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Terms modified by Broader Selected AbstractsRe-founding Representation: Wider, Broader, Closer, DeeperPOLITICAL STUDIES REVIEW, Issue 2 2010Lucy Taylor This article challenges conventional understandings and methodologies associated with the study of political representation. It imagines representation as a power relationship and shifts attention from elections to a closer examination of the interface between representatives and those they claim to represent. It argues for the need to make representation studies wider, moving our focus to study polities beyond the confines of prosperous, established democracies. Secondly, we should broaden our understanding of representation agents in two ways. We should consider how non-voters are represented and we should include diverse forms of social organisations, problematising relationships of representation within these groups and taking their political-representational role seriously. Thirdly, we should move closer, conducting not only macro-level analyses but also micro-level studies, exploring representation among and between individuals and groups in order to understand the complex relationships, motives and dynamics of power at work. Finally we need to go deeper, looking at our own subject positions as scholars critically and challenging the neutrality of the ideas and assumptions that we use as intellectual tools. Moreover, we should promote deeper relationships of representation, reconnecting it to ideas and practices of participation, and promoting the role of accountability in ,closing the loop' and enhancing democracy. [source] Broader, Greener, and More Efficient: Recent Advances in Asymmetric Transfer HydrogenationCHEMISTRY - AN ASIAN JOURNAL, Issue 10 2008Chao Wang Abstract Asymmetric transfer hydrogenation has become a practically useful tool in reduction chemistry in the last decade or so. This was largely triggered by the seminal work of Noyori and co-workers in the mid-1990s and is driven by its complementing chemistry to hydrogenation employing H2. This Focus Review attempts to present a "holistic" overview on the advances in the area, focusing on the achievements recorded around the last three years. These include more-efficient and "greener" metal catalysts, catalysts that enable hydrogenation as well as transfer hydrogenation, biomimetic and organocatalysts, and their applications in the reduction of CO, CN, and CC bonds. Also highlighted are efforts in the development of environmentally benign and reusable catalytic systems. [source] Achieving Integrative, Collaborative Ecosystem ManagementCONSERVATION BIOLOGY, Issue 5 2006HEATHER L. KEOUGH beneficios sociales y ecológicos; gestión; participación pública; toma de decisiones cooperativa Abstract:,Although numerous principles have been identified as being important for successfully integrating social and ecological factors in collaborative management, few authors have illustrated how these principles are used and why they are effective. On the basis of a review of the ecosystem management and collaboration literature, we identified eight factors important for integrative, collaborative ecosystem management,integrated and balanced goals, inclusive public involvement, stakeholder influence, consensus group approach, collaborative stewardship, monitoring and adaptive management, multidisciplinary data, and economic incentives. We examined four cases of successful ecosystem management to illustrate how the factors were incorporated and discuss the role they played in each case's success. The cases illustrate that balancing social and ecosystem sustainability goals is possible. Collaborative efforts resulted in part from factors aimed at making plans economically feasible and from meaningful stakeholder participation in ongoing management. It also required participation in monitoring programs to ensure stakeholder interests were protected and management efforts were focused on agreed-upon goals. Data collection efforts were not all-inclusive and systematic; rather, they addressed the ecological, economic, and social aspects of key issues as they emerged over time. Economic considerations appear to be broader than simply providing economic incentives; stakeholders seem willing to trade some economic value for recreational or environmental benefits. The cases demonstrate that it is not idealistic to believe integrative, collaborative ecosystem management is possible in field applications. Resumen:,Aunque numerosos principios han sido identificados como importantes para la integración exitosa de factores sociales y ecológicos en la gestión cooperativa, pocos autores han ilustrado como son utilizados estos principios y porque son efectivos. Con base en una revisión de la literatura sobre gestión de ecosistemas y colaboración, identificamos cinco factores,metas integradas y balanceadas, inclusive participación pública, influencia de grupos de interés, estrategia de consenso en el grupo, gestión cooperativa, gestión adaptativa y monitoreo, datos multidisciplinarios e incentivos económicos,que son importantes para la gestión integradora y cooperativa de ecosistemas. Examinamos cuatro casos de gestión exitosa de ecosistemas para ilustrar como fueron incorporados los factores y discutimos el papel que jugaron en el éxito de cada caso. Los casos ilustran que el balance de metas de sustentabilidad social y ecológica es posible. En parte, los esfuerzos cooperativos resultaron de factores orientados a hacer que los planes fueran económicamente viables y de la participación significativa de grupos de interés en la gestión en curso. También se requirió la participación en programas de monitoreo para asegurar que los intereses de los grupos fueran protegidos y los esfuerzos de gestión se enfocaran en las metas acordadas. No todos los esfuerzos de recolecta de datos fueron incluyentes y sistemáticos, más bien, eran dirigidos a los aspectos ecológicos, económicos y sociales de temas clave a medida que emergían. Las consideraciones económicas parecen ser más amplias que simplemente proporcionar incentivos económicos, los grupos de interés parecen dispuestos a cambiar algo de valor económico por beneficios recreativos o ambientales. Los casos demuestran que no es idealista pensar que es posible aplicar la gestión integradora y cooperativa de ecosistemas en el campo. [source] Women's Careers Beyond the Classroom: Changing Roles in a Changing WorldCURRICULUM INQUIRY, Issue 3 2001Nina Bascia Drawing from our own and others' research over the past decade and a half, we present four "readings," each illuminating a different dimension of women educators' career development, particularly their movement into work beyond the classroom. The majority of the participants in our studies are women who work for change in their classrooms, schools, and district organizations, using the opportunities, vehicles, and channels available,or apparent,to them. They do this work in professional and personal contexts that are continually changing, sometimes as a result of their own choices and actions and sometimes not. While there is a growing body of literature on women's movement into, and their lives in, educational administration, we are concerned here with the broader and more varied manifestations of leadership beyond the classroom. In the four readings, we bring together several strands in the literature on women educators' lives and careers. We first lay out the taken-for-granted oppositional contrasts in the educational discourses that have tended to obscure more complex understandings of work lives and careers. Next, we explore how the particular kinds of work available to women actually encourage some to move beyond narrow conceptions of the distinctions between classroom and nonclassroom work. Third, we discuss the developmental nature of individual career paths. Fourth, we note the spatial and temporal nature of leadership work by showing how it is influenced and changed by greater economic, social, and political forces. We believe that these multiple interpretations are required to understand the range and combination of influences that propel and compel women educators to take up various forms of leadership work beyond the classroom. [source] The Science of Surge: Detection and Situational AwarenessACADEMIC EMERGENCY MEDICINE, Issue 11 2006John McManus MD As part of the broader "science of surge" consensus initiative sponsored by Academic Emergency Medicine, this report addresses the issues of detection and situational awareness as they relate to surge in the practice of emergency medicine. The purpose of this report, and the breakout group that contributed to its content, was to provide emergency physicians and other stakeholders in the emergency medicine community a sense of direction as they plan, prepare for, and respond to surge in their practice. [source] Comparing agglomerative clustering and three weed classification frameworks to assess the invasiveness of alien species across spatial scalesDIVERSITY AND DISTRIBUTIONS, Issue 6 2006Roger A. Lawes ABSTRACT To prioritize weed management at the catchment scale, information is required on the species present, their relatively frequency, abundance, and likely spread and impact. The objective of this study was to classify the invasiveness of alien species that have invaded the Upper Burdekin Catchment in Queensland, Australia, at three spatial scales. A combination of three published weed classification frameworks and multivariate techniques were employed to classify species based on their frequency and cover at a range of spatial scales. We surveyed the Upper Burdekin Catchment for alien species, and for each species determined the following distribution indices , site frequency, total cover, transect frequency per site frequency and quadrat frequency per site frequency, cover per quadrat when present, cover per transect when present, and cover per site when present. These indices capture the effect of species abundance and frequency between sites (site frequency and total cover), within sites (transect frequency per site and cover per transect when present), and within transects (quadrat frequency per site frequency and cover per site). They were used to classify the species into seven groups using a hierarchical cluster analysis. The relationship between the indices was explored to determine how effective the small scale, site-specific indices were at predicting the broader, landscape-scale patterns. Strong correlations were observed between transect frequency per site and frequency (r2 = 0.89) and cover per transect when present and total cover (r2 = 0.62). This suggests that if a weed is abundant at the site level, it has the potential to occupy large areas of the catchment. The species groupings derived from the application of the three published weed classification frameworks were compared graphically to the groupings derived from the cluster analysis. One of the frameworks classified species into three groups. The other two frameworks classified species into four groups. There was a high degree of subjectivity in applying the frameworks to the survey data. Some of the data were of no relevance to the classification frameworks and were therefore ignored. We suggest that the weed classification frameworks should be used in conjunction with existing multivariate techniques to ensure that classifications capture important natural variations in observed data that may reflect invasion processes. The combined use of the frameworks and multivariate techniques enabled us to aggregate species into categories appropriate for management. [source] The operating costs of taxation: a review of the researchECONOMIC AFFAIRS, Issue 2 2001Chris Evans This paper considers key aspects of the literature on the operating costs of taxation, identifying the factors that have led to its development and evaluating its impact on policy responses to compliance and administrative costs issues. It starts by identifying the key components of the operating costs of the taxation system. The paper then identifies the main research trends over the past 60 years or so around the world, placing current concerns about taxation compliance and administrative costs within a broader - deregulatory - context and analyzing governmental responses to concerns about compliance costs highlighted by the literature. Finally, it offers some tentative views on the likely directions that research in the area may take in the coming decades. [source] EDUCATING COMMUNAL AGENTS: BUILDING ON THE PERSPECTIVISM OF G.H. MEADEDUCATIONAL THEORY, Issue 4 2007Jack Martin In this essay, Jack Martin aims to remedy such oversight by interpreting Mead's social-psychological and educational theorizing of selfhood and agency through the lenses of the perspectival realism Mead developed in the last decade of his life. This interpretation understands education as concerned with the cultivation and coordination of cultural, societal, interpersonal, and personal perspectives. Within this framework, communal agency is understood as a self-interpreting, self-determining capability of persons. This agentive capability derives from immersion and participation with others within sociocultural practices and perspectives, but also includes reactivity to those same practices and perspectives. The education of communal agents as envisioned here emphasizes the social nature of education, students' experience and development, and the critical role of the teacher as a mediator between student development and social process. Such an education is grounded in the immediate experiences and perspectives of learners, but increasingly assists learners to move beyond their own experiences through engaged interaction with others and with resources for acquiring broader, more organized perspectives on themselves, others, and the world. [source] Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaquesEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 7 2010Maximillian Rosario Abstract A novel T-cell vaccine strategy designed to deal with the enormity of HIV-1 variation is described and tested for the first time in macaques to inform and complement approaching clinical trials. T-cell immunogen HIVconsv, which directs vaccine-induced responses to the most conserved regions of the HIV-1, proteome and thus both targets diverse clades in the population and reduces the chance of escape in infected individuals, was delivered using six different vaccine modalities: plasmid DNA (D), attenuated human (A) and chimpanzee (C) adenoviruses, modified vaccinia virus Ankara (M), synthetic long peptides, and Semliki Forest virus replicons. We confirmed that the initial DDDAM regimen, which mimics one of the clinical schedules (DDDCM), is highly immunogenic in macaques. Furthermore, adjuvanted synthetic long peptides divided into sub-pools and delivered into anatomically separate sites induced T-cell responses that were markedly broader than those elicited by traditional single-open-reading-frame genetic vaccines and increased by 30% the overall response magnitude compared with DDDAM. Thus, by improving both the HIV-1-derived immunogen and vector regimen/delivery, this approach could induce stronger, broader, and theoretically more protective T-cell responses than vaccines previously used in humans. [source] The functional properties of the human ether-à-go-go -like (HELK2) K+ channelEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2002Andrea Becchetti Abstract The voltage-dependent K+ channels belonging to the ether-à-go-go family (eag, erg, elk) are widely expressed in the mammalian CNS. Their neuronal function, however, is poorly understood. Among the elk clones, elk2 is the most abundantly expressed in the brain. We have characterized the human ELK2 channel (HELK2) expressed in mammalian cell lines. Moreover, we have detected helk2 mRNA and ELK2-like currents in freshly dissociated human astrocytoma cells. HELK2 was inhibited by Cs+ in a voltage-dependent way (Kd was 0.7 mm, at ,120 mV). It was not affected by Way 123398 (5 µm), dofetilide (10 µm), quinidine (10 µm), verapamil (20 µm), haloperidol (2 µm), astemizole (1 µm), terfenadine (1 µm) and hydroxyzine (30 µm), compounds known to inhibit the biophysically related HERG channel. The crossover of the activation and inactivation curves produced a steady state ,window' current with a peak around ,20 mV and considerably broader than it usually is in voltage-dependent channels, including HERG. Similar features were observed in the ELK2 clone from rat, in the same experimental conditions. Thus, ELK2 channels are active within a wide range of membrane potentials, both sub- and suprathreshold. Moreover, the kinetics of channel deactivation and removal of inactivation was about one order of magnitude quicker in HELK2, compared to HERG. Overall, these properties suggest that ELK2 channels are very effective at dampening the neuronal excitability, but less so at producing adaptation of action potential firing frequency. In addition, we suggest experimental ways to recognize HELK2 currents in vivo and raise the issue of the possible function of these channels in astrocytoma. [source] Off the Back or on the Side: Comparison of meso and 2-Substituted Donor-Acceptor Difluoroborondipyrromethene (Bodipy) DyadsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 15 2010Andrew C. Benniston Abstract The preparation of several difluoroborondipyrromethene (Bodipy) dyads is described incorporating covalently attached hydroquinone/quinone groups at the 2-position (BD-SHQ, BD-SQ, BD-SPHQ, BD-SPQ). The compounds, currently under investigation as chemical sensors for reactive oxygen species, show various levels of fluorescence depending on the oxidation state of the appended group. The 19F NMR spectrum for BD-SHQ in CDCl3 at room temperature reveals the two fluorines are inequivalent on the NMR timescale. In contrast, the 19F NMR spectrum for the counterpart quinone compound, BD-SQ, is consistent with two equivalent fluorine atoms. The two results are interpreted as the quinone is free to rotate around the connector bond, whereas this motion is restricted for the hydroquinone group and makes the fluorines chemically inequivalent. Cyclic voltammograms recorded for all derivatives in CH2Cl2 electrolyte solution are consistent with typical Bodipy-based redox chemistry; the potentials of which depend on factors such as presence of the phenylene spacer and oxidation state of the appended group. A comparison of the electrochemical behaviour with the counterpart meso derivatives reveals some interesting trends which are associated with the location of the HOMO/LUMOs. The absorption profiles for the compounds in CH3CN are again consistent with Bodipy-based derivatives, though there are some subtle differences in the band-shapes of the closely-coupled systems. In particular, the absorption spectra for the dyad, BD-SQ, in a wide range of solvents are appreciably broader than for BD-SHQ. Femtosecond transient absorption spectroscopy performed on the hydroquinone derivatives, BD-SHQ and its meso analogue is interpreted as electron transfer occurs from the hydroquinone unit to the first-excited singlet (S1) state of the Bodipy center, followed by ultrafast charge recombination to reinstate the ground state. The coupling of OH vibrations to the return electron transfer process is invoked to explain the lack of clear identification of the charge-separated state in the transient records. [source] German lexical personality factors: relations with the HEXACO modelEUROPEAN JOURNAL OF PERSONALITY, Issue 1 2007Michael C. Ashton Abstract We correlated the scales of the HEXACO Personality Inventory (HEXACO-PI) with adjective scale markers of factors previously obtained in indigenous lexical studies of personality structure in the German language. Self-ratings obtained from a sample of 323 German participants showed a pattern of strong convergent and weak discriminant correlations, supporting the content-based interpretation of the German lexical factors in terms of the HEXACO dimensions. Notably, convergent correlations were strong for both the broader and the narrower variants of the Honesty-Humility factor as observed in German lexical studies. Also, convergent correlations for HEXACO Openness to Experience were, as expected, stronger for German adjectives describing a creative and intellectual orientation than for German adjectives describing intellectual ability. Copyright © 2006 John Wiley & Sons, Ltd. [source] Courts, the new constitutionalism and immigrant rights: The case of the French Conseil ConstitutionnelEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 6 2004Christian Joppke Immigrant rights are located within a broader ,new constitutionalism' (especially in postwar Europe), in which courts have abandoned their traditional passiveness toward the political process and taken on the role of de facto legislator. Analyzing the immigration jurisprudence of the French Conseil Constitutionnel, we argue that courts are torn between two opposite imperatives: to protect an especially vulnerable category of people from the enormous police powers of the modern administrative state; and to respect an elementary exigency of sovereign stateness , that is, the capacity to draw a distinction between ,citizens' and ,aliens' as differently situated persons without a right of entry and permanence. [source] Gender Differences in Time Availability: Evidence from FranceGENDER, WORK & ORGANISATION, Issue 4 2009François-Xavier Devetter The aim of the article is to examine differences in work time from a gender perspective. To this end, a concept broader than mere duration of work time is constructed. This concept, which we call time availability, encompasses not only the volume of hours worked but also the scheduling and predictability of those hours. It is measured by a synthetic indicator showing the extent to which a given group of workers exceeds the societal time norm. After a presentation of the French context, we show that women seem to have less time availability, particularly at the ages that are most decisive in career terms. But these differences do not concern the same aspects of time availability. Thus the time constraints experienced mainly by women are less socially visible and hence undervalued by employers. This lower visibility comes, for a large part, from the social perception of women professionals. [source] Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patientGENES, CHROMOSOMES AND CANCER, Issue 5 2007Lorenza Pecciarini Renal-cell carcinoma (RCC) constitutes a heterogeneous group of tumors with specific chromosome aberrations. Recently, a new small group of RCC, occurring in children and young adults, has been described as characterized by t(6;11)(p21;q12). It has been shown that this translocation results in the fusion of the 5, portion of the ALPHA gene (11q12) with the transcription factor gene TFEB (6p21). Herewith, we report the first complete cytogenetic and molecular characterization of a t(6;11)-positive RCC of an adult patient, a 54-year-old woman. The tumor was histologically defined as RCC with peculiar features and it was negative for epithelial markers and positive for melanocytic markers. Chromosome QFQ banding analysis of short-term cultured cells from the RCC showed t(6;11)(p21;q12) as the sole cytogenetic abnormality. The translocation was confirmed by FISH analysis. RT-PCR analysis, performed on total RNA isolated from both neoplastic and normal tissue samples, revealed an ALPHA,TFEB chimeric transcript in the tumor sample; sequencing of the RT-PCR product defined a novel TFEB gene breakpoint cluster region, broader than the one reported thus far. Western blot analysis showed a band at the expected size of wild-type TFEB in the neoplastic tissue compared to the normal sample, supporting that the fusion gene does not encode for a chimeric protein but it causes an upregulation of the wild-type TFEB. Our data contribute to define better this rare RCC type, which is typical not only of childhood but can also be found in adulthood. © 2007 Wiley-Liss, Inc. [source] Early Cretaceous bivalves of the Neuquén Basin, west-central Argentina: notes on taxonomy, palaeobiogeography and palaeoecologyGEOLOGICAL JOURNAL, Issue 2 2007Dario G. Lazo Abstract This paper provides an updated taxonomic inventory of the bivalve fauna collected in the Pilmatué Member of the Agrio Formation of the Neuquén Basin, west-central Argentina, places the fauna in its palaeobiogeographic setting, and addresses its palaeoecological significance. Thirty-one Late Valanginian to Early Hauterivian bivalve species within 24 genera were identified. A large part (32%) of the identified bivalve species occur over a wide geographical area: from the Pacific coast of South America to Europe, North Africa, Central Asia and East and South Africa; some are also recorded in Japan. A relatively high degree of endemism (26%) is shown, suggesting that some of the bivalve species had barriers to their dispersal; larval strategy and length of larval development were probably important. A significant number (42%) of the bivalve taxa are left in open nomenclature as they are probably new species. Bivalve guilds are described to interpret palaeoecology, in particular the ecospace utilization. Guilds are based on tiering, life habit, and feeding category. Eight guilds are recognized: free-lying epifaunal, cemented epifaunal, epibyssate, boring, endobyssate, shallow burrowing, deep burrowing and deep burrowing with symbiotic bacteria. The fauna is composed only of suspension-feeders indicating that food resources were dominantly in suspension, in agreement with the predominantly shallow-water aspect of the study deposits. The ecospace utilization in the shoreface is broader than in the offshore shelf, suggesting more favourable living conditions and/or a wider range of different habitat types represented. Copyright © 2007 John Wiley & Sons, Ltd. [source] FedEx Ground retools its succession planning and development processes to deliver business resultsGLOBAL BUSINESS AND ORGANIZATIONAL EXCELLENCE, Issue 3 2009Heather D'Alesandro A revamped succession planning process at FedEx Ground keeps succession and development decisions clearly focused on the road ahead to ensure the company has its best talent ready for those roles that drive its business strategies and critical initiatives. Changes to the annual talent review process were designed to find and close talent gaps in pivotal leadership roles and competencies, where near-term talent shortages could pose significant business risks. Prework and the review meeting agenda concentrate the discussion on whether the high-potential and promotable individuals are filling these pivotal roles and being developed as rapidly as possible. Enabled by a robust technology platform, officers can also devise broader targeted actions across the organization for addressing shared developmental needs related to critical leadership competencies. © 2009 Wiley Periodicals, Inc. [source] Predicting the impacts of climate change on the distribution of species: are bioclimate envelope models useful?GLOBAL ECOLOGY, Issue 5 2003Richard G. Pearson ABSTRACT Modelling strategies for predicting the potential impacts of climate change on the natural distribution of species have often focused on the characterization of a species' bioclimate envelope. A number of recent critiques have questioned the validity of this approach by pointing to the many factors other than climate that play an important part in determining species distributions and the dynamics of distribution changes. Such factors include biotic interactions, evolutionary change and dispersal ability. This paper reviews and evaluates criticisms of bioclimate envelope models and discusses the implications of these criticisms for the different modelling strategies employed. It is proposed that, although the complexity of the natural system presents fundamental limits to predictive modelling, the bioclimate envelope approach can provide a useful first approximation as to the potentially dramatic impact of climate change on biodiversity. However, it is stressed that the spatial scale at which these models are applied is of fundamental importance, and that model results should not be interpreted without due consideration of the limitations involved. A hierarchical modelling framework is proposed through which some of these limitations can be addressed within a broader, scale-dependent context. [source] Electroactive Films of Multicomponent Building Blocks,ADVANCED FUNCTIONAL MATERIALS, Issue 5 2007I. Yildiz Abstract A ligand consisting of a 2,2,-bipyridine core and two 4,4,-bipyridinium arms terminated by a thiol group is prepared following a multistep synthetic procedure. Two of these ligands assemble around a single CuI center as a result of the tetrahedral coordination of their 2,2,-bipyridine cores by the metal. Both the ligand and the complex adsorb spontaneously on the surface of polycrystalline-gold electrodes. The surface coverage of the films prepared by immersing a gold substrate into a solution of the ligand increases from monolayer to multilayer values with immersion time. Instead, the complex can only form monolayers. The cyclic voltammograms of the resulting films show the characteristic response for the reversible reduction of the 4,4,-bipyridinium dications to their radical cations. In the case of the complex, a wave for the monoelectronic oxidation of the metal center can also be observed. The back reduction wave, however, is markedly broader and appears at significantly lower potentials. Model studies in solution indicate that this response is a result of the presence of free thiol groups and is consistent with a change in the coordination geometry of the metal. Specifically, the oxidation of the CuI center to a CuII ion is, presumably, accompanied by the folding of one of the thiol groups back to interact with the metal. Thus, oxidation/reduction cycles of the metal center can, in principle, be exploited to control reversibly large amplitude molecular motions at the electrode/solution interface in the shape of the folding/unfolding of oligomethylene chains. [source] Bread, Cheese and Genocide: Imagining the Destruction of Peoples in Medieval Western EuropeHISTORY, Issue 307 2007LEN SCALES Western European society in the middle ages is generally perceived as lying, in its modes of thought and action, far remote from those acts of mass ethnic destruction which have been a recurrent element in world history since the early twentieth century. Yet medieval Europeans too were capable of envisaging the violent obliteration of peoples. Indeed, the view that such acts had occurred in times past and were liable to occur again was deeply embedded in medieval thought and assumption. For some commentators, the destruction of certain peoples was inseparable from the making of others, an essential motor of historical change, underpinned by biblical narratives of divine election and condemnation. Such notions constituted a matrix within which medieval writers interpreted real acts of social and political violence, the scale and the ethnic foundations of which they were thus naturally inclined to inflate. Nevertheless, their belief in the recurrent historical reality of ethnic destruction was, in their own terms, well founded , although medieval conceptions of what constituted the undoing of peoples were broader than most modern definitions of ,genocide'. By the later middle ages, moreover, government was increasingly perceived , not without justification , as a powerful agent for remaking the ethnic map. [source] HISTORY IN THE SIKH PAST,HISTORY AND THEORY, Issue 3 2007ANNE MURPHY ABSTRACT This article offers a reading of an early eighteenth-century Punjabi text,Gur Sobha or "The Splendor of the Guru",as a form of historical representation, suggesting reasons for the importance of the representation of the past as history within Sikh discursive contexts. The text in question provides an account of the life, death, and teachings of the last of the ten living Sikh Gurus or teachers, Guru Gobind Singh. The article argues that the construction of history in this text is linked to the transition of the Sikh community at the death of the last living Guru whereby authority was invested in the canonical text (granth) and community (panth). As such a particular rationale for history was produced within Sikh religious thought and intellectual production around the discursive construction of the community in relation to the past and as a continuing presence. As such, the text provides an alternative to modern European forms of historical representation, while sharing some features of the "historical" as defined in that context. The essay relates this phenomenon to a broader exploration of history in South Asian contexts, to notions of historicality that are plural, and to issues particular to the intersection of history and religion. Later texts, through the middle of the nineteenth century, are briefly considered, to provide a sense of the significance of Gur Sobha within a broader, historically and religiously constituted Sikh imagination of the past. [source] Update of the Pompe disease mutation database with 107 sequence variants and a format for severity rating,HUMAN MUTATION, Issue 6 2008Marian Kroos Abstract Pompe disease was named after the Dutch pathologist Dr JC Pompe who reported about a deceased infant with idiopathic hypertrophy of the heart. The clinical findings were failure to thrive, generalized muscle weakness and cardio-respiratory failure. The key pathologic finding was massive storage of glycogen in heart, skeletal muscle and many other tissues. The disease was classified as glycogen storage disease type II and decades later shown to be a lysosomal disorder caused by acid ,-glucosidase deficiency. The clinical spectrum of Pompe disease appeared much broader than originally recognized. Adults with the same enzyme deficiency, alternatively named acid maltase deficiency, were reported to have slowly progressive skeletal muscle weakness and respiratory problems, but no cardiac involvement. The clinical heterogeneity is largely explained by the kind and severity of mutations in the acid ,-glucosidase gene (GAA), but secondary factors, as yet unknown, have a substantial impact. The Pompe disease mutation database aims to list all GAA sequence variations and describe their effect. This update with 107 sequence variations (95 being novel) brings the number of published variations to 289, the number of non-pathogenic mutations to 67 and the number of proven pathogenic mutations to 197. Further, this article introduces a tool to rate the various mutations by severity, which will improve understanding of the genotype-phenotype correlation and facilitate the diagnosis and prognosis in Pompe disease. © 2008 Wiley-Liss, Inc. [source] A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcoholHUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 6 2009George A. Kenna Abstract Objective There are no reports examining the safety of taking both topiramate and aripiprazole together with alcohol. The ultimate aim for this research is to determine whether this combination is safe and is superior to either drug taken alone in reducing alcohol use in alcohol dependent patients. Method This was an open-label trial. Thirteen heavy drinking participants not seeking treatment for alcoholism were randomized. Participants were titrated up to 300,mg of topiramate and 30,mg of aripiprazole a day over 35 days. Participants reported adverse events (AEs) daily alcohol use and participated in an alcohol challenge session (ACS). Results The eight participants who completed the study achieved the maximum doses of drugs. The AEs of the drugs would suggest that the AEs profile is broader but not additive. Alcohol use from the 28 days before screening to the seven days before the ACS was reduced (p,=,0.08). Conclusion There was no evidence that AEs of aripiprazole and topiramate are additive and can, therefore, be administered safely together with a modest amount of alcohol. There was also a trend for a reduction of alcohol use by participants. This finding has implications for further investigation of this combination of drugs for alcohol dependence. Copyright © 2009 John Wiley & Sons, Ltd. [source] HR strategy and competitive advantage in the service sectorHUMAN RESOURCE MANAGEMENT JOURNAL, Issue 3 2003Peter Boxall While taking its cue from studies of high-performance work systems in manufacturing, this article examines theory and research on the potential for HR advantage in the service sector, building directly on recent studies of market segmentation and HR strategy in the sector. The article uses these studies, along with strategic management theory, to put forward a new typology of market characteristics, competitive dynamics and HR strategy in services. Three broad types of competition, ranging from mass market to knowledge-intensive services, are identified. This framework helps the article to explore the issue of whether competitive differentiation through human resources is possible only in high-skill areas such as professional services. It argues that opportunities for HR advantage are broader; they exist where quality and/or knowledge are important in competitive strategy. However, seeing the opportunity is not the same as achieving the result. Service firms that identify and pursue these opportunities face the problems of building and maintaining barriers to imitation, and of managing the ,politics of appropriation'. [source] Catchment-scale contribution of forest roads to stream exports of sediment, phosphorus and nitrogenHYDROLOGICAL PROCESSES, Issue 23 2007Gary J. Sheridan Abstract The relative contribution of forest roads to total catchment exports of suspended sediment, phosphorus, and nitrogen was estimated for a 13 451 ha forested catchment in southeastern Australia. Instrumentation was installed for 1 year to quantify total in-stream exports of suspended sediment, phosphorus, and nitrogen. In addition, a total of 101 road,stream crossings were mapped and characterized in detail within the catchment to identify the properties of the road section where the road network and the stream network intersect. Sediment and nutrient generation rates from different forest road types within the catchment were quantified using permanent instrumentation and rainfall simulation. Sediment and nutrient generation rates, mapped stream crossing information, traffic data and annual rainfall data were used to estimate annual loads of sediment, phosphorus, and nitrogen from each stream crossing in the catchment. The annual sum of these loads was compared with the measured total catchment exports to estimate the proportional contribution of loads from roads within the catchment. The results indicated that 3·15 ha of near-stream unsealed road surface with an average slope of 8·4% delivered an estimated 50 t of the 1142 t of total suspended sediment exported from the catchment, or about 4·4% of the total sediment load from the forest. Stream discharge over this period was 69 573 Ml. The unsealed road network delivered an estimated maximum of 22 kg of the 1244 kg of total phosphorus from the catchment, or less than 1·8% of the total load from the forest. The average sediment and phosphorous load per crossing was estimated at 0·5 t (standard deviation 1·0 t) and 0·22 kg (standard deviation 0·30 kg) respectively. The lower proportional contribution of total phosphorus resulted from a low ratio of total phosphorus to total suspended sediment for the road-derived sediment. The unsealed road network delivered approximately 33 kg of the 20 163 kg of total nitrogen, about 0·16% of the total load of nitrogen from the forest. The data indicate that, in this catchment, improvement of stream crossings would yield only small benefits in terms of net catchment exports of total suspended sediment and total phosphorus, and no benefit in terms of total nitrogen. These results are for a catchment with minimal road-related mass movement, and extrapolation of these findings to the broader forested estate requires further research. Copyright © 2007 John Wiley & Sons, Ltd. [source] Introduction: Local Democratic Governance, Poverty Reduction and Inequality: The Hybrid Character of Public ActionIDS BULLETIN, Issue 6 2009Peter K. Spink It has largely been assumed that as societies get better at being broader and more open (decentralisation, local government, participation and governance), so services tend to improve and things will get better for those in situations of poverty. In testing this assumption, the LogoLink network has drawn on studies of innovative experiences by members of its partner organisations. The emphasis of the joint project was on the local actors and the social processes involved. The results show how effective action and impact requires not only community-based organisations, social movements and NGO networks, but also public sector actors who can make links between the institutional environment, the public sector and communities. Recognising this hybrid character of public action has been a key conclusion from the studies. [source] Anti-inflammatory effects in the skin of thymosin-,4 splice-variantsIMMUNOLOGY, Issue 1 2003Michael Girardi Summary The intraepithelial lymphocyte (IEL) network of T-cell receptor ,,+ (V,5+) dendritic epidermal T cells (DETC) in murine skin down-regulates cutaneous inflammation, although the mechanism is unknown. Thymosin-,4 (T,4), identified by serial analysis of gene expression as a predominant transcript in gut IEL, encodes both a ubiquitous actin-binding protein (UT,4) with demonstrated capacity to inhibit neutrophilic infiltration, and a splice-variant limited to lymphoid tissue (LT,4) with unknown bioactivity. Freshly isolated V,5+ DETCs expressed both forms, while only LT,4 was preferentially up-regulated after cellular activation in vitro. To compare the anti-inflammatory properties of LT,4 and UT,4 in the skin in vivo, the biological activities of synthesized polypeptides were assessed using three different strategies: neutrophil infiltration by footpad ,-carrageenan injection; irritant contact dermatitis to 12-O-tetradecanoylphorbol 13-acetate; and allergic contact dermatitis to 2,4-dinitrofluorobenzene. These studies clearly showed that the anti-inflammatory activities of LT,4 were broader and most often stronger than those of UT,4. Thus, the activation-responsive expression of the lymph-specific form of T,4 may be one mechanism by which DETC, and possibly other IELs, down-regulate local inflammation. [source] Community engagement for counterterrorism: lessons from the United KingdomINTERNATIONAL AFFAIRS, Issue 4 2010RACHEL BRIGGS This article explores the development of community engagement within the UK's strategy to tackle international terrorism linked to and inspired by Al-Qaeda, commonly known as CONTEST. It focuses mostly on the ,Prevent' strand of the strategy which seeks to prevent radicalization towards violence, reduce tacit support for violence, and increase the resilience of communities to tackle radicalization and extremist messages themselves. Community engagement for counterterrorism also relates to certain aspects of the ,Pursue' strand of CONTEST, and these are highlighted. The article outlines the case for a community-based approach to counterterrorism and outlines a number of the key developments in its emergence from 2005 onwards. It analyses the performance of this aspect of the counterterrorism strategy, pointing to a number of shortcomings in relation to the establishment of partnerships, the integration of the approach, capacity shortfalls at the local level, and the wider challenges of a hostile political and media environment. Written as the new UK coalition government announces a review of the ,Prevent' strategy, it offers a number of recommendations for the future direction of this area of policy. It calls for an overhaul in working styles, a focus on people rather than projects, and the need to draw a much clearer line between downstream and targeted ,Prevent' work and the broader and longer-term community development work, with the latter encapsulated within the government's Big Society Programme and aimed at all fragile communities, not just Muslims. [source] Community Participatory Ecological Art and EducationINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 1 2009Young Imm Kang Song This paper presents a phenomenological case study on ecological artist Lynne Hull by investigating the connections between ecological art, nature, and education. The research examines Hull's ,positive gesture towards the Earth' as conceptualized in her work of creating habitats for wildlife (Hull, 2004, para 1). It illustrates how she seeks to inspire changes in human behaviour through her artwork in addition to developing action steps based on her works. Through an examination of Hull's work, the researcher explores how ecological art can inspire environmental education by presenting innovative ways of thinking about existing concepts. The paper discusses how educators can incorporate inquiries about ecological art into the school curriculum. Furthermore, it considers ways in which educators can adopt Hull's art-making processes and integrate these into the curriculum. It argues that educators can help students to interact with these artworks and develop their own creative processes in a meaningful way that involves art, aesthetics, and nature , all of which may raise students' consciousness about the environment in themselves and others. Ultimately, appreciating the elements of nature and their connection to the aesthetic can become a vehicle for raising awareness about broader [source] Intention and Meaning in Young Children's DrawingINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 2 2005Sue Cox In this article I present some ideas, based on qualitative research into young children's drawing, related to the developing discourse on young children's thinking and meaning making. I question the relationship between perception and conception and the nature of representation, challenging traditional ideas around stage theory and shifting the focus from the drawings themselves to the process of drawing, and thus to the children's own purposes. I analyse examples of my observations (made in naturalistic settings within a nursery classroom) to reveal the range of representational purposes and meaning in children's drawing activity. My analysis shows that, rather than being developmentally determined, the way children configure their drawings is purposeful; children can recognise the power of drawing to represent, and that they themselves can be in control of this. I explore aspects of the process, including transformation and talk to show the importance of understanding drawing in its specific contexts. I show how children's drawing activity is illuminated by the way in which it occurs and the other activities linked to it, presenting drawing as part of children's broader, intentional, meaning-making activity. As an aspect of the interactive, communicative practices through which children's thinking develops, representation is a constructive, self-directed, intentional process of thinking in action, through which children bring shape and order to their experience, rather than a developing ability to make visual reference to objects in the world. I suggest that in playing with the process, children are actively defining reality rather than passively reflecting a given reality. [source] | |||||||||||||||||||||||||||||||||||||||||||