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Catalyzed Domino Reaction (catalyze + domino_reaction)
Selected AbstractsPalladium(II)-Catalyzed Domino Reaction of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles: Scope, Mechanism and Synthetic Application in the Synthesis of 3,4-Fused Bicyclic Tetrasubstituted FuransADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 4 2009Yuanjing Xiao Abstract Described herein is the development of a palladium(II)-catalyzed two- or three-component reaction of 2-(1-alkynyl)-2-alken-1-ones with nucleophiles and allylic chlorides. Various types of nucleophiles such as O- , N- , C -based nucleophiles and olefin-tethered O- , N- , C -based nucleophiles were investigated. The scope, mechanism and application of this Pd(II)-catalyzed domino reaction were studied. In these transformations, the palladium catalyst exhibits a dual role, serving simultaneously as a Lewis acid and a transition metal. Two possible reaction pathways (cross-coupling reaction vs. Heck reaction) from the same intermediate furanylpalladium species were observed. The reaction pathway is dependent on the property of the nucleophile and the length of the tethered chain as well. When olefin-tethered O -based nucleophiles were used, only the cross-coupling reaction pathway was observed, in contrast, both reaction pathways were observed when olefin-tethered C -based nucleophiles were employed. The product ratio is dependent on the length of the tethered chain. Furthermore, ring-closing metathesis (RCM) of corresponding furans with CC bonds provides an easy method for the preparation of functionalized oxygen-heterocycles , 3,4-fused bicyclic furans. It is also noteworthy that allylic chloride can be as an oxidant besides its well known function as an alkylating reagent. [source] A Highly Efficient Synthesis of 1,2,3,4-Tetrahydroquinolines by Molecular Iodine Catalyzed Domino Reaction of Anilines with Cyclic Enol Ethers.CHEMINFORM, Issue 40 2006Xu-Feng Lin Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] ChemInform Abstract: Pd(OAc)2 -Catalyzed Domino Reactions of 1,2-Dihaloarenes and 2-Haloaryl Arenesulfonates with Grignard Reagents: Efficient Synthesis of Substituted Fluorenes.CHEMINFORM, Issue 34 2008Cheng-Guo Dong Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] PdCl2 -Catalyzed Domino Reactions of 2-Alkynylbenzaldehydes with Indoles: Synthesis of Fluorescent 5H -Benzo[b]carbazol-6-yl KetonesCHEMISTRY - A EUROPEAN JOURNAL, Issue 16 2010Ri-Yuan Tang Synthetic methods: A new, selective Pd-catalyzed domino reaction of 2-alkynylbenzaldehydes with indoles has been developed for the synthesis of 5H -benzo[b]carbazol-6-yl ketones. The isobenzopyrylium complex is trapped by indole at room temperature to give 3-(1H -isochromen-1-yl)-1H -indoles, which can be transformed into 5H -benzo[b]carbazol-6-yl ketones by raising the temperature (see scheme). These ketones exhibit intense fluorescence and interact with metal ions to enhance the fluorescence intensity. [source] | ||||||||||