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Case Stories (case + story)
Selected AbstractsMajor histocompatibility complex class I binding predictions as a tool in epitope discoveryIMMUNOLOGY, Issue 3 2010Claus Lundegaard Summary Over the last decade, in silico models of the major histocompatibility complex (MHC) class I pathway have developed significantly. Before, peptide binding could only be reliably modelled for a few major human or mouse histocompatibility molecules; now, high-accuracy predictions are available for any human leucocyte antigen (HLA) -A or -B molecule with known protein sequence. Furthermore, peptide binding to MHC molecules from several non-human primates, mouse strains and other mammals can now be predicted. In this review, a number of different prediction methods are briefly explained, highlighting the most useful and historically important. Selected case stories, where these ,reverse immunology' systems have been used in actual epitope discovery, are briefly reviewed. We conclude that this new generation of epitope discovery systems has become a highly efficient tool for epitope discovery, and recommend that the less accurate prediction systems of the past be abandoned, as these are obsolete. [source] The nature of advocacy vs. paternalism in nursing: clarifying the ,thin line'JOURNAL OF ADVANCED NURSING, Issue 8 2009Meg Zomorodi Abstract Title.,The nature of advocacy vs. paternalism in nursing: clarifying the ,thin line'. Aim., This paper is an exploration of the concepts of advocacy and paternalism in nursing and discusses the thin line between the two. Background., Nurses are involved in care more than any other healthcare professionals and they play a central role in advocating for patients and families. It is difficult to obtain a clear definition of advocacy, yet the concepts of advocacy and paternalism must be compared, contrasted, and discussed extensively. In many situations, only a thin line distinguishes advocacy from paternalism. Data sources., A literature search was conducted using PubMed and CINAHL databases (2000,2008) as well as a library catalogue for texts. Discussion., Four case stories were described in order to discuss the ,thin line' between advocacy and paternalism and develop communication strategies to eliminate ambiguity. Weighing the ethical principles of beneficence and autonomy helps to clarify advocacy and paternalism and provides an avenue for discussion among nurses practicing in a variety of settings. Implications for nursing., Advocacy and paternalism should be discussed at interdisciplinary rounds, and taken into consideration when making patient care decisions. It is difficult to clarify advocacy vs. paternalism, but strategies such as knowing the patient, clarifying information, and educating all involved are initial steps in distinguishing advocacy from paternalism. Conclusion., Truly ,knowing' patients, their life experiences, values, beliefs and wishes can help clarify the ,thin line' and gain a grasp of these difficult to distinguish theoretical concepts. [source] Being there, experiencing and creating space for dialogue: about working with children in family therapyJOURNAL OF FAMILY THERAPY, Issue 4 2008Peter Rober While most authors agree that it is important to mobilize the active participation of children in the family therapy session, a lot of family therapists exclude children from participating because they do not feel comfortable with children. Teaching family therapists to feel more comfortable around children is a good idea, but perhaps it is not enough. In this article, the author reflects on the complexity of the issue of the comfort of the therapist in a session with children and families. In the discussion of the case story of Elly and her mother, practitioners are reminded that the therapist's experiencing in the session can help her to understand something of what goes on in the families she is working with. [source] How Far Could Free Religious Thinking Go?JOURNAL OF RELIGIOUS HISTORY, Issue 4 2008The Case of Johann Rudolf Werdmüller, Zurich 165 In 1658, Johann(es) Rudolf Werdmüller, a renowned Zurich general and diplomat, was accused of blasphemy. As it referred to essential religious matters, the accusation had a considerable public impact. The court files of the case provide evidence of wider battles over the desirability and nature of religious tolerance. Instead of narrating a case story this analysis suggests a different approach to the history of religion. The sources are not taken as documents expressing a discursive system of philosophical points of view and their appearance in religious polemics. Rather, the court files stand for specific speech acts, i.e. verbal performances in the linguistic sense. Thus, Werdmüller's example is taken to demonstrate that those considered to be blasphemers in the era of confessionalisation did not simply express religious scepticism in the form of "discourses," nor did they rebel against authority figures or resort to forms of magic. Rather, they provoked their society, discussed religious matters, entertained their audience and competed wittingly with those interested in religious issues. In conclusion, it is proposed that the history of religion should not be confined to a history of ideas and religious doctrines but should integrate linguistic approaches. [source] | |||||||||||||