Capillary Force Lithography (capillary + force_lithography)

Distribution by Scientific Domains
Polymers and Materials Science100%

Selected Abstracts

Nanopatterning by an Integrated Process Combining Capillary Force Lithography and Microcontact Printing

ADVANCED FUNCTIONAL MATERIALS, Issue 4 2010
Xuexin Duan
Abstract A novel nanopatterning process was developed by combining capillary force lithography (CFL) and microcontact printing (µCP). Flat polydimethylsiloxane (PDMS) was used as the substrate in CFL, and after chemical functionalization, as the stamp in µCP, which increased the resolution of both methods. The polymer patterns, produced by CFL on a thin polymer film on the flat PDMS substrate, acted as a mask to oxidize the uncovered regions of the PDMS. The chemical patterns were subsequently formed by gas phase evaporation of a fluorinated silane. After removal of the polymer, these stamps were used to transfer thiol inks to a gold substrate by µCP. Gold patterns at a scale of less than 100,nm were successfully replicated by these chemically patterned flat PDMS stamps. [source]

Cell,Material Interfaces: Capillary Force Lithography: A Versatile Tool for Structured Biomaterials Interface Towards Cell and Tissue Engineering (Adv. Funct.

ADVANCED FUNCTIONAL MATERIALS, Issue 17 2009
Mater.
An in-depth overview of the recently developed molding technology termed capillary force lithography (CFL) is presented by K.-Y. Suh et al. on page 2699, with particular emphasis on control of the properties of the cellular microenvironment, such as cell,protein, cell,cell, and cell,topography interactions. The cover image demonstrates that the adhesion and growth of NIH 3T3 fibroblasts is extremely sensitive to multi-scale, hierarchical structures, with the cells elongated along the nanoscale bridges. [source]

Capillary Force Lithography: A Versatile Tool for Structured Biomaterials Interface Towards Cell and Tissue Engineering,

ADVANCED FUNCTIONAL MATERIALS, Issue 17 2009
Kahp-Yang Suh
Abstract This Feature Article aims to provide an in-depth overview of the recently developed molding technologies termed capillary force lithography (CFL) that can be used to control the cellular microenvironment towards cell and tissue engineering. Patterned polymer films provide a fertile ground for controlling various aspects of the cellular microenvironment such as cell,substrate and cell,cell interactions at the micro- and nanoscale. Patterning thin polymer films by molding typically involves several physical forces such as capillary, hydrostatic, and dispersion forces. If these forces are precisely controlled, the polymer films can be molded into the features of a polymeric mold with high pattern fidelity and physical integrity. The patterns can be made either with the substrate surface clearly exposed or unexposed depending on the pattern size and material properties used in the patterning. The former (exposed substrate) can be used to adhere proteins or cells on pre-defined locations of a substrate or within a microfluidic channel using an adhesion-repelling polymer such as poly(ethylene glycol) (PEG)-based polymer and hyaluronic acid (HA). Also, the patterns can be used to co-culture different cells types with molding-assisted layer-by-layer deposition. In comparison, the latter (unexposed substrate) can be used to control the biophysical surrounding of a cell with tailored mechanical properties of the material. The surface micropatterns can be used to engineer cellular and multi-cellular architecture, resulting in changes of the cell shape and the cytoskeletal structures. Also, the nanoscale patterns can be used to affect various aspects of the cellular behavior, such as adhesion, proliferation, migration, and differentiation. [source]

Stamps for Submicrometer Soft Lithography Fabricated by Capillary Force Lithography ,

ADVANCED MATERIALS, Issue 13 2004
M. Bruinink
A convenient, inexpensive technique for fabrication of stamps for submicrometer soft lithography from masters with micrometer-size features is presented. Templates fabricated by capillary-force lithography are robust against replica molding of stamps. The Figure shows the resulting metal structure after employing such a second-generation stamp in microcontact printing of octadecanethiol and subsequent wet chemical etching of the underlying gold. [source]

Nanopatterning by an Integrated Process Combining Capillary Force Lithography and Microcontact Printing

ADVANCED FUNCTIONAL MATERIALS, Issue 4 2010
Xuexin Duan
Abstract A novel nanopatterning process was developed by combining capillary force lithography (CFL) and microcontact printing (µCP). Flat polydimethylsiloxane (PDMS) was used as the substrate in CFL, and after chemical functionalization, as the stamp in µCP, which increased the resolution of both methods. The polymer patterns, produced by CFL on a thin polymer film on the flat PDMS substrate, acted as a mask to oxidize the uncovered regions of the PDMS. The chemical patterns were subsequently formed by gas phase evaporation of a fluorinated silane. After removal of the polymer, these stamps were used to transfer thiol inks to a gold substrate by µCP. Gold patterns at a scale of less than 100,nm were successfully replicated by these chemically patterned flat PDMS stamps. [source]

Cell,Material Interfaces: Capillary Force Lithography: A Versatile Tool for Structured Biomaterials Interface Towards Cell and Tissue Engineering (Adv. Funct.

ADVANCED FUNCTIONAL MATERIALS, Issue 17 2009
Mater.
An in-depth overview of the recently developed molding technology termed capillary force lithography (CFL) is presented by K.-Y. Suh et al. on page 2699, with particular emphasis on control of the properties of the cellular microenvironment, such as cell,protein, cell,cell, and cell,topography interactions. The cover image demonstrates that the adhesion and growth of NIH 3T3 fibroblasts is extremely sensitive to multi-scale, hierarchical structures, with the cells elongated along the nanoscale bridges. [source]

Capillary Force Lithography: A Versatile Tool for Structured Biomaterials Interface Towards Cell and Tissue Engineering,

ADVANCED FUNCTIONAL MATERIALS, Issue 17 2009
Kahp-Yang Suh
Abstract This Feature Article aims to provide an in-depth overview of the recently developed molding technologies termed capillary force lithography (CFL) that can be used to control the cellular microenvironment towards cell and tissue engineering. Patterned polymer films provide a fertile ground for controlling various aspects of the cellular microenvironment such as cell,substrate and cell,cell interactions at the micro- and nanoscale. Patterning thin polymer films by molding typically involves several physical forces such as capillary, hydrostatic, and dispersion forces. If these forces are precisely controlled, the polymer films can be molded into the features of a polymeric mold with high pattern fidelity and physical integrity. The patterns can be made either with the substrate surface clearly exposed or unexposed depending on the pattern size and material properties used in the patterning. The former (exposed substrate) can be used to adhere proteins or cells on pre-defined locations of a substrate or within a microfluidic channel using an adhesion-repelling polymer such as poly(ethylene glycol) (PEG)-based polymer and hyaluronic acid (HA). Also, the patterns can be used to co-culture different cells types with molding-assisted layer-by-layer deposition. In comparison, the latter (unexposed substrate) can be used to control the biophysical surrounding of a cell with tailored mechanical properties of the material. The surface micropatterns can be used to engineer cellular and multi-cellular architecture, resulting in changes of the cell shape and the cytoskeletal structures. Also, the nanoscale patterns can be used to affect various aspects of the cellular behavior, such as adhesion, proliferation, migration, and differentiation. [source]

Cell Migration: Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy (Adv. Funct.

ADVANCED FUNCTIONAL MATERIALS, Issue 10 2009
Mater.
A novel microtextured cell substrate with variable local density and anisotropy as a platform for guided cell migration is presented by A. Levchenko, K.-Y. Suh, et al. on page 1579. A simple, scalable, and cost-effective technique, capillary force lithography, is used to fabricate precise microtopographic features on an optically transparent glass coverslip. Live cell motility is found to be extremely sensitive to variation in the local density and anisotropy of rectangular lattices, with cell elongation and speed decreasing on a symmetric lattice. Cells integrate orthogonal contact guidance cues when determining the direction of their orientation and movement. [source]

Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy

ADVANCED FUNCTIONAL MATERIALS, Issue 10 2009
Deok-Ho Kim
Abstract This work reports the design of and experimentation with a topographically patterned cell culture substrate of variable local density and anisotropy as a facile and efficient platform to guide the organization and migration of cells in spatially desirable patterns. Using UV-assisted capillary force lithography, an optically transparent microstructured layer of a UV curable poly(urethane acrylate) resin is fabricated and employed as a cell-culture substrate after coating with fibronectin. With variable local pattern density and anisotropy present in a single cell-culture substrate, the differential polarization of cell morphology and movement in a single experiment is quantitatively characterized. It is found that cell shape and velocity are exquisitely sensitive to variation in the local anisotropy of the two-dimensional rectangular lattice arrays, with cell elongation and speed decreasing on symmetric lattice patterns. It is also found that cells could integrate orthogonal spatial cues when determining the direction of cell orientation and movement. Furthermore, cells preferentially migrate toward the topographically denser areas from sparser ones. Consistent with these results, it is demonstrated that systematic variation of local densities of rectangular lattice arrays enable a planar assembly of cells into a specified location. It is envisioned that lithographically defined substrates of variable local density and anisotropy not only provide a new route to tailoring the cell-material interface but could serve as a template for advanced tissue engineering. [source]