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Causal Evidence (causal + evidence)
Selected AbstractsGenetic manipulation, whole-cell recordings and functional imaging of the sensorimotor cortex of behaving miceACTA PHYSIOLOGICA, Issue 1 2009C. C. H. Petersen Abstract Sensory processing, sensorimotor integration and motor control are amongst the most basic functions of the brain and yet our understanding of how the underlying neuronal networks operate and contribute to behaviour is very limited. The relative simplicity of the mouse whisker sensorimotor system is helpful for detailed quantitative analyses of motor control and perception during active sensory processing. Recent technical advances now allow the measurement of membrane potential in awake-behaving mice, using whole-cell recordings and voltage-sensitive dye imaging. With these recording techniques, it is possible to directly correlate neuronal activity with behaviour. However, in order to obtain causal evidence for the specific contributions of different neuronal networks to behaviour, it is critical to manipulate the system in a highly controlled manner. Advances in molecular neurobiology, gene delivery and mouse genetics provide techniques capable of layer, column and cell-type specific control of gene expression in the mouse neocortex. Over the next years, we anticipate considerable advances in our understanding of brain function through measuring and manipulating neuronal activity with unprecedented precision to probe the molecular and synaptic mechanisms underlying simple forms of active sensory perception and associative learning. [source] The governance and performance of universities: evidence from Europe and the USECONOMIC POLICY, Issue 61 2010Philippe Aghion Summary We test the hypothesis that universities are more productive when they are both more autonomous and face more competition. Using survey data, we construct indices of university autonomy and competition for both Europe and the United States. We show that there are strong positive correlations between these indices and multiple measures of university output. To obtain causal evidence, we investigate exogenous shocks to US universities' expenditures over three decades. These shocks arise through the political appointment process, which we use to generate instrumental variables. We find that an exogenous increase in a university's expenditure generates more output, measured by either patents or publications, if the university is more autonomous and faces more competition. Exploiting variation over time in the ,stakes' of competitions for US federal research grants, we also find that universities generate more output for a given expenditure when research competitions are high stakes. We draw lessons, arguing that European universities could benefit from a combination of greater autonomy and greater accountability. Greater accountability might come through increased reliance on competitive grants, enhanced competition for students and faculty (promoted by reforms that increase mobility), and yardstick competitions (which often take the form of assessment exercises). --- Philippe Aghion, Mathias Dewatripont, Caroline Hoxby, Andreu Mas-Colell and André Sapir [source] A methodology for inferring the causes of observed impairments in aquatic ecosystems,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 6 2002Glenn W. Suter II Abstract Biological surveys have become a common technique for determining whether aquatic communities have been injured. However, their results are not useful for identifying management options until the causes of apparent injuries have been identified. Techniques for determining causation have been largely informal and ad hoc. This paper presents a logical system for causal inference. It begins by analyzing the available information to generate causal evidence; available information may include spatial or temporal associations of potential cause and effect, field or laboratory experimental results, and diagnostic evidence from the affected organisms. It then uses a series of three alternative methods to infer the cause: Elimination of causes, diagnostic protocols, and analysis of the strength of evidence. If the cause cannot be identified with sufficient confidence, the reality of the effects is examined, and if the effects are determined to be real, more information is obtained to reiterate the process. [source] What Research Tells Us About the Intersecting Streams of Homelessness and Foster CareAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 3 2009Cheryl Zlotnick RN This paper reviews mourning evidence linking foster care and homelessness and considers new approaches for intervention. Although there is no causal evidence that family homelessness leads to foster care or vice versa, the association no longer originates solely from samples of homeless people, but also from samples of people with childhood histories of foster care. Many programs work with families, children or youth based on their current living situations and limits imposed by funders. This results in discontinued services when the living situations change. Given the strong and consistent associations between homelessness and foster care, a better approach is to design programs that work with transient families regardless of their living situation. Parenting is key. Whether the parents arc living with their children in homeless circumstances or arc formerly homeless parents working to reunify with their children, coordinated, comprehensive, trauma-informed and family focused programs are needed to support parenting and family stability. [source] | ||||||||||