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Bottles
Kinds of Bottles Terms modified by Bottles Selected AbstractsCuH in a Bottle: A Convenient Reagent for Asymmetric Hydrosilylations.CHEMINFORM, Issue 5 2006Bruce H. Lipshutz Abstract For Abstract see ChemInform Abstract in Full Text. [source] OF SAILORS AND POETS: ON CELAN, GRÜNBEIN, AND BRODSKYGERMAN LIFE AND LETTERS, Issue 3 2007Michael Eskin ABSTRACT In this essay, I trace the metamorphoses of the trope of poetry as ,message in a bottle' in the works of Paul Celan, Durs Grünbein, and Joseph Brodsky. Beginning from a juxtaposition of Osip Mandelstam's conception of the poetic text as a ,letter in a bottle' with Bertolt Brecht's depiction of lyric poetry as ,Flaschenpost' in light of their conceptual discrepancies, I inquire into the different ways in which three of Brecht's and, above all, Mandelstam's most notable successors , Celan, Grünbein, and Brodsky , have appropriated and deployed the trope in response to their singular socio-historical situations. Through a number of close readings of contextually relevant texts (including Celan's Bremen Prize Speech, Grünbein's discussion of Celan and Mandelstam as avatars of what he calls the ,new Robinson', and Brodsky's programmatic poem, ,Letter in a Bottle'), I disclose important differences, poetic and ethical, between Celan's, Grünbein's, and Brodsky's (and, by extension, others') recourse to the ostensibly monosemous figure of poetry as ,Flaschenpost', as it was signally launched, in the twentieth century, by Mandelstam in particular. [source] New Bottles for New Wine: A Pericentric Framework for the Study of the Cold WarDIPLOMATIC HISTORY, Issue 4 2000Tony Smith First page of article [source] The Efficiency of TBHQ, ,-carotene, Citric Acid, and Tinuvin 234® on the Sensory Stability of Soybean Oil Packaged in PET BottlesJOURNAL OF FOOD SCIENCE, Issue 1 2003H.M.C. de Azeredo ABSTRACT: The use of plastic packaging for oils permits exposure to light, increasing oxidation. The goal of this work was to maximize sensory stability of soybean oil packaged in PET bottles. A central composite design was used to combine different levels of TBHQ, ,-carotene, and citric acid, added to oil, and Tinuvin 234®, added to bottles. After 6 mo of storage, the oxidation degree was assessed by sensory and peroxide tests. TBHQ and Tinuvin 234 were the most effective antioxidants, and the minimum concentrations required to keep a reasonable stability during storage were: 120 ppm of TBHQ; 7 ppm of ,-carotene; 15 ppm of citric acid and 0.1% of Tinuvin 234. [source] Old Wine in New Bottles: Delivering Nursing in the 21st CenturyJOURNAL OF NURSING SCHOLARSHIP, Issue 1 2000Dame June Clark [source] Finding New Wine in Old Bottles: What Historians Must Do When Leontief Coefficients Are No Longer the Designated Drivers of EconomicsAMERICAN JOURNAL OF ECONOMICS AND SOCIOLOGY, Issue 1 2010Laurence S. Moss First page of article [source] Advantages of Sodium Hypochlorite or Sodium Dichloroisocyanurate Disinfection for Teats and Bottles in Newborn Infants' FeedingPUBLIC HEALTH NURSING, Issue 2 2008Matteo Vitali No abstract is available for this article. [source] The Design in WineDESIGN MANAGEMENT REVIEW, Issue 2 2010Ronna Chisholm In the wine industry, design can be crucial,and its uses go far beyond the label on the bottle. From the systems responsible for making the wine in the first place to all the details that go into creating a brand experience, design plays a part before the first glass is poured. [source] Nonnutritive sucking: One of the major determinants of filial loveDEVELOPMENTAL PSYCHOBIOLOGY, Issue 3 2006David Val-Laillet Abstract The present study investigated the rewarding effects of nonnutritive sucking on the development of a filial preference. Two experiments were conducted to test whether nonnutritive visceral and oral stimuli have reinforcing properties independent from each other or act in synergy. Lambs could interact freely with their dam but were deprived of suckling by covering the udder for the first 12 hr. In Experiment 1, suckling was prevented and replaced by human giving, in the presence of the mother, either a bottle of water (B5 and B2.5: 5% or 2.5% birth weight, BW, divided into seven portions over 12 hr) or water via tube-feeding (I5 and I2.5: 5% or 2.5% BW, also divided into seven portions over 12 hr). During a two-choice test performed at 12 hr after birth, only B5 and I5 lambs preferred their mother to an alien ewe however, B5 were faster at choosing their mother at the beginning of the test. B2.5 and I2.5 lambs made a random choice. In Experiment 2, suckling was prevented and replaced by human giving, in the presence of the mother, either a bottle of water (B2.5: 2.5% BW, divided into seven portions over 12 hr) or water via tube-feeding (I10 and I2.5: 10% or 2.5% BW, also divided into seven portions over 12 hr). During a two-choice test at 12 hr, tube-fed lambs (I10 and I2.5) preferred their mother to a human. B2.5 lambs were equally attracted to both partners and spent more time near the human than lambs from the other groups. In a test of reactivity to a human performed on neonates isolated from their mother, B2.5 lambs explored the human much more than the other lambs. The presence of the human had soothing properties in B2.5 lambs and once the human left, they were the only lambs displaying enhanced vocal and locomotor activity. In these experiments, nonnutritive gastrointestinal stimuli induced a preference for the mother whereas nonnutritive sucking led to a strong positive relationship with the human. These results suggest that when lambs suckle their dam, the development of filial bonding is facilitated through the combined effects of oral and gastrointestinal stimuli. © 2006 Wiley Periodicals, Inc. Dev Psyshobiol 48: 220,232, 2006. [source] Children and adults represent proper names as referring to unique individualsDEVELOPMENTAL SCIENCE, Issue 4 2001Cristina M. Sorrentino Adults represent proper names (e.g. ,Katharine Hepburn') as referring to unique individuals (i.e. Katharine Hepburn), and studies of children's proper name learning have been taken to show that children represent proper names in like manner. However, almost all of these studies leave open the possibility that children represent proper names as referring to restricted kinds of highly similar animals. We provide direct evidence against this possibility: both adults and 3-year-old children presented with a novel word for a toy animal (e.g. ,daxy') assumed that the animal continued to be referred to with the word, despite a change in the animal's appearance and location, and despite the introduction at the old location of an animal identical in appearance to the original animal at the time the word was introduced. Participants presented with a simple artifact (e.g. a bottle) did not interpret the word as a proper name, consistent with previous work. [source] Visualization study and analysis on preform growth in polyethylene terephthalate stretch blow moldingJOURNAL OF APPLIED POLYMER SCIENCE, Issue 1 2007Han-Xiong Huang Abstract In stretch blow molding (SBM) process, the preform growth during the stretching and blowing is critical to the thickness distribution and properties of the final bottle. Whereas the thickness distribution is one of the most important criteria in the production of bottles. So this work focused on the polyethylene terephthalate (PET) preform growth using a transparent mold, through which the instantaneous images of the preform in the stretching and blowing stage were captured. By changing the delay time of the preblow, the three preform growth types, referred to as dolphin, sandpile, and two-bubble, were observed. The longitudinal and hoop stresses acting on the preform segment during the stretching and blowing were analyzed. Two parameters, on which the longitudinal and hoop stresses depend, respectively, were defined. Then combining the geometry and sizes of the preform, the stresses and temperature distribution on it, and the stress,strain curves of the PET material used, the cause for different preform growth types was systematically analyzed. On the basis of preform growth types, the thickness distributions of the bottles obtained under different delay times of the preblow were explained. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 564,573, 2007 [source] Fabrication and surface modification of macroporous poly(L -lactic acid) and poly(L -lactic- co -glycolic acid) (70/30) cell scaffolds for human skin fibroblast cell cultureJOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 3 2002Jian Yang Abstract The fabrication and surface modification of a porous cell scaffold are very important in tissue engineering. Of most concern are high-density cell seeding, nutrient and oxygen supply, and cell affinity. In the present study, poly(L -lactic acid) and poly(L -lactic- co -glycolic acid) (70/30) cell scaffolds with different pore structures were fabricated. An improved method based on Archimedes' Principle for measuring the porosity of scaffolds, using a density bottle, was developed. Anhydrous ammonia plasma treatment was used to modify surface properties to improve the cell affinity of the scaffolds. The results show that hydrophilicity and surface energy were improved. The polar N-containing groups and positive charged groups also were incorporated into the sample surface. A low-temperature treatment was used to maintain the plasma-modified surface properties effectively. It would do help to the further application of plasma treatment technique. Cell culture results showed that pores smaller than 160 ,m are suitable for human skin fibroblast cell growth. Cell seeding efficiency was maintained at above 99%, which is better than the efficiency achieved with the common method of prewetting by ethanol. The plasma-treatment method also helped to resolve the problem of cell loss during cell seeding, and the negative effects of the ethanol trace on cell culture were avoided. The results suggest that anhydrous ammonia plasma treatment enhances the cell affinity of porous scaffolds. Mass transport issues also have been considered. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 62: 438,446, 2002 [source] Climbing Exercise Increases Bone Mass and Trabecular Bone Turnover Through Transient Regulation of Marrow Osteogenic and Osteoclastogenic Potentials in Mice,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 11 2003Toshiharu Mori Abstract To investigate the relationship between the effects of bone turnover and bone marrow cell development in bone cells, we developed a mouse voluntary climbing exercise model. Climbing exercise increased bone volume and transient osteogenic potential of bone marrow. This model would be suitable for investigating the mechanistic roles of mechanical loading. Introduction: The relationship between bone mass gain and local bone formation and resorption in mechanically loaded bone is not well understood. Materials and Methods: Sixty-five C57BL/6J mice, 8 weeks of age, were assigned to five groups: a baseline control and two groups each of ground control and climbing exercise mice for 2 and 4 weeks. Mice were housed in a 100-cm tower and had to climb toward a bottle placed at the top to drink water. Results: Compared with the ground control, bone mineral density of the left femur increased in the climbing mice at 4 weeks. At 2 and 4 weeks, bone formation rate (BFR/BS) of periosteal surface, the cross-sectional area, and moment of inertia were increased in the climbing mice, whereas BFR/BS and eroded surface (ES/BS) of endosteal surface did not differ. The trabecular bone volume (BV/TV) of the proximal tibia increased in climbing mice, and osteoclast surface (Oc.S/BS) and osteoclast number decreased at 2 weeks. At 4 weeks, there were increases in BV/TV and parameters of bone formation, including mineralized surface, mineral apposition rate, and bone formation rate. In marrow cell cultures from the tibia, the number of alkaline phosphatase+ colony forming units-fibroblastic and the area of mineralized nodule formation in climbing mice were increased, and the number of osteoclast-like TRACP+ multinucleated cells was lower at 2 weeks. At 4 weeks, these parameters recovered to the levels of the ground controls. Conclusion: Our results indicate that climbing increased trabecular bone volume and reduced bone resorption, with a subsequent increase in bone formation. Intermittent climbing downregulates marrow osteoclastogenic cells and upregulates osteogenic cells initially, but further exercise seemed to desensitize them. Cortical envelopes were enlarged earlier, but the response seems to differ from trabecular bone. [source] Interfacing biocatalysis and organic synthesis,JOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 12 2007Roland Wohlgemuth Abstract The path to new chemical entities often shows the limitations of existing tools both in biocatalysis and organic chemistry. Organic synthetic procedures to prepare a compound in a target-oriented synthesis can damage other functional parts of the molecule. Protection,deprotection schemes can lead to a dead end, when a certain protecting group cannot be cleaved off. In biocatalysis, on the other hand, the required biocatalytic toolbox and methodology might not be readily available, therefore limiting a biocatalytic approach. New toolboxes, ingredients, and methodologies at the interface of classical organic synthesis and biocatalytic reactions bridge the gap between these two areas. Since product isolation and purification involves a substantial amount of time in the preparation of chemicals, methodologies to simplify these tasks are necessary to get the pure product into the bottle with less work-up time. Efficient and safe new pharmaceuticals, intermediates and analytical reagents need to be prepared under certain safety, health, environmental and economical boundary conditions. Biocatalytic reactions have been shown to overcome these limitations successfully and are becoming increasingly important in industrial manufacturing. Building bridges between biocatalysis and organic synthesis will therefore create roads to new synthetic strategies and technological frontiers of both fundamental and practical interest. Copyright © 2007 Society of Chemical Industry [source] Anthocyanin Degradation of Blueberry,Aronia Nectar in Glass Compared with Carton during StorageJOURNAL OF FOOD SCIENCE, Issue 8 2008K. Tro ABSTRACT:, Blueberry,aronia nectar is known as a rich source of anthocyanins, which are mostly destroyed during commercial storage of the product. The factors influencing the rate of degradation are connected to the oxygen protection offered by the packaging, as well as the type of anthocyanidin and the amount of glycosylated sugar. The current study was aimed to compare the stability of total anthocyanin between glass and carton packaging as well as to determine the stability of individual anthocyanin with respect to aglycone and glycosylated sugar. The degradation rate of total anthocyanin degradation rate was 22% higher in carton packaging than glass bottle. The ranking order of the stability of individual anthocyanin with respect to aglycone was as follows (from the most to least stable): cyanindin > peonidin > petunidin > malvidin = delphinidin. The ranking order of the stability of anthocyanins with respect to glycosylated sugars was as follows (from the most to least stable): glucose > galactose > arabinose. As individual anthocyanins have different degradation rates this study can be used to determine the most stable natural colorant and the most sensitive antioxidant among the anthocyanins tested. [source] Ghrelin Receptor Antagonism Decreases Alcohol Consumption and Activation of Perioculomotor Urocortin-Containing NeuronsALCOHOLISM, Issue 9 2010Simranjit Kaur Background:, The current therapies for alcohol abuse disorders are not effective in all patients, and continued development of pharmacotherapies is needed. One approach that has generated recent interest is the antagonism of ghrelin receptors. Ghrelin is a gut-derived peptide important in energy homeostasis and regulation of hunger. Recent studies have implicated ghrelin in alcoholism, showing altered plasma ghrelin levels in alcoholic patients as well as reduced intakes of alcohol in ghrelin receptor knockout mice and in mice treated with ghrelin receptor antagonists. The aim of this study was to determine the neuroanatomical locus/loci of the effect of ghrelin receptor antagonism on alcohol consumption using the ghrelin receptor antagonist, D-Lys3-GHRP-6. Methods:, In Experiment 1, male C57BL/6J mice were injected with saline 3 hours into the dark cycle and allowed access to 15% (v/v) ethanol or water for 2 hours in a 2-bottle choice experiment. On test day, the mice were injected with either saline or 400 nmol of the ghrelin receptor antagonist, D-Lys3-GHRP-6, and allowed to drink 15% ethanol or water for 4 hours. The preference for alcohol and alcohol intake were determined. In Experiment 2, the same procedure was followed as in Experiment 1 but mice were only allowed access to a single bottle of 20% ethanol (v/v), and alcohol intake was determined. Blood ethanol levels were analyzed, and immunohistochemistry for c-Fos was carried out to investigate changes in neural activity. To further elucidate the mechanism by which D-Lys3-GHRP-6 affects alcohol intake, in Experiment 3, the effect of D-Lys3-GHRP-6 on the neural activation induced by intraperitoneal ethanol was investigated. For the c-Fos studies, brain regions containing ghrelin receptors were analyzed, i.e. the perioculomotor urocortin population of neurons (pIIIu), the ventral tegmental area (VTA), and the arcuate nucleus (Arc). In Experiment 4, to test if blood ethanol concentrations were affected by D-Lys3-GHRP-6, blood samples were taken at 2 time-points after D-Lys3-GHRP-6 pretreatment and systemic ethanol administration. Results:, In Experiment 1, D-Lys3-GHRP-6 reduced preference to alcohol and in a follow-up experiment (Experiment 2) also dramatically reduced alcohol intake when compared to saline-treated mice. The resulting blood ethanol concentrations were lower in mice treated with the ghrelin receptor antagonist. Immunohistochemistry for c-Fos showed fewer immunopositive cells in the pIIIu of the antagonist-treated mice but no difference was seen in the VTA or Arc. In Experiment 3, D-Lys3-GHRP-6 reduced the induction of c-Fos by intraperitoneal ethanol in the pIIIu but had no effect in the VTA. In the Arc, there was a significant increase in the number of c-Fos immunopositive cells after D-Lys3-GHRP-6 administration, but the antagonist had no effect on ethanol-induced expression of c-Fos. D-Lys3-GHRP-6-pretreatment also did not affect the blood ethanol concentrations observed after a systemic injection of ethanol when compared to saline-pretreated mice (Experiment 4). Conclusions:, These findings indicate that the action of ghrelin on the regulation of alcohol consumption may occur via the pIIIu. [source] In-vitro release of bupivacaine from injectable lipid formulations investigated by a single drop technique , relation to duration of action in-vivoJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 6 2002Lars Söderberg The aim of this study was to develop an in-vitro release method suitable for injectable slow-release lipid formulations of local anaesthetics (or other drugs). We also aimed that the results of the in-vitro measurements should have a clear relationship to duration of action in-vivo. Six formulations of bupivacaine base in medium-chain triglyceride-glyceryl dilaurate mixtures were developed. A new apparatus was constructed for determination of their in-vitro release profiles. A bulbous glass tube was fixed inside a standard glass bottle, which was then filled with release medium. A stirring magnet was enclosed in the perforated polypropylene cylinder holding the glass tube. The stirring created a continuous, rotating downward flow of medium inside the tube, which kept the lipid phase, introduced by means of a syringe, suspended as a single, free drop. Release profiles were obtained by sampling of the release medium for up to 72 h and analysis by gas-liquid chromatography. The duration of action in-vivo of the respective formulations was tested by the hot-plate method in rats. The release profiles of bupivacaine in-vitro were mono-exponential for four formulations and bi-exponential for the other two. There was a positive correlation between the proportion of glyceryl dilaurate in the formulation and the slow half-life of release of bupivacaine. All formulations showed prolonged duration of action in-vivo, median values within the range 4.5,12 h, as compared with a 2-h effect of bupivacaine hydrochloride solution. A comparison of in-vitro release curves and durations of action in-vivo suggested that to maintain nerve blockade in-vivo the formulations must release bupivacaine at a rate of approximately 350 ,g h,1 under the in-vitro conditions. To conclude, we designed and tested a novel apparatus for measuring release of a local anaesthetic (or other drug) from a fluid or semi-solid formulation in-vitro. Release rates obtained in-vitro by means of this technique may be used to guide the development of formulations with suitable durations of action in-vivo. The apparatus is, however, as yet a prototype. Rigorous evaluation of performance should be carried out on devices built to specific standards according to their intended application. [source] Glycine Receptors in the Nucleus Accumbens Involved in the Ethanol Intake-Reducing Effect of AcamprosateALCOHOLISM, Issue 1 2010PeiPei Chau Background:, We have previously demonstrated that strychnine-sensitive glycine receptors (GlyRs) in the nucleus accumbens (nAc) and nicotinic acetylcholine receptors (nAChRs) in the ventral tegmental area are involved in mediating ethanol (EtOH)-induced elevation of dopamine in the rat mesolimbic dopamine system. This neuronal circuitry was also demonstrated to mediate dopamine elevation in the nAc after both taurine, an endogenous agonist of GlyRs, and acamprosate, a synthetic derivate of homotaurine. The aim of this study was to investigate whether the EtOH intake-reducing effect of acamprosate involves accumbal GlyRs. Methods:, For this purpose, we used a voluntary EtOH consumption model where EtOH medium- and high-preferring rats were implanted with guide cannulae in the nAc. The animals received daily injections of acamprosate or 0.9% NaCl before accessing a bottle of 6% EtOH and a bottle of water. After 2 days, a microinjection of strychnine or vehicle preceded the daily systemic injection and bottle-access period. Results:, Acamprosate, but not saline, decreased EtOH intake. Pretreatment with Ringer in the nAc did not influence EtOH intake in saline or acamprosate-treated animals. Pretreatment with strychnine had no effect on EtOH intake in saline-treated animals, whereas it completely reversed the EtOH intake-reducing effect of acamprosate. Conclusions:, Based on current and previous results, we suggest that acamprosate primarily interacts with accumbal GlyRs and secondarily with ventral tegmental nAChRs, in a similar manner to that previously observed with EtOH and taurine. The interaction between acamprosate and GlyRs does not only influence dopamine output in the nAc but also EtOH consumption, giving further support for our hypothesis that GlyRs are of importance in EtOH reinforcement. [source] Availability and Characteristics of Nonbeverage Alcohols Sold in 17 Russian Cities in 2007ALCOHOLISM, Issue 1 2009Artyom Gil Background:, It is known that a range of nonbeverage alcohols including eau-de-colognes and medicinal tinctures are consumed by sections of the Russian population. Research conducted in a city in the Urals (2003 to 2005) showed that consumption of such products is associated with very high mortality from a wide range of causes. However, there have been no systematic attempts to investigate the extent to which such products are available in other cities of the Russian Federation. There is particular interest in establishing this following the introduction of new federal regulations in January 2006 aimed at restricting the availability of these products. Methods:, In the first half of 2007, we conducted a survey in 17 cities that spanned the full range of city types in the Russian Federation excluding those in the Far East. In each city, fieldworkers visited pharmacies and other types of retail outlets and purchased samples of nonbeverage alcohols. These were defined as being typically 10 to 15 roubles per bottle, with an ethanol concentration of at least 60% by volume. Results:, We were able to purchase samples of nonbeverage alcohols in each of the 17 cities we investigated. The majority of the 271 products included were a cheaper and more affordable source of ethanol than standard Russian vodka. Medicinal tinctures, sold almost exclusively in pharmacies, were particularly common with an average concentration of 78% ethanol by volume. Most importantly, the majority of the products were of a sort that our previous research in 2004 to 2005 had established were drunk by working-age men. Conclusions:, While the 2006 federal regulations introduced in part to reduce the availability and consumption of nonbeverage alcohols may have had some effect on certain classes of nonmedicinal products, up until June 2007 at least, medicinal tinctures as well as some other nonbeverage alcohols that are consumed appear to have been readily available. [source] Blockade of the Corticotropin Releasing Factor Type 1 Receptor Attenuates Elevated Ethanol Drinking Associated With Drinking in the Dark ProceduresALCOHOLISM, Issue 2 2008Dennis R. Sparta Background:, Drinking in the dark (DID) procedures have recently been developed to induce high levels of ethanol drinking in C57BL/6J mice, which result in blood ethanol concentrations (BECs) reaching levels that have measurable affects on physiology and/or behavior. The present experiments determined whether the increased ethanol drinking caused by DID procedures can be attenuated by pretreatment with CP-154,526; a corticotropin releasing factor type-1 (CRF1) receptor antagonist. Methods:, In Experiment 1, male C57BL/6J mice received ethanol (20% v/v) in place of water for 4 hours, beginning with 3 hours into the dark cycle. On the fourth day, mice were given an intraperitoneal injection of one of the 4 doses of CP-154,526 (0, 1, 3, 10 mg/kg) 30 minutes before receiving their ethanol bottle. In Experiment 2, C57BL/6J mice had 2 hours of access to the 20% ethanol solution, beginning with 3 hours into the dark cycle on days 1 to 3, and 4 hours of access to the ethanol bottle on day 4 of DID procedures. Mice were given an intraperitoneal injection of one of the 4 doses of CP-154,526 (0, 1, 3, 10 mg/kg) 30 minutes before receiving their ethanol bottle on day 4. Tail blood samples were collected immediately after the 4-hour ethanol access period on the fourth day of each experiment. Additional control experiments assessed the effects of CP-154,526 on 4-hour consumption of a 10% (w/v) sucrose solution and open-field locomotor activity. Results:, In Experiment 1, the vehicle-treated group consumed approximately 4.0 g/kg/4 h of ethanol and achieved BECs of approximately 30 mg%. Furthermore, pretreatment with the CRF1 receptor antagonist did not alter ethanol consumption. On the other hand, procedures used in Experiment 2 resulted in vehicle-treated mice consuming approximately 6.0 g/kg/4 h of ethanol with BECs of about 80 mg%. Additionally, the 10 mg/kg dose of CP-154,526 significantly reduced ethanol consumption and BECs to approximately 3.0 g/kg/4 h and 27 mg%, respectively, relative to vehicle-treated mice. Importantly, the 10 mg/kg dose of the CRF1R antagonist did not significantly alter 4-hour sucrose consumption or locomotor activity. Conclusions:, These data indicate that CRF1R signaling modulates high, but not moderate, levels of ethanol drinking associated with DID procedures. [source] CURRENT-STATUS SURVIVAL ANALYSIS METHODOLOGY APPLIED TO ESTIMATING SENSORY SHELF LIFE OF READY-TO-EAT LETTUCE (LACTUCA SATIVA)JOURNAL OF SENSORY STUDIES, Issue 2 2008MABEL ARANEDA ABSTRACT The objective of the present work was to develop a method for predicting sensory shelf life for situations in which each consumer evaluates only one sample corresponding to one storage time. This type of data is known as current-status data in survival analysis statistics. The methodology was applied to estimate the sensory shelf life of ready-to-eat lettuce (Lactuca sativa var. capitata cv."Alpha"). For each of six storage times, 50,52 consumers answered yes or no to whether they would normally consume the presented sample. The results were satisfactory, showing that the methodology can be applied when necessary. The Weibull model was found adequate to model the data. Estimated shelf lives ± 95% confidence intervals were 11.3 ± 1.2 days and 15.5 ± 0.9 days for a 25% and a 50% consumer rejection probability, respectively. PRACTICAL APPLICATIONS When considering shelf-life evaluations by consumers, the first idea is to have each consumer evaluate six or seven samples with different storage times in a single session. To do this, a reverse storage design is necessary, and in the case of a product such as lettuce, it would lead to different batches being confused with storage times. The methodology proposed in this article avoids this problem by having each consumer evaluate a single sample. Another issue with consumers tasting several samples in a single session is how representative this situation is of real consumption. The present methodology allows for a consumer to take home, e.g., a bottle of beer with an established storage time, and later collecting the information as to whether they found the beer acceptable or not. This is a situation much closer to real consumption. [source] Ethanol as a Reinforcer in the Newborn's First Suckling ExperienceALCOHOLISM, Issue 3 2001Sarah J. Cheslock Background: Recent evidence suggests that human infants prefer alcohol-flavored milk when fed through a bottle. Animal models also indicate a surprising predisposition for neonatal and infant rats to voluntarily and willingly ingest ethanol. These findings suggest high susceptibility to the reinforcing properties of ethanol early in ontogeny. Methods: A surrogate nipple technique,a highly effective tool for investigation of the reinforcing properties of different fluids,was applied in the present study. Tests of ethanol reinforcement were accomplished in terms of two basic paradigms of Pavlovian conditioning. In one paradigm, the conditioned stimulus (CS) was the surrogate nipple, and in the other, the CS was a novel odor. Results: Newborn rats showed sustained attachment to the nipple providing 5% ethanol, and later reproduced this behavioral pattern toward the empty nipple (CS alone). Ingestion of ethanol yielding appetitive reinforcement was accompanied by detectable blood alcohol concentrations, with most in the range of 20,30 mg/dl. The reinforcing efficacy of ethanol was also confirmed in the classical olfactory conditioning paradigm: following pairing with intraoral ethanol infusions, the odor (CS) alone elicited sustained attachment to an empty nipple. Females showed better olfactory conditioning with low concentrations of ethanol, whereas males were effectively more conditioned to high concentrations. Although there were no reinforcing consequences of intraperitoneally injected ethanol [as an unconditioned stimulus (US)] when a neutral odor was the CS, when paired with ingestion of water from a nipple, the injection of ethanol had a reinforcing effect. Conclusions: The present series of experiments revealed ethanol reinforcement in the newborn rat. Two varieties of Pavlovian conditioning established that ethanol can serve as an effective US, and hence reinforcer, in such a way as to increase the approach and responsiveness toward stimuli paired with that US, indicating appetitive reinforcement. [source] Infant feeding in the neonatal unitMATERNAL & CHILD NUTRITION, Issue 4 2010Rhona J. McInnes Abstract Infants admitted to a neonatal unit (NNU) are frequently unable to feed by breast or bottle because of ill health or prematurity. These infants require nutritional support until they can start oral feeding. Breastfeeding is advocated for these infants, and mothers are frequently encouraged to express breast milk to be fed via the enteral tube. However, by discharge, breastfeeding rates tend to be low. Oral feeding requires careful management, and although practices may vary because of clinical need, some may be informed by unit norms. There is limited evidence for effective breastfeeding support in this environment and little exploration of the effect of routine feeding decisions. This study aimed to explore feeding decisions and considered how these might affect outcomes. The staff in the two large urban NNUs who participated in the feeding decisions were interviewed and the data were analysed using a theoretical framework. Feeding decisions were made mainly by the unit staff, with limited parental involvement. Subsequent management varied, with differences being related to staff experience and beliefs, unit norms, parent's expectations and physical constraints within the unit. The staff were overtly supportive of breastfeeding, but the need to monitor and quantify milk intake may undermine breastfeeding. Furthermore, feeding breastfed infants during the mothers' absence was controversial and provoked debate. There is a need for clear guidelines and increased parental involvement in feeding decisions. Routine practices within the system may discourage mothers from initiating and persisting with breastfeeding. A change in unit culture is required to fully support the parent's feeding choices. [source] Effect of local application of cold or heat for relief of pricking painNURSING & HEALTH SCIENCES, Issue 3 2002Yuka Saeki RN, phdArticle first published online: 17 SEP 200 Abstract The present study was designed to determine the effect of the application of cold or heat on the sensation of pricking pain based on autonomic responses. Electrical stimulation was applied to the antebrachium or brachium of subjects as an artificial pricking pain, and skin blood flow (BF) and skin conductance level (SCL) at the fingertip were measured. Pain sensation was evaluated using the visual analog scale. Pain stimulation produced a significant increase in SCL and a significant decrease in BF at both the antebrachium and brachium. Application of cold to the stimulation site using an ice-water pack reduced BF and SCL responses and pain sensation. Application of heat using a hot water bottle caused a significant increase in pain sensation and enhancement of BF and SCL responses. These results suggest that application of cold promotes relief of pricking pain sensation and suppression of autonomic responses, and that application of heat has no such effect. It is important that nurses ascertain the type of pain or source of pain and take proper measures for its relief. [source] Quality of orange juice in barrier packaging materialPACKAGING TECHNOLOGY AND SCIENCE, Issue 5 2008C. Berlinet Abstract The vitamin C content and the colour of orange juice made from concentrate were measured during 9 months of storage at 20°C either under artificial light or in darkness. The packaging materials used were glass, standard monolayer polyethylene terephthalate (PET) and multilayer PET (PET/nylon and oxygen scavenger/PET) containers. In this experiment, all bottles were sealed with aluminium foil in order to avoid any cap effect. The results showed that in plastic packaging materials, the loss of vitamin C was related to the oxygen permeability, and that glass provided the best preservation of ascorbic acid. No statistical difference (p < 0.05) was revealed between the vitamin C content in the juice stored under artificial light or in darkness, whatever the packaging used. The modification of colour was studied with the L, a* and b* values during storage at 20°C under artificial light. L and b* decreased, revealing a reduction of lightness and yellow colour of the juice, whereas a* increased, due to the formation of brown pigments. This change in colour was partly related to the oxygen permeability of the packaging used. The losses of aroma compounds by permeation through the bottle (PET) and the cap (high-density polyethylene, HDPE) have also been investigated. The results showed that permeation mainly took place through the cap. The use of a multilayer cap [HDPE with internal barrier layer of low-density polyethylene (LDPE)/EvOH/LDPE] considerably limited the permeation of the aroma compounds studied, whatever the PET bottle used. Copyright © 2007 John Wiley & Sons, Ltd. [source] Influence of PET bottle weight, closure performance and filling Technique on the oxygen content of soya cooking oilPACKAGING TECHNOLOGY AND SCIENCE, Issue 5 2001Léa Mariza de Oliveira Abstract The use of PET bottles for edible oil in Brazil is increasing but there is a trend to reduce bottle weight for economic reasons, which decreases the oxygen barrier of the package. The barrier performance of a 20,g PET bottle for 900,ml soya oil, submitted to gas flushing with gaseous N2 and pressurization with liquid N2, was compared with a 27,g PET conventional bottle. During 8 months storage at 25°C the internal pressure, dissolved oxygen and oxygen in the headspace were evaluated and did not change significantly. Liquid N2 pressurization did not improve the efficiency of reducing O2 in the headspace compared to N2 gas flushing. Copyright © 2001 John Wiley & Sons, Ltd. [source] Treatment of perennial allergic rhinitis with lactic acid bacteriaPEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 2 2004Ming Fuu Wang Probiotics are perceived to exert beneficial effects in the prevention and treatment of allergic diseases via modifying the gut ecosystem. The aim of this study was to assess whether ingestion of fermented milk containing Lactobacillus paracasei-33 (LP-33), a strain newly isolated from the human intestinal tract, can improve the quality of life of patients with perennial allergic rhinitis. In a randomized, double-blind, placebo-controlled trial, we gave patients fermented milk with (n = 60) or without (n = 20) the addition of LP-33 (2 × 109 colony-forming units per bottle) for 30 days. A modified questionnaire concerning pediatric rhinoconjunctivitis quality of life was administered to all subjects or their parents at each clinical visit. Scores for the overall quality of life significantly decreased in the LP-33 group as compared with the placebo group, in both frequency (,16.02 ± 2.14 vs. ,7.27 ± 3.55, respectively; p = 0.037) and level of bother (,16.35 ± 2.33 vs. ,6.20 ± 3.13, respectively; p = 0.022) after the 30-day treatment. Subjects reported no severe adverse effects such as fever, abdominal pain, or diarrhea. The results suggest that ingestion of LP-33-fortified fermented milk for 30 days can effectively and safely improve the quality of life of patients with allergic rhinitis, and may serve as an alternative treatment for allergic rhinitis. [source] A 500-ml plastic bottle: An effective spacer for children with asthmaPEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 3 2002Heather J. Zar Inhaled therapy using a metered-dose inhaler (MDI) with attached spacer has been increasingly recognized as the optimal method for delivering asthma medication for acute attacks and chronic prophylaxis. However, in developing countries the cost and availability of commercially produced spacers limit the use of MDI-spacer delivery systems. A 500-ml plastic bottle has been recently adapted to function as a spacer. This article reviews the current data on the efficacy of this bottle-spacer and discusses its advantages and limitations. It is concluded that a modified 500-ml plastic bottle is an effective spacer; modification and use of this device should be incorporated into international guidelines for the management of children with asthma. [source] Environmental stress cracking behavior of bottle and fiber grade poly(ethylene terephthalate) in contact with aqueous amine solutionsPOLYMER ENGINEERING & SCIENCE, Issue 10 2008Nadir de B. Sanches The environmental stress cracking (ESC) resistance of commercial virgin bottle and fiber grade poly(ethylene terephthalate) (PET) in contact with aqueous amine solutions was investigated. The ESC resistance, in terms of time to failure, was evaluated taking into account some factors, such as test temperature, molar volume (Vo) of the ESC agent, and molecular weight and degree of crystallinity (Xc) of PET. The specimens were tested in flexural mode using a constant load flexural creep test apparatus and also in tensile mode using a dynamometer. After the creep tests, the specimens were photographed with a digital camera and analyzed by scanning electron microscopy (SEM). It was found that ESC resistance was higher with the increase of ESC agent molar volume as well as with the increase of molecular weight and degree of crystallinity of PET. The highest temperature (60°C) lowered the ESC resistance of the specimens, except for the crystalline specimens in n -butylamine that exhibited a higher ESC resistance at 60°C, which can probably be attributed to the induced crystallization of the remaining amorphous phase by the plasticizing effect of n -butylamine. POLYM. ENG. SCI., 2008. © 2008 Society of Plastics Engineers [source] Old wine in a new bottle?ANAESTHESIA, Issue 9 2002Article first published online: 20 AUG 200 No abstract is available for this article. [source] | ||||||||||||||||||||||||||||