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Block Copolymer Nanoparticles (block + copolymer_nanoparticle)
Selected AbstractsAmphiphilic Block Copolymers Bearing Ortho Ester Side-Chains: pH-Dependent Hydrolysis and Self-Assembly in WaterMACROMOLECULAR BIOSCIENCE, Issue 2 2010Rupei Tang Abstract A new type of pH-responsive block copolymer nanoparticle has been synthesized and characterized. The amphiphilic diblock copolymer, PEG- b -PMYM, contains acid-labile ortho ester side-chains in the hydrophobic block and can self-assemble into micelle-like nanoparticles in water at neutral pH. Hydrolysis of the ortho ester side-chains follows a distinct exocyclic mechanism and shows pH-dependent kinetics, which triggers changes in nanoparticle size and morphology. The nanoparticles have been found to be non-toxic to cells in vitro. The ability to tune the size and morphology of biocompatible block copolymer nanoparticles by controlling the pH-sensitive side-chain hydrolysis represents a unique approach that may be exploited to improve the efficacy of nanometer-scale drug delivery. [source] Biofunctionalized block copolymer nanoparticles based on ring-opening metathesis polymerizationJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 2 2006Alvaro Carrillo Abstract We present an approach to the synthesis of biofunctionalized block copolymer nanoparticles based on ring-opening metathesis polymerization; these nanoparticles may serve as novel scaffolds for the multivalent display of ligands. The nanoparticles are formed by the self-assembly of diblock copolymers composed of a hydrophobic block and a hydrophilic activated block that can be functionalized with thiolated ligands in aqueous media. The activated block enables control over the orientation of the displayed ligands, which may be sugars, peptides, or proteins engineered to contain cysteine residues at suitable locations. The nanoparticle diameter can be varied over a wide range through changes in the composition of the block copolymer, and biofunctionalization of the nanoparticles has been demonstrated by the attachment of a peptide previously shown to inhibit the assembly of anthrax toxin. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 928,939, 2006 [source] Amphiphilic Block Copolymers Bearing Ortho Ester Side-Chains: pH-Dependent Hydrolysis and Self-Assembly in WaterMACROMOLECULAR BIOSCIENCE, Issue 2 2010Rupei Tang Abstract A new type of pH-responsive block copolymer nanoparticle has been synthesized and characterized. The amphiphilic diblock copolymer, PEG- b -PMYM, contains acid-labile ortho ester side-chains in the hydrophobic block and can self-assemble into micelle-like nanoparticles in water at neutral pH. Hydrolysis of the ortho ester side-chains follows a distinct exocyclic mechanism and shows pH-dependent kinetics, which triggers changes in nanoparticle size and morphology. The nanoparticles have been found to be non-toxic to cells in vitro. The ability to tune the size and morphology of biocompatible block copolymer nanoparticles by controlling the pH-sensitive side-chain hydrolysis represents a unique approach that may be exploited to improve the efficacy of nanometer-scale drug delivery. [source] | ||||||||||