difficult to treat and highlight that noncultured melanocyte,keratinocyte transplantation (MKT) does not require any special precautions to treat these anatomical sites. METHODS AND MATERIALS Forty patients (13 male and 27 female) with bilateral vitiligo and nine (4 male and 5 female) with unilateral vitiligo were treated using noncultured MKT, for "difficult-to-treat" sites at the National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia, and were analyzed for response according to region. Repigmentation was graded as excellent with 95% to 100% pigmentation, good with 65% to 94%, fair with 25% to 64%, and poor with 0% to 24% of the treated area. RESULTS For bilateral vitiligo, more than 50% of patients treated for difficult sites showed more than 65% repigmentation of the treated areas. For unilateral vitiligo, all of the patients except for two treated for the eyelids showed more than 65% repigmentation of the treated area. CONCLUSIONS The concept of a "difficult-to-treat site" is a relative term and depends upon the technique used. The noncultured MKT does not require any special precautions to treat these anatomical sites. This review may help physicians to change the concept of "difficult-to-treat site." [source] Trends in Pediatric Melanoma Mortality in the United States, 1968 through 2004DERMATOLOGIC SURGERY, Issue 2 2008KEVAN G. LEWIS MD BACKGROUND AND OBJECTIVE Mortality from melanoma in children is a poorly understood and controversial problem in dermatology. There is paucity of research into this important public health dilemma. The purpose of this study was to characterize pediatric melanoma mortality in the United States and to evaluate trends over time. METHODS AND MATERIALS Deaths were derived from a database of more than 75 million records of the U.S. Center for National Health Statistics based on routine death certification. Information on age, race, gender, and geographic location was available for years 1968 through 2004. RESULTS During the 37-year period, there were 643 deaths attributed to melanoma in children under 20 years of age in the United States, an average of 18 per year. The overall age-adjusted mortality rate for melanoma in children was 2.25 deaths per year (per 10 million at-risk individuals). Mortality rates were strongly associated with age. In the oldest age group (age 15,19 years) the mortality rate was approximately an order of magnitude 8,18 times higher compared to younger age groups. Mortality among males was 25% higher than females. Mortality rates for white children were more than twice as high as black children. Overall mortality from melanoma in children declined steadily from 1968 to 2004. The highest mortality rates were observed in Idaho, Nevada, Arizona, and New Mexico. CONCLUSIONS Although mortality from melanoma among children in the United State is low, the magnitude of the public health burden from this preventable cause of death is substantial. In contrast to results of studies suggesting that the incidence of melanoma may be rising in children and adolescents, the data suggest that mortality in these groups may be falling. Additional study is warranted to further characterize and ultimately reduce mortality from childhood melanoma. [source] A clinical analysis of diabetic patients with hand ulcer in a diabetic foot centreDIABETIC MEDICINE, Issue 7 2010C. Wang Diabet. Med. 27, 848,851 (2010) Abstract Aims, The aim of the study was to explore the prevalence and clinical characteristics of hand ulcer in hospitalized patients with diabetes. Methods, We analysed 17 subjects with hand ulcer among diabetic inpatients, who were admitted to the Diabetic Foot Care Center, Department of Endocrinology and Metabolism at the West China Hospital of Sichuan University from April 2003 to December 2008. Results, The prevalence of diabetic hand ulcer among hospitalized patients (0.37%) was significantly lower than that of diabetic foot ulcers (9.7%, P = 0.000). The mean age was 62.1 ± 9.4 years. The average known durations of diabetes and glycated haemoglobin (HbA1c) were 5.3 ± 4.9 years and 10.9 ± 2.4%, respectively. All patients lived in the subtropical zone. Fifteen patients (88.2%) were diagnosed with diabetic peripheral neuropathy. Ten patients had hand infection. After therapy, the ulcers healed in 13 patients (76.5%) and none of them experienced amputation. The average hospital stay for patients with local infection was characteristically longer than that for patients without infection (P = 0.012). The prognosis of the hand ulcer was poorer in the patients who had diabetes for > 3 years compared with those who had diabetes for < 3 years (P = 0.009). Conclusions, Diabetic hand ulcer is a relatively rare complication of diabetes in South-West China. Long duration of diabetes, poorly controlled blood glucose, minor trauma and delayed treatment are the risk factors. Diabetic peripheral neuropathy may play an important role in the pathogenesis of hand ulcer. Early control of blood glucose with insulin and early anti-microbial therapy with appropriate antibiotics are crucial. Debridement and drainage are necessary for hand abscesses. [source] Are symptoms of depression more common in diabetes?DIABETIC MEDICINE, Issue 11 2008Results from the Heinz Nixdorf Recall study Abstract Aims To estimate the association between depressive symptoms and Type 2 diabetes, as well as previously undetected diabetes, in a large population-based sample in Germany and to determine associated variables. Methods We used baseline data on 4595 participants (age 45,75 years, 50.2% women) from the German Heinz Nixdorf Recall study, a population-based, prospective cohort study which started in 2000. Diabetes mellitus was assessed by self report (physician diagnosis or medication), undiagnosed diabetes based on blood glucose levels. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale short form (cut-off , 15 points). We fitted multiple logistic regression models. Results The prevalence of diagnosed and previously undetected diabetes was 9.3% (95% confidence interval 8.2,11.6) and 7.6% (6.6,8.8) in men and 6.0% (5.1,7.1) and 3.2% (2.5,4.0) in women, respectively. Compared with non-diabetic women, the prevalence of depressive symptoms was not significantly different in diabetic women (age-adjusted odds ratio, 95% confidence interval 1.48; 0.98,2.24) and women with undiagnosed diabetes (0.67; 0.33,1.36). In men, the prevalence of depressive symptoms tended to be lower in diabetic than in non-diabetic subjects (0.62; 0.35,1.09), but the depressive symptoms were significantly less frequent in men with undiagnosed diabetes (0.30; 0.13,0.70). The pattern remained after further adjustment. Significant associations with depressive symptoms were found for co-morbidities and living without a partner in both women and in men, and for body mass index and activity level in women only. Conclusions After adjustment for relevant covariates, the association between depressive symptoms and Type 2 diabetes was heterogenous in our population-based study. In subjects with undiagnosed diabetes, however, depressive symptoms were less frequent in men. Co-morbidities and psychosocial conditions are strongly associated with depressive symptoms. [source] Serum ,-glutamyltransferase within its normal concentration range is related to the presence of diabetes and cardiovascular risk factorsDIABETIC MEDICINE, Issue 9 2005D.-J. Kim Abstract Aims Although many studies have reported an association between serum ,-glutamyltransferase (GGT) and cardiovascular risk factors, the mechanism of this relationship has not been clarified. Methods The medical records of 29 959 subjects (age, median 48, range 14,90 years; 16 706 men, 13 253 women) who visited the Center for Health Promotion at Samsung Medical Center for a medical check-up between January 2001 and December 2003, were investigated. Subjects with hepatic enzyme/GGT concentrations higher than three times the upper limit of the reference range, a positive test for hepatitis C virus antibody, a positive test for hepatitis B virus surface antigen, currently taking anti-diabetic/anti-hypertensive/anti-lipid medication, or a white blood cell (WBC) count higher than 10 000 cells/ml, were excluded. The subjects of each gender were classified into five groups according to their serum GGT concentrations, into quartiles of the normal range of GGT (groups 1, 2, 3 and 4) and into a group with elevated GGT (group 5). Results As the group number increased (group 1 , 5), the frequencies of all of the following increased: (i) diabetes and impaired fasting glucose (IFG); (ii) hypertension, obesity (body mass index , 27 kg/m2), dyslipidaemia (LDL-cholesterol , 4.1 mmol/l and/or triglyceride , 2.46 mmol/l, or HDL-cholesterol < 1.16 mmol/l); (iii) metabolic syndrome. Moreover, these significant relationships between GGT concentrations within its normal range and the presence of diabetes/IFG, hypertension, obesity, dyslipidaemia, and metabolic syndrome persisted after adjusting for several clinical and biochemical variables and for the presence of fatty liver based on ultrasonographic findings. Odds ratios (95% CI) for group 4 (highest quartile of normal range of GGT) vs. group 1 (lowest quartile of normal range of GGT); the referent group, were 3.16 (2.15,4.65) for diabetes, 2.24 (1.73,2.90) for IFG, 1.93 (1.59,2.33) for obesity, 1.38 (1.23,1.55) for dyslipidaemia and 2.88 (2.28,3.65) for metabolic syndrome in men. In women, the odds ratios were 2.72 (1.34,5.52), 3.67 (2.26,5.97), 2.10 (1.61,2.74), 1.80 (1.58,2.04) and 3.57 (2.52,5.07), respectively. Conclusions Our data show that, even within its normal range, serum GGT concentrations are closely associated with the presence of diabetes and cardiovascular risk factors, and that these associations are independent of a fatty liver by ultrasonography. [source] Depression in Croatian Type 2 diabetic patients: prevalence and risk factors.DIABETIC MEDICINE, Issue 7 2005A Croatian survey from the European Depression in Diabetes (EDID) Research Consortium Abstract Aims To determine the prevalence rate of and risk factors for depression in Croatian Type 2 diabetic patients. Methods Depressive mood was examined in 384 randomly selected outpatients with Type 2 diabetes. Center for Epidemiological Studies Depression Scale (CES-D) and Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) were used to identify depressive disturbances. The groups with CES-D , 16 and < 16 were compared with respect to demographic, psychological and clinical characteristics. Regression analysis was used to determine risk factors for depression. Results Of the examined patients, 22% had CES-D scores , 16, and in 33% of them clinical depression was confirmed by the psychiatric interview. Depressed patients compared with the non-depressed ones reported more diabetes-related problems and poorer well-being (t = 6.71, P < 0.001 and t = 11.98, P < 0.001, respectively). Multiple regression analysis indicated female gender, experienced support and the level of emotional well-being to predict depression (R = 0.74, F = 15.3, P < 0.001). Conclusions The obtained data indicate that the prevalence rate in Croatian Type 2 diabetic patients is comparable to findings from other cultural settings. Depressive symptoms can be predicted by psychological rather than disease-related variables. Psychological care for diabetic patients may be necessary to prevent depressive symptomatology. [source] Cytological features of lipoblastoma: A report of three casesDIAGNOSTIC CYTOPATHOLOGY, Issue 3 2005Ph.D., V. Veronika Kloboves-Prevodnik M.D. Abstract Lipoblastoma is a rare benign neoplasm occurring mostly in children under the age of three. Accurate preoperative diagnosis is mandatory for planning the treatment. The main aim of this study is to establish the cytological features of lipoblastoma and to answer the question: "Is cytological diagnosis of lipoblastoma reliable?" Preoperative fine-needle aspiration biopsy (FNAB) and tissue sections of three children treated for lipoblastoma at the Division of Pediatrics, University Medical Center, Ljubljana, Slovenia, in the period from 1997 to 2004 were reexamined. The Giemsa- and Papanicolaou-stained FNAB smears were moderately or poorly cellular and contained lipocytes, lipoblasts, and spindle cells in various proportions. The tumor cells were in clusters and tissue fragments or as single cells. Thin branching capillaries were observed in most of the clusters and tissue fragments. In the background, abundant myxoid extracellular material and naked oval nuclei were present. In the first case, the cytological diagnosis was benign soft-tissue tumor, in the second the diagnosis was not conclusive and the last case was correctly diagnosed as lipoblastoma. In the differential diagnosis of the second case, both lipoblastoma and liposarcoma were considered cytologically as well as histologically. At 7-yr follow-up, there is no evidence of the disease. Thus, we conclude that lipoblastoma with typical cytological features could be accurately diagnosed by FNAB. However, tumors containing numerous lipoblasts could pose a diagnostic problem. Diagn. Cytopathol. 2005;33:195,200. © 2005 Wiley-Liss, Inc. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||