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Broader Definition (broader + definition)
Selected AbstractsEntrepreneurial Founder Teams: Factors Associated with Member Entry and ExitENTREPRENEURSHIP THEORY AND PRACTICE, Issue 2 2003Deniz Ucbasaran This exploratory study provides a review of the neglected area of entrepreneurial founder team turnover. A novel distinction is made between entrepreneurial founder team member entry and team member exit. Ninety owner-managed ventures were monitored between 1990 and 2000. Presented hypotheses relating to a team's human capital were explored using multivariate logistic regression analysis. Variables associated with entry were found not to be the same as those associated with exit. The size of the founding team was significantly negatively associated with subsequent team member entry. The link between team turnover and entrepreneurial team heterogeneity was mixed. Functional heterogeneity was weakly significantly positively associated with team member entry. Heterogeneity of prior entrepreneurial experience was significantly positively associated with team member exit. In addition, family firms were significantly negatively associated with team member exit. The average age of the team was not significantly associated with team member entry or exit. Additional insights in future research may be gathered if a broader definition of team turnover (i.e., considering team member entry and exit) is considered. Practitioner awareness of the different factors associated with team member entry and exit may encourage them to provide assistance, which facilitates the team building process over time in developing firms. Promising areas for additional research are highlighted. [source] Back to the Future: Middle Molecules, High Flux Membranes, and Optimal DialysisHEMODIALYSIS INTERNATIONAL, Issue 1 2003Raymond C. Vanholder Middle molecules can be defined as compounds with a molecular weight (MW) above 500 Da. An even broader definition includes those molecules that do not cross the membranes of standard low-flux dialyzers, not only because of molecular weight, but also because of protein binding and/or multicompartmental behavior. Recently, several of these middle molecules have been linked to the increased tendency of uremic patients to develop inflammation, malnutrition, and atheromatosis. Other toxic actions can also be attributed to the middle molecules. In the present publication we will consider whether improved removal of middle molecules by large pore membranes has an impact on clinical conditions related to the uremic syndrome. The clinical benefits of large pore membranes are reduction of uremia-related amyloidosis; maintenance of residual renal function; and reduction of inflammation, malnutrition, anemia, dyslipidemia, and mortality. It is concluded that middle molecules play a role in uremic toxicity and especially in the processes related to inflammation, atherogenesis, and malnutrition. Their removal seems to be related to a better outcome, although better biocompatibility of membranes might be a confounding factor. [source] A critical appraisal of evidence-based medicine: some ethical considerationsJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 2 2003M. Gupta MD CM FRCPC MA Abstract Evidence-based medicine (EBM) is a concept that has grown to dominate the medical literature over the last decade. EBM has provoked a variety of criticisms, scientific, philosophical and sociological. However, while its basic conclusion , that we should practise EBM , is ethical, there has been limited ethical analysis of EBM. This paper aims to provide an analysis of EBM from an ethical perspective and identify some of EBM's potential ethical implications. Following a description of what constitutes EBM, this paper will identify and assess some of the basic values and epistemological assumptions of EBM that provide support for the moral duty to practise EBM. It will then examine potential ethical implications that could arise from practising EBM, given the challenges that have been made of EBM's assumptions and claims to authority. This paper will conclude by arguing that practitioners could strengthen the ethics of EBM by embracing a broader definition of evidence and including ethical criteria in the critical appraisal of research studies. [source] Association Between GABRA1 and Drinking Behaviors in the Collaborative Study on the Genetics of Alcoholism SampleALCOHOLISM, Issue 7 2006Danielle M. Dick Background: A wealth of literature supports the role of , -aminobutyric acid (GABA) in neurobiological pathways contributing to alcohol dependence and related phenotypes. Animal studies have consistently tied rodent homologs of the GABAA receptor genes on human chromosome 5q to alcohol-related behaviors; however, human studies have produced mixed results. Family-based association analyses previously conducted in the Collaborative Study on the Genetics of Alcoholism (COGA) sample yielded no evidence of association with Diagnostic and Statistical Manual of Mental Disorder,fourth edition (DSM-IV) alcohol dependence and these genes. As a follow-up to that study, we examined several alcohol-related behaviors in the COGA sample as follows: (1) a broader definition of alcohol dependence, including DSM-III-R symptoms and Feighner criteria (referred to as COGA alcohol dependence); (2) withdrawal; (3) history of alcohol-induced blackouts; (4) level of response to alcohol; (5) age of onset of regular drinking; and (6) age at first drunkenness. Methods: Family-based association tests were conducted, using multiple single-nucleotide polymorphisms (SNPs) in each of the 4 GABAA receptor genes on chromosome 5q. Results: In GABRA1, we found evidence of association with several of the drinking behavior phenotypes, including COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol. We did not find consistent evidence of association with the remaining genes and any of the phenotypes. Conclusions: We found evidence for association between GABRA1 and COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol. These analyses suggest that efforts to characterize genetic contributions to alcohol dependence may benefit by examining alcohol-related behaviors in addition to clinical alcohol dependence diagnoses. [source] Deception Through Telling the Truth?!THE ECONOMIC JOURNAL, Issue 534 2009Experimental Evidence From Individuals, Teams Informational asymmetries abound in economic decision making and often provide an incentive for deception through telling a lie or misrepresenting information. In this article I use a cheap-talk sender-receiver experiment to show that telling the truth should be classified as deception too if the sender chooses the true message with the expectation that the receiver will not follow the sender's (true) message. The experimental data reveal a large degree of ,sophisticated' deception through telling the truth. The robustness of my broader definition of deception is confirmed in an experimental treatment where teams make decisions. [source] The extent and nature of family alcohol and drug use: findings from the belfast youth development studyCHILD ABUSE REVIEW, Issue 6 2008Andrew Percy Abstract Using data from an ongoing longitudinal study of adolescent drug use, this study examines the proportion of teenagers living with parents who are problem alcohol or drug users. Around two per cent of parents report high levels of problem drinking and one per cent report problem drug use. If a broader definition of hazardous drinking is used, the proportion of teenagers exposed increases to over 15 per cent. When substance use is examined at a family level (taking account of alcohol and drug use amongst dependent children in addition to that of parents), the proportion of families experiencing some form of substance use is considerable. These findings add further support to the call for increased recognition of the needs of dependent children within adult treatment services when working with parents. Likewise, the reduction of harm to children as a result of parental substance use should be an increasingly important priority for family support services. This is likely to be achieved through the closer integration of addiction and family services. Copyright © 2008 John Wiley & Sons, Ltd. [source] From Modernism to McDonald'sJOURNAL OF ARCHITECTURAL EDUCATION, Issue 2 2007Controversy, Ideology, the Movement to Preserve the Recent Past Following successful 1970s efforts to save Miami Beach's Art Deco district, a preservation movement focusing on the recent past has grown nationally,championing everything from suburban subdivisions to civil rights sites. This article explores that controversial movement's efforts,including its (and its opposition's) motivations and ideologies. Proponents use broader definitions of history and significance than preservationists used previously,with age, aesthetics, and pedigree no longer crucial, instead emphasizing sociocultural context. As they fight traditional conceptualizations, deal with divisive sites, and often work without benefiting from (age-specific) preservation laws, activists face strong resistance. Nonetheless, the movement has increased in size, strength, and successes. [source] Bullying among mentally-ill patients detained in a high-secure hospital: an exploratory study of the perceptions of staff and patients into how bullying is definedAGGRESSIVE BEHAVIOR, Issue 5 2006Jane L. Ireland Abstract The present study is the first to explore patient-to-patient bullying within a secure psychiatric hospital housing mentally-ill patients. Its main aim was to provide an outline of the perceptions held by both patients and staff with regards to patient-to-patient bullying as opposed to providing an objective study of bullying. The total sample comprised 104 participants, 44 patients and 60 staff. These were sampled from wards housing male patients and wards housing female patients. All participants took part in a semi-structured interview based on that developed by Ireland and Ireland [2003] and Ireland [2005, 2004]. One quarter of participants stated they had seen a patient being bullied in the previous week, with staff perceiving a higher extent of bullying than patients. Differences between wards were minimal. It was predicted that theft-related bullying would be reported most frequently, that staff would identify a wider range of bullying behaviours than patients and that direct forms of aggression would be identified more readily as bullying than indirect forms. All predictions were supported. Problems in attempting to obtain a definition of bullying were also identified, with participants operating broader definitions than those found in the school-based literature. For example, bullying was not generally considered a repeated form of aggression, the severity of the aggression or provocative behaviour of the victim were not defining features, and it was felt bullying could be accidental. In summary, the current study highlights how patient-to-patient bullying does occur in services housing mentally-ill patients and that researching the behaviour may require the adoption of broader hospital-specific definitions of bullying. Aggr. Behav. 32:1,13, 2006. © 2006 Wiley-Liss, Inc. [source] Human security,national perspectives and global agendas: insights from national human development reports,JOURNAL OF INTERNATIONAL DEVELOPMENT, Issue 4 2007Richard Jolly Abstract Since its introduction in UNDP's Human Development Report 1994, ,human security' has been a topic of lively debate. The purpose of this paper is to explore empirically how human security has been treated in National Human Development Reports (NHDRs), produced in 13 countries since 1997 with different definitions and points of focus. We use an inductive approach to examine how these stand up to the criticisms levelled in the literature against broader concepts of human security. The NHDRs of Afghanistan, Latvia, Macedonia and Bangladesh are of particular interest, both because of their rich analysis and because of the originality of the methodology they use. The paper concludes that broader definitions of human security are operational for both analysis and policy making. Limits to define a core of high-priority concerns with human security can be set after exploring the concerns of people in specific situations rather than before. Copyright © 2007 John Wiley & Sons, Ltd. [source] | ||||||||||||||||