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Bioactive Natural Products (bioactive + natural_products)
Selected AbstractsScreening by NMR: A New Approach for the Study of Bioactive Natural Products?EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 7 2005The Example of Pleurotus ostreatus Hot Water Extract Abstract Direct NMR screening of natural products obtained from hot water extracts of medicinal species is accomplished through STD and tr-NOESY experiments on a crude mixture and a given protein receptor. It is shown, with use of a mushroom extract as model case, that this protocol may provide a fast and simple method, particularly useful in natural products chemistry, through which to detect the presence of ligands for a target receptor. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source] Medicinal Chemistry of Bioactive Natural Products.CHEMMEDCHEM, Issue 2 2007Edited by Xiao-Tian Liang, Wei-Shuo Fang. No abstract is available for this article. [source] Bioactive natural products from soil microorganismsENVIRONMENTAL MICROBIOLOGY, Issue 4 2000Web alert No abstract is available for this article. [source] Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosisMEDICINAL RESEARCH REVIEWS, Issue 5 2008Masami Ishibashi Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive natural products from various natural resources such as plants and microorganisms, we recently identified several natural products which exhibited activities related to TRAIL signaling. Dimeric sesquiterpenoids isolated from Zingiberaceous plant, Curcuma parviflora, showed enhancement activity of gene expression of TRAIL-receptor and TRAIL-receptor protein level. Several new isoflavone natural products, named brandisianins, were isolated from Leguminosaeous plant, Millettia brandisiana, by our screening study targeting TRAIL-receptor expression enhancement activity. A dihydroflavonol (BB1) that was extracted from Compositaeous plant, Blumea balsamifera, and fuligocandin B, a new anthranilylproline-indole alkaloid isolated from myxomycete were found to exhibit reversal effect of TRAIL resistance activity. © 2008 Wiley Periodicals, Inc. Med Res Rev, 28, No. 5, 688,714, 2008 [source] Marine cytotoxic macrolides haterumalides and biselides, and related natural productsTHE CHEMICAL RECORD, Issue 4 2007Hideo Kigoshi Abstract Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products. © 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 7: 254,264; 2007: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.20119 [source] Wirkstoffe auf Basis biologisch aktiver NaturstoffeCHEMIE IN UNSERER ZEIT (CHIUZ), Issue 5 2007Jörg Heilmann Prof. Dr. Im Bereich der Wirkstoffsuche sind Naturstoffe unverzichtbar. Problematisch bei der Gewinnung von Naturstoffen sind die Beschaffung des biologischen Materials, die Auffindung und Isolierung aus einer inaktiven oder sogar die biologische Testung störenden Matrix und die Gewinnung ausreichender Mengen zur chemischen und pharmakologischen Charakterisierung bzw. für die klinische Nutzung. Oft stellen Naturstoffe ideale Leitstrukturen für die synthetische oder semisynthetische Entwicklung von Wirkstoffen dar. Besonders attraktiv sind Naturstoffe dann, wenn die biologische Quelle erneuerbar bzw. sogar in Kultur modifizierbar ist. Dies ist ein wesentlicher Aspekt für die gegenwärtige Attraktivität der Wirkstoffsuche in Mikroorganismen wie Bakterien und Pilzen. Diese können im Idealfall nicht nur in Fermentern kultiviert, sondern dort auch genetisch so verändert werden, dass neuartige Strukturen entstehen. The potential of natural products as sources for new drugs and lead structures is still largely unexplored and due to their unmatched structural diversity, secondary natural products continue to play a highly significant role in drug discovery. This article gives an overview on different strategies, chemical and biological methods as well as limiting problems for the search, screening, isolation and characterization of bioactive natural products from different sources. Ecological aspects and the importance of biodiversity and sustainable sourcing are also discussed. [source] Marine Drugs , MacrolactinsCHEMISTRY & BIODIVERSITY, Issue 9 2008Xiao-Ling Lu Abstract The increasing demands for new lead compounds in pharmaceutical and agrochemical industries have driven scientists to search for new bioactive natural products. Marine microorganisms are rich sources of novel, bioactive secondary metabolites, and have attracted much attention of chemists, pharmacologists, and molecular biologists. This mini-review mainly focuses on macrolactins, a group of 24-membered lactone marine natural products, aiming at giving an overview on their sources, structures, biological activities, as well as their potential medical applications. [source] | ||||||||||||||||||||||