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Central Question (central + question)
Selected AbstractsAn environment for prosperity and quality living accommodating growth in the Thames ValleyCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 1 2004Hugh Howes The Thames Valley is seen as the powerhouse of the British economy, and one of the best performing regions in Europe. This economic base offers opportunities for expansion with the potential for it to become the knowledge capital of Europe. Business interests view the area as a highly desirable location, not only because of its markets, skills and proximity to the City and Heathrow but also because of its high quality environment. Companies, however, complain of skills shortages, traffic congestion, lack of suitable premises and housing that is affordable to the workforce. Much of the Thames Valley is either Green Belt or Areas of Outstanding Natural Beauty. Furthermore, the availability of future water supplies, the maintenance of the quality of water in the rivers and managing flood risk are also likely to act as constraints on development in the future. How economic growth is to be achieved with minimal additional development and without detriment to the environment is the central question that is likely to dominate planning in the this region over the next few years. Is it possible to achieve more with existing resources? Copyright © 2004 John Wiley & Sons, Ltd and ERP Environment. [source] CE-ESI-MS/MS as a rapid screening tool for the comparison of protein,ligand interactionsELECTROPHORESIS, Issue 7 2010Thomas Hoffmann Abstract In drug development, the combinatorial synthesis of drug libraries is common use, therefore efficient tools for the characterization of drug candidates and the extent of interaction between a drug and its target protein is a central question of analytical interest. While biological activity is tested today by enzyme assays, MS techniques attract more and more attention as an alternative for a rapid comparison of drug,target interactions. CE enables the separation of proteins and drug,enzyme complexes preserving their physiological activity in aqueous media. By hyphenating CE with ESI-MS/MS, the binding strength of enzyme inhibitors can be deduced from MS/MS experiments, which selectively release the inhibitor from the drug,target complex after CID. In this study, ,-chymotrypsin (CT), a serine protease, was chosen as a model compound. Chymostatin is a naturally occurring peptide aldehyde binding to CT through a hemiacetal bond and electrostatic interaction. First, a CE separation was developed, which allows the analysis of ,-CT and a chymotrypsin,chymostatin complex under MS-compatible conditions. The use of neutral-coated CE capillaries was mandatory to reduce analyte,wall interactions. ESI-quadrupole ion trap-MS was worked out to demonstrate the selective drug release after CID. Fragmentation of the drug,enzyme complex was monitored in dependence from the excitation energy in the ion trap, leading to the V50 voltage that enables 50% complex fragmentation as a reference value for chymotrypsin,chymostatin complex. A stable CE-ESI-MS/MS setup was established, which preserves the drug,enzyme complexes during ionization,desolvation processes. With this optimized setup, different CT inhibitors could be investigated and compared. [source] The Central Question in Entrepreneurial Cognition Research 2007ENTREPRENEURSHIP THEORY AND PRACTICE, Issue 1 2007Ronald K. Mitchell In this article, we take note of advances in the entrepreneurial cognition research stream. In doing so, we bring increasing attention to the usefulness of entrepreneurial cognition research. First, we offer and develop a central research question to further enable entrepreneurial cognition inquiry. Second, we present the conceptual background and some representative approaches to entrepreneurial cognition research that form the context for this question. Third, we introduce the articles in this Special Issue as framed by the central question and approaches to entrepreneurial cognition research, and suggest how they further contribute to this developing stream. Finally, we offer our views concerning the challenges and opportunities that await the next generation of entrepreneurial cognition scholarship. We therefore invite (and seek to enable) the growing community of entrepreneurship researchers from across multiple disciplines to further develop the "thinking,doing" link in entrepreneurship research. It is our goal to offer colleagues an effective research staging point from which they may embark upon many additional research expeditions and investigations involving entrepreneurial cognition. [source] Maurice Ravel and right-hemisphere musical creativity: influence of disease on his last musical works?EUROPEAN JOURNAL OF NEUROLOGY, Issue 1 2002L. Amaducci The problem of finding correspondence between a particular neuronal organization and a specific function of the human brain remains a central question of neuroscience. It is sometimes thought that language and music are two sides of the same intellectual coin, but research on brain-damaged patients has shown that the loss of verbal functions (aphasia) is not necessarily accompanied by a loss of musical abilities (amusia). Amusia without aphasia has also been described. This double dissociation indicates functional autonomy in these mental processes. Yet verbal and musical impairments often occur together. The global picture that emerges from studies of music and its neural substrate is by no means clear and much depends on which subjects and which aspect of musical abilities are investigated. An illustration of these concepts is provided by the case of the French composer Maurice Ravel, who suffered from a progressive cerebral disease of uncertain aetiology, with prominent involvement of the left hemisphere. As a result, Ravel experienced aphasia and apraxia and became unable to compose. The available facts favour a clinical diagnosis of primary progressive aphasia (PPA), with the possibility of an overlap with corticobasal degeneration (CBD). In view of Ravel's clinical history, we propose that two of his final compositions, the Bolero and the Concerto for the Left Hand, include certain patterns characteristic of right-hemisphere musical abilities and may show the influence of disease on the creative process. [source] Odor vapor pressure and quality modulate local field potential oscillatory patterns in the olfactory bulb of the anesthetized ratEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 6 2008Tristan Cenier Abstract A central question in chemical senses is the way that odorant molecules are represented in the brain. To date, many studies, when taken together, suggest that structural features of the molecules are represented through a spatio-temporal pattern of activation in the olfactory bulb (OB), in both glomerular and mitral cell layers. Mitral/tufted cells interact with a large population of inhibitory interneurons resulting in a temporal patterning of bulbar local field potential (LFP) activity. We investigated the possibility that molecular features could determine the temporal pattern of LFP oscillatory activity in the OB. For this purpose, we recorded the LFPs in the OB of urethane-anesthetized, freely breathing rats in response to series of aliphatic odorants varying subtly in carbon-chain length or functional group. In concordance with our previous reports, we found that odors evoked oscillatory activity in the LFP signal in both the beta and gamma frequency bands. Analysis of LFP oscillations revealed that, although molecular features have almost no influence on the intrinsic characteristics of LFP oscillations, they influence the temporal patterning of bulbar oscillations. Alcohol family odors rarely evoke gamma oscillations, whereas ester family odors rather induce oscillatory patterns showing beta/gamma alternation. Moreover, for molecules with the same functional group, the probability of gamma occurrence is correlated to the vapor pressure of the odor. The significance of the relation between odorant features and oscillatory regimes along with their functional relevance are discussed. [source] Implicit and explicit measures of prejudice and stereotyping: do they assess the same underlying knowledge structure?EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 6 2004Michaël Dambrun Do implicit and explicit measures of ethnic attitudes assess the same underlying knowledge structure in long term memory? This study uses both a correlational and an experimental design (N,=,133) in order to address this central question. In the first part, we suggest that self-presentational strategies can partly explain why the relation between implicit and explicit measures is inconsistent in the existing literature. More specifically, we show that when there are strong norms against prejudice, implicit and explicit measures are significantly negatively related. In the second part, an experimental manipulation of relative gratification (RG), the opposite of relative deprivation, reveals that when the level of explicit prejudice increases (RG condition), a similar effect is also observed at the implicit level. Together, these results suggest that implicit and explicit measures assess similar knowledge structure. Copyright © 2004 John Wiley & Sons, Ltd. [source] Darfur and the failure of the responsibility to protectINTERNATIONAL AFFAIRS, Issue 6 2007ALEX DE WAAL When official representatives of more than 170 countries adopted the principle of the ,responsibility to protect' (R2P) at the September 2005 World Summit, Darfur was quickly identified as the test case for this new doctrine. The general verdict is that the international community has failed the test due to lack of political will. This article argues that the failure is real but that it is more fundamentally located within the doctrine of R2P itself. Fulfilling the aspiration of R2P demands an international protection capability that does not exist now and cannot be realistically expected. The critical weakness in R2P is that the ,responsibility to react' has been framed as coercive protection, which attempts to be a middle way between classic peacekeeping and outright military intervention that can be undertaken without the consent of the host government. Thus far, theoretical and practical attempts to create this intermediate space for coercive protection have failed to resolve basic strategic and operational issues. In addition, the very act of raising the prospect of external military intervention for human protection purposes changes and distorts the political process and can in fact make a resolution more difficult. Following an introductory section that provides background to the war in Darfur and international engagement, this article examines the debates over the R2P that swirled around the Darfur crisis and operational concepts developed for the African Union Mission in Sudan (AMIS) and its hybrid successor, the UN,African Union Mission in Darfur (UNAMID), especially during the Abuja peace negotiations. Three operational concepts are examined: ceasefire, disarmament and civilian protection. Unfortunately, the international policy priority o bringing UN troops to Darfur had an adverse impact on the Darfur peace talks without grappling with the central question of what international forces would do to resolve the crisis. Advocacy for the R2P set an unrealistic ideal which became the enemy of achievable goals. [source] Trade and Domestic Policy Linkage in International Agreements,INTERNATIONAL ECONOMIC REVIEW, Issue 4 2002Josh Ederington A central question in discussions of integrating negotiations over domestic policy (e.g., environmental policy or labor standards) into traditional trade agreements is the degree to which the trade policy and domestic policy provisions of an agreement should be explicitly linked. For example, should the World Trade Organization enforce domestic policy obligations with the threat of the suspension of trade concessions? This article considers the conditions under which linking trade and domestic policy agreements within a self-enforcing agreement is beneficial, and argues that the benefits of such policy linkage may be lower than is commonly thought. [source] The Urban Question as Cargo Cult: Opportunities for a New Urban PedagogyINTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 3 2008ROB SHIELDS Abstract Urban research is unreflexive toward its object of study, the city, compromising its methodologies and theoretical capacity. This polemic draws on examples such as ,creative cities', which have been profiled and analysed for their local recipes for economic success. ,Global cities' have become stereotypes of a neoliberal form of the ,good life' to which much recent urban research is a handmaiden, a hegemonic knowledge project. These ,metro-poles' of value are a form of urban pedagogy that presents lesser local elites with lessons to be followed. A form of cargo cult theory suggests, build it and wealth will come , hence the symmetry of urban scholarship with the fad for city rankings in pop journalism. In contrast to neo-structural analyses of the global city, other research focuses too closely on regional geographies, local forces and urban affordances. A synthetic level of theory is proposed to bridge the divide which marks urban and regional studies. The ,urban' needs to be rediscovered as a central question. The urban is an object of theory and the city is a truth spot. The urban is more than infrastructure and bodies but an intangible good or ,virtuality' that requires an appropriate methodological toolkit. Résumé La recherche urbaine manque de réflexivitéà l'égard de son objet d'étude, la ville, ce qui compromet ses méthodologies et sa capacité théorique. Cette critique part d'exemples tels que les "villes créatives" dont on a établi le profil et l'analyse pour en déterminer les recettes locales de réussite économique. Les "villes planétaires" sont devenues des stéréotypes d'une forme néolibérale de la "bonne vie" au service de laquelle se met généralement la recherche urbaine, un projet de savoir hégémonique. Ces métro-pôles de valeur constituent une sorte de pédagogie urbaine qui expose aux moindres élites locales des leçons à suivre. Un genre de théorie du culte du cargo suggère qu'il suffit de construire pour voir la richesse arriver, d'où la symétrie entre les travaux de recherche urbaine et la mode pour les palmarès de villes dans le journalisme populaire. Contrairement aux analyses néo-structuralistes de la ville planétaire, d'autres études se consacrent de trop près aux géographies régionales, aux forces locales et aux affordances urbaines. Un niveau de théorie synthétique est proposé pour franchir la ligne de démarcation des études urbaines et régionales. Il faut redécouvrir "l'urbain" en tant que question centrale. L'urbain est un objet de théorie, la ville est un lieu de vérité. L'urbain est plus qu'une infrastructure et des entités, c'est un bien intangible, une "virtualité", qui nécessite un jeu d'outils méthodologiques approprié. [source] Toward an Anti-disciplinary Global StudiesINTERNATIONAL STUDIES PERSPECTIVES, Issue 1 2003Stephen J. Rosow Abstract This article investigates the prospects for interdisciplinary global studies in the changing context of university education. Its central question is: as power and structure in the university become more and more integrated with the transformations of globalization, how can global studies become an authorized site of research and teaching while resisting the rules and micro-powers in the university that constitute it as such an authorized site which is increasingly determined by neoliberal globalization? [source] When and where to fuel before crossing the Sahara desert , extended stopover and migratory fuelling in first-year garden warblers Sylvia borinJOURNAL OF AVIAN BIOLOGY, Issue 2 2008Thord Fransson Large numbers of passerine migrants cross the Sahara desert every year on their way to-and-from wintering areas in tropical Africa. In the desert, hardly any fuelling opportunities exist and most migrants have to prepare in advance. A central question is how inexperienced birds know where to fuel. Inexperienced garden warblers Sylvia borin were studied in Greece just before the desert crossing in autumn. Body mass data collected at two sites indicate that most birds do not fuel for the desert crossing further north. For the first time, detailed information about stopover duration close to the Sahara desert was studied by using light weight radio-transmitters. Results from Crete show that most first-year garden warblers arrive with relatively small fuel loads in relation to lean body mass (<30%), stay for 13,20 d and depart with an average fuel load of about 100%. Radio-tagged birds performed small scale movements initially and took advantage of fig fruits. Birds trapped at fig trees were heavier than birds trapped with tape lures, showing that tape lures can bias the sample of migrants trapped. The precise fuelling pattern found indicates that first-year migrants must also include external spatial cues to make the preparation for crossing the desert in the right area. [source] An Essay on the History and Future of Reliability from the Perspective of ReplicationsJOURNAL OF EDUCATIONAL MEASUREMENT, Issue 4 2001Robert L. Brennan This article provides a review of some important milestones in the history of reliability, some current issues concerning reliability, and some likely prospects for reliability, from the perspective of one central question: "What constitutes a replication of a measurement procedure?" Special attention is given to the fixed/random aspects of facets that characterize replications. [source] Consuming Projects in Uncertain Times: Making Selves in the Galilee1JOURNAL OF HISTORICAL SOCIOLOGY, Issue 3 2003TANIA FORTE This article proposes a different approach. It explores how ordinary people, through projects of their own which exhibit particular forms of intentional cultural production and consumption, manifest historically situated notions of selves. I use the idea of "projects" to understand the interconnections between global consumer culture, identity, and nationalism as they are manifested in the everyday lives of Palestinian citizens of Israel. To exemplify these interconnections, I focus on two significant, creative projects through which Palestinian inhabitants of the Western Galilee shape and manifest selves in history. Though these projects appear very different on the surface, they are used to address the same central question , that is, to understand how senses of self in history and attending identities are materially and discursively constituted by members of a national minority in the ever-present context of political conflict. They show that people are not passive consumers of homogenizing rituals and discourse and reveal how, through a bricolage of objects and ideas, people inscribe intentions, meanings, ways of thinking, and self-narration in places and histories. [source] Understanding the elements of empathy as a component of care-driven leadershipJOURNAL OF LEADERSHIP STUDIES, Issue 1 2009Yosep Undung Empathy plays a pivotal role in educational leadership practice. It creates and maintains a sound and dynamic interpersonal milieu in dynamic social enterprises such as schools, colleges, and universities. A phenomenological study was conducted to probe deeper the meaning of empathy as it is lived and constituted in the awareness of a select group of 13 Filipino academic administrators representing colleges in the Philippines. Anchored on the central question, "how do Filipino academic administrators collectively typify in their school leadership practices the elements of empathic concern, perspective taking, and empathic matching," semistructured (Patton, 1990) and in-depth interviews were conducted. Field texts were analyzed via a repertory grid. Through constant comparative analyses, an interesting set of conceptual categories notably describes the human and humane side of a caring leader, typified in the ability to effect listening, confluencing, and scaffolding in the journey with the faculty. [source] Explaining Family Change and Variation: Challenges for Family DemographersJOURNAL OF MARRIAGE AND FAMILY, Issue 4 2005Judith A. Seltzer Twenty years ago, the National Institute of Child Health and Human Development (NICHD) issued a request for proposals that resulted in the National Survey of Families and Households (NSFH), a unique survey valuable to a wide range of family scholars. This paper describes the efforts of an interdisciplinary group of family demographers to build on the progress enabled by the NSFH and many other theoretical and methodological innovations. Our work, also supported by NICHD, will develop plans for research and data collection to address the central question of what causes family change and variation. We outline the group's initial assessments of orienting frameworks, key aspects of family life to study, and theoretical and methodological challenges for research on family change. Finally, we invite family scholars to follow our progress and to help develop this shared public good. [source] In Defense of Asbestos Tort Litigation: Rethinking Legal Process Analysis in a World of Uncertainty, Second Bests, and Shared Policy-Making ResponsibilityLAW & SOCIAL INQUIRY, Issue 1 2009Jeb Barnes A central question in American policy making is when should courts address complex policy issues, as opposed to defer to other forums? Legal process analysis offers a standard answer. It holds that judges should act when adjudication offers advantages over other modes of social ordering such as contracts, legislation, or agency rule making. From this vantage, the decision to use common law adjudication to address a sprawling public health crisis was a terrible mistake, as asbestos litigation has come to represent the very worst of mass tort litigation. This article questions this view, arguing that legal process analysis distorts the institutional choices underlying the American policy-making process. Indeed, once one considers informational and political constraints, as well as how the branches of government can fruitfully share policy-making functions, the asbestos litigation seems a reasonable and, in some ways, exemplary, use of judicial power. [source] Mindreading and the Cognitive Architecture Underlying Altruistic MotivationMIND & LANGUAGE, Issue 4 2001Shaun Nichols In recent attempts to characterize the cognitive mechanisms underlying altruistic motivation, one central question is the extent to which the capacity for altruism depends on the capacity for understanding other minds, or ,mindreading'. Some theorists maintain that the capacity for altruism is independent of any capacity for mindreading; others maintain that the capacity for altruism depends on fairly sophisticated mindreading skills. I argue that none of the prevailing accounts is adequate. Rather, I argue that altruistic motivation depends on a basic affective system, a ,Concern Mechanism', which requires only a minimal capacity for mindreading. [source] Uncertainty as Environmental EducationPOLICY STUDIES JOURNAL, Issue 3 2000Walter A. Rosenbaum Here we focus particularly upon some implications of the symposium articles for future research agendas and priorities in environmental policy. First, however, we return to the central question posed by this symposium: "How can environmental policies achieve a combination of democracy with legitimacy and adequacy with effectiveness under conditions of great uncertainty?" In different ways, all articles addressed this problem in reconciling democracy with competent environmental management under conditions of uncertainty. Together, they provide the rudiments of an answer. [source] Is a gene-centric human proteome project the best way for proteomics to serve biology?PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 17 2010Thierry Rabilloud Abstract With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In "proteomics speak", the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far. [source] Economic Insecurity and the Globalization of ProductionAMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 4 2004Kenneth Scheve A central question in the international and comparative political economy literatures on globalization is whether economic integration increases worker insecurity in advanced economies. Previous research has focused on the role of international trade and has failed to produce convincing evidence that such a link exists. In this article, we argue that globalization increases worker insecurity, but that foreign direct investment (FDI) by multinational enterprises (MNEs) is the key aspect of integration generating risk. FDI by MNEs increases firms' elasticity of demand for labor. More-elastic labor demands, in turn, raise the volatility of wages and employment, all of which tends to make workers feel less secure. We present new empirical evidence, based on the analysis of panel data from Great Britain collected from 1991 to 1999, that FDI activity in the industries in which individuals work is positively correlated with individual perceptions of economic insecurity. This correlation holds in analyses accounting for individual-specific effects and a wide variety of control variables. [source] A missense mutation in the vacuolar protein GOLD36 causes organizational defects in the ER and aberrant protein trafficking in the plant secretory pathwayTHE PLANT JOURNAL, Issue 6 2010Lucia Marti Summary A central question in cell biology is how the identity of organelles is established and maintained. Here, we report on GOLD36, an EMS mutant identified through a screen for partial displacement of the Golgi marker, ST-GFP, to other organelles. GOLD36 showed partial distribution of ST-GFP into a modified endoplasmic reticulum (ER) network, which formed bulges and large skein-like structures entangling Golgi stacks. GOLD36 showed defects in ER protein export as evidenced by our observations that, besides the partial retention of Golgi markers in the ER, the trafficking of a soluble bulk-flow marker to the cell surface was also compromised. Using a combination of classical mapping and next-generation DNA sequencing approaches, we linked the mutant phenotype to a missense mutation of a proline residue in position 80 to a leucine residue in a small endomembrane protein encoded by the gold36 locus (At1g54030). Subcellular localization analyses indicated that GOLD36 is a vacuolar protein and that its mutated form is retained in the ER. Interestingly also, a gold36 knock-out mutant mirrored the GOLD36 subcellular phenotype. These data indicate that GOLD36 is a protein destined to post-ER compartments and suggest that its export from the ER is a requirement to ensure steady-state maintenance of the organelle's organization and functional activity in relation to other secretory compartments. We speculate that GOLD36 may be a factor that is necessary for ER integrity because of its ability to limit deleterious effects of other secretory proteins on the ER. [source] The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?,,ANNALS OF NEUROLOGY, Issue 3 2009Howard L. Weiner MD Multiple sclerosis is (MS) a T-cell autoimmune disease characterized by a relapsing-remitting followed by a progressive phase. Relapses are driven by the adaptive immune system and involve waves of T helper cell 1 (Th1), Th17, and CD8 cells that infiltrate the nervous system and provoke a attack. These cells are modulated by regulatory T and B cells. Infiltration of T cells into the nervous system initiates a complex immunological cascade consisting of epitope spreading, which triggers new attacks, and activation of the innate immune system (microglia, dendritic cells, astrocytes, B cells), which leads to chronic inflammation. The secondary progressive phase is due to neurodegeneration triggered by inflammation and is driven by the innate immune system. Why a shift to the progressive stage occurs and how to prevent it is a central question in MS. Effective treatment of MS must affect multiple disease pathways: suppression of proinflammatory T cells, induction of regulatory T cells, altering traffic of cells into the nervous system, protecting axons and myelin, and controlling innate immune responses. Without biomarkers, the clinical and pathological heterogeneity of MS makes treatment difficult. Treatment is further hampered by untoward adverse effects caused by immune suppression. Nonetheless, major progress has been made in the understanding and treatment of MS. There are three definitions of cure as it applies to MS: (1) halt progression of disease, (2) reverse neurological deficits, and (3) prevent MS. Although the pathways to each of these cures are linked, each requires a unique strategy. Ann Neurol 2009;65:239,248 [source] Fold evolution and drainage development in the Zagros mountains of Fars province, SE IranBASIN RESEARCH, Issue 1 2008Lucy A. Ramsey ABSTRACT A central question in structural geology is whether, and by what mechanism, active faults (and the folds often associated with them) grow in length as they accumulate displacement. An obstacle in our understanding of these processes is the lack of examples in which the lateral growth of active structures can be demonstrated definitively, as geomorphic indicators of lateral propagation are often difficult, or even impossible to distinguish from the effects of varying lithology or non-uniform displacement and slip histories. In this paper we examine, using the Zagros mountains of southern Iran as our example, the extent to which qualitative analysis of satellite imagery and digital topography can yield insight into the growth, lateral propagation, and interaction of individual fold segments in regions of active continental shortening. The Zagros fold-and-thrust belt contains spectacular whaleback anticlines that are well exposed in resistant Tertiary and Mesozoic limestone, are often >100 km in length, and which contain a large proportion of the global hydrocarbon reserves. In one example, Kuh-e Handun, where an anticline is mantled by soft Miocene sediments, direct evidence of lateral fold propagation is recorded in remnants of consequent drainage patterns on the fold flanks that do not correspond to the present-day topography. We suggest that in most other cases, the soft Miocene and Pliocene sediments that originally mantled the folds, and which would have recorded early stages in the growth histories, have been completely stripped away, thus removing any direct geomorphic evidence of lateral propagation. However, many of the long fold chains of the Zagros do appear to be formed from numerous segments that have coalesced. If our interpretations are correct, the merger of individual fold segments that have grown in length is a major control on the development of through-going drainage and sedimentation patterns in the Zagros, and may be an important process in other regions of crustal shortening as well. Abundant earthquakes in the Zagros show that large seismogenic thrust faults must be present at depth, but these faults rarely reach the Earth's surface, and their relationship to the surface folding is not well constrained. The individual fold segments that we identify are typically 20,40 km in length, which correlates well with the maximum length of the seismogenic basement faults suggested from the largest observed thrusting earthquakes. This correlation between the lengths of individual fold segments and the lengths of seismogenic faults at depth suggest that it is possible, at least in some cases, that there may be a direct relationship between folding and faulting in the Zagros, with individual fold segments underlain by discrete thrusts. [source] Predicting phenotypic effects of gene perturbations in C. elegans using an integrated network modelBIOESSAYS, Issue 8 2008Karsten Borgwardt Predicting the phenotype of an organism from its genotype is a central question in genetics. Most importantly, we would like to find out if the perturbation of a single gene may be the cause of a disease. However, our current ability to predict the phenotypic effects of perturbations of individual genes is limited. Network models of genes are one tool for tackling this problem. In a recent study, (Lee et al.) it has been shown that network models covering the majority of genes of an organism can be used for accurately predicting phenotypic effects of gene perturbations in multicellular organisms. BioEssays 30:707,710, 2008. © 2008 Wiley Periodicals, Inc. [source] RESPONSIBILITY FOR CONTROL; ETHICS OF PATIENT PREPARATION FOR SELF-MANAGEMENT OF CHRONIC DISEASEBIOETHICS, Issue 5 2007BARBARA K. REDMAN ABSTRACT Patient self-management (SM) of chronic disease is an evolving movement, with some forms documented as yielding important outcomes. Potential benefits from proper preparation and maintenance of patient SM skills include quality care tailored to the patient's preferences and life goals, and increase in skills in problem solving, confidence and success, generalizable to other parts of the patient's life. Four central ethical issues can be identified: 1) insufficient patient/family access to preparation that will optimize their competence to SM without harm to themselves, 2) lack of acknowledgement that an ethos of patient empowerment can mask transfer of responsibility beyond patient/family competency to handle that responsibility, 3) prevailing assumptions that preparation for SM cannot result in harm and that its main purpose is to deliver physician instructions, and 4) lack of standards for patient selection, which has the potential to exclude individuals who could benefit from learning to SM. Technology assessment offers one framework through which to examine available data about efficacy of patient SM and to answer the central question of what conditions must be put in place to optimize the benefits of SM while assuring that potential harms are controlled. [source] AN EXPERIMENTAL TEST ON RETIREMENT DECISIONSECONOMIC INQUIRY, Issue 3 2007ENRIQUE FATAS As part of the current debate on the reform of pension systems, this paper presents an original experimental test where subjects face three different payoff sequences with identical expected value. Two central questions are analyzed. First, whether the distribution of retirement benefits across time influences the retirement decision. And second, whether actuarially fair pension systems distort the retirement decision. The results indicate both that a lump-sum payment rather than annuity benefits is far more effective in delaying the retirement decision and that recent reforms that encourage the link between lifetime contributions and pension benefits to delay the retirement decision should take into account timing considerations. (JEL C91, H55, J26) [source] Legislation, Delegation and Implementation under the Treaty of Lisbon: Typology Meets RealityEUROPEAN LAW JOURNAL, Issue 4 2009Herwig Hofmann This reform, the first since the Treaty of Rome, will have an impact on some of the most contested topics of EU law, touching several central questions of a constitutional nature. This article critically analyses which potential effects and consequences the reform will have. It looks, inter alia, at the aspects of the shifting relation between EU institutions, the distribution of powers between the EU and its Member States, as well as the future of rule-making and implementation structures such as comitology and agencies. [source] Englishness and the Union in Contemporary Conservative ThoughtGOVERNMENT AND OPPOSITION, Issue 4 2009Richard English This article analyses the importance of arguments developed since 1997 by influential right-wing commentators concerning Englishness and the United Kingdom. Drawing on historical, cultural and political themes, public intellectuals and commentators of the right have variously addressed the constitutional structure of the UK, the politics of devolved government in Wales and Scotland, and the emergence of a more salient contemporary English sensibility. This article offers case studies of the arguments of Simon Heffer, Peter Hitchens and Roger Scruton, all of whom have made controversial high-profile interventions on questions of national identity, culture and history. Drawing on original interviews with these as well as other key figures, the article addresses three central questions. First, what are the detailed arguments offered by Heffer, Hitchens and Scruton in relation to Englishness and the UK? Second, what does detailed consideration of these arguments reveal about the evolution of the politics of contemporary conservatism in relation to the Union? And, third, what kinds of opportunity currently exist for intellectuals and commentators on the fringes of mainstream politics to influence the terms of debate on these issues? [source] Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell,macrophage lineageIMMUNOLOGICAL REVIEWS, Issue 1 2010R. Maarten Egeler Summary:, In its rare occurrence, Langerhans cell histiocytosis (LCH) is a dangerous but intriguing deviation of mononuclear phagocytes, especially dendritic cells (DCs). Clinically, the disease ranges from self-resolving or well manageable to severe and even fatal. LCH lesions in skin, bone, and other sites contain high numbers of cells with phenotypic features resembling LCs admixed with macrophages, T cells, eosinophils, and multinucleated giant cells. Here we review current progress in the LCH field based on two central questions: (i) are LCH cells intrinsically aberrant, and (ii) how does the lesion drive pathogenesis? We argue that LCH cells may originate from different sources, including epidermal LCs, tissue Langerin+ DCs, or mononuclear phagocyte precursors. Current and prospective in vitro and in vivo models are discussed. Finally, we discuss recent insights into plasticity of T-helper cell subsets in light of the lesion microenvironment. LCH continues to provide urgent clinical questions thereby inspiring innovative DC lineage research. [source] Future eating and country keeping: what role has environmental history in the management of biodiversity?JOURNAL OF BIOGEOGRAPHY, Issue 5 2001D.M.J.S. Bowman In order to understand and moderate the effects of the accelerating rate of global environmental change land managers and ecologists must not only think beyond their local environment but also put their problems into a historical context. It is intuitively obvious that historians should be natural allies of ecologists and land managers as they struggle to maintain biodiversity and landscape health. Indeed, ,environmental history' is an emerging field where the previously disparate intellectual traditions of ecology and history intersect to create a new and fundamentally interdisciplinary field of inquiry. Environmental history is rapidly becoming an important field displacing many older environmentally focused academic disciplines as well as capturing the public imagination. By drawing on Australian experience I explore the role of ,environmental history' in managing biodiversity. First I consider some of the similarities and differences of the ecological and historical approaches to the history of the environment. Then I review two central questions in Australian environment history: landscape-scale changes in woody vegetation cover since European settlement and the extinction of the marsupials in both historical and pre-historical time. These case studies demonstrate that environmental historians can reach conflicting interpretations despite using essentially the same data. The popular success of some environmental histories hinges on the fact that they narrate a compelling story concerning human relationships and human value judgements about landscape change. Ecologists must learn to harness the power of environmental history narratives to bolster land management practices designed to conserve biological heritage. They can do this by using various currently popular environmental histories as a point of departure for future research, for instance by testing the veracity of competing interpretations of landscape-scale change in woody vegetation cover. They also need to learn how to write parables that communicate their research findings to land managers and the general public. However, no matter how sociologically or psychologically satisfying a particular environmental historical narrative might be, it must be willing to be superseded with new stories that incorporate the latest research discoveries and that reflects changing social values of nature. It is contrary to a rational and publicly acceptable approach to land management to read a particular story as revealing the absolute truth. [source] | ||||||||||||||||||||||||||||