Capillary Leak Syndrome (capillary + leak_syndrome)

Distribution by Scientific Domains
Medical Sciences100%

Kinds of Capillary Leak Syndrome

  • systemic capillary leak syndrome
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    Selected Abstracts

    A case report of systemic capillary leak syndrome (Clarkson's disease)

    ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 5 2010
    J. HOLLENBERG
    Systemic capillary leak syndrome (SCLS) is a very rare disorder also known as Clarkson's disease. The condition is characterized by recurrent episodes of severe capillary hyperpermeability resulting in severe hemoconcentration, hypoalbuminemia, hypovolemia and shock. We describe a 41-year-old previously healthy man who was admitted to hospital on several occasions with rapidly developing hypovolemic shock accompanied by extreme hemoconcentration and hypoalbuminemia. Our case is similar to other reports describing patients with SCLS where the initial suspicions have been pointing towards septic shock. He received a combination of prophylactic treatment with theophylline, ,-agonists, immunoglobulins and statins but eventually died after a severe episode of SCLS that ended with recurrent cardiac arrest. Clinical autopsy revealed pulmonary edema and acute and chronical organic fluid overload. SCLS should be kept in mind when treating patients suffering from attacks of severe idiopathic edema and mimics recurrent septic shock where no pathogen is found. The pathogenesis is unknown and the attacks may be lethal. [source]

    Systemic capillary leak syndrome resulting in compartment syndrome and the requirement for a surgical airway

    ANAESTHESIA, Issue 6 2009
    J. Perry
    Summary We report on a case of systemic capillary leak syndrome associated with a monoclonal band on plasma electrophoresis. In our patient hospital admission was precipitated by ischaemic pain in the left lower limb, associated with polycythaemia, renal failure and hypovolaemic shock. Fluid resuscitation, venesection and renal replacement therapy were instituted but a compartment syndrome developed necessitating surgery. Failure of tracheal intubation resulted in the requirement for a surgical airway. Despite surgical and resuscitative efforts the outcome was fatal from hypovolaemia and hyperkalaemia. We aim to highlight the difficulties in managing this condition and to remind healthcare workers to include it in the differential diagnoses for patients presenting with polycythaemia; in particular polycythaemic patients with a monoclonal band on plasma electrophoresis. [source]

    The Aachen MiniHLM,A Miniaturized Heart-Lung Machine for Neonates With an Integrated Rotary Blood Pump

    ARTIFICIAL ORGANS, Issue 9 2010
    Jutta Arens
    Abstract The operation of congenital heart defects in neonates often requires the use of heart-lung machines (HLMs) to provide perfusion and oxygenation. This is prevalently followed by serious complications inter alia caused by hemodilution and extrinsic blood contact surfaces. Thus, one goal of developing a HLM for neonates is the reduction of priming volume and contact surface. The currently available systems offer reasonable priming volumes for oxygenators, reservoirs, etc. However, the necessary tubing system contains the highest volumes within the whole system. This is due to the use of roller pumps; hence, the resulting placement of the complete HLM is between 1 and 2 m away from the operating table due to connective tubing between the components. Therefore, we pursued a novel approach for a miniaturized HLM (MiniHLM) by integrating all major system components in one single device. In particular, the MiniHLM is a HLM with the rotary blood pump centrically integrated into the oxygenator and a heat exchanger integrated into the cardiotomy reservoir which is directly connected to the pump inlet. Thus, tubing is only necessary between the patient and MiniHLM. A total priming volume of 102 mL (including arterial filter and a/v line) could be achieved. To validate the overall concept and the specific design we conducted several in vitro and in vivo test series. All tests confirm the novel concept of the MiniHLM. Its low priming volume and blood contact surface may significantly reduce known complications related to cardiopulmonary bypass in neonates (e.g., inflammatory reaction and capillary leak syndrome). [source]

    Fluid shifts during cardiopulmonary bypass with special reference to the effects of hypothermia

    BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 7 2000
    J. K. Heltne
    Background Generalized overhydration, oedema and organ dysfunction occurs in patients undergoing open heart surgery using cardiopulmonary bypass (CPB) and hypothermia. Inflammatory reactions induced by contact between blood and the foreign surfaces of the extracorporeal circuit are commonly held responsible for the disturbances in fluid balance (,capillary leak syndrome'). Using the CPB circuit reservoir as a fluid gauge (measuring continuous extracorporeal blood volume), fluid shifts between the intravascular and the extravascular space, and differences between normothermic and moderately hypothermic CPB, were examined. Methods Piglets were placed on CPB (thoracotomy) under general anaesthesia. In the normothermic group (n = 7) the core temperature was kept at 38°C before and during 2 h on CPB, whereas in the hypothermic group (n = 7) the temperature was lowered to 29°C during bypass. In addition to accurate recording of fluid during operation, the extracorporeal blood volume was kept constant by maintaining a certain blood level in the CPB circuit's reservoir. Acetated Ringer was used as priming solution in the CPB, as maintenance fluid and for adding fluid to the reservoir if necessary. Results Cardiac output, serum electrolytes and arterial blood gases were all similar in the two groups. Haematocrit fell significantly following the start of CPB in both groups. The reservoir fluid level fell markedly in both groups necessitating fluid supplementation. This extra fluid requirement was transient in the normothermic group, but persisted in hypothermic animals. At the end of 2 h of CPB the hypothermic animals had received seven times more extra fluid than the normothermic pigs. Conclusion There were strong indications of a greater fluid extravasation induced by hypothermia. The model described, using the PBC circuit reservoir as a fluid gauge, provides the opportunity for further study of fluid volume shifts, their causes and potential ways to manipulate fluid pathophysiology related to hypothermia and to PBC. © 2000 British Journal of Surgery Society Ltd [source]